IT1270021B - Polypeptide compounds containing D-2-methyltryptophan having activity increasing intracellular cAMP - Google Patents
Polypeptide compounds containing D-2-methyltryptophan having activity increasing intracellular cAMPInfo
- Publication number
- IT1270021B IT1270021B ITMI941954A ITMI941954A IT1270021B IT 1270021 B IT1270021 B IT 1270021B IT MI941954 A ITMI941954 A IT MI941954A IT MI941954 A ITMI941954 A IT MI941954A IT 1270021 B IT1270021 B IT 1270021B
- Authority
- IT
- Italy
- Prior art keywords
- phe
- tyr
- ala
- methyltryptophan
- trp
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- BXJSOEWOQDVGJW-SNVBAGLBSA-N (2r)-2-azaniumyl-3-(2-methyl-1h-indol-3-yl)propanoate Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=C(C)NC2=C1 BXJSOEWOQDVGJW-SNVBAGLBSA-N 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 230000003834 intracellular effect Effects 0.000 title 1
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 2
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-STHAYSLISA-N D-threonine Chemical compound C[C@H](O)[C@@H](N)C(O)=O AYFVYJQAPQTCCC-STHAYSLISA-N 0.000 abstract 1
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- 150000008575 L-amino acids Chemical class 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- SDNVRAKIJVKAGS-LKTVYLICSA-N Tyr-Ala-His Chemical compound C[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)N SDNVRAKIJVKAGS-LKTVYLICSA-N 0.000 abstract 1
- ZQOOYCZQENFIMC-STQMWFEESA-N Tyr-His Chemical compound C([C@H](N)C(=O)N[C@@H](CC=1N=CNC=1)C(O)=O)C1=CC=C(O)C=C1 ZQOOYCZQENFIMC-STQMWFEESA-N 0.000 abstract 1
- 239000000122 growth hormone Substances 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Abstract
A peptide of formula: A-D-Mrp-Ala-B-C where A is any L-amino acid present in nature or its D isomer with the exception that it is not His if B is Trp and C is D-Phe-Lys-NH2, imidazole acetyl, Glu-Tyr-Ala- His, Tyr-Ala-His, Tyr-His, D-Thr-His and more preferably A is D-Ala, D-Thr, Tyr; D refers to the dextrorotatory isomer, Mrp is 2-alkyltryptophan, B is Trp or Phe, C is NH2, D-Phe-LysNH2, D-Trp-LysNH2, D-Phe-Lys-ThrNH2, D-Phe- Lys-D-ThrNH2, and the addition salts of any of the said polypeptides with pharmaceutically acceptable organic or inorganic acids, these compounds being able to promote the release of growth hormone, and being active via the oral route.
Priority Applications (25)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI941954A IT1270021B (en) | 1994-09-27 | 1994-09-27 | Polypeptide compounds containing D-2-methyltryptophan having activity increasing intracellular cAMP |
AT95932735T ATE225806T1 (en) | 1994-09-27 | 1995-09-13 | D-2-ALKYLTRYPTOPHANE CONTAINING POLYPEPTIDES WITH GROWTH HORMONE RELEASING ACTIVITY |
CZ1997914A CZ291798B6 (en) | 1994-09-27 | 1995-09-13 | Peptides, their use and pharmaceutical composition in which the peptides are comprised |
SK399-97A SK284550B6 (en) | 1994-09-27 | 1995-09-13 | Peptides, pharmaceutical composition containing them and their use |
CN95195323A CN1121413C (en) | 1994-09-27 | 1995-09-13 | Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone |
PT95932735T PT783521E (en) | 1994-09-27 | 1995-09-13 | POLYPROPHTY COMPOUNDS CONTAINING D-2-ALQUILTRIPTOFANO ABLE TO PROMOTE FREQUENCY OF GROWTH HORMONE |
RU97107089/04A RU2157378C2 (en) | 1994-09-27 | 1995-09-13 | Polypeptide compounds containing d-2-alkyltryptophan that stimulates growth hormone release |
DE69528531T DE69528531T2 (en) | 1994-09-27 | 1995-09-13 | D-2-ALKYLTRYPTOPHAN CONTAINING POLYPEPTIDES WITH GROWTH HUMOR RELEASING ACTIVITY |
DK95932735T DK0783521T3 (en) | 1994-09-27 | 1995-09-13 | Polypeptide compounds containing D-2-alkyltryptophan which are capable of promoting the release of growth hormone |
JP51131596A JP3810083B2 (en) | 1994-09-27 | 1995-09-13 | Peptide compound containing 2-alkyltryptophan capable of promoting growth factor release |
ES95932735T ES2186730T3 (en) | 1994-09-27 | 1995-09-13 | OLIGOPPEPTIDIC COMPOUNDS CONTAINING A D-2-ALKYL TRIPTOPHAN AMINO ACID AND THAT ARE ABLE TO RELEASE GROWTH HORMONE. |
KR1019970701987A KR100369105B1 (en) | 1994-09-27 | 1995-09-13 | Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the secretion of growth hormone |
EP95932735A EP0783521B8 (en) | 1994-09-27 | 1995-09-13 | Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone |
MX9702275A MX9702275A (en) | 1994-09-27 | 1995-09-13 | Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone. |
HU9800136A HU221481B (en) | 1994-09-27 | 1995-09-13 | Oligopeptides containing d-2-alkyltryptophan capable of promoting the release of growth hormone, their use and pharmaceutical compositions comprising thereof |
PL95319382A PL181588B1 (en) | 1994-09-27 | 1995-09-13 | Polypeptidic compounds containing d-2-alkylotryptophane capable to promote liberation of growth hormone |
PCT/EP1995/003601 WO1996010040A1 (en) | 1994-09-27 | 1995-09-13 | Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone |
CA002201122A CA2201122A1 (en) | 1994-09-27 | 1995-09-13 | Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone |
AU35668/95A AU700066B2 (en) | 1994-09-27 | 1995-09-13 | Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone |
US08/530,853 US5795957A (en) | 1994-09-27 | 1995-09-20 | Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone |
ZA957977A ZA957977B (en) | 1994-09-27 | 1995-09-21 | Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone |
IL11538195A IL115381A (en) | 1994-09-27 | 1995-09-21 | Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone |
US08/871,418 US5872100A (en) | 1990-05-11 | 1997-06-09 | Peptides containing D-2-Alkyl-Tryptophan |
US08/971,032 US5955421A (en) | 1990-05-11 | 1997-11-14 | Peptides containing D-2-alkyl-Tryptophan |
HK98100002A HK1001207A1 (en) | 1994-09-27 | 1998-01-02 | Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI941954A IT1270021B (en) | 1994-09-27 | 1994-09-27 | Polypeptide compounds containing D-2-methyltryptophan having activity increasing intracellular cAMP |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI941954A0 ITMI941954A0 (en) | 1994-09-27 |
ITMI941954A1 ITMI941954A1 (en) | 1996-03-27 |
IT1270021B true IT1270021B (en) | 1997-04-16 |
Family
ID=11369598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI941954A IT1270021B (en) | 1990-05-11 | 1994-09-27 | Polypeptide compounds containing D-2-methyltryptophan having activity increasing intracellular cAMP |
Country Status (2)
Country | Link |
---|---|
IT (1) | IT1270021B (en) |
ZA (1) | ZA957977B (en) |
-
1994
- 1994-09-27 IT ITMI941954A patent/IT1270021B/en active IP Right Grant
-
1995
- 1995-09-21 ZA ZA957977A patent/ZA957977B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA957977B (en) | 1996-03-15 |
ITMI941954A0 (en) | 1994-09-27 |
ITMI941954A1 (en) | 1996-03-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970926 |