IT1277373B1 - Impiego di composti agonisti o antagonisti dei recettori purinici p2 per la prevenzione della citotossicita' da glutammato - Google Patents
Impiego di composti agonisti o antagonisti dei recettori purinici p2 per la prevenzione della citotossicita' da glutammatoInfo
- Publication number
- IT1277373B1 IT1277373B1 IT95MI001649A ITMI951649A IT1277373B1 IT 1277373 B1 IT1277373 B1 IT 1277373B1 IT 95MI001649 A IT95MI001649 A IT 95MI001649A IT MI951649 A ITMI951649 A IT MI951649A IT 1277373 B1 IT1277373 B1 IT 1277373B1
- Authority
- IT
- Italy
- Prior art keywords
- prevention
- glutamate
- purine
- agonist
- receptors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT95MI001649A IT1277373B1 (it) | 1995-07-28 | 1995-07-28 | Impiego di composti agonisti o antagonisti dei recettori purinici p2 per la prevenzione della citotossicita' da glutammato |
EP96927588A EP0841907B1 (en) | 1995-07-28 | 1996-07-24 | Use of agonists or antagonists of p2 purinoceptors for the prevention of glutamate-evoked cytotoxicity |
JP9507214A JPH11511126A (ja) | 1995-07-28 | 1996-07-24 | グルタメートにより誘発される細胞毒性の防止のためのp▲下2▼プリノセプターの作動薬または拮抗薬の使用 |
AU67366/96A AU707808B2 (en) | 1995-07-28 | 1996-07-24 | Use of agonists or antagonists of p2 purinoceptors for the prevention of glutamate-evoked cytotoxicity |
US09/000,403 US6326370B1 (en) | 1995-07-28 | 1996-07-24 | Use of agonists or antagonists of P2 purinoceptors for the prevention of glutamate-evoked cytotoxicity |
BR9609856A BR9609856A (pt) | 1995-07-28 | 1996-07-24 | Compostos agonistas ou antagonistas de purinoceptores P2 uso dos mesmos e composição farmacológica |
DK96927588T DK0841907T3 (da) | 1995-07-28 | 1996-07-24 | Anvendelse af agonister eller antagonister for P2 purinreceptorer til forebyggelse af glutamatfremkaldt cytotoksicitet |
CA002224293A CA2224293A1 (en) | 1995-07-28 | 1996-07-24 | Use of agonists or antagonists of p2 purinoceptors for the prevention of glutamate-evoked cytotoxicity |
IL12291596A IL122915A (en) | 1995-07-28 | 1996-07-24 | Agonists and antagonists of p2 purinoceptor for use in the prevention of glutamate-evoked cytotoxicity and pharmaceutical compositions containing said agonist or antagonist |
PCT/EP1996/003254 WO1997004760A1 (en) | 1995-07-28 | 1996-07-24 | Use of agonists or antagonists of p2 purinoceptors for the prevention of glutamate-evoked cytotoxicity |
AT96927588T ATE216878T1 (de) | 1995-07-28 | 1996-07-24 | Verwendung von agonisten oder antagonisten der p2 purinozeptoren zur vermeidung der durch glutamat bedingten zytotoxizitaet |
RU98103500/14A RU2211707C2 (ru) | 1995-07-28 | 1996-07-24 | Применение агонистов или антагонистов p2-пуриноцепторов для предупреждения цитотоксичности, вызываемой глютаматом |
DE69621022T DE69621022T2 (de) | 1995-07-28 | 1996-07-24 | Verwendung von agonisten oder antagonisten der p2 purinozeptoren zur vermeidung der durch glutamat bedingten zytotoxizitaet |
ES96927588T ES2173307T3 (es) | 1995-07-28 | 1996-07-24 | Utilizacion de agonistas o antigonistas de los purinoreceptores p2 para la citotoxicidad provocada por el glutamato. |
HK99100850A HK1015698A1 (en) | 1995-07-28 | 1999-03-02 | Use of agonists or antagonists of p2 purinoceptors for the prevention of glutamate-evoked cytotoxicity |
US09/987,075 US20020028790A1 (en) | 1995-07-28 | 2001-11-13 | Use of agonists or antagonists of P2 purinoceptors for the prevention glutamate-evoked cytotoxicity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT95MI001649A IT1277373B1 (it) | 1995-07-28 | 1995-07-28 | Impiego di composti agonisti o antagonisti dei recettori purinici p2 per la prevenzione della citotossicita' da glutammato |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI951649A0 ITMI951649A0 (it) | 1995-07-27 |
ITMI951649A1 ITMI951649A1 (it) | 1997-01-27 |
IT1277373B1 true IT1277373B1 (it) | 1997-11-10 |
Family
ID=11372076
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT95MI001649A IT1277373B1 (it) | 1995-07-28 | 1995-07-28 | Impiego di composti agonisti o antagonisti dei recettori purinici p2 per la prevenzione della citotossicita' da glutammato |
Country Status (15)
Country | Link |
---|---|
US (2) | US6326370B1 (it) |
EP (1) | EP0841907B1 (it) |
JP (1) | JPH11511126A (it) |
AT (1) | ATE216878T1 (it) |
AU (1) | AU707808B2 (it) |
BR (1) | BR9609856A (it) |
CA (1) | CA2224293A1 (it) |
DE (1) | DE69621022T2 (it) |
DK (1) | DK0841907T3 (it) |
ES (1) | ES2173307T3 (it) |
HK (1) | HK1015698A1 (it) |
IL (1) | IL122915A (it) |
IT (1) | IT1277373B1 (it) |
RU (1) | RU2211707C2 (it) |
WO (1) | WO1997004760A1 (it) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9615202D0 (en) * | 1996-07-19 | 1996-09-04 | Smithkline Beecham Plc | Pharmaceuticals |
SE9702002D0 (sv) * | 1997-05-28 | 1997-05-28 | Astra Pharma Prod | Novel compounds |
US6462028B2 (en) * | 1997-07-25 | 2002-10-08 | Inspire Pharmaceuticals, Inc. | Method of promoting cervical and vaginal secretions |
IT1303815B1 (it) * | 1998-12-02 | 2001-02-23 | Consiglio Nazionale Ricerche | Impiego di selettivi composti modulatori dei recettori purinici p2 perla prevenzione dei danni e della mortalita' causata da ischemia |
US7141511B2 (en) * | 2004-04-27 | 2006-11-28 | Micron Technology Inc. | Method and apparatus for fabricating a memory device with a dielectric etch stop layer |
GB0520405D0 (en) * | 2005-10-07 | 2005-11-16 | Imp College Innovations Ltd | Biological agents and method |
EP3323415A1 (en) * | 2016-11-16 | 2018-05-23 | Institut du Cerveau et de la Moelle Epiniere-ICM | Treatment of neurodegenerative diseases |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4230493A1 (de) | 1992-09-11 | 1994-03-17 | Institut Fuer Bioanalytik Gmbh | Arzneimittel zur Behandlung des zentralen Nervensystems |
-
1995
- 1995-07-28 IT IT95MI001649A patent/IT1277373B1/it active IP Right Grant
-
1996
- 1996-07-24 EP EP96927588A patent/EP0841907B1/en not_active Expired - Lifetime
- 1996-07-24 JP JP9507214A patent/JPH11511126A/ja active Pending
- 1996-07-24 ES ES96927588T patent/ES2173307T3/es not_active Expired - Lifetime
- 1996-07-24 DE DE69621022T patent/DE69621022T2/de not_active Expired - Fee Related
- 1996-07-24 AU AU67366/96A patent/AU707808B2/en not_active Ceased
- 1996-07-24 US US09/000,403 patent/US6326370B1/en not_active Expired - Fee Related
- 1996-07-24 WO PCT/EP1996/003254 patent/WO1997004760A1/en active IP Right Grant
- 1996-07-24 CA CA002224293A patent/CA2224293A1/en not_active Abandoned
- 1996-07-24 AT AT96927588T patent/ATE216878T1/de not_active IP Right Cessation
- 1996-07-24 IL IL12291596A patent/IL122915A/xx not_active IP Right Cessation
- 1996-07-24 RU RU98103500/14A patent/RU2211707C2/ru not_active IP Right Cessation
- 1996-07-24 BR BR9609856A patent/BR9609856A/pt not_active Application Discontinuation
- 1996-07-24 DK DK96927588T patent/DK0841907T3/da active
-
1999
- 1999-03-02 HK HK99100850A patent/HK1015698A1/xx not_active IP Right Cessation
-
2001
- 2001-11-13 US US09/987,075 patent/US20020028790A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ATE216878T1 (de) | 2002-05-15 |
ES2173307T3 (es) | 2002-10-16 |
IL122915A (en) | 2003-05-29 |
DE69621022T2 (de) | 2003-02-27 |
DK0841907T3 (da) | 2002-07-15 |
CA2224293A1 (en) | 1997-02-13 |
HK1015698A1 (en) | 1999-10-22 |
EP0841907A1 (en) | 1998-05-20 |
AU707808B2 (en) | 1999-07-22 |
ITMI951649A1 (it) | 1997-01-27 |
DE69621022D1 (de) | 2002-06-06 |
RU2211707C2 (ru) | 2003-09-10 |
BR9609856A (pt) | 1999-03-16 |
ITMI951649A0 (it) | 1995-07-27 |
WO1997004760A1 (en) | 1997-02-13 |
IL122915A0 (en) | 1998-08-16 |
JPH11511126A (ja) | 1999-09-28 |
US20020028790A1 (en) | 2002-03-07 |
US6326370B1 (en) | 2001-12-04 |
EP0841907B1 (en) | 2002-05-02 |
AU6736696A (en) | 1997-02-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted |