IT201900009489A1 - Analoghi della temporina l con attivita' antiinfiammatoria e antimicrobica - Google Patents

Analoghi della temporina l con attivita' antiinfiammatoria e antimicrobica

Info

Publication number
IT201900009489A1
IT201900009489A1 IT102019000009489A IT201900009489A IT201900009489A1 IT 201900009489 A1 IT201900009489 A1 IT 201900009489A1 IT 102019000009489 A IT102019000009489 A IT 102019000009489A IT 201900009489 A IT201900009489 A IT 201900009489A IT 201900009489 A1 IT201900009489 A1 IT 201900009489A1
Authority
IT
Italy
Prior art keywords
temporina
analogs
inflammatory
antimicrobial activity
antimicrobial
Prior art date
Application number
IT102019000009489A
Other languages
English (en)
Inventor
Nicola Mascolo
Francesco Maione
Alfonso Carotenuto
Ettore Novellino
Francesco Merlino
Rosa Bellavita
Elisabetta Buommino
Paolo Grieco
Original Assignee
Usp Union Of Pharmaceutical Sciences S R L
Paolo Grieco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Usp Union Of Pharmaceutical Sciences S R L, Paolo Grieco filed Critical Usp Union Of Pharmaceutical Sciences S R L
Priority to IT102019000009489A priority Critical patent/IT201900009489A1/it
Publication of IT201900009489A1 publication Critical patent/IT201900009489A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/463—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from amphibians
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
IT102019000009489A 2019-06-19 2019-06-19 Analoghi della temporina l con attivita' antiinfiammatoria e antimicrobica IT201900009489A1 (it)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IT102019000009489A IT201900009489A1 (it) 2019-06-19 2019-06-19 Analoghi della temporina l con attivita' antiinfiammatoria e antimicrobica

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102019000009489A IT201900009489A1 (it) 2019-06-19 2019-06-19 Analoghi della temporina l con attivita' antiinfiammatoria e antimicrobica

Publications (1)

Publication Number Publication Date
IT201900009489A1 true IT201900009489A1 (it) 2020-12-19

Family

ID=68073101

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102019000009489A IT201900009489A1 (it) 2019-06-19 2019-06-19 Analoghi della temporina l con attivita' antiinfiammatoria e antimicrobica

Country Status (1)

Country Link
IT (1) IT201900009489A1 (it)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202100027173A1 (it) * 2021-10-22 2023-04-22 Rosaria Santangelo Peptidi antimicrobici come conservanti ed effetti sul microbioma umano e animale
IT202100029738A1 (it) * 2021-11-24 2023-05-24 Pharma Biomateck Srl Peptide ad attività antimicotica e antibatterica

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
A. GIACOMETTI ET AL: "Interaction of Antimicrobial Peptide Temporin L with Lipopolysaccharide In Vitro and in Experimental Rat Models of Septic Shock Caused by Gram-Negative Bacteria", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 50, no. 7, 26 June 2006 (2006-06-26), US, pages 2478 - 2486, XP055663943, ISSN: 0066-4804, DOI: 10.1128/AAC.01553-05 *
ELISABETTA BUOMMINO ET AL: "The Outcomes of Decorated Prolines in the Discovery of Antimicrobial Peptides from Temporin-L", CHEMMEDCHEM, vol. 14, no. 13, 3 June 2019 (2019-06-03), DE, pages 1283 - 1290, XP055663945, ISSN: 1860-7179, DOI: 10.1002/cmdc.201900221 *
F. JAVIER CABANES: "Malassezia yeasts: how many species infect humans and animals?", PLOS PATHOGENS, vol. 10, 2014, pages e1003892
F. MERLINOA. CAROTENUTOB. CASCIAROF. MARTORAM. R. LOFFREDOR. DI GRAZIAA. M. YOUSIFD. BRANCACCIOL. PALOMBAE. NOVELLINO: "Glycine-replaced derivatives of [Pro3,DLeu9]TL, a temporin L analogue: Evaluation of antimicrobial, cytotoxic and hemolytic activities", EUR. J. MED. CHEM., vol. 139, 2017, pages 750 - 761
FRANCESCO MERLINO ET AL: "Glycine-replaced derivatives of [Pro 3, DLeu 9]TL, a temporin L analogue: Evaluation of antimicrobial, cytotoxic and hemolytic activities", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 139, October 2017 (2017-10-01), AMSTERDAM, NL, pages 750 - 761, XP055663567, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2017.08.040 *
J. DAVIES, D. DAVIES: "Microbiol. Origins and evolution of antibiotic resistance", MOL. BIOL. REV., vol. 74, 2010, pages 417 - 433
K. E. GREBERM. G. DAWGUL: "Antimicrobial Peptides Under Clinical Trials", CURR. TOP. MED. CHEM., vol. 17, 2016, pages 620 - 628
M. L. MANGONI: "Temporins, anti-infective peptides with expanding properties", CELL. MOL. LIFE SCI., vol. 63, 2006, pages 1060 - 1069, XP019419142, doi:10.1007/s00018-005-5536-y
M. L. MANGONIA. C. RINALDIA. D. GIULIOG. MIGNOGNAA. BOZZID. BARRAM. SIMMACO: "Structure-function relationships of temporins, small antimicrobial peptides from amphibian skin", EUR. J. BIOCHEM., vol. 267, 2000, pages 1447 - 1454
M. MAHLAPUUJ. HAKANSSONL. RINGSTADC. BJGRN: "Antimicrobial Peptides: An Emerging Category of Therapeutic Agents", FRONT. CELL. INFECT. MICROBIOL., vol. 6, 2016, pages 194
MARIA LUISA MANGONI ET AL: "Structure-Activity Relationship, Conformational and Biological Studies of Temporin L Analogues", JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, no. 5, 10 March 2011 (2011-03-10), US, pages 1298 - 1307, XP055663559, ISSN: 0022-2623, DOI: 10.1021/jm1012853 *
PAOLO GRIECO ET AL: "The effect of d-amino acid substitution on the selectivity of temporin L towards target cells: Identification of a potent anti-Candida peptide", BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - BIOMEMBRANES, vol. 1828, no. 2, February 2013 (2013-02-01), AMSTERDAM, NL, pages 652 - 660, XP055663583, ISSN: 0005-2736, DOI: 10.1016/j.bbamem.2012.08.027 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202100027173A1 (it) * 2021-10-22 2023-04-22 Rosaria Santangelo Peptidi antimicrobici come conservanti ed effetti sul microbioma umano e animale
IT202100029738A1 (it) * 2021-11-24 2023-05-24 Pharma Biomateck Srl Peptide ad attività antimicotica e antibatterica

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