IT1278094B1 - Variants of human ciliar neurotrophic factor (hCNTF) with improved receptor binder affinity - Google Patents
Variants of human ciliar neurotrophic factor (hCNTF) with improved receptor binder affinityInfo
- Publication number
- IT1278094B1 IT1278094B1 IT95RM000380A ITRM950380A IT1278094B1 IT 1278094 B1 IT1278094 B1 IT 1278094B1 IT 95RM000380 A IT95RM000380 A IT 95RM000380A IT RM950380 A ITRM950380 A IT RM950380A IT 1278094 B1 IT1278094 B1 IT 1278094B1
- Authority
- IT
- Italy
- Prior art keywords
- hcntf
- variants
- human
- ciliar
- neurotrophic factor
- Prior art date
Links
- 108010025020 Nerve Growth Factor Proteins 0.000 title abstract 2
- 102000007072 Nerve Growth Factors Human genes 0.000 title abstract 2
- 239000003900 neurotrophic factor Substances 0.000 title abstract 2
- 239000011230 binding agent Substances 0.000 title 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 abstract 2
- 230000004083 survival effect Effects 0.000 abstract 2
- 108010005939 Ciliary Neurotrophic Factor Proteins 0.000 abstract 1
- 102100031614 Ciliary neurotrophic factor Human genes 0.000 abstract 1
- 208000003098 Ganglion Cysts Diseases 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- 208000005400 Synovial Cyst Diseases 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 210000000653 nervous system Anatomy 0.000 abstract 1
- 210000002569 neuron Anatomy 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000004088 simulation Methods 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Variants of human ciliar neurotrophic factor (hCNTF) characterised in the main by the fact that they are variants of hCNTF in which the glutamine residue (Gln) at position 167 is substituted by an amino acid residue selected from the group comprising alanine (Ala) histidine (His), threonine (Thr) and tyrosine (Tyr). These proteins are important active ingredients in the preparation of drugs for the cure of diseases of the nervous system. Figure 5 shows the effect of hCNTF variants according to the invention on the survival of the embryonal neurones of chick ciliar ganglion in culture. ^ Simulation of cell survival (% of maximum effect) > [CNTF or mutant] (Ng/ml) <IMAGE>
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95RM000380A IT1278094B1 (en) | 1995-06-07 | 1995-06-07 | Variants of human ciliar neurotrophic factor (hCNTF) with improved receptor binder affinity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95RM000380A IT1278094B1 (en) | 1995-06-07 | 1995-06-07 | Variants of human ciliar neurotrophic factor (hCNTF) with improved receptor binder affinity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITRM950380A0 ITRM950380A0 (en) | 1995-06-07 |
| ITRM950380A1 ITRM950380A1 (en) | 1996-12-07 |
| IT1278094B1 true IT1278094B1 (en) | 1997-11-17 |
Family
ID=11403418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT95RM000380A IT1278094B1 (en) | 1995-06-07 | 1995-06-07 | Variants of human ciliar neurotrophic factor (hCNTF) with improved receptor binder affinity |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1278094B1 (en) |
-
1995
- 1995-06-07 IT IT95RM000380A patent/IT1278094B1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ITRM950380A1 (en) | 1996-12-07 |
| ITRM950380A0 (en) | 1995-06-07 |
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