IT1293805B1 - Piperazine derivatives which bind to 5-HT1A serotonergic receptors - used to treat neuromuscular dysfunctions of lower urinary tract - Google Patents
Piperazine derivatives which bind to 5-HT1A serotonergic receptors - used to treat neuromuscular dysfunctions of lower urinary tractInfo
- Publication number
- IT1293805B1 IT1293805B1 ITMI971862A IT1293805B1 IT 1293805 B1 IT1293805 B1 IT 1293805B1 IT MI971862 A ITMI971862 A IT MI971862A IT 1293805 B1 IT1293805 B1 IT 1293805B1
- Authority
- IT
- Italy
- Prior art keywords
- urinary tract
- lower urinary
- bind
- piperazine derivatives
- serotonergic receptors
- Prior art date
Links
Abstract
Piperazine derivatives of formula (I) and their salts and N-oxides and active metabolites are used for the treatment of neuromuscular dysfunction of the lower urinary tract. n = 1 or 2; Het = monocyclic heteroaryl; R = cycloalkyl or monocyclic heteroaryl; R3 = H or lower alkyl; Z = a bond, CH2, CH2CH2, CH2C(O), CH2CH(OH), O, OCH2,or CO; B' = optionally substituted aryl or heteroaryl; R1 = H, halo, alkoxy, NO2, NH2, acylamino or alkylsulphonylamino and R2 = halo, alkoxy, polyfluoroalkoxy, CN or carbamoyl. (I) are new provided that when Z = a bond, B' = a substituted phenyl of formula (a); and if R1 is not acylamino or alkylsulphonylamino, then R2 = polyfluoroalkoxy. 14 Compounds (I) are specifically claimed e.g: 1-[N-cyclohexylcarbonyl-N-(2-pyridyl)-2-aminoethyl]-4-(2-trifluoromethoxyphenyl)-piperazine.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI971862 IT1293805B1 (en) | 1997-08-01 | 1997-08-01 | Piperazine derivatives which bind to 5-HT1A serotonergic receptors - used to treat neuromuscular dysfunctions of lower urinary tract |
JP2000505141A JP2001512110A (en) | 1997-08-01 | 1998-07-31 | 1,4-disubstituted piperazine |
EP98945130A EP1000045A1 (en) | 1997-08-01 | 1998-07-31 | 1,4-disubstituted piperazines |
PCT/EP1998/004796 WO1999006382A1 (en) | 1997-08-01 | 1998-07-31 | 1,4-disubstituted piperazines |
AU92564/98A AU9256498A (en) | 1997-08-01 | 1998-07-31 | 1,4-disubstituted piperazines |
US09/266,534 US6271234B1 (en) | 1997-08-01 | 1999-03-11 | 1,4-disubstituted piperazines |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI971862 IT1293805B1 (en) | 1997-08-01 | 1997-08-01 | Piperazine derivatives which bind to 5-HT1A serotonergic receptors - used to treat neuromuscular dysfunctions of lower urinary tract |
Publications (2)
Publication Number | Publication Date |
---|---|
ITMI971862A1 ITMI971862A1 (en) | 1999-02-01 |
IT1293805B1 true IT1293805B1 (en) | 1999-03-10 |
Family
ID=11377706
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI971862 IT1293805B1 (en) | 1997-08-01 | 1997-08-01 | Piperazine derivatives which bind to 5-HT1A serotonergic receptors - used to treat neuromuscular dysfunctions of lower urinary tract |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1293805B1 (en) |
-
1997
- 1997-08-01 IT ITMI971862 patent/IT1293805B1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ITMI971862A1 (en) | 1999-02-01 |
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