IT1274356B - Semisynthetic taxanes having antitumoural activity - Google Patents

Semisynthetic taxanes having antitumoural activity

Info

Publication number
IT1274356B
IT1274356B ITMI941592A ITMI941592A IT1274356B IT 1274356 B IT1274356 B IT 1274356B IT MI941592 A ITMI941592 A IT MI941592A IT MI941592 A ITMI941592 A IT MI941592A IT 1274356 B IT1274356 B IT 1274356B
Authority
IT
Italy
Prior art keywords
antitumoural activity
semisynthetic
taxanes
antitumoural
activity
Prior art date
Application number
ITMI941592A
Other languages
Italian (it)
Inventor
Ezio Bombardelli
Bellis Paolo De
Bruno Gabetta
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of ITMI941592A0 publication Critical patent/ITMI941592A0/en
Priority to ITMI941592A priority Critical patent/IT1274356B/en
Priority to CZ1997199A priority patent/CZ293076B6/en
Priority to RO97-00125A priority patent/RO115875B1/en
Priority to RU97102722A priority patent/RU2134688C1/en
Priority to PL95318289A priority patent/PL187579B1/en
Priority to SI9520078A priority patent/SI9520078B/en
Priority to ROA200000502A priority patent/RO116549B1/en
Priority to EP95927699A priority patent/EP0773938B1/en
Priority to CN95194333A priority patent/CN1073105C/en
Priority to SK100-97A priority patent/SK281526B6/en
Priority to PCT/EP1995/002896 priority patent/WO1996003394A1/en
Priority to KR1019970700442A priority patent/KR100220490B1/en
Priority to DE69507702T priority patent/DE69507702T2/en
Priority to ES95927699T priority patent/ES2126919T3/en
Priority to AT95927699T priority patent/ATE176464T1/en
Priority to AU31641/95A priority patent/AU684218B2/en
Priority to DK95927699T priority patent/DK0773938T3/en
Priority to CA002195844A priority patent/CA2195844C/en
Priority to HU9700206A priority patent/HU222496B1/en
Priority to JP8505456A priority patent/JP2986550B2/en
Priority to US08/505,924 priority patent/US5756776A/en
Publication of ITMI941592A1 publication Critical patent/ITMI941592A1/en
Priority to NO19970296A priority patent/NO315116B1/en
Priority to FI970271A priority patent/FI120398B/en
Priority to BG101165A priority patent/BG62851B1/en
Application granted granted Critical
Publication of IT1274356B publication Critical patent/IT1274356B/en
Priority to HK98112903A priority patent/HK1011687A1/en
Priority to GR990400393T priority patent/GR3029309T3/en
Priority to CN00129056A priority patent/CN1128795C/en
Priority to CN00129054A priority patent/CN1120161C/en
Priority to CN00129055A priority patent/CN1130356C/en

Links

Landscapes

  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention relates to new derivatives which can be obtained by the stereospecific oxidation and reduction of 10-deacetyl baccatine III and subsequent esterification with a variously substituted isoserine chain in order to obtain taxol analogues. The products according to the invention have cytotoxic and antitumoural activity and can be administered by injection and/or orally when suitably formulated.
ITMI941592A 1994-07-26 1994-07-26 Semisynthetic taxanes having antitumoural activity IT1274356B (en)

Priority Applications (29)

Application Number Priority Date Filing Date Title
ITMI941592A IT1274356B (en) 1994-07-26 1994-07-26 Semisynthetic taxanes having antitumoural activity
AT95927699T ATE176464T1 (en) 1994-07-26 1995-07-21 SEMISYNTHETIC TAXAL DERIVATIVES WITH ANTI-TUMOR EFFECT
CA002195844A CA2195844C (en) 1994-07-26 1995-07-21 Semi-synthetic taxanes with anti-tumoural activity
AU31641/95A AU684218B2 (en) 1994-07-26 1995-07-21 Semi-synthetic taxanes with anti-tumoural activity
PL95318289A PL187579B1 (en) 1994-07-26 1995-07-21 Semi-synthetic taxanes of anticarcinogenic activity
SI9520078A SI9520078B (en) 1994-07-26 1995-07-21 Semi-synthetic taxanes with anti-tumoural activity
ROA200000502A RO116549B1 (en) 1994-07-26 1995-07-21 Taxane derivatives, process for preparing the same, intermediate for preparing the same and pharmaceutical composition containing said derivatives
EP95927699A EP0773938B1 (en) 1994-07-26 1995-07-21 Semi-synthetic taxanes with anti-tumoural activity
CN95194333A CN1073105C (en) 1994-07-26 1995-07-21 Semi-synthetic taxanes with anti-tumoural activity
SK100-97A SK281526B6 (en) 1994-07-26 1995-07-21 Semi-synthetic taxanes, method of their preparation and intermediates, semi-synthetic secotaxanes, method of their preparation, pharmaceutical compositions containing thereof anmd their use
PCT/EP1995/002896 WO1996003394A1 (en) 1994-07-26 1995-07-21 Semi-synthetic taxanes with anti-tumoural activity
KR1019970700442A KR100220490B1 (en) 1994-07-26 1995-07-21 Semi-synthethic taxanes with anti-tumoural activity
RO97-00125A RO115875B1 (en) 1994-07-26 1995-07-21 Taxane derivatives, process for preparing the same, intermediate for their preparation and pharmaceutical composition containing the same
ES95927699T ES2126919T3 (en) 1994-07-26 1995-07-21 SEMI-SYNTHETIC TAXANES WITH ANTITUMORAL ACTIVITY.
CZ1997199A CZ293076B6 (en) 1994-07-26 1995-07-21 Semisynthetic taxanes, process of their preparation, pharmaceutical compositions in which the taxanes are comprised and intermediates for their preparation
RU97102722A RU2134688C1 (en) 1994-07-26 1995-07-21 Semisynthetic taxane, intermediate compounds, methods of synthesis and pharmaceutical composition
DK95927699T DK0773938T3 (en) 1994-07-26 1995-07-21 Semi-synthetic taxanes with anti-tumor activity
DE69507702T DE69507702T2 (en) 1994-07-26 1995-07-21 SEMISYNTHETIC TAXAL DERIVATIVES WITH ANTITUMOR EFFECT
HU9700206A HU222496B1 (en) 1994-07-26 1995-07-21 Semi-synthetic taxane derivatives, process for producing them and pharmaceutical compositions containing them
JP8505456A JP2986550B2 (en) 1994-07-26 1995-07-21 Semi-synthetic taxane with antitumor activity
US08/505,924 US5756776A (en) 1994-07-26 1995-07-24 Semi-synthetic taxanes with anti-tumoural activity
BG101165A BG62851B1 (en) 1994-07-26 1997-01-23 Semi-synthetic taxanes with anti-tumoural activity, method for their preparation and application
FI970271A FI120398B (en) 1994-07-26 1997-01-23 Semi-synthetic taxanes with antitumor activity, processes, intermediates and pharmaceutical compositions thereof
NO19970296A NO315116B1 (en) 1994-07-26 1997-01-23 Semi-synthetic taxanes with anti-tumor activity
HK98112903A HK1011687A1 (en) 1994-07-26 1998-12-07 Semi-synthetic taxanes with anti-tumoural activity
GR990400393T GR3029309T3 (en) 1994-07-26 1999-02-09 Semi-synthetic taxanes with anti-tumoural activity
CN00129056A CN1128795C (en) 1994-07-26 2000-09-29 Semi-synthetic taxane having antineoplastic activity
CN00129054A CN1120161C (en) 1994-07-26 2000-09-29 Partially synthetic taxinane with antineoplastic activity
CN00129055A CN1130356C (en) 1994-07-26 2000-09-29 Partially synthetic seco-taxinane with antineoplastic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI941592A IT1274356B (en) 1994-07-26 1994-07-26 Semisynthetic taxanes having antitumoural activity

Publications (3)

Publication Number Publication Date
ITMI941592A0 ITMI941592A0 (en) 1994-07-26
ITMI941592A1 ITMI941592A1 (en) 1996-01-26
IT1274356B true IT1274356B (en) 1997-07-17

Family

ID=11369367

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI941592A IT1274356B (en) 1994-07-26 1994-07-26 Semisynthetic taxanes having antitumoural activity

Country Status (1)

Country Link
IT (1) IT1274356B (en)

Also Published As

Publication number Publication date
ITMI941592A1 (en) 1996-01-26
ITMI941592A0 (en) 1994-07-26

Similar Documents

Publication Publication Date Title
GR3029309T3 (en) Semi-synthetic taxanes with anti-tumoural activity
SG97813A1 (en) Synthesis of taxol and its derivatives
AU4242993A (en) Cultured (taxus) tissues as a source of taxol, related taxanes and other novel anti-tumor/anti-viral compounds
PL307089A1 (en) Taxane exhibiting anticarcinogenic properties
GR3022355T3 (en) Novel compositions based on taxane class derivatives
DK0717041T3 (en) Crystalline paclitaxel hydrates
IL109613A0 (en) Inclusion complexes of taxol or taxotere or taxus extract formed with cyclodextrins, their preparation and use
HK1005242A1 (en) 10-Deacetylbaccatine iii and 10-deacetyl 14 beta-hydroxybaccatine iii derivatives a process for the preparation thereof and pharmaceutical composition containing them
GR3019871T3 (en) Taxane derivatives, their preparation and use in oncology
ATE334115T1 (en) METHOD FOR PRODUCING TAXAND DERIVATIVES AND BETA-LACTAM INTERMEDIATE PRODUCTS
DE69434373D1 (en) Beta-lactams for the preparation of taxanes with furyl or thienyl substituted side chain
AU5425794A (en) Process for the preparation of taxane derivatives, novel taxanes so obtained and antitumour and antileukaemia compositions containing same
IL107554A (en) Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
IT1274356B (en) Semisynthetic taxanes having antitumoural activity
IT1278108B1 (en) Secotaxanes having anti-tumoural activity
ITPS920002V0 (en) ARTICULATED SUPPORT SUITABLE FOR ALLOWING THE APPLICATION, ON STAIRS OF DIFFERENT INCLINATION, OF THE SLIDING TRACK OF A WALL-SAW SAW WITH MECHANICAL OR HYDRAULIC ADVANCE
NZ507349A (en) Spisulosine Compounds having antitumour activity

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970729