IT1260157B - Acilazione selettiva del gruppo 6-idrossile dei residui n-acetilglucosamina dei derivati dell'acido ialuronico - Google Patents
Acilazione selettiva del gruppo 6-idrossile dei residui n-acetilglucosamina dei derivati dell'acido ialuronicoInfo
- Publication number
- IT1260157B IT1260157B ITPD920205A ITPD920205A IT1260157B IT 1260157 B IT1260157 B IT 1260157B IT PD920205 A ITPD920205 A IT PD920205A IT PD920205 A ITPD920205 A IT PD920205A IT 1260157 B IT1260157 B IT 1260157B
- Authority
- IT
- Italy
- Prior art keywords
- hydroxyl group
- hyaluronic acid
- acid derivatives
- selective
- acilation
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 2
- HOSGXJWQVBHGLT-UHFFFAOYSA-N 6-hydroxy-3,4-dihydro-1h-quinolin-2-one Chemical group N1C(=O)CCC2=CC(O)=CC=C21 HOSGXJWQVBHGLT-UHFFFAOYSA-N 0.000 title abstract 2
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 150000002905 orthoesters Chemical class 0.000 abstract 1
Landscapes
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
La presente invenzione descrive un nuovo processo per la preparazione di nuovi derivati dell'acido ialuronico, ovvero dei 6-acil-derivati di HYAFF-11 come composti predominati e dei 4-acil-derivati di HYAFF-11 come composti minori, attraverso l'acilazione selettiva del gruppo 6-idrossile dei residui N-acetilglucosamina.Si descrive altresì un processo per la preparazione di 4,6 ortoesteri di HYAFF 11.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITPD920205A IT1260157B (it) | 1992-11-16 | 1992-11-16 | Acilazione selettiva del gruppo 6-idrossile dei residui n-acetilglucosamina dei derivati dell'acido ialuronico |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITPD920205A IT1260157B (it) | 1992-11-16 | 1992-11-16 | Acilazione selettiva del gruppo 6-idrossile dei residui n-acetilglucosamina dei derivati dell'acido ialuronico |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITPD920205A0 ITPD920205A0 (it) | 1992-11-16 |
| ITPD920205A1 ITPD920205A1 (it) | 1994-05-16 |
| IT1260157B true IT1260157B (it) | 1996-03-28 |
Family
ID=11390097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITPD920205A IT1260157B (it) | 1992-11-16 | 1992-11-16 | Acilazione selettiva del gruppo 6-idrossile dei residui n-acetilglucosamina dei derivati dell'acido ialuronico |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1260157B (it) |
-
1992
- 1992-11-16 IT ITPD920205A patent/IT1260157B/it active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ITPD920205A1 (it) | 1994-05-16 |
| ITPD920205A0 (it) | 1992-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950925 |