IT1264078B1 - Uso di anticorpi anti-molecole hla classe i libere da beta-2 microglobulina per saggi di evidenziazione dell'esposizione al virus - Google Patents
Uso di anticorpi anti-molecole hla classe i libere da beta-2 microglobulina per saggi di evidenziazione dell'esposizione al virusInfo
- Publication number
- IT1264078B1 IT1264078B1 IT93RM000613A ITRM930613A IT1264078B1 IT 1264078 B1 IT1264078 B1 IT 1264078B1 IT 93RM000613 A IT93RM000613 A IT 93RM000613A IT RM930613 A ITRM930613 A IT RM930613A IT 1264078 B1 IT1264078 B1 IT 1264078B1
- Authority
- IT
- Italy
- Prior art keywords
- hla
- fhc
- complex
- microglobulin
- analyte
- Prior art date
Links
- 238000003556 assay Methods 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title 1
- 102000015736 beta 2-Microglobulin Human genes 0.000 title 1
- 108010081355 beta 2-Microglobulin Proteins 0.000 title 1
- 239000012491 analyte Substances 0.000 abstract 5
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 230000036436 anti-hiv Effects 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
- G01N33/56988—HIV or HTLV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- AIDS & HIV (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Uso di un anticorpo in grado di riconoscere sia epitopi della proteina gp160 del virus HIV che della catena pesante di HLA di classe 1, libera dalla microglobulina ?-2, (HLA FHC) per la produzione di un saggio diagnostico per la evidenziazione dell'infezione da HIV in un analito negativo per la presenza di anticorpi specifici anti-HIV, detto saggio caratterizzato dai seguenti passaggi:- incubare detto analito con un campione comprendente molecole di HLA FHC. immobilizzate su un supporto solido, in condizioni tali da permettere la formazione di un complesso analito-HLA FHC;- lavare con un tampone in condizioni non dissocianti per detto complesso;- incubare detto complesso con detto anticorpo in condizioni tali da permettere la formazione di un complesso analito HLA FHC-anticorpo;- rivelare detto complesso analito-HLA FHC-anticorpo.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT93RM000613A IT1264078B1 (it) | 1993-09-10 | 1993-09-10 | Uso di anticorpi anti-molecole hla classe i libere da beta-2 microglobulina per saggi di evidenziazione dell'esposizione al virus |
EP94927036A EP0717847B1 (en) | 1993-09-10 | 1994-09-06 | Use of antibodies against beta-2 microglobulin-free, class i hla molecules to provide hiv diagnostic tests as well as compositions having a protective action against hiv infections |
DE69424054T DE69424054D1 (de) | 1993-09-10 | 1994-09-06 | Verwendung von antikörpern gegen beta-2-mikroglobulin-freie klasse-i-hla-molekülen zum erhalt eines diagnostischen hiv-tests und zusammensetzungen mit schutzwirkung gegen hiv-infektionen |
AU76641/94A AU7664194A (en) | 1993-09-10 | 1994-09-06 | Use of antibodies against beta -2 microglobulin-free, class i hla molecules to provide hiv diagnostic tests as well as compositions having a protective action against hiv infections |
PCT/IT1994/000146 WO1995007465A2 (en) | 1993-09-10 | 1994-09-06 | USE OF ANTIBODIES AGAINST β-2 MICROGLOBULIN-FREE, CLASS I HLA MOLECULES TO PROVIDE HIV DIAGNOSTIC TESTS AS WELL AS COMPOSITIONS HAVING A PROTECTIVE ACTION AGAINST HIV INFECTIONS |
AT94927036T ATE191975T1 (de) | 1993-09-10 | 1994-09-06 | Verwendung von antikörpern gegen beta-2- mikroglobulin-freie klasse-i-hla-molekülen zum erhalt eines diagnostischen hiv-tests und zusammensetzungen mit schutzwirkung gegen hiv- infektionen |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT93RM000613A IT1264078B1 (it) | 1993-09-10 | 1993-09-10 | Uso di anticorpi anti-molecole hla classe i libere da beta-2 microglobulina per saggi di evidenziazione dell'esposizione al virus |
Publications (3)
Publication Number | Publication Date |
---|---|
ITRM930613A0 ITRM930613A0 (it) | 1993-09-10 |
ITRM930613A1 ITRM930613A1 (it) | 1995-03-10 |
IT1264078B1 true IT1264078B1 (it) | 1996-09-10 |
Family
ID=11401948
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT93RM000613A IT1264078B1 (it) | 1993-09-10 | 1993-09-10 | Uso di anticorpi anti-molecole hla classe i libere da beta-2 microglobulina per saggi di evidenziazione dell'esposizione al virus |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0717847B1 (it) |
AT (1) | ATE191975T1 (it) |
AU (1) | AU7664194A (it) |
DE (1) | DE69424054D1 (it) |
IT (1) | IT1264078B1 (it) |
WO (1) | WO1995007465A2 (it) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1254360B (it) * | 1992-05-11 | 1995-09-14 | San Romanello Centro Fond | Epitopi immunologicamente omologhi di hla e proteine del virus hiv. |
-
1993
- 1993-09-10 IT IT93RM000613A patent/IT1264078B1/it active IP Right Grant
-
1994
- 1994-09-06 EP EP94927036A patent/EP0717847B1/en not_active Expired - Lifetime
- 1994-09-06 AU AU76641/94A patent/AU7664194A/en not_active Abandoned
- 1994-09-06 WO PCT/IT1994/000146 patent/WO1995007465A2/en active IP Right Grant
- 1994-09-06 DE DE69424054T patent/DE69424054D1/de not_active Expired - Lifetime
- 1994-09-06 AT AT94927036T patent/ATE191975T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69424054D1 (de) | 2000-05-25 |
ITRM930613A1 (it) | 1995-03-10 |
ATE191975T1 (de) | 2000-05-15 |
EP0717847A1 (en) | 1996-06-26 |
AU7664194A (en) | 1995-03-27 |
WO1995007465A2 (en) | 1995-03-16 |
WO1995007465A3 (en) | 1995-04-13 |
ITRM930613A0 (it) | 1993-09-10 |
EP0717847B1 (en) | 2000-04-19 |
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