IT1291372B1 - Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie - Google Patents
Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattieInfo
- Publication number
- IT1291372B1 IT1291372B1 IT97MI001190A ITMI971190A IT1291372B1 IT 1291372 B1 IT1291372 B1 IT 1291372B1 IT 97MI001190 A IT97MI001190 A IT 97MI001190A IT MI971190 A ITMI971190 A IT MI971190A IT 1291372 B1 IT1291372 B1 IT 1291372B1
- Authority
- IT
- Italy
- Prior art keywords
- preparation
- treatment
- pyrimidins
- triazole
- diseases
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical compound C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 2
- 208000006011 Stroke Diseases 0.000 abstract 1
- 208000030886 Traumatic Brain injury Diseases 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI001190A IT1291372B1 (it) | 1997-05-21 | 1997-05-21 | Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie |
| DE69802679T DE69802679D1 (de) | 1997-05-21 | 1998-05-14 | Verwendung von 1,2,4-triazolo(1,5-c)pyrimidine heterocyclischen analogen zur herstellung von arzneimitteln zur behandlung von zerebrovascularen störungen |
| AU76546/98A AU740475B2 (en) | 1997-05-21 | 1998-05-14 | The use of 1,2,4-triazolo(1,5-c)pyrimidine heterocyclic analogues for the preparation of medicaments useful for the treatment of cerebrovascular disturbances |
| JP54991798A JP2002502370A (ja) | 1997-05-21 | 1998-05-14 | 脳血管障害の処置に有用な薬剤の調製のための1,2,4−トリアゾロ[1,5−c]ピリミジン複素環アナログの使用 |
| PCT/EP1998/002852 WO1998052568A1 (en) | 1997-05-21 | 1998-05-14 | THE USE OF 1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE HETEROCYCLIC ANALOGUES FOR THE PREPARATION OF MEDICAMENTS USEFUL FOR THE TREATMENT OF CEREBROVASCULAR DISTURBANCES |
| CA002289847A CA2289847A1 (en) | 1997-05-21 | 1998-05-14 | The use of 1,2,4-triazolo[1,5-c]pyrimidine heterocyclic analogues for the preparation of medicaments useful for the treatment of cerebrovascular disturbances |
| AT98924313T ATE209492T1 (de) | 1997-05-21 | 1998-05-14 | Verwendung von 1,2,4-triazolo(1,5-c)pyrimidine heterocyclischen analogen zur herstellung von arzneimitteln zur behandlung von zerebrovascularen störungen |
| CN98805120A CN1255854A (zh) | 1997-05-21 | 1998-05-14 | 1,2,4-三唑并[1,5-c]嘧啶杂环类似物在制备用于治疗心血管疾病的药物中的用途 |
| EP98924313A EP0983068B1 (en) | 1997-05-21 | 1998-05-14 | THE USE OF 1,2,4-TRIAZOLO 1,5-c]PYRIMIDINE HETEROCYCLIC ANALOGUES FOR THE PREPARATION OF MEDICAMENTS USEFUL FOR THE TREATMENT OF CEREBROVASCULAR DISTURBANCES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI001190A IT1291372B1 (it) | 1997-05-21 | 1997-05-21 | Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI971190A0 ITMI971190A0 (instruction) | 1997-05-21 |
| ITMI971190A1 ITMI971190A1 (it) | 1998-11-21 |
| IT1291372B1 true IT1291372B1 (it) | 1999-01-07 |
Family
ID=11377184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT97MI001190A IT1291372B1 (it) | 1997-05-21 | 1997-05-21 | Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0983068B1 (instruction) |
| JP (1) | JP2002502370A (instruction) |
| CN (1) | CN1255854A (instruction) |
| AT (1) | ATE209492T1 (instruction) |
| AU (1) | AU740475B2 (instruction) |
| CA (1) | CA2289847A1 (instruction) |
| DE (1) | DE69802679D1 (instruction) |
| IT (1) | IT1291372B1 (instruction) |
| WO (1) | WO1998052568A1 (instruction) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA02011625A (es) | 2000-05-26 | 2003-03-27 | Schering Corp | Antagonistas receptores de adenosina a2a. |
| GB0100624D0 (en) * | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds VII |
| KR20040066788A (ko) | 2001-08-31 | 2004-07-27 | 더 락커펠러 유니버시티 | 프스포다이에스터레이즈 활성 및 뇌에서프스포다이에스터레이즈 1b 매개되는 신호의 조절 |
| CA2430328A1 (en) * | 2001-09-28 | 2003-04-10 | Kyowa Hakko Kogyo Co., Ltd. | Receptor antagonist |
| US6653315B2 (en) * | 2001-10-15 | 2003-11-25 | Schering Corporation | Adenosine A2a receptor antagonists |
| KR20050044593A (ko) | 2001-11-30 | 2005-05-12 | 쉐링 코포레이션 | 아데노신 A2a 수용체 길항제 |
| PE20030739A1 (es) | 2001-11-30 | 2003-08-28 | Schering Corp | Antagonistas del receptor de adenosina a2a |
| KR20050044600A (ko) | 2001-11-30 | 2005-05-12 | 쉐링 코포레이션 | [1,2,4]-트리아졸 바이사이클릭 아데노신 A2a 수용체길항제 |
| CA2522813C (en) | 2003-04-23 | 2009-09-08 | Schering Corporation | 2-alkynyl-and 2-alkenyl-pyrazolo-¬4,3-e|-1,2,4-triazolo-¬1,5-c|-pyrimidine adenosine a2a receptor antagonists |
| NZ550591A (en) | 2004-04-21 | 2010-10-29 | Schering Corp | Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2A receptor antagonists |
| CN101248050B (zh) | 2005-06-06 | 2013-07-17 | 武田药品工业株式会社 | 有机化合物 |
| CN101312978A (zh) | 2005-09-19 | 2008-11-26 | 先灵公司 | 作为腺苷A2a受体拮抗剂的2-杂芳基-吡唑并-[4,3-e]-1,2,4-三唑并-[1,5-c]-嘧啶 |
| AR056080A1 (es) | 2005-09-23 | 2007-09-19 | Schering Corp | 7-[2-[4-(6-fluoro-3-metil-1,2-benciosoxazol-5-il)-1-piperazinil]etil]-2-(1-propinil)-7h-pirazol-[4,3-e]-[1,2,4]-triazol-[1,5-c] -pirimidin-5-amine |
| ES2273599B1 (es) | 2005-10-14 | 2008-06-01 | Universidad De Barcelona | Compuestos para el tratamiento de la fibrilacion auricular. |
| MX2008015489A (es) | 2006-06-06 | 2009-01-13 | Intra Cellular Therapies Inc | Compuestos organicos. |
| US9198924B2 (en) | 2006-11-13 | 2015-12-01 | Intra-Cellular Therapies, Inc. | Organic compounds |
| US9006258B2 (en) | 2006-12-05 | 2015-04-14 | Intra-Cellular Therapies, Inc. | Method of treating female sexual dysfunction with a PDE1 inhibitor |
| US7691869B2 (en) | 2007-03-30 | 2010-04-06 | King Pharmaceuticals Research And Development, Inc. | Pyrrolotriazolopyrimidine derivatives, pharmaceutical compositions containing them and methods of treating conditions and diseases mediated by the adenosine A2A receptor activity |
| CA2707218A1 (en) | 2007-12-06 | 2009-06-11 | Intra-Cellular Therapies, Inc. | Organic compounds |
| CN104370918A (zh) | 2007-12-06 | 2015-02-25 | 武田药品工业株式会社 | 有机化合物 |
| US8222259B2 (en) | 2008-03-04 | 2012-07-17 | Schering Corporation | 1,2,4-triazolo[4,3-c]pyrimidin-3-one and pyrazolo[4,3-e]-1,2,4-triazolo[4,3-c]pyrimidin-3-one compounds for use as adenosine A2a receptor antagonists |
| JP2011528363A (ja) * | 2008-07-16 | 2011-11-17 | キング・ファーマシューティカルズ・リサーチ・アンド・デベロプメント・インコーポレイティッド | アテローム性動脈硬化症の治療 |
| MX2011005934A (es) | 2008-12-06 | 2011-12-16 | Intra Cellular Therapies Inc | Compuestos organicos. |
| ES2580759T3 (es) | 2008-12-06 | 2016-08-26 | Intra-Cellular Therapies, Inc. | Compuestos orgánicos |
| EP2358723B1 (en) | 2008-12-06 | 2015-05-13 | Intra-Cellular Therapies, Inc. | 4,5,7,8-tetrahydro-2H-imidazo[1,2-a]pyrrolo[3,4-e]pyrimidine compounds as PDE1 inhibitors |
| CA2740398A1 (en) | 2008-12-06 | 2010-06-10 | Intra-Cellular Therapies, Inc. | Organic compounds |
| PE20110922A1 (es) | 2008-12-06 | 2012-01-22 | Intra Cellular Therapies Inc | DERIVADOS DE PIRAZOLO[4,3-e]PIRIMIDIN COMO INHIBIDORES DE LA FOSFODIESTERASA 1 (PDE1) |
| PE20110995A1 (es) | 2008-12-06 | 2012-02-06 | Intra Cellular Therapies Inc | DERIVADOS DE PIRROLO[3,4-e]PIRIMIDINA COMO INHIBIDORES DE PDE1 |
| JP2012518685A (ja) | 2009-02-25 | 2012-08-16 | イントラ−セルラー・セラピーズ・インコーポレイテッド | 眼障害のためのpde1阻害剤 |
| WO2010132127A1 (en) | 2009-05-13 | 2010-11-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2011016861A2 (en) | 2009-08-05 | 2011-02-10 | Intra-Cellular Therapies, Inc. | Novel regulatory proteins and inhibitors |
| TW201206937A (en) | 2010-05-31 | 2012-02-16 | Intra Cellular Therapies Inc | Organic compounds |
| EP2576551A4 (en) | 2010-05-31 | 2014-04-16 | Intra Cellular Therapies Inc | ORGANIC CONNECTIONS |
| US9371327B2 (en) | 2010-05-31 | 2016-06-21 | Intra-Cellular Therapies, Inc. | PDE1 inhibitor compounds |
| EP2575817A4 (en) | 2010-05-31 | 2014-01-08 | Intra Cellular Therapies Inc | ORGANIC CONNECTIONS |
| WO2012171016A1 (en) | 2011-06-10 | 2012-12-13 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2014101120A1 (en) | 2012-12-28 | 2014-07-03 | Merck Sharp & Dohme Corp. | Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties |
| JP6549040B2 (ja) | 2013-02-17 | 2019-07-24 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 新規使用 |
| CA2906640C (en) | 2013-03-15 | 2021-07-20 | Intra-Cellular Therapies, Inc. | Substituted imidazo-[1,2-a]pyrazolo[4.3-e]pyrimidin-4[5h]-one compounds and pharmaceutical compositions and use therof as pde1 inhibitors |
| EP2968338B1 (en) | 2013-03-15 | 2019-01-09 | Intra-Cellular Therapies, Inc. | Pde1 inhibitors for use in the treatment and/or prevention of cns injuries, and pns diseases, disorders or injuries |
| WO2015106032A1 (en) | 2014-01-08 | 2015-07-16 | Intra-Cellular Therapies, Inc. | Products and pharmaceutical compositions |
| WO2015196186A1 (en) | 2014-06-20 | 2015-12-23 | Intra-Cellular Therapies, Inc. | Organic compounds |
| ES2745819T3 (es) | 2014-08-07 | 2020-03-03 | Intra Cellular Therapies Inc | Derivados de imidazo[1,2-a]-pirazolo[4,3-e]-pirimidin-4-ona con actividad inhibidora de la PDE1 |
| US9546175B2 (en) | 2014-08-07 | 2017-01-17 | Intra-Cellular Therapies, Inc. | Organic compounds |
| US10285992B2 (en) | 2014-08-07 | 2019-05-14 | Intra-Cellular Therapies, Inc. | Combinations of PDE1 inhibitors and NEP inhibitors and associated methods |
| IL292225B2 (en) | 2014-09-17 | 2024-12-01 | Intra Cellular Therapies Inc | Derivatives of 5,7,7-trimethyl-[2H]-imidazo-[1,2-a]pyrazolo[4,3-e]pyrimidin-4(5H)-one and pharmaceutical compositions comprising them. |
| RU2727805C2 (ru) | 2014-11-18 | 2020-07-24 | Мерк Шарп И Доум Корп. | Аминопиразиновые соединения со свойствами антагониста a2a |
| CN107205999B (zh) | 2014-12-06 | 2021-08-03 | 细胞内治疗公司 | 有机化合物 |
| RU2702732C1 (ru) | 2014-12-06 | 2019-10-10 | Интра-Селлулар Терапиз, Инк. | Органические соединения |
| WO2016126570A1 (en) | 2015-02-06 | 2016-08-11 | Merck Sharp & Dohme Corp. | Aminoquinazoline compounds as a2a antagonist |
| EP3307067B1 (en) | 2015-06-11 | 2022-11-02 | Merck Sharp & Dohme LLC | Aminopyrazine compounds with a2a antagonist properties |
| WO2017008205A1 (en) | 2015-07-10 | 2017-01-19 | Merck Sharp & Dohme Corp. | Substituted aminoquinazoline compounds as a2a antagonist |
| WO2017172795A1 (en) | 2016-03-28 | 2017-10-05 | Intra-Cellular Therapies, Inc. | Novel compositions and methods |
| US11291666B2 (en) | 2016-09-12 | 2022-04-05 | Intra-Cellular Therapies, Inc. | Uses |
| WO2019118313A1 (en) | 2017-12-13 | 2019-06-20 | Merck Sharp & Dohme Corp. | Imidazo [1,2-c] quinazolin-5-amine compounds with a2a antagonist properties |
| JP7401442B2 (ja) | 2018-01-31 | 2023-12-19 | イントラ-セルラー・セラピーズ・インコーポレイテッド | 新規使用 |
| US12410175B2 (en) | 2019-09-03 | 2025-09-09 | Intra-Cellular Therapies, Inc. | Compounds |
| CN111072676B (zh) * | 2019-12-12 | 2021-07-16 | 广东东阳光药业有限公司 | 含氮稠合三环衍生物及其用途 |
| US12364695B2 (en) | 2020-06-02 | 2025-07-22 | Intra-Cellular Therapies, Inc. | Methods of treating inflammatory disease |
-
1997
- 1997-05-21 IT IT97MI001190A patent/IT1291372B1/it active IP Right Grant
-
1998
- 1998-05-14 WO PCT/EP1998/002852 patent/WO1998052568A1/en active IP Right Grant
- 1998-05-14 CN CN98805120A patent/CN1255854A/zh active Pending
- 1998-05-14 AU AU76546/98A patent/AU740475B2/en not_active Ceased
- 1998-05-14 EP EP98924313A patent/EP0983068B1/en not_active Expired - Lifetime
- 1998-05-14 AT AT98924313T patent/ATE209492T1/de active
- 1998-05-14 DE DE69802679T patent/DE69802679D1/de not_active Expired - Lifetime
- 1998-05-14 JP JP54991798A patent/JP2002502370A/ja active Pending
- 1998-05-14 CA CA002289847A patent/CA2289847A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1255854A (zh) | 2000-06-07 |
| WO1998052568A1 (en) | 1998-11-26 |
| EP0983068B1 (en) | 2001-11-28 |
| CA2289847A1 (en) | 1998-11-26 |
| ATE209492T1 (de) | 2001-12-15 |
| JP2002502370A (ja) | 2002-01-22 |
| DE69802679D1 (de) | 2002-01-10 |
| AU740475B2 (en) | 2001-11-08 |
| AU7654698A (en) | 1998-12-11 |
| ITMI971190A0 (instruction) | 1997-05-21 |
| ITMI971190A1 (it) | 1998-11-21 |
| EP0983068A1 (en) | 2000-03-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |