IT1276734B1 - Polypeptide compounds containing D-2-alkyl tryptophane capable of promoting the release of growth hormone - Google Patents
Polypeptide compounds containing D-2-alkyl tryptophane capable of promoting the release of growth hormoneInfo
- Publication number
- IT1276734B1 IT1276734B1 IT95MI001293A ITMI951293A IT1276734B1 IT 1276734 B1 IT1276734 B1 IT 1276734B1 IT 95MI001293 A IT95MI001293 A IT 95MI001293A IT MI951293 A ITMI951293 A IT MI951293A IT 1276734 B1 IT1276734 B1 IT 1276734B1
- Authority
- IT
- Italy
- Prior art keywords
- phe
- lys
- promoting
- release
- growth hormone
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000018997 Growth Hormone Human genes 0.000 title abstract 2
- 108010051696 Growth Hormone Proteins 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000000122 growth hormone Substances 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 230000001737 promoting effect Effects 0.000 title abstract 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 title 1
- 239000006035 Tryptophane Substances 0.000 title 1
- 229960004799 tryptophan Drugs 0.000 title 1
- -1 imidazolacetyl Chemical group 0.000 abstract 4
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 abstract 1
- 150000008575 L-amino acids Chemical class 0.000 abstract 1
- SDNVRAKIJVKAGS-LKTVYLICSA-N Tyr-Ala-His Chemical compound C[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)N SDNVRAKIJVKAGS-LKTVYLICSA-N 0.000 abstract 1
- ZQOOYCZQENFIMC-STQMWFEESA-N Tyr-His Chemical compound C([C@H](N)C(=O)N[C@@H](CC=1N=CNC=1)C(O)=O)C1=CC=C(O)C=C1 ZQOOYCZQENFIMC-STQMWFEESA-N 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A peptide of formula A-D-Mrp-(Ala)n-B-C where A is any L-amino acid present in nature or its D isomer with the exception that it is not His if B is Trp and C is D-Phe-Lye-NH2, imidazolacetyl, isonipecotyl, 4- aminobutylryl, 4-(aminomethyl) cyclohexancarbonyl, Glu- Tyr-Ala-His, Tyr-Ala-His, Tyr-His, D-Thr-His, D relates to the dextrorotatory isomer, Mrp is 1-alkyltryptophane, n is 0 or 1, B is L- or D-Trp, Phe or D-β-naphthyl alanine, C is NH2, D-Phe-LysNH2, D-Trp-LysNH2, D-Phe-Lys- NH2, Phe-Lys-NH2, D-Phe-Lys-ThrNH2, D-Phe-Lys-D-ThrNH2 and addition salts with pharmaceutically acceptable organic or inorganic acids of any one of the said polypeptides, these compounds are capable of promoting the release of growth hormone, and are active when administered orally.
Priority Applications (24)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT95MI001293A IT1276734B1 (en) | 1995-06-16 | 1995-06-16 | Polypeptide compounds containing D-2-alkyl tryptophane capable of promoting the release of growth hormone |
SK399-97A SK284550B6 (en) | 1994-09-27 | 1995-09-13 | Peptides, pharmaceutical composition containing them and their use |
CA002201122A CA2201122A1 (en) | 1994-09-27 | 1995-09-13 | Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone |
AT95932735T ATE225806T1 (en) | 1994-09-27 | 1995-09-13 | D-2-ALKYLTRYPTOPHANE CONTAINING POLYPEPTIDES WITH GROWTH HORMONE RELEASING ACTIVITY |
RU97107089/04A RU2157378C2 (en) | 1994-09-27 | 1995-09-13 | Polypeptide compounds containing d-2-alkyltryptophan that stimulates growth hormone release |
PT95932735T PT783521E (en) | 1994-09-27 | 1995-09-13 | POLYPROPHTY COMPOUNDS CONTAINING D-2-ALQUILTRIPTOFANO ABLE TO PROMOTE FREQUENCY OF GROWTH HORMONE |
AU35668/95A AU700066B2 (en) | 1994-09-27 | 1995-09-13 | Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone |
PL95319382A PL181588B1 (en) | 1994-09-27 | 1995-09-13 | Polypeptidic compounds containing d-2-alkylotryptophane capable to promote liberation of growth hormone |
DE69528531T DE69528531T2 (en) | 1994-09-27 | 1995-09-13 | D-2-ALKYLTRYPTOPHAN CONTAINING POLYPEPTIDES WITH GROWTH HUMOR RELEASING ACTIVITY |
CZ1997914A CZ291798B6 (en) | 1994-09-27 | 1995-09-13 | Peptides, their use and pharmaceutical composition in which the peptides are comprised |
EP95932735A EP0783521B8 (en) | 1994-09-27 | 1995-09-13 | Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone |
CN95195323A CN1121413C (en) | 1994-09-27 | 1995-09-13 | Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone |
HU9800136A HU221481B (en) | 1994-09-27 | 1995-09-13 | Oligopeptides containing d-2-alkyltryptophan capable of promoting the release of growth hormone, their use and pharmaceutical compositions comprising thereof |
JP51131596A JP3810083B2 (en) | 1994-09-27 | 1995-09-13 | Peptide compound containing 2-alkyltryptophan capable of promoting growth factor release |
ES95932735T ES2186730T3 (en) | 1994-09-27 | 1995-09-13 | OLIGOPPEPTIDIC COMPOUNDS CONTAINING A D-2-ALKYL TRIPTOPHAN AMINO ACID AND THAT ARE ABLE TO RELEASE GROWTH HORMONE. |
KR1019970701987A KR100369105B1 (en) | 1994-09-27 | 1995-09-13 | Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the secretion of growth hormone |
DK95932735T DK0783521T3 (en) | 1994-09-27 | 1995-09-13 | Polypeptide compounds containing D-2-alkyltryptophan which are capable of promoting the release of growth hormone |
PCT/EP1995/003601 WO1996010040A1 (en) | 1994-09-27 | 1995-09-13 | Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone |
MX9702275A MX9702275A (en) | 1994-09-27 | 1995-09-13 | Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone. |
US08/530,853 US5795957A (en) | 1994-09-27 | 1995-09-20 | Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone |
IL11538195A IL115381A (en) | 1994-09-27 | 1995-09-21 | Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone |
US08/871,418 US5872100A (en) | 1990-05-11 | 1997-06-09 | Peptides containing D-2-Alkyl-Tryptophan |
US08/971,032 US5955421A (en) | 1990-05-11 | 1997-11-14 | Peptides containing D-2-alkyl-Tryptophan |
HK98100002A HK1001207A1 (en) | 1994-09-27 | 1998-01-02 | Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT95MI001293A IT1276734B1 (en) | 1995-06-16 | 1995-06-16 | Polypeptide compounds containing D-2-alkyl tryptophane capable of promoting the release of growth hormone |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI951293A0 ITMI951293A0 (en) | 1995-06-16 |
ITMI951293A1 ITMI951293A1 (en) | 1996-12-16 |
IT1276734B1 true IT1276734B1 (en) | 1997-11-03 |
Family
ID=11371826
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT95MI001293A IT1276734B1 (en) | 1990-05-11 | 1995-06-16 | Polypeptide compounds containing D-2-alkyl tryptophane capable of promoting the release of growth hormone |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1276734B1 (en) |
-
1995
- 1995-06-16 IT IT95MI001293A patent/IT1276734B1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ITMI951293A1 (en) | 1996-12-16 |
ITMI951293A0 (en) | 1995-06-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE417622T1 (en) | REGULATION OF GASTROINTESTINAL MOBILITY | |
DE3686200D1 (en) | BIOLOGICALLY ACTIVE LYSINE CONTAINING OCTAPEPTIDES. | |
BR1100309A (en) | Peptide and pharmaceutical composition to promote the release of growth hormone levels in animals | |
MX9702275A (en) | Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone. | |
RU97107089A (en) | POLYEPEPTIDE COMPOUNDS CONTAINING D-2-ALKYLTRIPTOPHANE, STIMULATING THE RELEASE OF GROWTH HORMONE | |
MY103251A (en) | Biologically active molecules | |
ATE3416T1 (en) | PHARMACOLOGICALLY ACTIVE PEPTIDES AND MEDICATIONS CONTAINING THEM. | |
ATE42308T1 (en) | PHARMACOLOGICALLY ACTIVE PEPTIDES. | |
IT1276734B1 (en) | Polypeptide compounds containing D-2-alkyl tryptophane capable of promoting the release of growth hormone | |
ES2171439T3 (en) | COMPOSITION BASED ON AMINO ACIDS FOR THE TREATMENT OF INFECTIONS. | |
DE3751398D1 (en) | Substrate peptides. | |
NO894720L (en) | PHARMASOEYTIC ACTIVE PROTEIN. | |
ATE92078T1 (en) | PHARMACOLOGICALLY ACTIVE PEPTIDES. | |
ATE46173T1 (en) | PHARMACOLOGICALLY ACTIVE PEPTIDES. | |
IT1270021B (en) | Polypeptide compounds containing D-2-methyltryptophan having activity increasing intracellular cAMP | |
NO980103D0 (en) | Stabilized pharmaceutical composition comprising a growth hormone and a peptide comprising at least one basic amino acid residue and at least one acidic amino acid residue | |
ATE59393T1 (en) | PEPTIDES. | |
KR950704358A (en) | Cathepsin L specific inhibitory polypeptide | |
TH26711A (en) | "Homone secretion of growth factor" | |
DE3689850T2 (en) | Peptides and their use in therapy. | |
TH35998A (en) | LH-RH Peptide analogues, their benefits and the pharmaceutical constituents they contain. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted |