IT1276734B1 - Polypeptide compounds containing D-2-alkyl tryptophane capable of promoting the release of growth hormone - Google Patents

Polypeptide compounds containing D-2-alkyl tryptophane capable of promoting the release of growth hormone

Info

Publication number
IT1276734B1
IT1276734B1 IT95MI001293A ITMI951293A IT1276734B1 IT 1276734 B1 IT1276734 B1 IT 1276734B1 IT 95MI001293 A IT95MI001293 A IT 95MI001293A IT MI951293 A ITMI951293 A IT MI951293A IT 1276734 B1 IT1276734 B1 IT 1276734B1
Authority
IT
Italy
Prior art keywords
phe
lys
promoting
release
growth hormone
Prior art date
Application number
IT95MI001293A
Other languages
Italian (it)
Inventor
Romano Deghenghi
Original Assignee
Romano Deghenghi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Romano Deghenghi filed Critical Romano Deghenghi
Publication of ITMI951293A0 publication Critical patent/ITMI951293A0/en
Priority to IT95MI001293A priority Critical patent/IT1276734B1/en
Priority to HU9800136A priority patent/HU221481B/en
Priority to ES95932735T priority patent/ES2186730T3/en
Priority to AT95932735T priority patent/ATE225806T1/en
Priority to RU97107089/04A priority patent/RU2157378C2/en
Priority to PT95932735T priority patent/PT783521E/en
Priority to AU35668/95A priority patent/AU700066B2/en
Priority to PL95319382A priority patent/PL181588B1/en
Priority to DE69528531T priority patent/DE69528531T2/en
Priority to CZ1997914A priority patent/CZ291798B6/en
Priority to EP95932735A priority patent/EP0783521B8/en
Priority to CN95195323A priority patent/CN1121413C/en
Priority to SK399-97A priority patent/SK284550B6/en
Priority to JP51131596A priority patent/JP3810083B2/en
Priority to CA002201122A priority patent/CA2201122A1/en
Priority to KR1019970701987A priority patent/KR100369105B1/en
Priority to DK95932735T priority patent/DK0783521T3/en
Priority to PCT/EP1995/003601 priority patent/WO1996010040A1/en
Priority to MX9702275A priority patent/MX9702275A/en
Priority to US08/530,853 priority patent/US5795957A/en
Priority to IL11538195A priority patent/IL115381A/en
Publication of ITMI951293A1 publication Critical patent/ITMI951293A1/en
Priority to US08/871,418 priority patent/US5872100A/en
Application granted granted Critical
Publication of IT1276734B1 publication Critical patent/IT1276734B1/en
Priority to US08/971,032 priority patent/US5955421A/en
Priority to HK98100002A priority patent/HK1001207A1/en

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A peptide of formula A-D-Mrp-(Ala)n-B-C where A is any L-amino acid present in nature or its D isomer with the exception that it is not His if B is Trp and C is D-Phe-Lye-NH2, imidazolacetyl, isonipecotyl, 4- aminobutylryl, 4-(aminomethyl) cyclohexancarbonyl, Glu- Tyr-Ala-His, Tyr-Ala-His, Tyr-His, D-Thr-His, D relates to the dextrorotatory isomer, Mrp is 1-alkyltryptophane, n is 0 or 1, B is L- or D-Trp, Phe or D-β-naphthyl alanine, C is NH2, D-Phe-LysNH2, D-Trp-LysNH2, D-Phe-Lys- NH2, Phe-Lys-NH2, D-Phe-Lys-ThrNH2, D-Phe-Lys-D-ThrNH2 and addition salts with pharmaceutically acceptable organic or inorganic acids of any one of the said polypeptides, these compounds are capable of promoting the release of growth hormone, and are active when administered orally.
IT95MI001293A 1990-05-11 1995-06-16 Polypeptide compounds containing D-2-alkyl tryptophane capable of promoting the release of growth hormone IT1276734B1 (en)

Priority Applications (24)

Application Number Priority Date Filing Date Title
IT95MI001293A IT1276734B1 (en) 1995-06-16 1995-06-16 Polypeptide compounds containing D-2-alkyl tryptophane capable of promoting the release of growth hormone
SK399-97A SK284550B6 (en) 1994-09-27 1995-09-13 Peptides, pharmaceutical composition containing them and their use
CA002201122A CA2201122A1 (en) 1994-09-27 1995-09-13 Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone
AT95932735T ATE225806T1 (en) 1994-09-27 1995-09-13 D-2-ALKYLTRYPTOPHANE CONTAINING POLYPEPTIDES WITH GROWTH HORMONE RELEASING ACTIVITY
RU97107089/04A RU2157378C2 (en) 1994-09-27 1995-09-13 Polypeptide compounds containing d-2-alkyltryptophan that stimulates growth hormone release
PT95932735T PT783521E (en) 1994-09-27 1995-09-13 POLYPROPHTY COMPOUNDS CONTAINING D-2-ALQUILTRIPTOFANO ABLE TO PROMOTE FREQUENCY OF GROWTH HORMONE
AU35668/95A AU700066B2 (en) 1994-09-27 1995-09-13 Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone
PL95319382A PL181588B1 (en) 1994-09-27 1995-09-13 Polypeptidic compounds containing d-2-alkylotryptophane capable to promote liberation of growth hormone
DE69528531T DE69528531T2 (en) 1994-09-27 1995-09-13 D-2-ALKYLTRYPTOPHAN CONTAINING POLYPEPTIDES WITH GROWTH HUMOR RELEASING ACTIVITY
CZ1997914A CZ291798B6 (en) 1994-09-27 1995-09-13 Peptides, their use and pharmaceutical composition in which the peptides are comprised
EP95932735A EP0783521B8 (en) 1994-09-27 1995-09-13 Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone
CN95195323A CN1121413C (en) 1994-09-27 1995-09-13 Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone
HU9800136A HU221481B (en) 1994-09-27 1995-09-13 Oligopeptides containing d-2-alkyltryptophan capable of promoting the release of growth hormone, their use and pharmaceutical compositions comprising thereof
JP51131596A JP3810083B2 (en) 1994-09-27 1995-09-13 Peptide compound containing 2-alkyltryptophan capable of promoting growth factor release
ES95932735T ES2186730T3 (en) 1994-09-27 1995-09-13 OLIGOPPEPTIDIC COMPOUNDS CONTAINING A D-2-ALKYL TRIPTOPHAN AMINO ACID AND THAT ARE ABLE TO RELEASE GROWTH HORMONE.
KR1019970701987A KR100369105B1 (en) 1994-09-27 1995-09-13 Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the secretion of growth hormone
DK95932735T DK0783521T3 (en) 1994-09-27 1995-09-13 Polypeptide compounds containing D-2-alkyltryptophan which are capable of promoting the release of growth hormone
PCT/EP1995/003601 WO1996010040A1 (en) 1994-09-27 1995-09-13 Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone
MX9702275A MX9702275A (en) 1994-09-27 1995-09-13 Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone.
US08/530,853 US5795957A (en) 1994-09-27 1995-09-20 Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone
IL11538195A IL115381A (en) 1994-09-27 1995-09-21 Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone
US08/871,418 US5872100A (en) 1990-05-11 1997-06-09 Peptides containing D-2-Alkyl-Tryptophan
US08/971,032 US5955421A (en) 1990-05-11 1997-11-14 Peptides containing D-2-alkyl-Tryptophan
HK98100002A HK1001207A1 (en) 1994-09-27 1998-01-02 Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI001293A IT1276734B1 (en) 1995-06-16 1995-06-16 Polypeptide compounds containing D-2-alkyl tryptophane capable of promoting the release of growth hormone

Publications (3)

Publication Number Publication Date
ITMI951293A0 ITMI951293A0 (en) 1995-06-16
ITMI951293A1 ITMI951293A1 (en) 1996-12-16
IT1276734B1 true IT1276734B1 (en) 1997-11-03

Family

ID=11371826

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95MI001293A IT1276734B1 (en) 1990-05-11 1995-06-16 Polypeptide compounds containing D-2-alkyl tryptophane capable of promoting the release of growth hormone

Country Status (1)

Country Link
IT (1) IT1276734B1 (en)

Also Published As

Publication number Publication date
ITMI951293A1 (en) 1996-12-16
ITMI951293A0 (en) 1995-06-16

Similar Documents

Publication Publication Date Title
ATE417622T1 (en) REGULATION OF GASTROINTESTINAL MOBILITY
DE3686200D1 (en) BIOLOGICALLY ACTIVE LYSINE CONTAINING OCTAPEPTIDES.
BR1100309A (en) Peptide and pharmaceutical composition to promote the release of growth hormone levels in animals
MX9702275A (en) Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone.
RU97107089A (en) POLYEPEPTIDE COMPOUNDS CONTAINING D-2-ALKYLTRIPTOPHANE, STIMULATING THE RELEASE OF GROWTH HORMONE
MY103251A (en) Biologically active molecules
ATE3416T1 (en) PHARMACOLOGICALLY ACTIVE PEPTIDES AND MEDICATIONS CONTAINING THEM.
ATE42308T1 (en) PHARMACOLOGICALLY ACTIVE PEPTIDES.
IT1276734B1 (en) Polypeptide compounds containing D-2-alkyl tryptophane capable of promoting the release of growth hormone
ES2171439T3 (en) COMPOSITION BASED ON AMINO ACIDS FOR THE TREATMENT OF INFECTIONS.
DE3751398D1 (en) Substrate peptides.
NO894720L (en) PHARMASOEYTIC ACTIVE PROTEIN.
ATE92078T1 (en) PHARMACOLOGICALLY ACTIVE PEPTIDES.
ATE46173T1 (en) PHARMACOLOGICALLY ACTIVE PEPTIDES.
IT1270021B (en) Polypeptide compounds containing D-2-methyltryptophan having activity increasing intracellular cAMP
NO980103D0 (en) Stabilized pharmaceutical composition comprising a growth hormone and a peptide comprising at least one basic amino acid residue and at least one acidic amino acid residue
ATE59393T1 (en) PEPTIDES.
KR950704358A (en) Cathepsin L specific inhibitory polypeptide
TH26711A (en) "Homone secretion of growth factor"
DE3689850T2 (en) Peptides and their use in therapy.
TH35998A (en) LH-RH Peptide analogues, their benefits and the pharmaceutical constituents they contain.

Legal Events

Date Code Title Description
0001 Granted