IT1244660B - PHARMACEUTICAL PREPARATIONS FOR THE THERAPY OF CANCER CONTAINING COLCHICINE AS AN ACTIVE PRINCIPLE AND METHODS FOR THE USE OF THEMSELVES. - Google Patents
PHARMACEUTICAL PREPARATIONS FOR THE THERAPY OF CANCER CONTAINING COLCHICINE AS AN ACTIVE PRINCIPLE AND METHODS FOR THE USE OF THEMSELVES.Info
- Publication number
- IT1244660B IT1244660B ITRM910155A ITRM910155A IT1244660B IT 1244660 B IT1244660 B IT 1244660B IT RM910155 A ITRM910155 A IT RM910155A IT RM910155 A ITRM910155 A IT RM910155A IT 1244660 B IT1244660 B IT 1244660B
- Authority
- IT
- Italy
- Prior art keywords
- therapy
- themselves
- methods
- pharmaceutical preparations
- active principle
- Prior art date
Links
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 title abstract 4
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 229960001338 colchicine Drugs 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 235000019441 ethanol Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Preparato farmaceutico per la terapia dei tumori contenente da 1,3 a 4,9 mg di colchicina e da 5 a 54 mg di soluzione acquosa di acido acetico, glaciale al 7% per ogni 10 ml di alcol etilico. Il preparato così ottenuto viene somministrato in dosaggi subliminari e, preferibilimente, per via translinguale.Pharmaceutical preparation for tumor therapy containing from 1.3 to 4.9 mg of colchicine and from 5 to 54 mg of aqueous solution of acetic acid, 7% glacial for every 10 ml of ethyl alcohol. The preparation thus obtained is administered in subliminal dosages and, preferably, translingually.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM910155A IT1244660B (en) | 1991-03-06 | 1991-03-06 | PHARMACEUTICAL PREPARATIONS FOR THE THERAPY OF CANCER CONTAINING COLCHICINE AS AN ACTIVE PRINCIPLE AND METHODS FOR THE USE OF THEMSELVES. |
PCT/IT1992/000020 WO1992015291A1 (en) | 1991-03-06 | 1992-03-02 | Pharmaceutical preparations for the therapy of tumors containing colchicine as the active principle and methods for the use of the same |
EP92907582A EP0574504A1 (en) | 1991-03-06 | 1992-03-02 | Pharmaceutical preparations for the therapy of tumors containing colchicine as the active principle and methods for the use of the same |
AU14478/92A AU1447892A (en) | 1991-03-06 | 1992-03-02 | Pharmaceutical preparations for the therapy of tumors containing colchicine as the active principle and methods for the use of the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM910155A IT1244660B (en) | 1991-03-06 | 1991-03-06 | PHARMACEUTICAL PREPARATIONS FOR THE THERAPY OF CANCER CONTAINING COLCHICINE AS AN ACTIVE PRINCIPLE AND METHODS FOR THE USE OF THEMSELVES. |
Publications (3)
Publication Number | Publication Date |
---|---|
ITRM910155A0 ITRM910155A0 (en) | 1991-03-06 |
ITRM910155A1 ITRM910155A1 (en) | 1992-09-06 |
IT1244660B true IT1244660B (en) | 1994-08-08 |
Family
ID=11399943
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITRM910155A IT1244660B (en) | 1991-03-06 | 1991-03-06 | PHARMACEUTICAL PREPARATIONS FOR THE THERAPY OF CANCER CONTAINING COLCHICINE AS AN ACTIVE PRINCIPLE AND METHODS FOR THE USE OF THEMSELVES. |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0574504A1 (en) |
AU (1) | AU1447892A (en) |
IT (1) | IT1244660B (en) |
WO (1) | WO1992015291A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06199749A (en) * | 1992-12-28 | 1994-07-19 | Bigen Kenkyusho:Kk | N-methyldeacetylcolchiceinamide derivative |
JPH06211762A (en) * | 1993-01-20 | 1994-08-02 | Bigen Kenkyusho:Kk | N-methyldeacetylcolchiceinamide derivative |
WO2000035865A2 (en) * | 1998-12-17 | 2000-06-22 | Tularik Inc. | Tubulin-binding agents |
US20090093548A1 (en) | 2007-10-05 | 2009-04-09 | Mutual Pharmaceutical Company, Inc | Colchine compositions and methods |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4565806A (en) * | 1981-08-18 | 1986-01-21 | Setaelae Kai M E | Composition and method for rational treatment of cancer |
WO1989012444A1 (en) * | 1988-06-17 | 1989-12-28 | The Rockefeller University | The use of colchicine and related compounds for the control of retroviruses |
-
1991
- 1991-03-06 IT ITRM910155A patent/IT1244660B/en active IP Right Grant
-
1992
- 1992-03-02 WO PCT/IT1992/000020 patent/WO1992015291A1/en not_active Application Discontinuation
- 1992-03-02 EP EP92907582A patent/EP0574504A1/en not_active Withdrawn
- 1992-03-02 AU AU14478/92A patent/AU1447892A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ITRM910155A1 (en) | 1992-09-06 |
EP0574504A1 (en) | 1993-12-22 |
ITRM910155A0 (en) | 1991-03-06 |
AU1447892A (en) | 1992-10-06 |
WO1992015291A1 (en) | 1992-09-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19941026 |