IT1262997B - New protein homologous to human heat shock P27 protein - is obtd. from liposarcoma cells, used for treating oestrogen-dependent epithelial tumours - Google Patents

New protein homologous to human heat shock P27 protein - is obtd. from liposarcoma cells, used for treating oestrogen-dependent epithelial tumours

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Publication number
IT1262997B
IT1262997B ITRM920716A IT1262997B IT 1262997 B IT1262997 B IT 1262997B IT RM920716 A ITRM920716 A IT RM920716A IT 1262997 B IT1262997 B IT 1262997B
Authority
IT
Italy
Prior art keywords
protein
heat shock
obtd
human heat
homologous
Prior art date
Application number
Other languages
Italian (it)
Inventor
Aldo Mancini
Original Assignee
Aldo Mancini
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aldo Mancini filed Critical Aldo Mancini
Publication of ITRM920716A0 publication Critical patent/ITRM920716A0/en
Priority to IT92RM716 priority Critical patent/IT1262997B/en
Priority to EP93906779A priority patent/EP0630404A1/en
Priority to CA002130089A priority patent/CA2130089A1/en
Priority to HU9402317A priority patent/HUT70972A/en
Priority to AU37665/93A priority patent/AU3766593A/en
Priority to PCT/IT1993/000020 priority patent/WO1993018147A1/en
Priority to CN 93104064 priority patent/CN1078494A/en
Publication of ITRM920716A1 publication Critical patent/ITRM920716A1/en
Priority to KR1019940703052A priority patent/KR950700412A/en
Priority to FI944102A priority patent/FI944102A/en
Application granted granted Critical
Publication of IT1262997B publication Critical patent/IT1262997B/en

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Abstract

A proteinaceous cpd. or biologically active fragment is characterised in that (a) it is capable of hinhibiting selectively the cellular division of oestrogen-sensitive epithelial tumour cells and/or of exerting a cytotoxic activity on such cells, (b) it has a mol.wt. of 27-30 KD, (c) it comprises an amino acid sequence from aminoacids 1-193 which is homologous to the corresponding sequence of human heat shock p27 protein (HSp 27). The PILSA was isolated from culture medium of a cell line derived from a human liposarcoma. A nucleotide sequence encoding PILSA was isolated using RNA from the same cell line.
IT92RM716 1992-03-09 1992-09-30 New protein homologous to human heat shock P27 protein - is obtd. from liposarcoma cells, used for treating oestrogen-dependent epithelial tumours IT1262997B (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IT92RM716 IT1262997B (en) 1992-09-30 1992-09-30 New protein homologous to human heat shock P27 protein - is obtd. from liposarcoma cells, used for treating oestrogen-dependent epithelial tumours
AU37665/93A AU3766593A (en) 1992-03-09 1993-03-08 Protein compound capable of inhibiting tumoral growth
CA002130089A CA2130089A1 (en) 1992-03-09 1993-03-08 Protein compound, coding nucleotide sequences, producing cell line and uses thereof
HU9402317A HUT70972A (en) 1992-03-09 1993-03-08 Protein compound capable of inhibiting tumoral growth
EP93906779A EP0630404A1 (en) 1992-03-09 1993-03-08 Protein compound capable of inhibiting tumoral growth
PCT/IT1993/000020 WO1993018147A1 (en) 1992-03-09 1993-03-08 Protein compound capable of inhibiting tumoral growth
CN 93104064 CN1078494A (en) 1992-03-09 1993-03-09 Protein compound, coding nucleotide sequence produces clone and its application
KR1019940703052A KR950700412A (en) 1992-03-09 1994-09-01 Protein components that inhibit tumor growth (PROTEIN COMPOUND CAPABLE OF INHIBITING TUMORAL GROWTH)
FI944102A FI944102A (en) 1992-03-09 1994-09-07 Protein compound capable of inhibiting tumor growth

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT92RM716 IT1262997B (en) 1992-09-30 1992-09-30 New protein homologous to human heat shock P27 protein - is obtd. from liposarcoma cells, used for treating oestrogen-dependent epithelial tumours

Publications (3)

Publication Number Publication Date
ITRM920716A0 ITRM920716A0 (en) 1992-09-30
ITRM920716A1 ITRM920716A1 (en) 1994-03-30
IT1262997B true IT1262997B (en) 1996-07-23

Family

ID=11401219

Family Applications (1)

Application Number Title Priority Date Filing Date
IT92RM716 IT1262997B (en) 1992-03-09 1992-09-30 New protein homologous to human heat shock P27 protein - is obtd. from liposarcoma cells, used for treating oestrogen-dependent epithelial tumours

Country Status (1)

Country Link
IT (1) IT1262997B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116515754B (en) * 2023-03-17 2024-01-30 创芯国际生物科技(广州)有限公司 Liposarcoma organoid, culture medium and culture method

Also Published As

Publication number Publication date
ITRM920716A0 (en) 1992-09-30
ITRM920716A1 (en) 1994-03-30

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