IT1293806B1 - Piperazine derivatives which bind to 5-HT1A serotonergic receptors - used to treat neuromuscular dysfunctions of lower urinary tract - Google Patents

Piperazine derivatives which bind to 5-HT1A serotonergic receptors - used to treat neuromuscular dysfunctions of lower urinary tract

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Publication number
IT1293806B1
IT1293806B1 ITMI971863A IT1293806B1 IT 1293806 B1 IT1293806 B1 IT 1293806B1 IT MI971863 A ITMI971863 A IT MI971863A IT 1293806 B1 IT1293806 B1 IT 1293806B1
Authority
IT
Italy
Prior art keywords
urinary tract
lower urinary
bind
piperazine derivatives
serotonergic receptors
Prior art date
Application number
Other languages
Italian (it)
Inventor
Amedeo Leonardi
Gianni Motta
Carlo Riva
Elena Poggesi
Original Assignee
Recordati Chem Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm
Priority to ITMI971863 priority Critical patent/IT1293806B1/en
Priority to EP98945130A priority patent/EP1000045A1/en
Priority to JP2000505141A priority patent/JP2001512110A/en
Priority to PCT/EP1998/004796 priority patent/WO1999006382A1/en
Priority to AU92564/98A priority patent/AU9256498A/en
Publication of ITMI971863A1 publication Critical patent/ITMI971863A1/en
Application granted granted Critical
Publication of IT1293806B1 publication Critical patent/IT1293806B1/en
Priority to US09/266,534 priority patent/US6271234B1/en

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Abstract

Piperazine derivatives of formula (I) and their salts and N-oxides and active metabolites are used for the treatment of neuromuscular dysfunction of the lower urinary tract. n = 1 or 2; Het = monocyclic heteroaryl; R = cycloalkyl or monocyclic heteroaryl; R3 = H or lower alkyl; Z = a bond, CH2, CH2CH2, CH2C(O), CH2CH(OH), O, OCH2,or CO; B' = optionally substituted aryl or heteroaryl; R1 = H, halo, alkoxy, NO2, NH2, acylamino or alkylsulphonylamino and R2 = halo, alkoxy, polyfluoroalkoxy, CN or carbamoyl. (I) are new provided that when Z = a bond, B' = a substituted phenyl of formula (a); and if R1 is not acylamino or alkylsulphonylamino, then R2 = polyfluoroalkoxy. 14 Compounds (I) are specifically claimed e.g: 1-[N-cyclohexylcarbonyl-N-(2-pyridyl)-2-aminoethyl]-4-(2-trifluoromethoxyphenyl)-piperazine.
ITMI971863 1997-08-01 1997-08-01 Piperazine derivatives which bind to 5-HT1A serotonergic receptors - used to treat neuromuscular dysfunctions of lower urinary tract IT1293806B1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ITMI971863 IT1293806B1 (en) 1997-08-01 1997-08-01 Piperazine derivatives which bind to 5-HT1A serotonergic receptors - used to treat neuromuscular dysfunctions of lower urinary tract
EP98945130A EP1000045A1 (en) 1997-08-01 1998-07-31 1,4-disubstituted piperazines
JP2000505141A JP2001512110A (en) 1997-08-01 1998-07-31 1,4-disubstituted piperazine
PCT/EP1998/004796 WO1999006382A1 (en) 1997-08-01 1998-07-31 1,4-disubstituted piperazines
AU92564/98A AU9256498A (en) 1997-08-01 1998-07-31 1,4-disubstituted piperazines
US09/266,534 US6271234B1 (en) 1997-08-01 1999-03-11 1,4-disubstituted piperazines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI971863 IT1293806B1 (en) 1997-08-01 1997-08-01 Piperazine derivatives which bind to 5-HT1A serotonergic receptors - used to treat neuromuscular dysfunctions of lower urinary tract

Publications (2)

Publication Number Publication Date
ITMI971863A1 ITMI971863A1 (en) 1999-02-01
IT1293806B1 true IT1293806B1 (en) 1999-03-10

Family

ID=11377707

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI971863 IT1293806B1 (en) 1997-08-01 1997-08-01 Piperazine derivatives which bind to 5-HT1A serotonergic receptors - used to treat neuromuscular dysfunctions of lower urinary tract

Country Status (1)

Country Link
IT (1) IT1293806B1 (en)

Also Published As

Publication number Publication date
ITMI971863A1 (en) 1999-02-01

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