IT1262997B - New protein homologous to human heat shock P27 protein - is obtd. from liposarcoma cells, used for treating oestrogen-dependent epithelial tumours - Google Patents
New protein homologous to human heat shock P27 protein - is obtd. from liposarcoma cells, used for treating oestrogen-dependent epithelial tumoursInfo
- Publication number
- IT1262997B IT1262997B ITRM920716A IT1262997B IT 1262997 B IT1262997 B IT 1262997B IT RM920716 A ITRM920716 A IT RM920716A IT 1262997 B IT1262997 B IT 1262997B
- Authority
- IT
- Italy
- Prior art keywords
- protein
- heat shock
- obtd
- human heat
- homologous
- Prior art date
Links
- 239000000262 estrogen Substances 0.000 title abstract 2
- 206010024627 liposarcoma Diseases 0.000 title abstract 2
- 230000035939 shock Effects 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title 1
- 230000001419 dependent effect Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
A proteinaceous cpd. or biologically active fragment is characterised in that (a) it is capable of hinhibiting selectively the cellular division of oestrogen-sensitive epithelial tumour cells and/or of exerting a cytotoxic activity on such cells, (b) it has a mol.wt. of 27-30 KD, (c) it comprises an amino acid sequence from aminoacids 1-193 which is homologous to the corresponding sequence of human heat shock p27 protein (HSp 27). The PILSA was isolated from culture medium of a cell line derived from a human liposarcoma. A nucleotide sequence encoding PILSA was isolated using RNA from the same cell line.
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT92RM716 IT1262997B (en) | 1992-09-30 | 1992-09-30 | New protein homologous to human heat shock P27 protein - is obtd. from liposarcoma cells, used for treating oestrogen-dependent epithelial tumours |
AU37665/93A AU3766593A (en) | 1992-03-09 | 1993-03-08 | Protein compound capable of inhibiting tumoral growth |
CA002130089A CA2130089A1 (en) | 1992-03-09 | 1993-03-08 | Protein compound, coding nucleotide sequences, producing cell line and uses thereof |
HU9402317A HUT70972A (en) | 1992-03-09 | 1993-03-08 | Protein compound capable of inhibiting tumoral growth |
EP93906779A EP0630404A1 (en) | 1992-03-09 | 1993-03-08 | Protein compound capable of inhibiting tumoral growth |
PCT/IT1993/000020 WO1993018147A1 (en) | 1992-03-09 | 1993-03-08 | Protein compound capable of inhibiting tumoral growth |
CN 93104064 CN1078494A (en) | 1992-03-09 | 1993-03-09 | Protein compound, coding nucleotide sequence produces clone and its application |
KR1019940703052A KR950700412A (en) | 1992-03-09 | 1994-09-01 | Protein components that inhibit tumor growth (PROTEIN COMPOUND CAPABLE OF INHIBITING TUMORAL GROWTH) |
FI944102A FI944102A (en) | 1992-03-09 | 1994-09-07 | Protein compound capable of inhibiting tumor growth |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT92RM716 IT1262997B (en) | 1992-09-30 | 1992-09-30 | New protein homologous to human heat shock P27 protein - is obtd. from liposarcoma cells, used for treating oestrogen-dependent epithelial tumours |
Publications (3)
Publication Number | Publication Date |
---|---|
ITRM920716A0 ITRM920716A0 (en) | 1992-09-30 |
ITRM920716A1 ITRM920716A1 (en) | 1994-03-30 |
IT1262997B true IT1262997B (en) | 1996-07-23 |
Family
ID=11401219
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT92RM716 IT1262997B (en) | 1992-03-09 | 1992-09-30 | New protein homologous to human heat shock P27 protein - is obtd. from liposarcoma cells, used for treating oestrogen-dependent epithelial tumours |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1262997B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116515754B (en) * | 2023-03-17 | 2024-01-30 | 创芯国际生物科技(广州)有限公司 | Liposarcoma organoid, culture medium and culture method |
-
1992
- 1992-09-30 IT IT92RM716 patent/IT1262997B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ITRM920716A0 (en) | 1992-09-30 |
ITRM920716A1 (en) | 1994-03-30 |
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