IT1204422B - 6-Methyl-3-carboxy-4-phenyl -2-thio:methyl -1,4-di:hydro:pyridine - Google Patents

6-Methyl-3-carboxy-4-phenyl -2-thio:methyl -1,4-di:hydro:pyridine

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Publication number
IT1204422B
IT1204422B IT20966/86A IT2096686A IT1204422B IT 1204422 B IT1204422 B IT 1204422B IT 20966/86 A IT20966/86 A IT 20966/86A IT 2096686 A IT2096686 A IT 2096686A IT 1204422 B IT1204422 B IT 1204422B
Authority
IT
Italy
Prior art keywords
alkyl
opt
halo
substd
methyl
Prior art date
Application number
IT20966/86A
Other languages
Italian (it)
Other versions
IT8620966A0 (en
Inventor
Carmelo A Gandolfi
Marco Frigerio
Silvano Spinelli
Odoardo Tofanetti
Sergio Tognella
Original Assignee
Boehringer Biochemia Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Biochemia Srl filed Critical Boehringer Biochemia Srl
Publication of IT8620966A0 publication Critical patent/IT8620966A0/en
Priority to IT20966/86A priority Critical patent/IT1204422B/en
Priority to EP86904813A priority patent/EP0233228A1/en
Priority to AU62245/86A priority patent/AU593278B2/en
Priority to HU864090A priority patent/HU199796B/en
Priority to KR1019870700295A priority patent/KR930011486B1/en
Priority to PCT/EP1986/000445 priority patent/WO1987000836A1/en
Priority to IL79572A priority patent/IL79572A0/en
Priority to IE862066A priority patent/IE862066L/en
Priority to PT83143A priority patent/PT83143B/en
Priority to ES8600871A priority patent/ES2009136A6/en
Priority to CN198686106242A priority patent/CN86106242A/en
Priority to NO871445A priority patent/NO173544C/en
Priority to FI871492A priority patent/FI92194C/en
Priority to DK175487A priority patent/DK175487D0/en
Application granted granted Critical
Publication of IT1204422B publication Critical patent/IT1204422B/en
Priority to US07/333,080 priority patent/US4999362A/en
Priority to US07/413,896 priority patent/US5021436A/en

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Abstract

6-Methyl-3-carboxy-4-phenyl- 2-substd. methyl-1,4-dihydropyridine derivs. of the formula (I) and their salts, enantiomers and/or diastereoisomers and mixtures; R1=acetyl, benzoyl, CN, nitro, CO2R5, CONR6R7; R2=phenyl opt. substd. with one or more 1-6C alkyl, 1-6C alkoxy, halo(1-6C)alkyl halo, nitro, CN, 1-6C alkoxycarbonyl, 1-6C alkylthio, 1-6C alkylsulphinyl, pentafluorophenyl, alpha- or beta-naphthyl, 5- or 6-membered heterocyclyl, alpha-benzo(2,3-b)-1,4-dioxan -alpha-yl, alpha-; R3=CO2R5; Phi=(a) thiol opt. esterified with 2-12C fatty acid; (b) -S-C(=NR8)NR9R10(+) Y(-); (c) -S(O)n-R4; R8, R9, R10=H or 1-4C alkyl; n=0, 1 or 2; R4=(a) 1-5C alkyl, 3-5C alkenyl, 3-5C alkynyl unsubstd. groups; (b) 3-7C cycloaliphatic residue; (c) aryl, opt. substd. by one or more halo, OH, nitro, CN, acetyl, 1-6C alkyl, etc.; (d) opt. unsatd. heterocyclic ring opt. substd. by one or more halo, 1-6C alkyl, 1-6C alkoxy, halo(1-6C)alkyl, etc.; (e) 2-12C alkyl opt. interrupted by one or more O or S and opt. substd. by one or more OH, SH, CN, halo, amino, etc.; (f) a gp. (CH2)n-A-(CH2)p-B contg. 2-12C; (g) a gp. of formula (II) where A=as or trans oxirane ring or opt. masked carbonyl; B=H, 1-4C alkyl, CN, COOH, 1-4C alkoxycarbonyl, etc.; P=H, 1-8C alkyl or (CH2)p1W; NP1P2=primary, secondary or tertiary amino or amidic or imidic residue, etc.; n=1-6; m=1-3; p=0-6; p1=0-3 with the proviso that when Phi is -S(O)nR4 and R4=1-5C alkyl, n is not 0.
IT20966/86A 1985-08-06 1986-06-27 6-Methyl-3-carboxy-4-phenyl -2-thio:methyl -1,4-di:hydro:pyridine IT1204422B (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
IT20966/86A IT1204422B (en) 1986-06-27 1986-06-27 6-Methyl-3-carboxy-4-phenyl -2-thio:methyl -1,4-di:hydro:pyridine
EP86904813A EP0233228A1 (en) 1985-08-06 1986-07-29 Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines
AU62245/86A AU593278B2 (en) 1985-08-06 1986-07-29 Pharmaceutically active 2-thiomethyl-substituted-1,4- dihydropyridines
HU864090A HU199796B (en) 1985-08-06 1986-07-29 Process for producing 2-thiomethyl-substituted-1,4-dihydropyridines and pharmaceutical compositions comprising such compounds
KR1019870700295A KR930011486B1 (en) 1985-08-06 1986-07-29 Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines
PCT/EP1986/000445 WO1987000836A1 (en) 1985-08-06 1986-07-29 Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines
IL79572A IL79572A0 (en) 1985-08-06 1986-07-30 2-thiomethyl-substituted-1,4-dihydropyridines,method for their preparation and pharmaceutical compositions containing them
IE862066A IE862066L (en) 1985-08-06 1986-08-01 2-thiomethyl-substituted-1,4-dihydropyridines, method forĀ¹their preparation and pharmaceutical compositions containingĀ¹them
PT83143A PT83143B (en) 1985-08-06 1986-08-05 METHOD FOR THE PREPARATION OF 2-SUBSTITUTED 1,4-DIHYDRO-PYRIDINES WITH TIOMETHYL AND OF PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
ES8600871A ES2009136A6 (en) 1985-08-06 1986-08-05 Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines.
CN198686106242A CN86106242A (en) 1985-08-06 1986-08-05 2-sulphomethyl-replacement-1,4-dihydropyridine, its manufacture method and the pharmaceutical composition that contains these compounds
NO871445A NO173544C (en) 1985-08-06 1987-04-06 Analogous Procedure for Preparation of Therapeutically Active 2-Thiomethyl-substituted 1,4-dihydropyridines
FI871492A FI92194C (en) 1985-08-06 1987-04-06 Process for the preparation of 2-thiomethyl-substituted 1,4-dihydropyridines useful as a drug
DK175487A DK175487D0 (en) 1985-08-06 1987-04-06 PHARMACEUTICAL ACTIVE 2-THIOMETHYL-SUBSTITUTED-1,4-DIHYDRO-PYRIDINES
US07/333,080 US4999362A (en) 1985-08-06 1989-04-04 2-thiomethyl-substituted-1,4-dihydropyridines, method for their preparation and pharmaceutical compositions containing them
US07/413,896 US5021436A (en) 1985-08-06 1989-09-28 2-thiomethyl-substituted-1,4-dihydropyridines, and pharmaceutical compositions containing same and antihypertensive properties

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20966/86A IT1204422B (en) 1986-06-27 1986-06-27 6-Methyl-3-carboxy-4-phenyl -2-thio:methyl -1,4-di:hydro:pyridine

Publications (2)

Publication Number Publication Date
IT8620966A0 IT8620966A0 (en) 1986-06-27
IT1204422B true IT1204422B (en) 1989-03-01

Family

ID=11174733

Family Applications (1)

Application Number Title Priority Date Filing Date
IT20966/86A IT1204422B (en) 1985-08-06 1986-06-27 6-Methyl-3-carboxy-4-phenyl -2-thio:methyl -1,4-di:hydro:pyridine

Country Status (1)

Country Link
IT (1) IT1204422B (en)

Also Published As

Publication number Publication date
IT8620966A0 (en) 1986-06-27

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Effective date: 19970628