IT201800001315A1 - Nuovi agenti terapeutici antitumorali - Google Patents
Nuovi agenti terapeutici antitumoraliInfo
- Publication number
- IT201800001315A1 IT201800001315A1 IT201800001315A IT201800001315A IT201800001315A1 IT 201800001315 A1 IT201800001315 A1 IT 201800001315A1 IT 201800001315 A IT201800001315 A IT 201800001315A IT 201800001315 A IT201800001315 A IT 201800001315A IT 201800001315 A1 IT201800001315 A1 IT 201800001315A1
- Authority
- IT
- Italy
- Prior art keywords
- new therapeutic
- tumor agents
- therapeutic anti
- tumor
- agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
- A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
- A61K47/6939—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being a polysaccharide, e.g. starch, chitosan, chitin, cellulose or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70532—B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nanotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT201800001315A IT201800001315A1 (it) | 2018-01-18 | 2018-01-18 | Nuovi agenti terapeutici antitumorali |
CA3088835A CA3088835A1 (en) | 2018-01-18 | 2019-01-09 | Anti-tumor therapeutic agents based on b7h receptor ligands |
EP19704678.2A EP3740499A1 (en) | 2018-01-18 | 2019-01-09 | Anti-tumor therapeutic agents based on b7h receptor ligands |
US16/963,185 US20210128684A1 (en) | 2018-01-18 | 2019-01-09 | Anti-tumor therapeutic agents based on b7h receptor ligands |
CN201980009152.9A CN111902423A (zh) | 2018-01-18 | 2019-01-09 | 基于b7h受体的配体的抗肿瘤治疗剂 |
PCT/IB2019/050154 WO2019142070A1 (en) | 2018-01-18 | 2019-01-09 | Anti-tumor therapeutic agents based on b7h receptor ligands |
JP2020537603A JP2021513505A (ja) | 2018-01-18 | 2019-01-09 | 新規抗腫瘍治療剤 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT201800001315A IT201800001315A1 (it) | 2018-01-18 | 2018-01-18 | Nuovi agenti terapeutici antitumorali |
Publications (1)
Publication Number | Publication Date |
---|---|
IT201800001315A1 true IT201800001315A1 (it) | 2019-07-18 |
Family
ID=61873847
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT201800001315A IT201800001315A1 (it) | 2018-01-18 | 2018-01-18 | Nuovi agenti terapeutici antitumorali |
Country Status (7)
Country | Link |
---|---|
US (1) | US20210128684A1 (it) |
EP (1) | EP3740499A1 (it) |
JP (1) | JP2021513505A (it) |
CN (1) | CN111902423A (it) |
CA (1) | CA3088835A1 (it) |
IT (1) | IT201800001315A1 (it) |
WO (1) | WO2019142070A1 (it) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113230415B (zh) * | 2021-05-18 | 2022-04-12 | 南华大学 | 岩藻糖与环糊精修饰多肽靶向动脉粥样硬化相关巨噬细胞纳米载体系统及其制备方法和应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016189428A1 (en) * | 2015-05-27 | 2016-12-01 | Università Degli Studi Del Piemonte Orientale "Amedeo Avogadro" | Ligands of b7h receptor in the treatment of osteopenia and osteoporosis |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2006003999A1 (ja) * | 2004-07-05 | 2008-07-31 | 財団法人化学及血清療法研究所 | ヒト抗ヒトb7rp−1抗体およびその抗体フラグメント |
JPWO2011007747A1 (ja) * | 2009-07-16 | 2012-12-27 | 株式会社糖鎖工学研究所 | 糖鎖付加ailim細胞外ドメイン及びその製造方法 |
CN104968364A (zh) * | 2012-12-03 | 2015-10-07 | 百时美施贵宝公司 | 强化免疫调变性Fc融合蛋白的抗癌活性 |
KR20180066236A (ko) * | 2015-10-22 | 2018-06-18 | 조운스 테라퓨틱스, 인크. | Icos 발현을 계측하기 위한 유전자 특질 |
-
2018
- 2018-01-18 IT IT201800001315A patent/IT201800001315A1/it unknown
-
2019
- 2019-01-09 CN CN201980009152.9A patent/CN111902423A/zh active Pending
- 2019-01-09 JP JP2020537603A patent/JP2021513505A/ja active Pending
- 2019-01-09 CA CA3088835A patent/CA3088835A1/en active Pending
- 2019-01-09 EP EP19704678.2A patent/EP3740499A1/en active Pending
- 2019-01-09 WO PCT/IB2019/050154 patent/WO2019142070A1/en unknown
- 2019-01-09 US US16/963,185 patent/US20210128684A1/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016189428A1 (en) * | 2015-05-27 | 2016-12-01 | Università Degli Studi Del Piemonte Orientale "Amedeo Avogadro" | Ligands of b7h receptor in the treatment of osteopenia and osteoporosis |
Non-Patent Citations (5)
Title |
---|
C. DIANZANI ET AL: "B7h Triggering Inhibits the Migration of Tumor Cell Lines", THE JOURNAL OF IMMUNOLOGY, vol. 192, no. 10, 11 April 2014 (2014-04-11), US, pages 4921 - 4931, XP055224661, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1300587 * |
C. DIANZANI ET AL: "B7h Triggering Inhibits Umbilical Vascular Endothelial Cell Adhesiveness to Tumor Cell Lines and Polymorphonuclear Cells", THE JOURNAL OF IMMUNOLOGY, vol. 185, no. 7, 3 September 2010 (2010-09-03), US, pages 3970 - 3979, XP055223879, ISSN: 0022-1767, DOI: 10.4049/jimmunol.0903269 * |
DMITRIY ZAMARIN ET AL: "Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity", NATURE COMMUNICATIONS, vol. 8, 13 February 2017 (2017-02-13), pages 14340, XP055489812, DOI: 10.1038/ncomms14340 * |
GULSHAN ARA ET AL: "Potent activity of soluble B7RP-1-Fc in therapy of murine tumors in syngeneic hosts", INTERNATIONAL JOURNAL OF CANCER, vol. 103, no. 4, 10 February 2003 (2003-02-10), pages 501 - 507, XP055067328, ISSN: 0020-7136, DOI: 10.1002/ijc.10831 * |
TIHUI FU ET AL: "The ICOS/ICOSL pathway is required for optimal antitumor responses mediated by anti-CTLA-4 therapy", CANCER RESEARCH, 15 August 2011 (2011-08-15) - 15 August 2011 (2011-08-15), United States, pages 5445 - 5454, XP055315732, Retrieved from the Internet <URL:http://cancerres.aacrjournals.org/content/canres/71/16/5445.full.pdf> [retrieved on 20110815], DOI: 10.1158/0008-5472.CAN-11-1138 * |
Also Published As
Publication number | Publication date |
---|---|
US20210128684A1 (en) | 2021-05-06 |
JP2021513505A (ja) | 2021-05-27 |
EP3740499A1 (en) | 2020-11-25 |
CA3088835A1 (en) | 2019-07-25 |
CN111902423A (zh) | 2020-11-06 |
WO2019142070A1 (en) | 2019-07-25 |
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