IT1254703B - Process for the synthesis and purification of truncated forms of human ciliar neurotrophic factor - Google Patents

Process for the synthesis and purification of truncated forms of human ciliar neurotrophic factor

Info

Publication number
IT1254703B
IT1254703B ITPD910207A ITPD910207A IT1254703B IT 1254703 B IT1254703 B IT 1254703B IT PD910207 A ITPD910207 A IT PD910207A IT PD910207 A ITPD910207 A IT PD910207A IT 1254703 B IT1254703 B IT 1254703B
Authority
IT
Italy
Prior art keywords
human
purification
synthesis
cntf
neurotrophic factor
Prior art date
Application number
ITPD910207A
Other languages
Italian (it)
Inventor
Lanfranco Callegaro
Alessandro Negro
Original Assignee
Fidia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Spa filed Critical Fidia Spa
Priority to ITPD910207A priority Critical patent/IT1254703B/en
Publication of ITPD910207A0 publication Critical patent/ITPD910207A0/en
Priority to PCT/EP1992/002586 priority patent/WO1993010233A1/en
Priority to CA002123234A priority patent/CA2123234A1/en
Priority to AU29253/92A priority patent/AU2925392A/en
Priority to EP92923337A priority patent/EP0668911A1/en
Priority to JP5508954A priority patent/JPH07503128A/en
Publication of ITPD910207A1 publication Critical patent/ITPD910207A1/en
Application granted granted Critical
Publication of IT1254703B publication Critical patent/IT1254703B/en

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

This invention relates to a process for the synthesis and purification of truncated forms of human ciliar neurotrophic factor (CNTF) from Escherichia coli obtained by the application of recombinant DNA technology. Human CNTF polypeptides having a smaller number of amino acids than the corresponding natural form of CNTF are obtained as a consequence. These new forms have new chemical and chemical/physical properties in comparison with natural CNTF.
ITPD910207A 1991-11-11 1991-11-11 Process for the synthesis and purification of truncated forms of human ciliar neurotrophic factor IT1254703B (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ITPD910207A IT1254703B (en) 1991-11-11 1991-11-11 Process for the synthesis and purification of truncated forms of human ciliar neurotrophic factor
PCT/EP1992/002586 WO1993010233A1 (en) 1991-11-11 1992-11-11 Synthesis and purification of truncated and mutein forms of human ciliary neuronotrophic factor
CA002123234A CA2123234A1 (en) 1991-11-11 1992-11-11 Synthesis and purification of truncated and mutein forms of human ciliary neuronotrophic factor
AU29253/92A AU2925392A (en) 1991-11-11 1992-11-11 Synthesis and purification of truncated and mutein forms of human ciliary neuronotrophic factor
EP92923337A EP0668911A1 (en) 1991-11-11 1992-11-11 Synthesis and purification of truncated and mutein forms of human ciliary neuronotrophic factor
JP5508954A JPH07503128A (en) 1991-11-11 1992-11-11 Synthesis and purification of truncated and mutant protein forms of human ciliary neuron tropism factor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITPD910207A IT1254703B (en) 1991-11-11 1991-11-11 Process for the synthesis and purification of truncated forms of human ciliar neurotrophic factor

Publications (3)

Publication Number Publication Date
ITPD910207A0 ITPD910207A0 (en) 1991-11-11
ITPD910207A1 ITPD910207A1 (en) 1993-05-11
IT1254703B true IT1254703B (en) 1995-10-09

Family

ID=11389727

Family Applications (1)

Application Number Title Priority Date Filing Date
ITPD910207A IT1254703B (en) 1991-11-11 1991-11-11 Process for the synthesis and purification of truncated forms of human ciliar neurotrophic factor

Country Status (1)

Country Link
IT (1) IT1254703B (en)

Also Published As

Publication number Publication date
ITPD910207A1 (en) 1993-05-11
ITPD910207A0 (en) 1991-11-11

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Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19950925