IT1284425B1 - Barrier material for preventing surgical adhesions - comprising benzyl ester or self-crosslinked deriv. of hyaluronic acid, is biocompatible and biodegradable - Google Patents
Barrier material for preventing surgical adhesions - comprising benzyl ester or self-crosslinked deriv. of hyaluronic acid, is biocompatible and biodegradableInfo
- Publication number
- IT1284425B1 IT1284425B1 ITPD950166A IT1284425B1 IT 1284425 B1 IT1284425 B1 IT 1284425B1 IT PD950166 A ITPD950166 A IT PD950166A IT 1284425 B1 IT1284425 B1 IT 1284425B1
- Authority
- IT
- Italy
- Prior art keywords
- crosslinked
- deriv
- self
- hyaluronic acid
- biocompatible
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 8
- 229920002674 hyaluronan Polymers 0.000 title abstract 8
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 8
- 208000031737 Tissue Adhesions Diseases 0.000 title abstract 4
- 230000004888 barrier function Effects 0.000 title 1
- -1 benzyl ester Chemical class 0.000 title 1
- 239000000463 material Substances 0.000 title 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 239000012620 biological material Substances 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
Landscapes
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Materials For Medical Uses (AREA)
Abstract
A composite biomaterial (I) for preventing surgical tissue adhesions comprises at least one hyaluronic acid (HA) deriv. selected from (a) benzyl esters of HA in which 75-100% of the COOH gps. of HA are esterified with benzyl and up to 25% are esterified with 10-20C alkyl, provided that at least 80% of the COOH gps. are esterified; and (b) self-crosslinked HA derivs., in which 0.5-20% of the COOH gps. of HA are crosslinked to OH gps. of the same or different HA molecules. Also claimed is the use of (I) for preventing surgical adhesions and a method for preventing tissue adhesions using (I).
Priority Applications (28)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT95PD000166 IT1284425B1 (en) | 1995-08-29 | 1995-08-29 | Barrier material for preventing surgical adhesions - comprising benzyl ester or self-crosslinked deriv. of hyaluronic acid, is biocompatible and biodegradable |
CNB961975229A CN1301139C (en) | 1995-08-29 | 1996-08-29 | Biomaterials for preventing post-surgical adhesions comprised of hyaluronic acid derivs. |
CZ1998595A CZ293968B6 (en) | 1995-08-29 | 1996-08-29 | Compound biomaterial for inhibiting surgical adhesions of tissue, use thereof and method |
AT96930132T ATE297230T1 (en) | 1995-08-29 | 1996-08-29 | BIOMATERIALS CONSISTING OF HYALURONIC ACID DERIVATIVES TO INHIBIT POSTOPERATIVE ADHESION FORMATION |
JP9509858A JPH11511344A (en) | 1995-08-29 | 1996-08-29 | Biocompatible material consisting of hyaluronic acid derivative for preventing postoperative adhesion |
DK96930132T DK0850074T3 (en) | 1995-08-29 | 1996-08-29 | Biomaterials comprising hyaluronic acid derivatives for the prevention of postoperative adhesion |
KR1019980701548A KR100515314B1 (en) | 1995-08-29 | 1996-08-29 | Biomaterials to prevent adhesion after surgery containing hyaluronic acid derivatives |
NZ316944A NZ316944A (en) | 1995-08-29 | 1996-08-29 | Composite biomaterial for preventing surgical adhesions of tissue containing hyaluronic acid derivative |
EP96930132A EP0850074B1 (en) | 1995-08-29 | 1996-08-29 | Biomaterials for preventing post-surgical adhesions comprised of hyaluronic acid derivatives |
IL12350096A IL123500A (en) | 1995-08-29 | 1996-08-29 | Composite biomaterials for preventing post-surgical adhesions of tissues |
PT96930132T PT850074E (en) | 1995-08-29 | 1996-08-29 | BIOMATERIALS FOR THE PREVENTION OF POS-SURGICAL ADRENCES, CONSTITUTED BY HYALURONIC ACID DERIVATIVES |
PCT/EP1996/003805 WO1997007833A2 (en) | 1995-08-29 | 1996-08-29 | Biomaterials for preventing post-surgical adhesions comprised of hyaluronic acid derivatives |
PL96325240A PL186859B1 (en) | 1995-08-29 | 1996-08-29 | Biological materials containing derivatives of hialuronic acid for prevention of postoperative adhesions |
BR9610996A BR9610996A (en) | 1995-08-29 | 1996-08-29 | Biomaterials for prevention of post-surgical adhesions comprising derivatives of hyaluronic acids |
AU69300/96A AU718484B2 (en) | 1995-08-29 | 1996-08-29 | Biomaterials for preventing post-surgical adhesions comprised of hyaluronic acid derivatives |
DE69634823T DE69634823T2 (en) | 1995-08-29 | 1996-08-29 | BIOMATERIALS CONSISTING OF HYALURONIC ACID DERIVATIVES FOR INHIBITING POST-OPERATIVE ADHESION FORMATION |
SI9620106A SI9620106B (en) | 1995-08-29 | 1996-08-29 | Bio-materials for preventing post-surgical adhesions comprised of hyaluronic acid derivatives |
RU98105612/14A RU2177332C2 (en) | 1995-08-29 | 1996-08-29 | Biomaterial for prevention of postoperative commissures including hyaluronic acid (versions) and method of preventing postoperative tissue commissures |
CA002230530A CA2230530C (en) | 1995-08-29 | 1996-08-29 | Biomaterials for preventing post-surgical adhesions comprised of hyaluronic acid derivatives |
ES96930132T ES2244975T3 (en) | 1995-08-29 | 1996-08-29 | BIOMATERIALS FOR THE PREVENTION OF POST-SURGICAL ADHERENCES, FORMED BY HIALURONIC ACID DERIVATIVES. |
TR1998/00353T TR199800353T1 (en) | 1995-08-29 | 1996-08-29 | Post-operative anti-adhesion biomaterials. |
HU9903446A HU226962B1 (en) | 1995-08-29 | 1996-08-29 | Biomaterials for preventing post-surgical adhesions comprised of hyaluronic acid derivatives |
US09/031,835 US6723709B1 (en) | 1995-08-29 | 1998-02-27 | Biomaterials for preventing post-surgical adhesions comprised of hyaluronic acid derivatives |
MXPA/A/1998/001622A MXPA98001622A (en) | 1995-08-29 | 1998-02-27 | Biomaterials comprised of derivatives of hyaluronic acid to prevent post-quirurgi accessions |
NO19980888A NO311605B1 (en) | 1995-08-29 | 1998-02-27 | Biomaterials for the prevention of post-surgical adherences comprising hyaluronic acid derivatives |
HK99100963A HK1015714A1 (en) | 1995-08-29 | 1999-03-09 | Biomaterials for preventing post-surgical adhesions comprised of hyaluronic acid derivatives |
US10/812,587 US7504386B2 (en) | 1995-08-29 | 2004-03-29 | Biomaterials for preventing post-surgical adhesions comprised of hyaluronic acid derivatives |
JP2008184052A JP2008302235A (en) | 1995-08-29 | 2008-07-15 | Biomaterial for preventing post-surgical adhesions comprising hyaluronic acid derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT95PD000166 IT1284425B1 (en) | 1995-08-29 | 1995-08-29 | Barrier material for preventing surgical adhesions - comprising benzyl ester or self-crosslinked deriv. of hyaluronic acid, is biocompatible and biodegradable |
Publications (3)
Publication Number | Publication Date |
---|---|
ITPD950166A0 ITPD950166A0 (en) | 1995-08-29 |
ITPD950166A1 ITPD950166A1 (en) | 1997-03-01 |
IT1284425B1 true IT1284425B1 (en) | 1998-05-21 |
Family
ID=11391123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT95PD000166 IT1284425B1 (en) | 1995-08-29 | 1995-08-29 | Barrier material for preventing surgical adhesions - comprising benzyl ester or self-crosslinked deriv. of hyaluronic acid, is biocompatible and biodegradable |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1284425B1 (en) |
-
1995
- 1995-08-29 IT IT95PD000166 patent/IT1284425B1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ITPD950166A0 (en) | 1995-08-29 |
ITPD950166A1 (en) | 1997-03-01 |
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