IT1270021B - Polypeptide compounds containing D-2-methyltryptophan having activity increasing intracellular cAMP - Google Patents

Polypeptide compounds containing D-2-methyltryptophan having activity increasing intracellular cAMP

Info

Publication number
IT1270021B
IT1270021B ITMI941954A ITMI941954A IT1270021B IT 1270021 B IT1270021 B IT 1270021B IT MI941954 A ITMI941954 A IT MI941954A IT MI941954 A ITMI941954 A IT MI941954A IT 1270021 B IT1270021 B IT 1270021B
Authority
IT
Italy
Prior art keywords
phe
tyr
ala
methyltryptophan
trp
Prior art date
Application number
ITMI941954A
Other languages
Italian (it)
Inventor
Romano Deghenghi
Original Assignee
Europ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Europ filed Critical Europ
Publication of ITMI941954A0 publication Critical patent/ITMI941954A0/en
Priority to ITMI941954A priority Critical patent/IT1270021B/en
Priority to EP95932735A priority patent/EP0783521B8/en
Priority to HU9800136A priority patent/HU221481B/en
Priority to SK399-97A priority patent/SK284550B6/en
Priority to CN95195323A priority patent/CN1121413C/en
Priority to PT95932735T priority patent/PT783521E/en
Priority to RU97107089/04A priority patent/RU2157378C2/en
Priority to DE69528531T priority patent/DE69528531T2/en
Priority to DK95932735T priority patent/DK0783521T3/en
Priority to JP51131596A priority patent/JP3810083B2/en
Priority to ES95932735T priority patent/ES2186730T3/en
Priority to KR1019970701987A priority patent/KR100369105B1/en
Priority to AT95932735T priority patent/ATE225806T1/en
Priority to MX9702275A priority patent/MX9702275A/en
Priority to CZ1997914A priority patent/CZ291798B6/en
Priority to PL95319382A priority patent/PL181588B1/en
Priority to PCT/EP1995/003601 priority patent/WO1996010040A1/en
Priority to CA002201122A priority patent/CA2201122A1/en
Priority to AU35668/95A priority patent/AU700066B2/en
Priority to US08/530,853 priority patent/US5795957A/en
Priority to ZA957977A priority patent/ZA957977B/en
Priority to IL11538195A priority patent/IL115381A/en
Publication of ITMI941954A1 publication Critical patent/ITMI941954A1/en
Application granted granted Critical
Publication of IT1270021B publication Critical patent/IT1270021B/en
Priority to US08/871,418 priority patent/US5872100A/en
Priority to US08/971,032 priority patent/US5955421A/en
Priority to HK98100002A priority patent/HK1001207A1/en

Links

Abstract

A peptide of formula: A-D-Mrp-Ala-B-C where A is any L-amino acid present in nature or its D isomer with the exception that it is not His if B is Trp and C is D-Phe-Lys-NH2, imidazole acetyl, Glu-Tyr-Ala- His, Tyr-Ala-His, Tyr-His, D-Thr-His and more preferably A is D-Ala, D-Thr, Tyr; D refers to the dextrorotatory isomer, Mrp is 2-alkyltryptophan, B is Trp or Phe, C is NH2, D-Phe-LysNH2, D-Trp-LysNH2, D-Phe-Lys-ThrNH2, D-Phe- Lys-D-ThrNH2, and the addition salts of any of the said polypeptides with pharmaceutically acceptable organic or inorganic acids, these compounds being able to promote the release of growth hormone, and being active via the oral route.
ITMI941954A 1990-05-11 1994-09-27 Polypeptide compounds containing D-2-methyltryptophan having activity increasing intracellular cAMP IT1270021B (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
ITMI941954A IT1270021B (en) 1994-09-27 1994-09-27 Polypeptide compounds containing D-2-methyltryptophan having activity increasing intracellular cAMP
AT95932735T ATE225806T1 (en) 1994-09-27 1995-09-13 D-2-ALKYLTRYPTOPHANE CONTAINING POLYPEPTIDES WITH GROWTH HORMONE RELEASING ACTIVITY
CZ1997914A CZ291798B6 (en) 1994-09-27 1995-09-13 Peptides, their use and pharmaceutical composition in which the peptides are comprised
SK399-97A SK284550B6 (en) 1994-09-27 1995-09-13 Peptides, pharmaceutical composition containing them and their use
CN95195323A CN1121413C (en) 1994-09-27 1995-09-13 Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone
PT95932735T PT783521E (en) 1994-09-27 1995-09-13 POLYPROPHTY COMPOUNDS CONTAINING D-2-ALQUILTRIPTOFANO ABLE TO PROMOTE FREQUENCY OF GROWTH HORMONE
RU97107089/04A RU2157378C2 (en) 1994-09-27 1995-09-13 Polypeptide compounds containing d-2-alkyltryptophan that stimulates growth hormone release
DE69528531T DE69528531T2 (en) 1994-09-27 1995-09-13 D-2-ALKYLTRYPTOPHAN CONTAINING POLYPEPTIDES WITH GROWTH HUMOR RELEASING ACTIVITY
DK95932735T DK0783521T3 (en) 1994-09-27 1995-09-13 Polypeptide compounds containing D-2-alkyltryptophan which are capable of promoting the release of growth hormone
JP51131596A JP3810083B2 (en) 1994-09-27 1995-09-13 Peptide compound containing 2-alkyltryptophan capable of promoting growth factor release
ES95932735T ES2186730T3 (en) 1994-09-27 1995-09-13 OLIGOPPEPTIDIC COMPOUNDS CONTAINING A D-2-ALKYL TRIPTOPHAN AMINO ACID AND THAT ARE ABLE TO RELEASE GROWTH HORMONE.
KR1019970701987A KR100369105B1 (en) 1994-09-27 1995-09-13 Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the secretion of growth hormone
EP95932735A EP0783521B8 (en) 1994-09-27 1995-09-13 Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone
MX9702275A MX9702275A (en) 1994-09-27 1995-09-13 Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone.
HU9800136A HU221481B (en) 1994-09-27 1995-09-13 Oligopeptides containing d-2-alkyltryptophan capable of promoting the release of growth hormone, their use and pharmaceutical compositions comprising thereof
PL95319382A PL181588B1 (en) 1994-09-27 1995-09-13 Polypeptidic compounds containing d-2-alkylotryptophane capable to promote liberation of growth hormone
PCT/EP1995/003601 WO1996010040A1 (en) 1994-09-27 1995-09-13 Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone
CA002201122A CA2201122A1 (en) 1994-09-27 1995-09-13 Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone
AU35668/95A AU700066B2 (en) 1994-09-27 1995-09-13 Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone
US08/530,853 US5795957A (en) 1994-09-27 1995-09-20 Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone
ZA957977A ZA957977B (en) 1994-09-27 1995-09-21 Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone
IL11538195A IL115381A (en) 1994-09-27 1995-09-21 Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone
US08/871,418 US5872100A (en) 1990-05-11 1997-06-09 Peptides containing D-2-Alkyl-Tryptophan
US08/971,032 US5955421A (en) 1990-05-11 1997-11-14 Peptides containing D-2-alkyl-Tryptophan
HK98100002A HK1001207A1 (en) 1994-09-27 1998-01-02 Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI941954A IT1270021B (en) 1994-09-27 1994-09-27 Polypeptide compounds containing D-2-methyltryptophan having activity increasing intracellular cAMP

Publications (3)

Publication Number Publication Date
ITMI941954A0 ITMI941954A0 (en) 1994-09-27
ITMI941954A1 ITMI941954A1 (en) 1996-03-27
IT1270021B true IT1270021B (en) 1997-04-16

Family

ID=11369598

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI941954A IT1270021B (en) 1990-05-11 1994-09-27 Polypeptide compounds containing D-2-methyltryptophan having activity increasing intracellular cAMP

Country Status (2)

Country Link
IT (1) IT1270021B (en)
ZA (1) ZA957977B (en)

Also Published As

Publication number Publication date
ZA957977B (en) 1996-03-15
ITMI941954A0 (en) 1994-09-27
ITMI941954A1 (en) 1996-03-27

Similar Documents

Publication Publication Date Title
ATE78831T1 (en) BIOLOGICALLY ACTIVE LYSINE CONTAINING OCTAPEPTIDES.
JPS6434997A (en) Peptide, manufacture, lhrh antagonistic medicine and manufacture
DE69227462D1 (en) PEPTIDES WITH GROWTH HORMONE RELEASING ACTIVITY
ATE494902T1 (en) A CHICKEN GNRH-II ANALOG FOR USE IN REDUCING TUMOR CELL GROWTH
ES526201A0 (en) A PROCEDURE FOR PREPARING A PEPTIDE THAT HAS AN INFLUENCE ON THE FUNCTION OF THE PITUITARY GLAND
KR930701483A (en) GRF (MUF) Analog XI
MX9702275A (en) Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone.
RU97107089A (en) POLYEPEPTIDE COMPOUNDS CONTAINING D-2-ALKYLTRIPTOPHANE, STIMULATING THE RELEASE OF GROWTH HORMONE
RU98113920A (en) OLIGOPEPTIDES DERIVATIVES CONTAINING D-ALKYLTRIPTOPHANE AND ABLE TO ACTIVATE HORMONE HORMONE RELEASE
MY103251A (en) Biologically active molecules
IT1270021B (en) Polypeptide compounds containing D-2-methyltryptophan having activity increasing intracellular cAMP
ATE42308T1 (en) PHARMACOLOGICALLY ACTIVE PEPTIDES.
SE9403055D0 (en) A new human peptide antibiotic (FALL-39) and its use
NO894720L (en) PHARMASOEYTIC ACTIVE PROTEIN.
EP1074264A4 (en) Neovascularization inhibitors
EP0248231A3 (en) Pharmacologically active peptides
EP0328089A3 (en) Reduced size lhrh analogs
ATE59393T1 (en) PEPTIDES.
IT1276734B1 (en) Polypeptide compounds containing D-2-alkyl tryptophane capable of promoting the release of growth hormone
NO992668L (en) Topical composition for the introduction of pharmaceutically active peptide compounds into living organisms
DE3665462D1 (en) Pharmacologically active peptides
YU40492A (en) PRECURSOR FORM OF BOVINE GROWTH HORMONE RELEASE FACTORS AND RELATED DNA OF THE COMPOUND
DE3689850T2 (en) Peptides and their use in therapy.
TH26711A (en) "Homone secretion of growth factor"
Baturina et al. Paradoxical correlations of the effectiveness of the intranasal and intraperitoneal administration of dermorphins in rats

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970926