IT1251424B - Drug for human use having contraceptive action - Google Patents
Drug for human use having contraceptive actionInfo
- Publication number
- IT1251424B IT1251424B ITMI912833A ITMI912833A IT1251424B IT 1251424 B IT1251424 B IT 1251424B IT MI912833 A ITMI912833 A IT MI912833A IT MI912833 A ITMI912833 A IT MI912833A IT 1251424 B IT1251424 B IT 1251424B
- Authority
- IT
- Italy
- Prior art keywords
- drug
- human use
- iodomelatonin
- contraceptive action
- bromomelatonin
- Prior art date
Links
- 230000002254 contraceptive effect Effects 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- FJDDSMSDZHURBJ-UHFFFAOYSA-N N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]acetamide Chemical compound COC1=CC=C2NC(I)=C(CCNC(C)=O)C2=C1 FJDDSMSDZHURBJ-UHFFFAOYSA-N 0.000 abstract 3
- FNHLXIXCQDGUCQ-UHFFFAOYSA-N n-[2-(2-bromo-5-methoxy-1h-indol-3-yl)ethyl]acetamide Chemical compound COC1=CC=C2NC(Br)=C(CCNC(C)=O)C2=C1 FNHLXIXCQDGUCQ-UHFFFAOYSA-N 0.000 abstract 3
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 2
- 239000000583 progesterone congener Substances 0.000 abstract 2
- APJYDQYYACXCRM-UHFFFAOYSA-N tryptamine Chemical compound C1=CC=C2C(CCN)=CNC2=C1 APJYDQYYACXCRM-UHFFFAOYSA-N 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 abstract 1
- 229960003987 melatonin Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
This invention relates to a synthesis process for obtaining a category of products of the tryptamine type, in particular melatonin, which consists of introducing a halogen, bromine and/or iodine in the 2 position <IMAGE> in order to obtain a drug for human use having a contraceptive action in doses of 25-50 mg for 2- bromomelatonin and 20-40 mg for 2-iodomelatonin respectively, in association with a progestin. Administration is continued for 23 days using the association of 2-bromomelatonin and/or 2-iodomelatonin with a progestin, followed by 5 days of administration of the 2-bromo and/or 2-iodomelatonin alone.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI912833A IT1251424B (en) | 1991-10-24 | 1991-10-24 | Drug for human use having contraceptive action |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI912833A IT1251424B (en) | 1991-10-24 | 1991-10-24 | Drug for human use having contraceptive action |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI912833A0 ITMI912833A0 (en) | 1991-10-24 |
ITMI912833A1 ITMI912833A1 (en) | 1993-04-24 |
IT1251424B true IT1251424B (en) | 1995-05-09 |
Family
ID=11360948
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI912833A IT1251424B (en) | 1991-10-24 | 1991-10-24 | Drug for human use having contraceptive action |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1251424B (en) |
-
1991
- 1991-10-24 IT ITMI912833A patent/IT1251424B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ITMI912833A0 (en) | 1991-10-24 |
ITMI912833A1 (en) | 1993-04-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted |