IT1274356B - Semisynthetic taxanes having antitumoural activity - Google Patents
Semisynthetic taxanes having antitumoural activityInfo
- Publication number
- IT1274356B IT1274356B ITMI941592A ITMI941592A IT1274356B IT 1274356 B IT1274356 B IT 1274356B IT MI941592 A ITMI941592 A IT MI941592A IT MI941592 A ITMI941592 A IT MI941592A IT 1274356 B IT1274356 B IT 1274356B
- Authority
- IT
- Italy
- Prior art keywords
- antitumoural activity
- semisynthetic
- taxanes
- antitumoural
- activity
- Prior art date
Links
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- 229940123237 Taxane Drugs 0.000 title 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical group NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
- YWLXLRUDGLRYDR-ZHPRIASZSA-N 5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 YWLXLRUDGLRYDR-ZHPRIASZSA-N 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical class O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
This invention relates to new derivatives which can be obtained by the stereospecific oxidation and reduction of 10-deacetyl baccatine III and subsequent esterification with a variously substituted isoserine chain in order to obtain taxol analogues. The products according to the invention have cytotoxic and antitumoural activity and can be administered by injection and/or orally when suitably formulated.
Priority Applications (29)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI941592A IT1274356B (en) | 1994-07-26 | 1994-07-26 | Semisynthetic taxanes having antitumoural activity |
AT95927699T ATE176464T1 (en) | 1994-07-26 | 1995-07-21 | SEMISYNTHETIC TAXAL DERIVATIVES WITH ANTI-TUMOR EFFECT |
CA002195844A CA2195844C (en) | 1994-07-26 | 1995-07-21 | Semi-synthetic taxanes with anti-tumoural activity |
AU31641/95A AU684218B2 (en) | 1994-07-26 | 1995-07-21 | Semi-synthetic taxanes with anti-tumoural activity |
PL95318289A PL187579B1 (en) | 1994-07-26 | 1995-07-21 | Semi-synthetic taxanes of anticarcinogenic activity |
SI9520078A SI9520078B (en) | 1994-07-26 | 1995-07-21 | Semi-synthetic taxanes with anti-tumoural activity |
ROA200000502A RO116549B1 (en) | 1994-07-26 | 1995-07-21 | Taxane derivatives, process for preparing the same, intermediate for preparing the same and pharmaceutical composition containing said derivatives |
EP95927699A EP0773938B1 (en) | 1994-07-26 | 1995-07-21 | Semi-synthetic taxanes with anti-tumoural activity |
CN95194333A CN1073105C (en) | 1994-07-26 | 1995-07-21 | Semi-synthetic taxanes with anti-tumoural activity |
SK100-97A SK281526B6 (en) | 1994-07-26 | 1995-07-21 | Semi-synthetic taxanes, method of their preparation and intermediates, semi-synthetic secotaxanes, method of their preparation, pharmaceutical compositions containing thereof anmd their use |
PCT/EP1995/002896 WO1996003394A1 (en) | 1994-07-26 | 1995-07-21 | Semi-synthetic taxanes with anti-tumoural activity |
KR1019970700442A KR100220490B1 (en) | 1994-07-26 | 1995-07-21 | Semi-synthethic taxanes with anti-tumoural activity |
RO97-00125A RO115875B1 (en) | 1994-07-26 | 1995-07-21 | Taxane derivatives, process for preparing the same, intermediate for their preparation and pharmaceutical composition containing the same |
ES95927699T ES2126919T3 (en) | 1994-07-26 | 1995-07-21 | SEMI-SYNTHETIC TAXANES WITH ANTITUMORAL ACTIVITY. |
CZ1997199A CZ293076B6 (en) | 1994-07-26 | 1995-07-21 | Semisynthetic taxanes, process of their preparation, pharmaceutical compositions in which the taxanes are comprised and intermediates for their preparation |
RU97102722A RU2134688C1 (en) | 1994-07-26 | 1995-07-21 | Semisynthetic taxane, intermediate compounds, methods of synthesis and pharmaceutical composition |
DK95927699T DK0773938T3 (en) | 1994-07-26 | 1995-07-21 | Semi-synthetic taxanes with anti-tumor activity |
DE69507702T DE69507702T2 (en) | 1994-07-26 | 1995-07-21 | SEMISYNTHETIC TAXAL DERIVATIVES WITH ANTITUMOR EFFECT |
HU9700206A HU222496B1 (en) | 1994-07-26 | 1995-07-21 | Semi-synthetic taxane derivatives, process for producing them and pharmaceutical compositions containing them |
JP8505456A JP2986550B2 (en) | 1994-07-26 | 1995-07-21 | Semi-synthetic taxane with antitumor activity |
US08/505,924 US5756776A (en) | 1994-07-26 | 1995-07-24 | Semi-synthetic taxanes with anti-tumoural activity |
BG101165A BG62851B1 (en) | 1994-07-26 | 1997-01-23 | Semi-synthetic taxanes with anti-tumoural activity, method for their preparation and application |
FI970271A FI120398B (en) | 1994-07-26 | 1997-01-23 | Semi-synthetic taxanes with antitumor activity, processes, intermediates and pharmaceutical compositions thereof |
NO19970296A NO315116B1 (en) | 1994-07-26 | 1997-01-23 | Semi-synthetic taxanes with anti-tumor activity |
HK98112903A HK1011687A1 (en) | 1994-07-26 | 1998-12-07 | Semi-synthetic taxanes with anti-tumoural activity |
GR990400393T GR3029309T3 (en) | 1994-07-26 | 1999-02-09 | Semi-synthetic taxanes with anti-tumoural activity |
CN00129056A CN1128795C (en) | 1994-07-26 | 2000-09-29 | Semi-synthetic taxane having antineoplastic activity |
CN00129054A CN1120161C (en) | 1994-07-26 | 2000-09-29 | Partially synthetic taxinane with antineoplastic activity |
CN00129055A CN1130356C (en) | 1994-07-26 | 2000-09-29 | Partially synthetic seco-taxinane with antineoplastic activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI941592A IT1274356B (en) | 1994-07-26 | 1994-07-26 | Semisynthetic taxanes having antitumoural activity |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI941592A0 ITMI941592A0 (en) | 1994-07-26 |
ITMI941592A1 ITMI941592A1 (en) | 1996-01-26 |
IT1274356B true IT1274356B (en) | 1997-07-17 |
Family
ID=11369367
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI941592A IT1274356B (en) | 1994-07-26 | 1994-07-26 | Semisynthetic taxanes having antitumoural activity |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1274356B (en) |
-
1994
- 1994-07-26 IT ITMI941592A patent/IT1274356B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ITMI941592A1 (en) | 1996-01-26 |
ITMI941592A0 (en) | 1994-07-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970729 |