IT1397569B1 - Peptidi e loro derivati che inibiscono il rilascio extracellulare della proteina tat di hiv-1 e la replicazione di hiv-1. - Google Patents

Peptidi e loro derivati che inibiscono il rilascio extracellulare della proteina tat di hiv-1 e la replicazione di hiv-1.

Info

Publication number
IT1397569B1
IT1397569B1 ITRM2009A000650A ITRM20090650A IT1397569B1 IT 1397569 B1 IT1397569 B1 IT 1397569B1 IT RM2009A000650 A ITRM2009A000650 A IT RM2009A000650A IT RM20090650 A ITRM20090650 A IT RM20090650A IT 1397569 B1 IT1397569 B1 IT 1397569B1
Authority
IT
Italy
Prior art keywords
hiv
replication
peptides
inhibit
derivatives
Prior art date
Application number
ITRM2009A000650A
Other languages
English (en)
Inventor
Silvia Agostini
Mauro Giacca
Original Assignee
Icgeb
Scuola Normale Superiore Di Pisa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icgeb, Scuola Normale Superiore Di Pisa filed Critical Icgeb
Priority to ITRM2009A000650A priority Critical patent/IT1397569B1/it
Priority to PCT/IB2010/055715 priority patent/WO2011070533A1/en
Publication of ITRM20090650A1 publication Critical patent/ITRM20090650A1/it
Application granted granted Critical
Publication of IT1397569B1 publication Critical patent/IT1397569B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
    • C12Y306/03—Hydrolases acting on acid anhydrides (3.6) acting on acid anhydrides; catalysing transmembrane movement of substances (3.6.3)
    • C12Y306/03009—Na+/K+-exchanging ATPase (3.6.3.9)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
ITRM2009A000650A 2009-12-10 2009-12-10 Peptidi e loro derivati che inibiscono il rilascio extracellulare della proteina tat di hiv-1 e la replicazione di hiv-1. IT1397569B1 (it)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ITRM2009A000650A IT1397569B1 (it) 2009-12-10 2009-12-10 Peptidi e loro derivati che inibiscono il rilascio extracellulare della proteina tat di hiv-1 e la replicazione di hiv-1.
PCT/IB2010/055715 WO2011070533A1 (en) 2009-12-10 2010-12-10 Peptides and their derivatives inhibiting extracellular release of hiv-1 tat protein and hiv-1 replication

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM2009A000650A IT1397569B1 (it) 2009-12-10 2009-12-10 Peptidi e loro derivati che inibiscono il rilascio extracellulare della proteina tat di hiv-1 e la replicazione di hiv-1.

Publications (2)

Publication Number Publication Date
ITRM20090650A1 ITRM20090650A1 (it) 2011-06-11
IT1397569B1 true IT1397569B1 (it) 2013-01-16

Family

ID=42335280

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM2009A000650A IT1397569B1 (it) 2009-12-10 2009-12-10 Peptidi e loro derivati che inibiscono il rilascio extracellulare della proteina tat di hiv-1 e la replicazione di hiv-1.

Country Status (2)

Country Link
IT (1) IT1397569B1 (it)
WO (1) WO2011070533A1 (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115463146B (zh) * 2022-10-14 2024-01-23 浙大城市学院 哇巴因化合物作为在制备抗病毒药物中的应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3907562A1 (de) 1989-03-09 1990-09-13 Bayer Ag Antisense-oligonukleotide zur inhibierung der transaktivatorzielsequenz (tar) und der synthese des transaktivatorproteins (tat) aus hiv-1 und deren verwendung
EP0511285A4 (en) 1990-01-18 1993-05-26 Us Commerce Vector with multiple target response elements affecting gene expression
EP0522081A4 (en) 1990-03-30 1993-06-16 Smithkline Beecham Corporation Inhibition of disease associated with immunodeficiency virus infection
GB9016973D0 (en) 1990-08-02 1990-09-19 Medical Res Council Viral growth inhibition
EP0586515B1 (en) 1991-04-30 1997-09-17 Eukarion, Inc. Cationized antibodies against intracellular proteins
US5350835A (en) 1991-11-05 1994-09-27 Board Of Regents, University Of Texas Cellular nucleic acid binding protein and uses thereof in regulating gene expression and in the treatment of aids
FR2700169B1 (fr) 1993-01-04 1995-03-24 Transgene Sa Nouveaux variants trans-dominants TAT du virus de l'immunodéficience humaine.
WO1996028189A1 (en) 1995-03-06 1996-09-19 Baylor College Of Medicine A double transdominant fusion gene and protein
GB9511474D0 (en) 1995-06-07 1995-08-02 Ciba Geigy Ag Antiviral peptoid compounds
EP1011655A1 (en) * 1997-02-26 2000-06-28 Ciblex Corporation Inhibitors of leaderless protein export
US6251943B1 (en) 1997-02-28 2001-06-26 Warner-Lambert Company Method of treating or preventing septic shock by administering a MEK inhibitor
WO1998047913A2 (en) 1997-04-18 1998-10-29 The University Of Medicine And Dentistry Of New Jersey Inhibition of hiv-1 replication by a tat rna-binding domain peptide analog
US5843995A (en) 1997-07-07 1998-12-01 University Of Medicine And Dentistry Of New Jersey Inhibition of HIV-1 replication using oligocarbamate derivatives
AU8912698A (en) 1997-08-19 1999-03-08 University Of Medicine And Dentistry Of New Jersey Inhibition of hiv-1 replication using d-amino acid peptides
IL122343A0 (en) 1997-11-27 1998-04-05 Yissum Res Dev Co Inhibition of nuclear import by backbone cyclic peptide analogs
FR2775286B1 (fr) 1998-02-20 2001-09-07 Centre Nat Rech Scient Derives du triphenylene contre le sida
US6541208B1 (en) 1998-03-17 2003-04-01 University Of Maryland Biotechnology Institute Diagnostic method for distinguishing HIV-associated dementia from other forms of dementia
AU2631800A (en) 1999-01-25 2000-08-07 University Of Medicine And Dentistry Of New Jersey Tat-derived oligourea and its method of production and use in high affinity and specific binding of hiv-1 tar rna
EP1332187A1 (en) 2000-09-05 2003-08-06 John Lyndon Garnett Radiation polymerisable compositions having accelerated cure
US7244814B2 (en) 2002-02-21 2007-07-17 University Of Medicine & Dentistry Of New Jersey Variant Tat proteins and methods for use thereof
WO2003072709A2 (en) 2002-02-21 2003-09-04 University Of Medicine And Dentistry Of New Jersey Variant tat proteins and methods for use thereof
US7152611B2 (en) 2002-12-30 2006-12-26 International Tape Partners, Llc Coated multifilament dental devices overcoated with imbedded particulate
US7482016B2 (en) 2003-03-19 2009-01-27 The J. David Gladstone Institutes Immunogenic compositions comprising HIV-1 acetylated Tat polypeptides
FR2861086B1 (fr) 2003-10-20 2005-12-30 Centre Nat Rech Scient Methode d'induction d'une activite arni specifique dans des cellules et acides nucleiques pour sa mise en oeuvre
MX2009004890A (es) * 2006-11-09 2009-05-21 Unibioscreen Sa Direccionamiento de subunidades alpha-1 o alpha-3 de na+, k+-atpasa en el tratamiento de enfermedades proliferativas.

Also Published As

Publication number Publication date
WO2011070533A1 (en) 2011-06-16
ITRM20090650A1 (it) 2011-06-11

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