IT1209921B - Composto di beta-pentafuranosio,preparato antivirale che lo contiene emetodo per applicarlo - Google Patents

Composto di beta-pentafuranosio,preparato antivirale che lo contiene emetodo per applicarlo

Info

Publication number
IT1209921B
IT1209921B IT8448236A IT4823684A IT1209921B IT 1209921 B IT1209921 B IT 1209921B IT 8448236 A IT8448236 A IT 8448236A IT 4823684 A IT4823684 A IT 4823684A IT 1209921 B IT1209921 B IT 1209921B
Authority
IT
Italy
Prior art keywords
pentafuranose
emethod
beta
apply
compound
Prior art date
Application number
IT8448236A
Other languages
English (en)
Other versions
IT8448236A0 (it
Inventor
Elmer J Reist
Priscilla A Sturm
Original Assignee
Stanford Res Inst Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanford Res Inst Int filed Critical Stanford Res Inst Int
Publication of IT8448236A0 publication Critical patent/IT8448236A0/it
Application granted granted Critical
Publication of IT1209921B publication Critical patent/IT1209921B/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/10Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • C07H19/20Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
IT8448236A 1983-05-24 1984-05-22 Composto di beta-pentafuranosio,preparato antivirale che lo contiene emetodo per applicarlo IT1209921B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49772083A 1983-05-24 1983-05-24

Publications (2)

Publication Number Publication Date
IT8448236A0 IT8448236A0 (it) 1984-05-22
IT1209921B true IT1209921B (it) 1989-08-30

Family

ID=23978043

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8448236A IT1209921B (it) 1983-05-24 1984-05-22 Composto di beta-pentafuranosio,preparato antivirale che lo contiene emetodo per applicarlo

Country Status (7)

Country Link
EP (4) EP0273169A3 (it)
JP (1) JPS60501407A (it)
DE (1) DE3490262T1 (it)
GB (1) GB2150570B (it)
IT (1) IT1209921B (it)
NL (1) NL8420134A (it)
SE (1) SE461914B (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0338168A1 (en) * 1988-04-19 1989-10-25 Merrell Dow Pharmaceuticals Inc. Phosphonoalkylpurine derivatives
JPH04505005A (ja) * 1989-02-23 1992-09-03 ユニバーシティ カレッジ ロンドン ヌクレオシド類縁体
GB8921469D0 (en) * 1989-09-22 1989-11-08 Erba Carlo Spa 5'-alkylphosphonylnucleosides as antivirals
US5374626A (en) * 1989-09-22 1994-12-20 Farmitalia Carlo Erba 5'-alkylphosphonylnucleosides as antivirals
EP0477454A1 (en) * 1990-09-28 1992-04-01 Merrell Dow Pharmaceuticals Inc. Novel phosphonate derivatives of certain nucleosides
RU2183213C2 (ru) * 1996-11-05 2002-06-10 ЗАО "Производственно-коммерческая ассоциация АЗТ" Модифицированные нуклеозид-5'-трифосфаты как антивирусные агенты

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3238191A (en) * 1962-09-13 1966-03-01 Terrell C Myers Phosphonic acid analogs of nucleoside phosphates and method
US3524846A (en) * 1967-06-02 1970-08-18 Syntex Corp Process for the didealkylation of phosphonate esters
US3662031A (en) * 1967-07-18 1972-05-09 Syntex Corp Phosphorylated phosphonium ylids
US3878194A (en) * 1967-07-18 1975-04-15 Syntex Inc Novel phosphorylated phosphonium ylids
US3446793A (en) * 1967-10-30 1969-05-27 Syntex Corp 3'-cyclic esters of 5'-deoxy-5'-(dihydroxyphosphinylmethyl)-nucleosides
US3560478A (en) * 1968-06-14 1971-02-02 Terrell C Myers Analogues of nucleoside phosphates
CA931561A (en) * 1969-03-10 1973-08-07 Syntex Corporation Nucleoside phosphonates, phosphonic acids, phosphonic acid salts, and process for producing same
AU521577B2 (en) * 1977-02-24 1982-04-22 Wellcome Foundation Limited, The 9-hydroxyethoxymethyl guanine phosphates
US4287188A (en) * 1977-02-24 1981-09-01 Burroughs Wellcome Co. Purine derivatives
US4291024A (en) * 1978-04-10 1981-09-22 Turcotte Joseph G Cytotoxic liponucleotide analogs
EP0015584A3 (de) * 1979-03-12 1980-12-10 Kailash Kumar Dr. Prof. Gauri Neue Nukleotide, Verfahren zu ihrer Herstellung und Arzneimittel
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
DE3045375A1 (de) * 1980-12-02 1982-07-01 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen Neue substituierte pyrimidin-nukleoside mit antiviraler wirkung, verfahren zu deren herstellung und daraus zubereitete arzneiformen
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation

Also Published As

Publication number Publication date
EP0274025A2 (en) 1988-07-13
GB8500850D0 (en) 1985-02-20
EP0273169A3 (en) 1990-08-29
EP0145739B1 (en) 1989-02-08
GB2150570B (en) 1987-04-08
EP0272446B1 (en) 1992-11-11
SE8500307D0 (sv) 1985-01-23
EP0272446A1 (en) 1988-06-29
DE3490262T1 (de) 1985-11-28
SE8500307L (sv) 1985-01-23
IT8448236A0 (it) 1984-05-22
GB2150570A (en) 1985-07-03
WO1984004748A1 (en) 1984-12-06
EP0273169A2 (en) 1988-07-06
NL8420134A (nl) 1985-04-01
EP0274025A3 (en) 1990-08-29
EP0145739A1 (en) 1985-06-26
JPS60501407A (ja) 1985-08-29
SE461914B (sv) 1990-04-09

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19950529