IT1271703B - "6-OR 7-SUBSTITUTED DERIVATIVES OF 4-AMINOANDROSTADIENONE AND PROCEDURE FOR THEIR PREPARATION" - Google Patents

"6-OR 7-SUBSTITUTED DERIVATIVES OF 4-AMINOANDROSTADIENONE AND PROCEDURE FOR THEIR PREPARATION"

Info

Publication number
IT1271703B
IT1271703B ITMI942233A ITMI942233A IT1271703B IT 1271703 B IT1271703 B IT 1271703B IT MI942233 A ITMI942233 A IT MI942233A IT MI942233 A ITMI942233 A IT MI942233A IT 1271703 B IT1271703 B IT 1271703B
Authority
IT
Italy
Prior art keywords
hydrogen
formula
group
aminoandrostadienone
procedure
Prior art date
Application number
ITMI942233A
Other languages
Italian (it)
Inventor
Franco Buzzetti
Antonio Longo
Salle Enrico Di
Original Assignee
Franco Buzzetti
Antonio Longo
Salle Enrico Di
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Franco Buzzetti, Antonio Longo, Salle Enrico Di filed Critical Franco Buzzetti
Publication of ITMI942233A0 publication Critical patent/ITMI942233A0/en
Publication of ITMI942233A1 publication Critical patent/ITMI942233A1/en
Application granted granted Critical
Publication of IT1271703B publication Critical patent/IT1271703B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0011—Unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

La presente invenzione fornisce nuovi composti con la seguente formula generale (I) (FORMULA I) nella quale x rappresenta un legame singolo o doppio;A rappresenta un gruppo C-O3 oppure (FORMULA).ciascun sostituente R ed R rappresenta, indipendentemente, un idrogeno o un acile;R1 rappresenta un idrogeno o un gruppo -(CH2)n(FORMULA)R2 rappresenta un idrogeno o un gruppo -(CH2)n(FORMULA) o un gruppo -S-(CH2)n(FORMULA)R4 rappresenta un idrogeno, un alogeno, un alchile C1-C6, un alcossi C1-C6, o un trifluorometile;n rappresenta 1, 2 o 3; e m rappresenta 0, 1 o 2;A patto che, tra i sostituenti R1 e R2, uno sia un idrogeno e l'altro sia diverso dall'idrogeno, e i suoi sali farmaceuticamente accettabili.I composti dell'invenzione sono utili come inibitori dell'aromatasi.1The present invention provides new compounds with the following general formula (I) (FORMULA I) in which x represents a single or double bond; A represents a group C-O3 or (FORMULA). Each substituent R and R represents, independently, a hydrogen or an acyl; R1 represents a hydrogen or a group - (CH2) n (FORMULA) R2 represents a hydrogen or a group - (CH2) n (FORMULA) or a group -S- (CH2) n (FORMULA) R4 represents a hydrogen, a halogen, a C1-C6 alkyl, a C1-C6 alkoxy, or a trifluoromethyl; n represents 1, 2 or 3; em represents 0, 1 or 2; Provided that, between the substituents R1 and R2, one is a hydrogen and the other is different from hydrogen, and its pharmaceutically acceptable salts. The compounds of the invention are useful as inhibitors of the aromatasi.1

ITMI942233A 1993-12-09 1994-11-03 "6-OR 7-SUBSTITUTED DERIVATIVES OF 4-AMINOANDROSTADIENONE AND PROCEDURE FOR THEIR PREPARATION" IT1271703B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9325244A GB2284605A (en) 1993-12-09 1993-12-09 6-or 7-substituted 4-aminoandrostadienone derivatives

Publications (3)

Publication Number Publication Date
ITMI942233A0 ITMI942233A0 (en) 1994-11-03
ITMI942233A1 ITMI942233A1 (en) 1996-05-03
IT1271703B true IT1271703B (en) 1997-06-04

Family

ID=10746367

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI942233A IT1271703B (en) 1993-12-09 1994-11-03 "6-OR 7-SUBSTITUTED DERIVATIVES OF 4-AMINOANDROSTADIENONE AND PROCEDURE FOR THEIR PREPARATION"

Country Status (2)

Country Link
GB (1) GB2284605A (en)
IT (1) IT1271703B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8503940D0 (en) * 1985-02-15 1985-03-20 Erba Farmitalia 4-substituted androstendione derivatives

Also Published As

Publication number Publication date
GB2284605A (en) 1995-06-14
GB9325244D0 (en) 1994-02-09
ITMI942233A0 (en) 1994-11-03
ITMI942233A1 (en) 1996-05-03

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Legal Events

Date Code Title Description
0001 Granted