IT1219934B - Prepn. of new and known 5-acylamino- tri:halo-benzoic acid derivs. - Google Patents

Prepn. of new and known 5-acylamino- tri:halo-benzoic acid derivs.

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Publication number
IT1219934B
IT1219934B IT8847935A IT4793588A IT1219934B IT 1219934 B IT1219934 B IT 1219934B IT 8847935 A IT8847935 A IT 8847935A IT 4793588 A IT4793588 A IT 4793588A IT 1219934 B IT1219934 B IT 1219934B
Authority
IT
Italy
Prior art keywords
formula
acylamino
alkyl
c0ch
hydroxyalkyl
Prior art date
Application number
IT8847935A
Other languages
Italian (it)
Other versions
IT8847935A0 (en
Inventor
Ernst Felder
Carlo Musu
Luciano Fumagalli
Fulvio Uggeri
Original Assignee
Bracco Ind Chimica Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Ind Chimica Spa filed Critical Bracco Ind Chimica Spa
Publication of IT8847935A0 publication Critical patent/IT8847935A0/en
Priority to IT8847935A priority Critical patent/IT1219934B/en
Priority to AU17978/88A priority patent/AU618535B2/en
Priority to US07/424,216 priority patent/US5066823A/en
Priority to DE8888904526T priority patent/DE3873766T2/en
Priority to EP88904526A priority patent/EP0365541B1/en
Priority to AT88904526T priority patent/ATE79368T1/en
Priority to ES8801607A priority patent/ES2006951A6/en
Priority to IE151888A priority patent/IE63232B1/en
Priority to JP63504455A priority patent/JP2585087B2/en
Priority to PCT/EP1988/000453 priority patent/WO1988009328A1/en
Priority to NZ224743A priority patent/NZ224743A/en
Priority to KR1019890700112A priority patent/KR960016747B1/en
Priority to IL8645088A priority patent/IL86450A/en
Priority to CA000567436A priority patent/CA1327600C/en
Application granted granted Critical
Publication of IT1219934B publication Critical patent/IT1219934B/en

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

2,4,6-Trihalobenzoic acid derivs. of formula (Ia) are new, where X=I or Br; (a) A1 and A2=C00R1; A3=N(R)C0CH(0H)R1; R1=2-5C alkyl substd. by 1-3 0H gps.; R=Me or R1; R1=H or Me; (b) A1 and A2=C0NHCH(CH20H)2; A3=N(CH(CH20H)2)C0CH(0H)R1; (c) A1 and A2=C0N(R11)R1; A3=N(Q)C0CH(0H)R1; R11=H or R1; Q=a gp. of formula (i) where E=1-3C alkylene opt. interrupted by 0,S,S0 or S02; D=H or 1-3C mono- or dihydroxyalkyl; (d) A1=C0Y; A2 and A3=N(R)C0CH(0H)R1; Y=0H, alkoxy, hydroxyalkoxy, alkylamino or pref. NR2R1; and R2=H or 1-5C alkyl, hydroxyalkyl, alkoxyalkyl or alkoxyhydroxyalkyl. Prodn. of 2,4,6-trihalobenzoic acid derivs. of formula (I) is effected by rearrangement of cpds. of formula (II) in the presence of a base. In the formulae, R3=2-6C hydroxyalkanoyl, alkoxyalkanoyl or hydroxalkoxyalkanoyl or 2-4C unsubstd. alkanoyl; R4=H, 1-6C alkyl, 1-6C hydroxyalkyl, 2-6C alkoxyalkyl, 2-6C alkoxyhydroxyalkyl, (CH2CH20)nR5 or a gp. of formula (ii), where n=2-4; R5=H, Me or Et; A=2-8C alkylene opt. substd. by 0H and/or interrupted by 0,S,S0 or S02; Z-C0Y, C0NR2R1 or 2-5C acylamino, hydroxyacylamino, N-alkyl-acylamino, N-hydroxyalkyl-acylamino or acylaminomethyl; provided that at least one R3 or R4 gp. is 0H-substd. B=0CH(R6)C0NHR14 or 0CH(R6)CH2NHR3; R14 is as defined for R4 except that Z is replaced by Z1 in the formula; R6=H, 1-3C alkyl, 1-3C hydroxyalkyl or 2-3C alkoxyalkyl; Z1=Z or B.
IT8847935A 1987-05-22 1988-05-05 Prepn. of new and known 5-acylamino- tri:halo-benzoic acid derivs. IT1219934B (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
IT8847935A IT1219934B (en) 1988-05-05 1988-05-05 Prepn. of new and known 5-acylamino- tri:halo-benzoic acid derivs.
ES8801607A ES2006951A6 (en) 1987-05-22 1988-05-20 Preparation of 5-acylamino-2,4,6-triiodo- or tribromo-benzoic acid derivatives.
JP63504455A JP2585087B2 (en) 1987-05-22 1988-05-20 Method for producing 5-acylamino-2,4,6-triiodo- or -tribromo-benzoic acid derivative and novel 5-acylamino-2,4,6-triiodo or -tribromo-benzoic acid obtained by the method Derivative
DE8888904526T DE3873766T2 (en) 1987-05-22 1988-05-20 PREPARATION OF 5-ACYLAMINO-2,4,6-TRIJODO OR TRIBROMO-BENZOESIC ACID DERIVATIVES.
EP88904526A EP0365541B1 (en) 1987-05-22 1988-05-20 Preparation of 5-acylamino-2,4,6-triiodo- or tribromo-benzoic acid derivatives
AT88904526T ATE79368T1 (en) 1987-05-22 1988-05-20 PREPARATION OF 5-ACYLAMINO-2,4,6-TRIIODO OR TRIBROMO-BENZOACID DERIVATIVES.
AU17978/88A AU618535B2 (en) 1987-05-22 1988-05-20 Preparation of 5-acylamino-2,4,6-triiodo-or tribromo-benzoic acid derivatives
IE151888A IE63232B1 (en) 1987-05-22 1988-05-20 A process for the preparation of 5-acylamino-2,4,6-triiodo- or tribromo-benzoic acid derivatives and corresponding novel 5-acylamino-2,4,6-triiodo or tribromo-benzoic acid derivatives obtained by said process
US07/424,216 US5066823A (en) 1987-05-22 1988-05-20 Preparation of 5-acylamino-2,4,6-triiodo- or tribromo-benzoic acid derivatives
PCT/EP1988/000453 WO1988009328A1 (en) 1987-05-22 1988-05-20 Preparation of 5-acylamino-2,4,6-triiodo- or tribromo-benzoic acid derivatives
NZ224743A NZ224743A (en) 1987-05-22 1988-05-20 5-acylamino-2,4,6-tribromo- or triiodo-benzoic acid derivatives and intermediate compounds used in their preparation
KR1019890700112A KR960016747B1 (en) 1987-05-22 1988-05-20 Preparation of 5-acylamino-2,4,6 triiodo or tribromo benzoic acid derivatives
IL8645088A IL86450A (en) 1987-05-22 1988-05-20 Process for the preparation of 5-acylamino-2.4.6-triiodo- and tribromo-benzoic acid derivatives and some such novel compounds
CA000567436A CA1327600C (en) 1987-05-22 1988-05-20 Process for the preparation of 5-acylamino-2,4,6- triiodo-or tribromo-benzoic acid derivatives and corresponding novel 5-acylamino-2,4,6-triiodo or tribromo-benzoic acid derivatives obtained by said process

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8847935A IT1219934B (en) 1988-05-05 1988-05-05 Prepn. of new and known 5-acylamino- tri:halo-benzoic acid derivs.

Publications (2)

Publication Number Publication Date
IT8847935A0 IT8847935A0 (en) 1988-05-05
IT1219934B true IT1219934B (en) 1990-05-24

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Family Applications (1)

Application Number Title Priority Date Filing Date
IT8847935A IT1219934B (en) 1987-05-22 1988-05-05 Prepn. of new and known 5-acylamino- tri:halo-benzoic acid derivs.

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IT8847935A0 (en) 1988-05-05

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