IT201800005451A1 - PROCEDURE FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION FROM ORGANIC SUBSTRATES AND THE COMPOSITION SO OBTAINED - Google Patents
PROCEDURE FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION FROM ORGANIC SUBSTRATES AND THE COMPOSITION SO OBTAINED Download PDFInfo
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- IT201800005451A1 IT201800005451A1 IT102018000005451A IT201800005451A IT201800005451A1 IT 201800005451 A1 IT201800005451 A1 IT 201800005451A1 IT 102018000005451 A IT102018000005451 A IT 102018000005451A IT 201800005451 A IT201800005451 A IT 201800005451A IT 201800005451 A1 IT201800005451 A1 IT 201800005451A1
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- mixture
- organic substrate
- maceration
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- 238000000034 method Methods 0.000 title claims description 36
- 239000000203 mixture Substances 0.000 title claims description 34
- 239000000758 substrate Substances 0.000 title claims description 34
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 14
- 238000002360 preparation method Methods 0.000 title claims description 10
- 238000000605 extraction Methods 0.000 claims description 17
- 238000002803 maceration Methods 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 13
- 239000002904 solvent Substances 0.000 claims description 9
- 235000006965 Commiphora myrrha Nutrition 0.000 claims description 7
- 240000001812 Hyssopus officinalis Species 0.000 claims description 7
- 235000010650 Hyssopus officinalis Nutrition 0.000 claims description 7
- 240000009023 Myrrhis odorata Species 0.000 claims description 7
- 235000007265 Myrrhis odorata Nutrition 0.000 claims description 7
- 244000299790 Rheum rhabarbarum Species 0.000 claims description 7
- 235000009411 Rheum rhabarbarum Nutrition 0.000 claims description 7
- 240000007474 Aloe arborescens Species 0.000 claims description 6
- 235000004509 Aloe arborescens Nutrition 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 6
- 235000002917 Fraxinus ornus Nutrition 0.000 claims description 5
- 244000182067 Fraxinus ornus Species 0.000 claims description 5
- 241001071795 Gentiana Species 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 235000021513 Cinchona Nutrition 0.000 claims description 4
- 241000157855 Cinchona Species 0.000 claims description 4
- 240000009138 Curcuma zedoaria Species 0.000 claims description 4
- 235000003405 Curcuma zedoaria Nutrition 0.000 claims description 4
- 239000012634 fragment Substances 0.000 claims description 4
- 238000004062 sedimentation Methods 0.000 claims description 4
- 238000007654 immersion Methods 0.000 claims description 3
- 235000013311 vegetables Nutrition 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 208000017452 Epidermal disease Diseases 0.000 claims description 2
- 206010037660 Pyrexia Diseases 0.000 claims description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims description 2
- 238000013019 agitation Methods 0.000 claims description 2
- 125000003158 alcohol group Chemical group 0.000 claims description 2
- 239000000284 extract Substances 0.000 claims description 2
- 208000007565 gingivitis Diseases 0.000 claims description 2
- 238000000227 grinding Methods 0.000 claims description 2
- 208000014617 hemorrhoid Diseases 0.000 claims description 2
- 230000002440 hepatic effect Effects 0.000 claims description 2
- 206010022437 insomnia Diseases 0.000 claims description 2
- 230000000968 intestinal effect Effects 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 230000028016 temperature homeostasis Effects 0.000 claims description 2
- 208000006877 Insect Bites and Stings Diseases 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 description 5
- 244000062730 Melissa officinalis Species 0.000 description 4
- 235000010654 Melissa officinalis Nutrition 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 244000124209 Crocus sativus Species 0.000 description 2
- 235000015655 Crocus sativus Nutrition 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 235000013974 saffron Nutrition 0.000 description 2
- 239000004248 saffron Substances 0.000 description 2
- 241001116389 Aloe Species 0.000 description 1
- 244000163122 Curcuma domestica Species 0.000 description 1
- 235000003392 Curcuma domestica Nutrition 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000003373 curcuma longa Nutrition 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000005325 percolation Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 235000013976 turmeric Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
- A61K36/515—Gentiana
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
Description
Descrizione di Brevetto per Invenzione Industriale avente per titolo: Description of Patent for Industrial Invention entitled:
“PROCEDIMENTO PER LA PREPARAZIONE DI UNA COMPOSIZIONE FARMACEUTICA DA SUBSTRATI ORGANICI E COMPOSIZIONE COSÌ OTTENUTA”. "PROCEDURE FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION FROM ORGANIC SUBSTRATES AND THE COMPOSITION OBTAINED THUS".
DESCRIZIONE DESCRIPTION
La presente invenzione si riferisce ad un procedimento per la preparazione di una composizione farmaceutica da substrati organici e composizione così ottenuta. The present invention relates to a process for the preparation of a pharmaceutical composition from organic substrates and composition thus obtained.
Sono noti numerosi procedimenti di preparazione di composizioni farmaceutiche, tra i quali si annoverano i procedimenti di estrazione che permettono di estrarre composti da substrati organici, ad esempio di origine vegetale. Numerous processes for the preparation of pharmaceutical compositions are known, among which are the extraction processes which allow to extract compounds from organic substrates, for example of vegetable origin.
I procedimenti di estrazione hanno lo scopo di estrarre dal substrato organico le sostanze ed i composti attivi solubili nella composizione. The extraction processes have the purpose of extracting the soluble active substances and compounds in the composition from the organic substrate.
Ciascun substrato organico deve essere preparato prima di operare l’estrazione, riducendolo ad un opportuno grado di finezza. Each organic substrate must be prepared before operating the extraction, reducing it to an appropriate degree of fineness.
Nel dettaglio, i procedimenti di estrazione sono suddivisibili, in funzione della temperatura a cui vengono eseguiti, in procedimenti di estrazione a caldo e a freddo. In detail, the extraction processes can be divided, according to the temperature at which they are performed, into hot and cold extraction processes.
I primi comprendono la macerazione, la percolazione e la spremitura, i secondi invece comprendono la digestione, l’infusione, la decozione e la distillazione. The former include maceration, percolation and pressing, while the latter include digestion, infusion, decoction and distillation.
Con particolare riferimento ai procedimenti di estrazione a freddo, tra di essi è maggiormente diffusa la macerazione. With particular reference to cold extraction processes, maceration is the most common among them.
Tale procedimento consiste nell’immergere uniformemente il substrato da estrarre, precedentemente ridotto in pezzi di grandezza appropriata, con un solvente di estrazione prescelto. This procedure consists in uniformly immersing the substrate to be extracted, previously reduced into pieces of appropriate size, with a selected extraction solvent.
La miscela così ottenuta viene mantenuta a temperatura ambiente, all’interno di un recipiente chiuso, e per un tempo predefinito. The mixture thus obtained is kept at room temperature, inside a closed container, and for a predefined time.
Il residuo solido, consistente nel substrato organico sminuzzato, viene separato dal residuo liquido consistente nella miscela del solvente di estrazione e dei relativi composti estratti. The solid residue, consisting of the chopped organic substrate, is separated from the liquid residue consisting of the mixture of the extraction solvent and the relative extracted compounds.
Tuttavia, tale procedimento presenta numerosi inconvenienti in particolare legati ai tempi operativi necessari per la sua esecuzione. However, this process has numerous drawbacks in particular linked to the operating times necessary for its execution.
Infatti, i tempi operativi necessari per l’estrazione di uno o più composti dal substrato organico sono piuttosto lunghi e possono protrarsi anche per diverse settimane in funzione della tipologia di substrato da trattare e composto da estrarre. In fact, the operating times required for the extraction of one or more compounds from the organic substrate are quite long and can last for several weeks depending on the type of substrate to be treated and compound to be extracted.
Inoltre, accade sovente che anche a fronte di lunghi tempi operativi, l’efficienza di estrazione sia piuttosto insoddisfacente portando a rese estrattive di scarsa entità. Furthermore, it often happens that even in the face of long operating times, the extraction efficiency is rather unsatisfactory, leading to low extractive yields.
Il compito principale della presente invenzione è quello di escogitare un procedimento per la preparazione di una composizione farmaceutica da substrati organici che consenta di diminuire notevolmente i tempi operativi di preparazione rispetto ai procedimenti di tipo noto. The main task of the present invention is to devise a process for the preparation of a pharmaceutical composition from organic substrates which allows to considerably reduce the operating times of preparation with respect to known processes.
Altro scopo del presente trovato è quello di escogitare un procedimento per la preparazione di una composizione farmaceutica da substrati organici che consenta di aumentare la resa finale di estrazione dei principi attivi rispetto alle rese ottenute dai procedimenti noti. Another object of the present invention is to devise a process for the preparation of a pharmaceutical composition from organic substrates which allows to increase the final extraction yield of the active ingredients with respect to the yields obtained by known processes.
Ulteriore scopo del presente trovato è quello di escogitare un procedimento per la preparazione di una composizione farmaceutica da substrati organici che consenta di superare i menzionati inconvenienti della tecnica nota nell’ambito di una soluzione semplice, razionale, di facile ed efficace impiego e dal costo contenuto. A further object of the present invention is to devise a process for the preparation of a pharmaceutical composition from organic substrates which allows to overcome the aforementioned drawbacks of the prior art in the context of a simple, rational, easy and effective use and low cost solution. .
Gli scopi sopra esposti sono raggiunti dal presente procedimento per la preparazione di una composizione farmaceutica da substrati organici avente le caratteristiche di rivendicazione 1. The above objects are achieved by the present process for the preparation of a pharmaceutical composition from organic substrates having the characteristics of claim 1.
Inoltre, i suddetti scopi sono raggiunti dalla presente composizione farmaceutica avente le caratteristiche di rivendicazione 13. Furthermore, the aforesaid objects are achieved by the present pharmaceutical composition having the characteristics of claim 13.
Il procedimento comprende almeno una fase di fornitura di almeno un substrato organico. The process comprises at least one step of supplying at least one organic substrate.
Si specifica che nell’ambito della presente trattazione con l’espressione “substrato organico” si intende il materiale di partenza da cui estrarre sostante attive ad attività benefica sull’organismo umano. It is specified that in the context of this discussion the expression "organic substrate" means the starting material from which to extract active substances with beneficial activity on the human body.
Preferibilmente, il substrato organico è di origine vegetale. Preferably, the organic substrate is of vegetable origin.
Più nel dettaglio, il substrato organico è ottenuto da una superficie vegetale. Si specifica che nell’ambito della presente trattazione per “superficie vegetale” si intende un substrato ottenuto indistintamente da: foglie, fiori, rami, corteccia e arbusto di una pianta. More specifically, the organic substrate is obtained from a plant surface. It is specified that in the context of this discussion, "plant surface" means a substrate obtained indiscriminately from: leaves, flowers, branches, bark and shrub of a plant.
Vantaggiosamente, il suddetto substrato organico è in forma solida. Advantageously, the aforesaid organic substrate is in solid form.
A questo proposito, il procedimento può comprendere una fase di macinazione del substrato organico. In this regard, the process may comprise a step of grinding the organic substrate.
Infatti, al fine di aumentare il rapporto superficie/volume del substrato organico utilizzato, un operatore del settore può procedere alla macinazione del substrato mediante ad esempio un trituratore di tipo noto al tecnico del ramo. In fact, in order to increase the surface / volume ratio of the organic substrate used, an operator in the sector can proceed to grind the substrate by means of for example a shredder of a type known to those skilled in the art.
Inoltre, il suddetto substrato organico è ottenuto da almeno uno tra: China, Aloe Arborescens, Mirra, Teriaca, Rabarbaro, Issopo officinale, Curcuma zedoaria, Genziana, Agarico, Melissa, Zafferano, Manna o loro miscele. Con riferimento ad una preferita forma di realizzazione, il substrato organico comprende una miscela di frammenti solidi ottenuti da: China, Aloe Arborescens, Mirra, Teriaca, Rabarbaro, Issopo officinale, Curcuma zedoaria, Genziana, Agarico, Melissa, Zafferano, Manna. Furthermore, the aforementioned organic substrate is obtained from at least one of: China, Aloe Arborescens, Myrrh, Teriaca, Rhubarb, Hyssop officinale, Curcuma zedoaria, Gentian, Agaric, Lemon balm, Saffron, Manna or their mixtures. With reference to a preferred embodiment, the organic substrate comprises a mixture of solid fragments obtained from: China, Aloe Arborescens, Myrrh, Teriaca, Rhubarb, Hyssop officinale, Curcuma zedoaria, Gentian, Agaric, Lemon balm, Saffron, Manna.
A questo proposito si specifica che, la China è ottenuta dalla corteccia del relativo albero. In this regard, it is specified that Cinchona is obtained from the bark of the relative tree.
Con riferimento alla particolare soluzione realizzativa, la miscela di frammenti solidi comprende una quantità in peso di corteccia di China compresa tra 30 g e 80 g. With reference to the particular embodiment solution, the mixture of solid fragments comprises a quantity by weight of cinchona bark comprised between 30 g and 80 g.
Parallelamente, si riportano qui di seguito, a mero titolo esemplificativo, le quantità in peso di: At the same time, the quantities by weight of:
- Aloe Arborescens 30 g – 70 g - Mirra 5 g – 40 g - Teriaca 2 g – 35 g - Rabarbaro 5 g – 15 g - Issopo officinale 2 g – 35 g - Curcuma zedoaria 2 g – 35 g - Genziana 2 g – 35 g - Agarico 2 g – 35 g - Melissa 2 g – 35 g - Zafferano 0.1 g – 30 g - Manna 1 g – 30 g A seguire, il procedimento comprende una fase di immersione del substrato organico in almeno un solvente di estrazione ad ottenere una miscela di macerazione. - Aloe Arborescens 30 g - 70 g - Myrrh 5 g - 40 g - Teriaca 2 g - 35 g - Rhubarb 5 g - 15 g - Hyssop officinale 2 g - 35 g - Turmeric zedoaria 2 g - 35 g - Gentian 2 g - 35 g - Agaric 2 g - 35 g - Lemon balm 2 g - 35 g - Saffron 0.1 g - 30 g - Manna 1 g - 30 g Subsequently, the procedure includes a step of immersion of the organic substrate in at least one extraction solvent. obtain a maceration mixture.
A questo proposito si specifica che i quantitativi soprariportati sono esemplificativi delle rispettive quantità in peso realizzabili in fase di immersione al fine di ottenere 1,5 L di composizione farmaceutica. In this regard, it is specified that the quantities reported above are examples of the respective quantities by weight which can be obtained in the dipping phase in order to obtain 1.5 L of pharmaceutical composition.
Nel dettaglio, il solvente di estrazione è un alcol. In detail, the extraction solvent is an alcohol.
Preferibilmente, il solvente di estrazione è etanolo. Preferably, the extraction solvent is ethanol.
Inoltre, la fase di immersione comprende anche un ulteriore solvente di estrazione miscelato con l’alcol. In addition, the immersion phase also includes an additional extraction solvent mixed with alcohol.
Tale ulteriore solvente di estrazione è acqua denaturata e miscelata con etanolo definisce una soluzione idroalcolica. This further extraction solvent is denatured water and mixed with ethanol defines a hydroalcoholic solution.
Vantaggiosamente, la suddetta soluzione idroalcolica è concentrata al 40%. Inoltre, quest’ultima è contenuta all’interno di un recipiente di raccolta comprendente un corpo cavo di contenimento, una porzione di fondo ed una porzione di entrata della miscela di macerazione. Advantageously, the aforementioned hydroalcoholic solution is concentrated at 40%. Furthermore, the latter is contained within a collection container comprising a hollow containment body, a bottom portion and an inlet portion of the maceration mixture.
Il procedimento prosegue con una fase di termoregolazione della miscela di macerazione ad una temperatura di lavoro compresa tra 25°C e 70°C. The process continues with a thermoregulation phase of the maceration mixture at a working temperature between 25 ° C and 70 ° C.
Preferibilmente, la temperatura di lavoro è compresa tra 35°C e 40°C. Preferably, the working temperature is between 35 ° C and 40 ° C.
Vantaggiosamente, la temperatura di lavoro è compresa tra 30°C e 60°C. Secondo il trovato il procedimento comprende una fase di movimentazione della miscela di macerazione. Advantageously, the working temperature is between 30 ° C and 60 ° C. According to the invention, the method comprises a step for moving the maceration mixture.
La suddetta fase di movimentazione è eseguita mediante agitazione meccanica. The aforesaid handling step is performed by mechanical agitation.
Più nel dettaglio, il recipiente di raccolta è provvisto di mezzi di movimentazione della miscela di macerazione del tipo di un miscelatore a pale. More in detail, the collection container is provided with means for moving the maceration mixture of the type of a paddle mixer.
La fase di movimentazione presenta una durata compresa tra 1 ora e 240 ore. The handling phase lasts between 1 hour and 240 hours.
Preferibilmente, la fase di movimentazione presenta una durata compresa tra 4 ore e 168 ore. Preferably, the handling step has a duration of between 4 hours and 168 hours.
Al termine della fase di movimentazione, il procedimento comprende una fase di sedimentazione della miscela di macerazione. At the end of the handling phase, the process comprises a sedimentation phase of the maceration mixture.
A questo punto, il procedimento prosegue con una fase di filtrazione della miscela di macerazione ad ottenere una miscela filtrata. At this point, the procedure continues with a step of filtration of the maceration mixture to obtain a filtered mixture.
Non si esclude, altresì, che il procedimento comprenda un’ulteriore fase di sedimentazione a seguito della fase di filtrazione. It is also not excluded that the process includes a further sedimentation phase following the filtration phase.
Ancora, non si esclude che il procedimento comprenda un’ulteriore fase di filtrazione successiva all’ulteriore fase di sedimentazione. Furthermore, it is not excluded that the process includes a further filtration phase following the further sedimentation phase.
Il presente trovato riguarda anche una composizione farmaceutica comprendente una miscela di estratti ottenuti da: China, Aloe, Mirra, Teriaca, Rabarbaro, Issopo officinale, Zedoaria, Genziana, Agarico, Melissa, Zafferano e Manna. The present invention also relates to a pharmaceutical composition comprising a mixture of extracts obtained from: China, Aloe, Myrrh, Teriaca, Rhubarb, Hyssop officinale, Zedoaria, Gentian, Agaric, Lemon balm, Saffron and Manna.
Inoltre, la suddetta composizione comprende acqua denaturata ed alcol. Preferibilmente, l’alcol è etanolo. Furthermore, the above composition comprises denatured water and alcohol. Preferably, the alcohol is ethanol.
Il presente procedimento consente di ottenere rese estrattive superiori a Il presente trovato riguarda inoltre, la composizione precedentemente descritta per uso nel trattamento di febbre, emorroidi, gengiviti, patologie intestinali, ginecologiche, epatiche, renali, epidermiche, epitassi, ustioni, insonnia e punture di insetti. The present process allows to obtain extractive yields higher than The present invention also relates to the composition previously described for use in the treatment of fever, haemorrhoids, gingivitis, intestinal, gynecological, hepatic, renal, epidermal diseases, epitaxis, burns, insomnia and punctures of insects.
Si è in pratica constatato come l’invenzione descritta raggiunga gli scopi proposti. In practice it has been found that the described invention achieves the proposed purposes.
In particolare si sottolinea che il fatto di realizzare un procedimento per la realizzazione di una composizione farmaceutica che consenta di impostare la temperatura di lavoro in combinazione con la movimentazione della miscela di macerazione permette di ottenere rese estrattive del tutto inaspettate e notevolmente migliorate rispetto ai procedimenti di tipo noto. In particular, it is emphasized that the fact of realizing a process for the realization of a pharmaceutical composition that allows to set the working temperature in combination with the handling of the maceration mixture allows to obtain completely unexpected and significantly improved extractive yields compared to the procedures of known type.
Claims (17)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102018000005451A IT201800005451A1 (en) | 2018-05-16 | 2018-05-16 | PROCEDURE FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION FROM ORGANIC SUBSTRATES AND THE COMPOSITION SO OBTAINED |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102018000005451A IT201800005451A1 (en) | 2018-05-16 | 2018-05-16 | PROCEDURE FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION FROM ORGANIC SUBSTRATES AND THE COMPOSITION SO OBTAINED |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0606497A1 (en) * | 1992-07-31 | 1994-07-20 | TSUMURA & CO. | Remedy for biotoxin type bacterial intestinal infectious diseases |
| US20090306386A1 (en) * | 2005-11-10 | 2009-12-10 | Durand Herve Andre Gerard | Plant Extract Obtained by an Extraction Method by Means of Solvents of Plant Origin |
-
2018
- 2018-05-16 IT IT102018000005451A patent/IT201800005451A1/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0606497A1 (en) * | 1992-07-31 | 1994-07-20 | TSUMURA & CO. | Remedy for biotoxin type bacterial intestinal infectious diseases |
| US20090306386A1 (en) * | 2005-11-10 | 2009-12-10 | Durand Herve Andre Gerard | Plant Extract Obtained by an Extraction Method by Means of Solvents of Plant Origin |
Non-Patent Citations (5)
| Title |
|---|
| ANONYMOUS: "Macerazione", 1 January 2016 (2016-01-01), XP055528791, Retrieved from the Internet <URL:https://web.archive.org/web/20180215045534/https://www.inherba.it/tecniche-estrazione-distillazione-oli-essenziali-piante-officinali/macerazione/> [retrieved on 20181130] * |
| ANONYMOUS: "Mirra in Erboristeria: Proprietà della Mirra", 13 August 2017 (2017-08-13), XP055529218, Retrieved from the Internet <URL:https://web.archive.org/web/20170813194554/http://www.my-personaltrainer.it/erboristeria/mirra.html> [retrieved on 20181130] * |
| ANONYMOUS: "Rabarbaro in Erboristeria", 2 April 2018 (2018-04-02), XP055529216, Retrieved from the Internet <URL:https://web.archive.org/web/20180402025321/http://www.my-personaltrainer.it:80/erboristeria/rabarbaro.html> [retrieved on 20181130] * |
| ANONYMOUS: "Zafferano in Erboristeria: Proprietà dello Zafferano", 8 April 2018 (2018-04-08), XP055529219, Retrieved from the Internet <URL:https://web.archive.org/web/20180408081742/http://www.my-personaltrainer.it:80/erboristeria/zafferano.html> [retrieved on 20181130] * |
| DUSANKA KRAJNOVIC: "La Thériaque: médicament et antidote", 1 January 2003 (2003-01-01), XP055529220, Retrieved from the Internet <URL:https://www.researchgate.net/profile/Dusanka_Krajnovic/publication/8580991_Theriac_medicine_and_antidote/links/55b9232708ae9289a08ff9e7/Theriac-medicine-and-antidote.pdf> [retrieved on 20181130] * |
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