IT1241081B - Immunogenic compounds and their use for the preparation of genetically unrestricted synthetic vaccines for the immunoenzymatic determination of anti-plasmodium malariae sporozoite antibodies - Google Patents

Immunogenic compounds and their use for the preparation of genetically unrestricted synthetic vaccines for the immunoenzymatic determination of anti-plasmodium malariae sporozoite antibodies

Info

Publication number
IT1241081B
IT1241081B IT19800A IT1980090A IT1241081B IT 1241081 B IT1241081 B IT 1241081B IT 19800 A IT19800 A IT 19800A IT 1980090 A IT1980090 A IT 1980090A IT 1241081 B IT1241081 B IT 1241081B
Authority
IT
Italy
Prior art keywords
compounds
plasmodium malariae
formula
lysine
preparation
Prior art date
Application number
IT19800A
Other languages
Italian (it)
Other versions
IT9019800A1 (en
IT9019800A0 (en
Inventor
Antonello Pessi
Elisabetta Bianchi
Original Assignee
Eniricerche Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eniricerche Spa filed Critical Eniricerche Spa
Priority to IT19800A priority Critical patent/IT1241081B/en
Publication of IT9019800A0 publication Critical patent/IT9019800A0/en
Priority to ES90201244T priority patent/ES2063901T3/en
Priority to EP90201244A priority patent/EP0398443B1/en
Priority to DK90201244.2T priority patent/DK0398443T3/en
Priority to DE69014150T priority patent/DE69014150T2/en
Priority to AT90201244T priority patent/ATE114158T1/en
Publication of IT9019800A1 publication Critical patent/IT9019800A1/en
Application granted granted Critical
Publication of IT1241081B publication Critical patent/IT1241081B/en

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A new class of immunogenic compounds is described, definable by the formula (I): <IMAGE> where: D is L-lysine or poly(L-lysine) branched with a number n of L-lysine amino acid residues in α and ε amide bonds; n is an odd whole number variable from 1 to 15; m is a whole number variable from 3 to 40; R1 is the side-chain of an amino acid residue selected from L-Asp, L-His, L-Cys, L-Gln, L-Thr, L-Ala, L-Leu, L- Met, L-Phe, L-Glu, L-Arg, L-Tyr, L-Asn, L-Ser, L-Gly, L Val, L-Ile, L-Pro and L-Trp; R2 is OH or NH2; R is hydrogen or an acyl radical; and the corresponding pharmaceutically acceptable acid or base addition salts. Compounds of formula (I) are particularly suitable as antigens for the preparation of a genetically unrestricted anti-Plasmodium malariae sporozoite vaccine and in diagnostics for the determination of anti Plasmodium malariae sporozoite antibodies in samples of blood, serum and blood-spots by immunoenzymatic assay. Compounds of formula (I) are also suitable as molecule carriers for improving the immunogenicity of haptens.
IT19800A 1989-05-19 1990-03-23 Immunogenic compounds and their use for the preparation of genetically unrestricted synthetic vaccines for the immunoenzymatic determination of anti-plasmodium malariae sporozoite antibodies IT1241081B (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IT19800A IT1241081B (en) 1990-03-23 1990-03-23 Immunogenic compounds and their use for the preparation of genetically unrestricted synthetic vaccines for the immunoenzymatic determination of anti-plasmodium malariae sporozoite antibodies
ES90201244T ES2063901T3 (en) 1989-05-19 1990-05-16 IMMUNOGENOUS COMPOUNDS AND THEIR USE IN THE PREPARATION OF GENETICALLY RESTRICTED SYNTHETIC VACCINES AND IN THE IMMUNOENZYMATIC DETERMINATION OF ANTIESPOROZOITE ANTIBODIES OF PLASMODIUM MALARIAE.
EP90201244A EP0398443B1 (en) 1989-05-19 1990-05-16 Immunogenic compounds and their use in the preparation of genetically unrestricted synthetic vaccines and in the immunoenzymatic determination of antisporozoite antibodies of plasmodium malariae
DK90201244.2T DK0398443T3 (en) 1989-05-19 1990-05-16 Immunogenic compounds and their use in the preparation of genetically unrestricted synthetic vaccines and for the immunoenzymatic determination of antisporozoite antibodies against Plasmodium malariae
DE69014150T DE69014150T2 (en) 1989-05-19 1990-05-16 Immunogen compounds and their use in the production of genetically unrestricted synthetic vaccines and in the immunoenzymatic determination of antisporozoid antibodies from Plasmodium malariae.
AT90201244T ATE114158T1 (en) 1989-05-19 1990-05-16 IMMUNOGEN COMPOUNDS AND THEIR USE IN THE PRODUCTION OF GENETICALLY UNRESTRICTED SYNTHETIC VACCINES AND IN THE IMMUNOENZYMATIC DETERMINATION OF ANTISPOROZOID ANTIBODIES OF PLASMODIUM MALARIAE.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT19800A IT1241081B (en) 1990-03-23 1990-03-23 Immunogenic compounds and their use for the preparation of genetically unrestricted synthetic vaccines for the immunoenzymatic determination of anti-plasmodium malariae sporozoite antibodies

Publications (3)

Publication Number Publication Date
IT9019800A0 IT9019800A0 (en) 1990-03-23
IT9019800A1 IT9019800A1 (en) 1991-09-23
IT1241081B true IT1241081B (en) 1993-12-29

Family

ID=11161320

Family Applications (1)

Application Number Title Priority Date Filing Date
IT19800A IT1241081B (en) 1989-05-19 1990-03-23 Immunogenic compounds and their use for the preparation of genetically unrestricted synthetic vaccines for the immunoenzymatic determination of anti-plasmodium malariae sporozoite antibodies

Country Status (1)

Country Link
IT (1) IT1241081B (en)

Also Published As

Publication number Publication date
IT9019800A1 (en) 1991-09-23
IT9019800A0 (en) 1990-03-23

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970313