IT1251685B - PHARMACEUTICAL COMPOSITIONS CONTAINING A CALCITONIN - Google Patents
PHARMACEUTICAL COMPOSITIONS CONTAINING A CALCITONINInfo
- Publication number
- IT1251685B IT1251685B ITMI912703A ITMI912703A IT1251685B IT 1251685 B IT1251685 B IT 1251685B IT MI912703 A ITMI912703 A IT MI912703A IT MI912703 A ITMI912703 A IT MI912703A IT 1251685 B IT1251685 B IT 1251685B
- Authority
- IT
- Italy
- Prior art keywords
- calcitonin
- pharmaceutical compositions
- compositions containing
- glycyrrhizinate
- absorption
- Prior art date
Links
- 102000055006 Calcitonin Human genes 0.000 title abstract 3
- 108060001064 Calcitonin Proteins 0.000 title abstract 3
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 title abstract 3
- 229960004015 calcitonin Drugs 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 abstract 3
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 3
- 229940074774 glycyrrhizinate Drugs 0.000 abstract 2
- 229940124532 absorption promoter Drugs 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 235000019445 benzyl alcohol Nutrition 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000004400 mucous membrane Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invenzione si riferisce a nuove composizioni farmaceutiche contenenti calcitonine e a nuovo metodo per migliorare l'assorbimento di una calcitonina attraverso una membrana mucosa.Le composizioni farmaceutiche comprendono una calcitonina, una quantità efficace di un promotore dell'assorbimento che è un glicirrizinato, una quantità efficace di alcool benzilico e un veicolo farmaceuticamente accettabile; preferibilmente il glicirrizinato è glicirrizinato d'ammonio.The present invention relates to new pharmaceutical compositions containing calcitonins and to a new method for improving the absorption of a calcitonin through a mucous membrane. The pharmaceutical compositions comprise a calcitonin, an effective amount of an absorption promoter which is a glycyrrhizinate, a quantity effective benzyl alcohol and a pharmaceutically acceptable carrier; preferably the glycyrrhizinate is ammonium glycyrrhizinate.
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI912703A IT1251685B (en) | 1991-10-11 | 1991-10-11 | PHARMACEUTICAL COMPOSITIONS CONTAINING A CALCITONIN |
| AU26834/92A AU2683492A (en) | 1991-10-11 | 1992-10-08 | Pharmaceutical compositions comprising a calcitonin, a glycyrrhizinate as absorption enhancer and benzyl |
| BR9206707A BR9206707A (en) | 1991-10-11 | 1992-10-08 | Pharmaceutical compounds containing a calcitonin |
| EP92920956A EP0607229A1 (en) | 1991-10-11 | 1992-10-08 | Pharmaceutical compositions comprising a calcitonin, a glycyrrhizinate as absorption enhancer and benzyl |
| JP5506629A JPH07500099A (en) | 1991-10-11 | 1992-10-08 | Pharmaceutical composition consisting of calcitonin, glycyrrhizinate as absorption enhancer and benzyl |
| PCT/EP1992/002321 WO1993006854A1 (en) | 1991-10-11 | 1992-10-08 | Pharmaceutical compositions comprising a calcitonin, a glycyrrhizinate as absorption enhancer and benzyl |
| CA002120755A CA2120755A1 (en) | 1991-10-11 | 1992-10-08 | Pharmaceutical compositions comprising a calcitonin, a glycyrrhizinate as absorption enhancer and benzyl |
| PT100946A PT100946A (en) | 1991-10-11 | 1992-10-09 | PHARMACEUTICAL COMPOSITIONS CONTAINING A CALCITONIN AND ITS PREPARATION PROCESS |
| MX9205852A MX9205852A (en) | 1991-10-11 | 1992-10-09 | PHARMACEUTICAL COMPOSITIONS CONTAINING A CALCITONIN |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI912703A IT1251685B (en) | 1991-10-11 | 1991-10-11 | PHARMACEUTICAL COMPOSITIONS CONTAINING A CALCITONIN |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI912703A0 ITMI912703A0 (en) | 1991-10-11 |
| ITMI912703A1 ITMI912703A1 (en) | 1993-04-11 |
| IT1251685B true IT1251685B (en) | 1995-05-19 |
Family
ID=11360856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI912703A IT1251685B (en) | 1991-10-11 | 1991-10-11 | PHARMACEUTICAL COMPOSITIONS CONTAINING A CALCITONIN |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0607229A1 (en) |
| JP (1) | JPH07500099A (en) |
| AU (1) | AU2683492A (en) |
| BR (1) | BR9206707A (en) |
| CA (1) | CA2120755A1 (en) |
| IT (1) | IT1251685B (en) |
| MX (1) | MX9205852A (en) |
| PT (1) | PT100946A (en) |
| WO (1) | WO1993006854A1 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2285921A (en) * | 1994-01-31 | 1995-08-02 | Leilani Lea | Sublingual administration of medicaments |
| DE726075T1 (en) * | 1995-02-08 | 1996-12-12 | Therapicon Srl | Non-inorganic pharmaceutical saline solutions for endonasal administration |
| WO1997021448A1 (en) * | 1995-12-13 | 1997-06-19 | Dullatur Limited | A calcitonin preparation |
| IT1294191B1 (en) * | 1997-09-05 | 1999-03-22 | Alfa Wassermann Spa | Composition for treating osteoporosis, Paget's disease or hypercalcemia, comprises calcitonin dissolved in acidic sodium chloride solution |
| GB2368792A (en) * | 2000-10-06 | 2002-05-15 | Roger Randal Charles New | Absorption enhancers |
| ITRM20010048A1 (en) * | 2001-01-30 | 2002-07-30 | Gregorio Mauro De | METHOD FOR PREPARING PHYSIOLOGICALLY ACCEPTABLE AQUEOUS SOLUTIONS SO OBTAINED. |
| GB0308734D0 (en) | 2003-04-15 | 2003-05-21 | Axcess Ltd | Uptake of macromolecules |
| GB0308732D0 (en) * | 2003-04-15 | 2003-05-21 | Axcess Ltd | Absorption enhancers |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60188315A (en) * | 1984-03-07 | 1985-09-25 | Yamanouchi Pharmaceut Co Ltd | Antipruritic plaster containing glycyrretic acid |
| JPS61267528A (en) * | 1984-11-26 | 1986-11-27 | Yamanouchi Pharmaceut Co Ltd | Transnasal calcitonin agent containing absorbefacient |
| GB2212062B (en) * | 1987-11-13 | 1991-07-17 | Isf Spa | Pharmaceutical compositions containing a calcitonin and a glycyrrhizinate ab- sorption enhancer |
| JPH078806B2 (en) * | 1990-08-16 | 1995-02-01 | 旭化成工業株式会社 | Nasal emulsion containing calcitonin |
-
1991
- 1991-10-11 IT ITMI912703A patent/IT1251685B/en active IP Right Grant
-
1992
- 1992-10-08 WO PCT/EP1992/002321 patent/WO1993006854A1/en not_active Application Discontinuation
- 1992-10-08 BR BR9206707A patent/BR9206707A/en not_active Application Discontinuation
- 1992-10-08 AU AU26834/92A patent/AU2683492A/en not_active Abandoned
- 1992-10-08 JP JP5506629A patent/JPH07500099A/en active Pending
- 1992-10-08 CA CA002120755A patent/CA2120755A1/en not_active Abandoned
- 1992-10-08 EP EP92920956A patent/EP0607229A1/en not_active Withdrawn
- 1992-10-09 PT PT100946A patent/PT100946A/en not_active Application Discontinuation
- 1992-10-09 MX MX9205852A patent/MX9205852A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI912703A0 (en) | 1991-10-11 |
| MX9205852A (en) | 1993-06-01 |
| AU2683492A (en) | 1993-05-03 |
| ITMI912703A1 (en) | 1993-04-11 |
| JPH07500099A (en) | 1995-01-05 |
| CA2120755A1 (en) | 1993-04-15 |
| EP0607229A1 (en) | 1994-07-27 |
| WO1993006854A1 (en) | 1993-04-15 |
| BR9206707A (en) | 1995-10-31 |
| PT100946A (en) | 1993-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19951031 |