IT1293805B1 - Piperazine derivatives which bind to 5-HT1A serotonergic receptors - used to treat neuromuscular dysfunctions of lower urinary tract - Google Patents

Piperazine derivatives which bind to 5-HT1A serotonergic receptors - used to treat neuromuscular dysfunctions of lower urinary tract

Info

Publication number
IT1293805B1
IT1293805B1 ITMI971862A IT1293805B1 IT 1293805 B1 IT1293805 B1 IT 1293805B1 IT MI971862 A ITMI971862 A IT MI971862A IT 1293805 B1 IT1293805 B1 IT 1293805B1
Authority
IT
Italy
Prior art keywords
urinary tract
lower urinary
bind
piperazine derivatives
serotonergic receptors
Prior art date
Application number
Other languages
Italian (it)
Inventor
Amedeo Leonardi
Gianni Motta
Carlo Riva
Luciano Guarnieri
Original Assignee
Recordati Chem Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm
Priority to ITMI971862 priority Critical patent/IT1293805B1/en
Priority to JP2000505141A priority patent/JP2001512110A/en
Priority to EP98945130A priority patent/EP1000045A1/en
Priority to PCT/EP1998/004796 priority patent/WO1999006382A1/en
Priority to AU92564/98A priority patent/AU9256498A/en
Publication of ITMI971862A1 publication Critical patent/ITMI971862A1/en
Application granted granted Critical
Publication of IT1293805B1 publication Critical patent/IT1293805B1/en
Priority to US09/266,534 priority patent/US6271234B1/en

Links

Abstract

Piperazine derivatives of formula (I) and their salts and N-oxides and active metabolites are used for the treatment of neuromuscular dysfunction of the lower urinary tract. n = 1 or 2; Het = monocyclic heteroaryl; R = cycloalkyl or monocyclic heteroaryl; R3 = H or lower alkyl; Z = a bond, CH2, CH2CH2, CH2C(O), CH2CH(OH), O, OCH2,or CO; B' = optionally substituted aryl or heteroaryl; R1 = H, halo, alkoxy, NO2, NH2, acylamino or alkylsulphonylamino and R2 = halo, alkoxy, polyfluoroalkoxy, CN or carbamoyl. (I) are new provided that when Z = a bond, B' = a substituted phenyl of formula (a); and if R1 is not acylamino or alkylsulphonylamino, then R2 = polyfluoroalkoxy. 14 Compounds (I) are specifically claimed e.g: 1-[N-cyclohexylcarbonyl-N-(2-pyridyl)-2-aminoethyl]-4-(2-trifluoromethoxyphenyl)-piperazine.
ITMI971862 1997-08-01 1997-08-01 Piperazine derivatives which bind to 5-HT1A serotonergic receptors - used to treat neuromuscular dysfunctions of lower urinary tract IT1293805B1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ITMI971862 IT1293805B1 (en) 1997-08-01 1997-08-01 Piperazine derivatives which bind to 5-HT1A serotonergic receptors - used to treat neuromuscular dysfunctions of lower urinary tract
JP2000505141A JP2001512110A (en) 1997-08-01 1998-07-31 1,4-disubstituted piperazine
EP98945130A EP1000045A1 (en) 1997-08-01 1998-07-31 1,4-disubstituted piperazines
PCT/EP1998/004796 WO1999006382A1 (en) 1997-08-01 1998-07-31 1,4-disubstituted piperazines
AU92564/98A AU9256498A (en) 1997-08-01 1998-07-31 1,4-disubstituted piperazines
US09/266,534 US6271234B1 (en) 1997-08-01 1999-03-11 1,4-disubstituted piperazines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI971862 IT1293805B1 (en) 1997-08-01 1997-08-01 Piperazine derivatives which bind to 5-HT1A serotonergic receptors - used to treat neuromuscular dysfunctions of lower urinary tract

Publications (2)

Publication Number Publication Date
ITMI971862A1 ITMI971862A1 (en) 1999-02-01
IT1293805B1 true IT1293805B1 (en) 1999-03-10

Family

ID=11377706

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI971862 IT1293805B1 (en) 1997-08-01 1997-08-01 Piperazine derivatives which bind to 5-HT1A serotonergic receptors - used to treat neuromuscular dysfunctions of lower urinary tract

Country Status (1)

Country Link
IT (1) IT1293805B1 (en)

Also Published As

Publication number Publication date
ITMI971862A1 (en) 1999-02-01

Similar Documents

Publication Publication Date Title
ATE368655T1 (en) NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND MEDICINAL PRODUCTS THEREOF
NO20025118D0 (en) Dipeptyl peptidase IV inhibitors
ID23891A (en) COMBINED JOINT HETEROSICLIC COMPOUNDS
DE60129712D1 (en) OXAZOLYLARYLOXYACETIC ACID DERIVATIVES AND THEIR USE AS PPAR AGONISTS
ATE334975T1 (en) SULFONAMIDE DERIVATIVES, THEIR PRODUCTION AND USE
DK1277736T3 (en) New bicyclic compounds
IT1228293B (en) BENZODERIVATES OF HETEROCYCLIC COMPOUNDS CONTAINING NITROGEN.
HRP20090264T1 (en) Phenyl-piperazin methanone derivatives
AUPP150098A0 (en) Benzamide derivatives
IT1293805B1 (en) Piperazine derivatives which bind to 5-HT1A serotonergic receptors - used to treat neuromuscular dysfunctions of lower urinary tract
IT1293806B1 (en) Piperazine derivatives which bind to 5-HT1A serotonergic receptors - used to treat neuromuscular dysfunctions of lower urinary tract
DE60115569D1 (en) Phenoxazine analogues for the treatment of amyloidosis
WO2001002366A3 (en) Substituted isoquinoline derivatives and their use as inticonvulsants
ATE215075T1 (en) HYDROXYLAMINE DERIVATIVES HAVING ANTI-ISCHEMIC EFFECT AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
HK1029996A1 (en) Process for the preparation of n-[5-(diphenylphosphinoylmethyl)-4-(4-fluorphenyl)-6-isopropylpyrimidin-2-yl]-n-methylmethansulfonamide
DK0687257T3 (en) 4-Amino-2- (hetero) aryl-butanamides useful as 5HT1A antagonists
MY130617A (en) Inhibitors of dipeptidyl peptidase iv

Legal Events

Date Code Title Description
0001 Granted