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Application filed by Smithkline Beecham CorpfiledCriticalSmithkline Beecham Corp
Priority to NO92920441ApriorityCriticalpatent/NO920441L/en
Publication of NO920441D0publicationCriticalpatent/NO920441D0/en
Publication of NO920441LpublicationCriticalpatent/NO920441L/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Det beskrives bruk av en forbindelse med formel (I):. hvor. R.og R, uavhengig av hverandre utgjør -(CH2) -A;. m er 0 eller tallet 1, 2 eller 3;. A utgjør et substituert eller usubstituert cyklisk hydrokarbonradikal;. Rutgjør et halogenatom, en nitrogruppe eller en gruppe -R;. RRutør uavhengig av hverandre, hydrogen, alkyl eller alkylkarbonyl; eller hvorog R^ sammen med nitrogenatomet som de er tilknyttet, danner en eventuelt substituert heterocyklisk gruppe; og farmasøytisk akseptable salter derav,. for fremstilling av et farmasøytisk preparat for hemming av produksjonen av tumornekrosefaktor (TNF) i pattedyr.The use of a compound of formula (I) is described:. where. R. and R, independently of one another, constitute - (CH2) -A ;. m is 0 or the number 1, 2 or 3 ;. A constitutes a substituted or unsubstituted cyclic hydrocarbon radical; Forms a halogen atom, a nitro group or a group -R ;. RRutor independently, hydrogen, alkyl or alkylcarbonyl; or wherein R 2 together with the nitrogen atom to which they are attached form an optionally substituted heterocyclic group; and pharmaceutically acceptable salts thereof,. for the manufacture of a pharmaceutical composition for inhibiting the production of tumor necrosis factor (TNF) in mammals.
DEKAHYDROCHINOLIN DERIVATIVES, METHOD FOR THEIR PRODUCTION, INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION, THEIR USE AS MEDICINAL PRODUCTS AND PREPARATIONS THEREOF.
Benzimidazole derivatives as inhibitors of smooth muscle cell proliferation, process for producing them and pharmaceutical compositions containing them
NOVEL 20,21-DINOREBURNAMENINE DERIVATIVES SUBSTITUTED IN 15 BY AN AMINE GROUP, THEIR PREPARATION METHOD AND THE INTERMEDIATES THUS OBTAINED, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM