IT1260156B - NEURAMINIC ACID DERIVATIVES - Google Patents

NEURAMINIC ACID DERIVATIVES

Info

Publication number
IT1260156B
IT1260156B ITPD920146A ITPD920146A IT1260156B IT 1260156 B IT1260156 B IT 1260156B IT PD920146 A ITPD920146 A IT PD920146A IT PD920146 A ITPD920146 A IT PD920146A IT 1260156 B IT1260156 B IT 1260156B
Authority
IT
Italy
Prior art keywords
starches
neuraminic acid
carboxylic
acid derivatives
derivatives
Prior art date
Application number
ITPD920146A
Other languages
Italian (it)
Original Assignee
Fidia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Spa filed Critical Fidia Spa
Priority to ITPD920146A priority Critical patent/IT1260156B/en
Publication of ITPD920146A0 publication Critical patent/ITPD920146A0/en
Priority to EP93918621A priority patent/EP0652887A1/en
Priority to JP6505524A priority patent/JPH08502953A/en
Priority to CA002141679A priority patent/CA2141679C/en
Priority to PCT/US1993/007307 priority patent/WO1994003469A1/en
Priority to US08/379,602 priority patent/US5677285A/en
Priority to AU48014/93A priority patent/AU4801493A/en
Publication of ITPD920146A1 publication Critical patent/ITPD920146A1/en
Application granted granted Critical
Publication of IT1260156B publication Critical patent/IT1260156B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invenzione ha per oggetto dei nuovi derivati dell'acido neuraminico e più precisamente il gruppo formato dalle amidi carbossiliche di un composto della formula I, in cui Ac sta per un radicale acilico di un acido carbossilico della serie alifatica, aralifatica, aromatica, aliciclica o eterociclica, formato dalle amidi carbossiliche, dai loro 2-idrocarbil-glicosidi di tali amidi e dai derivati peracilati ai gruppi idrossilici di entrambe queste serie di amidi.The present invention relates to new derivatives of neuraminic acid and more precisely the group formed by the carboxylic starches of a compound of the formula I, in which Ac stands for an acyl radical of a carboxylic acid of the aliphatic, araliphatic, aromatic, alicyclic series or heterocyclic, formed by the carboxylic starches, by their 2-hydrocarbyl-glycosides of these starches and by the peracylated derivatives to the hydroxyl groups of both these starch series.

ITPD920146A 1992-08-03 1992-08-03 NEURAMINIC ACID DERIVATIVES IT1260156B (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ITPD920146A IT1260156B (en) 1992-08-03 1992-08-03 NEURAMINIC ACID DERIVATIVES
EP93918621A EP0652887A1 (en) 1992-08-03 1993-08-03 New derivatives of neuraminic acid
JP6505524A JPH08502953A (en) 1992-08-03 1993-08-03 New derivatives of neuraminic acid
CA002141679A CA2141679C (en) 1992-08-03 1993-08-03 New derivatives of neuraminic acid
PCT/US1993/007307 WO1994003469A1 (en) 1992-08-03 1993-08-03 New derivatives of neuraminic acid
US08/379,602 US5677285A (en) 1992-08-03 1993-08-03 Derivatives of neuraminic acid
AU48014/93A AU4801493A (en) 1992-08-03 1993-08-03 New derivatives of neuraminic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITPD920146A IT1260156B (en) 1992-08-03 1992-08-03 NEURAMINIC ACID DERIVATIVES

Publications (3)

Publication Number Publication Date
ITPD920146A0 ITPD920146A0 (en) 1992-08-03
ITPD920146A1 ITPD920146A1 (en) 1994-02-03
IT1260156B true IT1260156B (en) 1996-03-28

Family

ID=11390038

Family Applications (1)

Application Number Title Priority Date Filing Date
ITPD920146A IT1260156B (en) 1992-08-03 1992-08-03 NEURAMINIC ACID DERIVATIVES

Country Status (6)

Country Link
EP (1) EP0652887A1 (en)
JP (1) JPH08502953A (en)
AU (1) AU4801493A (en)
CA (1) CA2141679C (en)
IT (1) IT1260156B (en)
WO (1) WO1994003469A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW479061B (en) * 1993-12-24 2002-03-11 Mitsubishi Chem Corp Sialic acid derivatives
US5783564A (en) * 1993-12-24 1998-07-21 Mitsubishi Chemical Corporation Sialic acid derivatives
IT1271624B (en) * 1994-03-21 1997-06-04 Lifegroup Spa GLUCOSIDIC DERIVATIVES OF N-ACYL ALCHYLAMINES CAPABLE OF EXERCISING EFFECT OR NEUROPROTECTIVE USABLE IN ACUTE AND CHRONIC PATHOLOGIES OF THE CENTRAL NERVOUS SYSTEM RELATED TO EXCITOTOXICITY
US5849709A (en) * 1995-05-10 1998-12-15 Glycomed Incorporated Saccharopeptides and derivatives thereof
ES2169801T3 (en) 1995-06-23 2002-07-16 Mitsubishi Chem Corp DERIVATIVES OF SIALIC ACID.
US5824662A (en) * 1996-09-27 1998-10-20 Guilford Pharmaceuticals Inc. Treatment of global and focal ischemia using naaladase inhibitors
AU733880B2 (en) 1996-09-27 2001-05-31 Eisai Inc. Naaladase compositions and methods for treating glutamate abnormality and effecting neuronal activity in animals
KR100525275B1 (en) 1998-04-10 2005-11-02 미쓰비시 가가꾸 가부시키가이샤 Solid Dispersion Containing Sialic Acid Derivative
CN1523994A (en) * 2001-05-23 2004-08-25 钱吉子 Compositions comprising extract of ganoderma lucidum, oleamide and its structural analogue as an effective component for preventing or treating dementia
JP4005115B1 (en) * 2007-02-08 2007-11-07 日本臓器製薬株式会社 Pain disease treatment
JP5327839B2 (en) * 2008-06-09 2013-10-30 国立大学法人埼玉大学 Method for producing sialic acid derivative and its use as an influenza virus inhibitor
JP5298390B2 (en) * 2009-11-19 2013-09-25 学校法人福岡大学 Fluorosylated sialic acid derivative and analysis method thereof
TWI599354B (en) 2016-08-10 2017-09-21 國立臺灣師範大學 Use of tetrahydropyranol derivatives for manufacturing pharmaceutical composition of tau-associated diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3014027A (en) * 1956-01-20 1961-12-19 Ciba Pharm Prod Inc N-acylamino compounds
IL41409A (en) * 1972-02-04 1977-04-29 Richter Gedeon Vegyeszet Lysergic acid amides and process for their preparation
JPS60231690A (en) * 1984-05-01 1985-11-18 Kanto Ishi Pharma Co Ltd N-substituted neuraminic acid derivative and its preparation
HU906340D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Synthesis in solid phase for producing peptonic alcohols
JPH03151398A (en) * 1989-11-06 1991-06-27 Mect Corp Sialic acid-bonded physiologically active peptide and production thereof

Also Published As

Publication number Publication date
WO1994003469A1 (en) 1994-02-17
CA2141679A1 (en) 1994-02-17
ITPD920146A0 (en) 1992-08-03
CA2141679C (en) 2000-09-19
ITPD920146A1 (en) 1994-02-03
EP0652887A1 (en) 1995-05-17
JPH08502953A (en) 1996-04-02
AU4801493A (en) 1994-03-03

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Legal Events

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19990614