IT1251204B - Drug for human use having a contraceptive and menstrual cycle-regulating action, a preventive and therapeutic oncostatic action in tumours of the breast and melanomas, and an antikinetose action and method of synthesis - Google Patents
Drug for human use having a contraceptive and menstrual cycle-regulating action, a preventive and therapeutic oncostatic action in tumours of the breast and melanomas, and an antikinetose action and method of synthesisInfo
- Publication number
- IT1251204B IT1251204B ITMI912438A ITMI912438A IT1251204B IT 1251204 B IT1251204 B IT 1251204B IT MI912438 A ITMI912438 A IT MI912438A IT MI912438 A ITMI912438 A IT MI912438A IT 1251204 B IT1251204 B IT 1251204B
- Authority
- IT
- Italy
- Prior art keywords
- action
- dose
- bromomelatonin
- iodomelatonin
- melatonin
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 210000000481 breast Anatomy 0.000 title abstract 2
- 239000003433 contraceptive agent Substances 0.000 title abstract 2
- 230000002254 contraceptive effect Effects 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 201000001441 melanoma Diseases 0.000 title abstract 2
- 230000002175 menstrual effect Effects 0.000 title abstract 2
- 230000000247 oncostatic effect Effects 0.000 title abstract 2
- 230000003449 preventive effect Effects 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 abstract 6
- FJDDSMSDZHURBJ-UHFFFAOYSA-N N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]acetamide Chemical compound COC1=CC=C2NC(I)=C(CCNC(C)=O)C2=C1 FJDDSMSDZHURBJ-UHFFFAOYSA-N 0.000 abstract 6
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 abstract 6
- FNHLXIXCQDGUCQ-UHFFFAOYSA-N n-[2-(2-bromo-5-methoxy-1h-indol-3-yl)ethyl]acetamide Chemical compound COC1=CC=C2NC(Br)=C(CCNC(C)=O)C2=C1 FNHLXIXCQDGUCQ-UHFFFAOYSA-N 0.000 abstract 6
- 229960003987 melatonin Drugs 0.000 abstract 5
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 2
- 239000000583 progesterone congener Substances 0.000 abstract 2
- ZSLZBFCDCINBPY-ZSJPKINUSA-N Acetyl-CoA Natural products O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 abstract 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 229940100228 acetyl coenzyme a Drugs 0.000 abstract 1
- 239000005515 coenzyme Substances 0.000 abstract 1
Abstract
This invention relates to a drug for human use, having a contraceptive and menstrual cycle-regulating action characterised in that it provides for the use of N-acetyl- 5-methoxytryptamine or melatonin in a daily dose of 100- 200 mg, N-acetyl-2-bromo-5-methoxytryptamine or 2- bromomelatonin in a daily dose of 25-50 mg, N-acetyl-2- iodo-5-methoxytryptamine or 2-iodomelatonin in a daily dose of 20-40 mg in association with a progestin. Administration is continued for 23 days using the association of 2-iodomelatonin and/or melatonin and/or 2- bromomelatonin and a progestin, followed by 5 days administration of the 2-iodomelatonin and/or melatonin and/or 2-bromomelatonin alone; having a preventive and therapeutic oncostatic action in tumours of the breast and melanomas, characterised by the use of 2- iodomelatonin, melatonin and 2-bromomelatonin respectively in doses of 20-40 mg, 100-200 mg, 25-50 mg per day; having an antikinetose action, characterised by the use of 2-iodomelatonin in a dose of 2.5 mg per day, melatonin in a dose of 10 mg per day and 2-bromomelatonin in a dose of 3.5 mg per day, alone and/or in association with acetyl coenzyme A-(AcCOA)- in a dose of 8-10 mg per day.
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI912438A IT1251204B (en) | 1991-09-16 | 1991-09-16 | Drug for human use having a contraceptive and menstrual cycle-regulating action, a preventive and therapeutic oncostatic action in tumours of the breast and melanomas, and an antikinetose action and method of synthesis |
| DE69132061T DE69132061D1 (en) | 1990-09-28 | 1991-09-27 | Contraceptive and menstrual cycle-regulating preparation with oncostatic properties |
| ES91830402T ES2082959T3 (en) | 1990-09-28 | 1991-09-27 | PROCEDURE TO DEVELOP THE SYNTHESIS OF A CONTRACEPTIVE AND CONTROL DRUG OF THE MENSTRUAL CYCLE THAT HAS ANTICINETOSIC, ONCOSTATIC AND THERAPEUTIC PROPERTIES FOR THE TREATMENT OF BREAST TUMORS AND MELANOMAS. |
| AT94113848T ATE190490T1 (en) | 1990-09-28 | 1991-09-27 | CONTRACEPTIVE AND MENSTRUAL CYCLE REGULATING PREPARATION WITH ONCOSTATIC PROPERTIES |
| EP94113848A EP0641565B1 (en) | 1990-09-28 | 1991-09-27 | Contraceptive and menstrual cycle controlling drug having oncostatic properties |
| AT91830402T ATE131058T1 (en) | 1990-09-28 | 1991-09-27 | METHOD FOR SYNTHESIS OF A PREPARATION FOR REGULATION OF CONCEPTION AND THE MENSTRUAL CYCLE WITH ONCOSTATIC ANTIKINETOSIC, PREVENTIVE AND THERAPEUTIC PROPERTIES FOR THE TREATMENT OF BREAST CANCER AND MELANOMA. |
| EP91830402A EP0483077B1 (en) | 1990-09-28 | 1991-09-27 | A method for carrying out the synthesis of a contraceptive and menstrual cycle controlling drug having oncostatic, antikinetosic, preventive and therapeutic properties for treatment of mammary tumours and melanomas. |
| DK91830402.3T DK0483077T3 (en) | 1990-09-28 | 1991-09-27 | Process for the Synthesis of a Contraceptive and Menstrual Cycle Controlling Drug with Oncostatic, Antikinetosic, Preventive and Therapeutic Properties for the Treatment of Breast Tumors and Melanomas |
| DE69115221T DE69115221T2 (en) | 1990-09-28 | 1991-09-27 | Method for the synthesis of a preparation for regulating conception and the menstrual cycle with oncostatic, anti-kinetic, preventive and therapeutic properties for the treatment of breast cancer and melanoma. |
| US07/767,084 US5272141A (en) | 1990-09-28 | 1991-09-27 | Contraceptive and menstrual cycle controlling drug having oncostatic therapeutic properties for treatment of mammary tumors and melanomas, and method therefor |
| JP3251261A JP2849692B2 (en) | 1990-09-28 | 1991-09-30 | 2-Bromomelatonin, a contraceptive and menstrual cycle regulating agent having antitumor properties, and methods for producing the same |
| GR960400577T GR3019175T3 (en) | 1990-09-28 | 1996-03-04 | A method for carrying out the synthesis of a contraceptive and menstrual cycle controlling drug having oncostatic, antikinetosic, preventive and therapeutic properties for treatment of mammary tumours and melanomas. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI912438A IT1251204B (en) | 1991-09-16 | 1991-09-16 | Drug for human use having a contraceptive and menstrual cycle-regulating action, a preventive and therapeutic oncostatic action in tumours of the breast and melanomas, and an antikinetose action and method of synthesis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI912438A0 ITMI912438A0 (en) | 1991-09-16 |
| ITMI912438A1 ITMI912438A1 (en) | 1993-03-17 |
| IT1251204B true IT1251204B (en) | 1995-05-04 |
Family
ID=11360668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI912438A IT1251204B (en) | 1990-09-28 | 1991-09-16 | Drug for human use having a contraceptive and menstrual cycle-regulating action, a preventive and therapeutic oncostatic action in tumours of the breast and melanomas, and an antikinetose action and method of synthesis |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1251204B (en) |
-
1991
- 1991-09-16 IT ITMI912438A patent/IT1251204B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI912438A0 (en) | 1991-09-16 |
| ITMI912438A1 (en) | 1993-03-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970925 |