IT1244746B - Procedimento per la preparazione dell'1,3a,8,-trimetil-1,2,3,3a,8,-8a-esaidro pirrol (2,3-b) indolo-5(3as,8ar)-eptilcarbammato - Google Patents

Procedimento per la preparazione dell'1,3a,8,-trimetil-1,2,3,3a,8,-8a-esaidro pirrol (2,3-b) indolo-5(3as,8ar)-eptilcarbammato

Info

Publication number
IT1244746B
IT1244746B ITMI910388A ITMI910388A IT1244746B IT 1244746 B IT1244746 B IT 1244746B IT MI910388 A ITMI910388 A IT MI910388A IT MI910388 A ITMI910388 A IT MI910388A IT 1244746 B IT1244746 B IT 1244746B
Authority
IT
Italy
Prior art keywords
pirrol
trimethyl
preparation
hexaidro
eptilcarbammate
Prior art date
Application number
ITMI910388A
Other languages
English (en)
Inventor
Stefano Maiorana
Anna Bonura
Giorgio Chiodini
Original Assignee
Laboratorio Chimico Int Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorio Chimico Int Spa filed Critical Laboratorio Chimico Int Spa
Publication of ITMI910388A0 publication Critical patent/ITMI910388A0/it
Priority to ITMI910388A priority Critical patent/IT1244746B/it
Priority to IE920270A priority patent/IE73647B1/en
Priority to AT92904133T priority patent/ATE125810T1/de
Priority to AU11969/92A priority patent/AU1196992A/en
Priority to EP92904133A priority patent/EP0571434B1/en
Priority to DE69203856T priority patent/DE69203856T2/de
Priority to ES92904133T priority patent/ES2077398T3/es
Priority to PCT/EP1992/000278 priority patent/WO1992014735A1/en
Priority to EP92102199A priority patent/EP0499179A1/en
Priority to DK92904133.3T priority patent/DK0571434T3/da
Publication of ITMI910388A1 publication Critical patent/ITMI910388A1/it
Application granted granted Critical
Publication of IT1244746B publication Critical patent/IT1244746B/it
Priority to US08/416,572 priority patent/US5705657A/en
Priority to GR950402858T priority patent/GR3017758T3/el
Priority to CY190196A priority patent/CY1901A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Si descrive un procedimento per la preparazione dell'1, 3a, 8-trimetil-1, 2, 3, 3a, 8, 8a-esaidro-pirrol[2, 3-b]indolo-5(3aS, 8aR)-eptilcarbammato, di formula (I) (FORMULA I) mediante reazione dell'eserolina con eptilisocianato in presenza di un cianato metallico e di un sale ammonico quaternario, in solventi aprotici polari.
ITMI910388A 1991-02-14 1991-02-14 Procedimento per la preparazione dell'1,3a,8,-trimetil-1,2,3,3a,8,-8a-esaidro pirrol (2,3-b) indolo-5(3as,8ar)-eptilcarbammato IT1244746B (it)

Priority Applications (13)

Application Number Priority Date Filing Date Title
ITMI910388A IT1244746B (it) 1991-02-14 1991-02-14 Procedimento per la preparazione dell'1,3a,8,-trimetil-1,2,3,3a,8,-8a-esaidro pirrol (2,3-b) indolo-5(3as,8ar)-eptilcarbammato
IE920270A IE73647B1 (en) 1991-02-14 1992-01-28 A process for the preparation of 1,3a-8-trimethyl-1,2,3,3a,8,8a-hexahydro-pyrrole [2,3-b]indol-5(3as,8ar)-heptylcarbamate
ES92904133T ES2077398T3 (es) 1991-02-14 1992-02-10 Un procedimiento para la preparacion de 1,3a,8-trimetil-1,2,3,3a,8,8a-hexahidropirrol(2,3-b)indol-5(3as,8ar)-heptilcarbamato.
DK92904133.3T DK0571434T3 (da) 1991-02-14 1992-02-10 Fremgangsmåde til fremstilling af 1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrol(2,3-b)-indol-5 (3aS,8aR)-heptylcarbamat
EP92904133A EP0571434B1 (en) 1991-02-14 1992-02-10 A PROCESS FOR THE PREPARATION OF 1,3a,8-TRIMETHYL-1,2,3,3a,8,8a-HEXAHYDRO-PYRROLE 2,3-b]INDOL-5(3aS,8aR)-HEPTYLCARBAMATE
DE69203856T DE69203856T2 (de) 1991-02-14 1992-02-10 Verfahren zur Herstellung von 1,3A,8-Trimethyl-1,2,3,3A,8,8A-HEXAHYDROPYROLO(2,3-B)INDOL-5(3AS,8AR)-HEPTYLCARBAMAT.
AT92904133T ATE125810T1 (de) 1991-02-14 1992-02-10 Verfahren zur herstellung von 1,3a,8-trimethyl- 1,2,3,3a,8,8a-hexahydropyrolo(2,3-b)indol- 5(3as,8ar)-heptylcarbamat.
PCT/EP1992/000278 WO1992014735A1 (en) 1991-02-14 1992-02-10 A PROCESS FOR THE PREPARATION OF 1,3a,8-TRIMETHYL-1,2,3,3a,8,8a-HEXAHYDRO-PYRROLE[2,3-b]INDOL-5(3aS,8aR)-HEPTYLCARBAMATE
EP92102199A EP0499179A1 (en) 1991-02-14 1992-02-10 A process for the preparation of 1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydro-pyrrole/2,3-b/indol-5(3aS,8aR)-heptylcarbamate
AU11969/92A AU1196992A (en) 1991-02-14 1992-02-10 A process for the preparation of 1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydro-pyrrole{2,3-b}indol -5(3as,8ar)-heptylcarbamate
US08/416,572 US5705657A (en) 1991-02-14 1995-04-04 Isocyanate process for the preparation of 1,3A,8-trimethyl-1,2,3,3A, 8, 8A-hexahydro-pyrrole 2,3-B! indol-5 (3AS, 8AR) -hepthylcarbamate
GR950402858T GR3017758T3 (en) 1991-02-14 1995-10-18 A PROCESS FOR THE PREPARATION OF 1,3a,8-TRIMETHYL-1,2,3,3a,8,8a-HEXAHYDRO-PYRROLE 2,3-b]INDOL-5(3aS,8aR)-HEPTYLCARBAMATE.
CY190196A CY1901A (en) 1991-02-14 1996-11-22 A process for the preparation of 1,3a,8-trimethyl-1,2,3,3a 8,8a-hexahydro-pyrrole-2,3-b]indol-5(3aS,8aR)-heptylcarbamate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI910388A IT1244746B (it) 1991-02-14 1991-02-14 Procedimento per la preparazione dell'1,3a,8,-trimetil-1,2,3,3a,8,-8a-esaidro pirrol (2,3-b) indolo-5(3as,8ar)-eptilcarbammato

Publications (3)

Publication Number Publication Date
ITMI910388A0 ITMI910388A0 (it) 1991-02-14
ITMI910388A1 ITMI910388A1 (it) 1992-08-14
IT1244746B true IT1244746B (it) 1994-08-08

Family

ID=11358581

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI910388A IT1244746B (it) 1991-02-14 1991-02-14 Procedimento per la preparazione dell'1,3a,8,-trimetil-1,2,3,3a,8,-8a-esaidro pirrol (2,3-b) indolo-5(3as,8ar)-eptilcarbammato

Country Status (11)

Country Link
EP (2) EP0499179A1 (it)
AT (1) ATE125810T1 (it)
AU (1) AU1196992A (it)
CY (1) CY1901A (it)
DE (1) DE69203856T2 (it)
DK (1) DK0571434T3 (it)
ES (1) ES2077398T3 (it)
GR (1) GR3017758T3 (it)
IE (1) IE73647B1 (it)
IT (1) IT1244746B (it)
WO (1) WO1992014735A1 (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1276928B1 (it) * 1995-10-13 1997-11-03 Angelini Ricerche Spa Processo migliorato per produrre eptastigmina e nuovo intermedio utile allo scopo

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1225462B (it) * 1987-04-03 1990-11-14 Mediolanum Farmaceutici Srl Sali organici di derivati della fisostigmina

Also Published As

Publication number Publication date
WO1992014735A1 (en) 1992-09-03
ITMI910388A0 (it) 1991-02-14
DE69203856T2 (de) 1995-12-21
DE69203856D1 (de) 1995-09-07
IE920270A1 (en) 1992-08-12
CY1901A (en) 1996-11-22
IE73647B1 (en) 1997-06-18
EP0571434B1 (en) 1995-08-02
ES2077398T3 (es) 1995-11-16
EP0499179A1 (en) 1992-08-19
GR3017758T3 (en) 1996-01-31
ATE125810T1 (de) 1995-08-15
DK0571434T3 (da) 1995-12-04
ITMI910388A1 (it) 1992-08-14
AU1196992A (en) 1992-09-15
EP0571434A1 (en) 1993-12-01

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Legal Events

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19960227