IT1204422B - 6-Methyl-3-carboxy-4-phenyl -2-thio:methyl -1,4-di:hydro:pyridine - Google Patents
6-Methyl-3-carboxy-4-phenyl -2-thio:methyl -1,4-di:hydro:pyridineInfo
- Publication number
- IT1204422B IT1204422B IT20966/86A IT2096686A IT1204422B IT 1204422 B IT1204422 B IT 1204422B IT 20966/86 A IT20966/86 A IT 20966/86A IT 2096686 A IT2096686 A IT 2096686A IT 1204422 B IT1204422 B IT 1204422B
- Authority
- IT
- Italy
- Prior art keywords
- alkyl
- opt
- halo
- substd
- methyl
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
6-Methyl-3-carboxy-4-phenyl- 2-substd. methyl-1,4-dihydropyridine derivs. of the formula (I) and their salts, enantiomers and/or diastereoisomers and mixtures; R1=acetyl, benzoyl, CN, nitro, CO2R5, CONR6R7; R2=phenyl opt. substd. with one or more 1-6C alkyl, 1-6C alkoxy, halo(1-6C)alkyl halo, nitro, CN, 1-6C alkoxycarbonyl, 1-6C alkylthio, 1-6C alkylsulphinyl, pentafluorophenyl, alpha- or beta-naphthyl, 5- or 6-membered heterocyclyl, alpha-benzo(2,3-b)-1,4-dioxan -alpha-yl, alpha-; R3=CO2R5; Phi=(a) thiol opt. esterified with 2-12C fatty acid; (b) -S-C(=NR8)NR9R10(+) Y(-); (c) -S(O)n-R4; R8, R9, R10=H or 1-4C alkyl; n=0, 1 or 2; R4=(a) 1-5C alkyl, 3-5C alkenyl, 3-5C alkynyl unsubstd. groups; (b) 3-7C cycloaliphatic residue; (c) aryl, opt. substd. by one or more halo, OH, nitro, CN, acetyl, 1-6C alkyl, etc.; (d) opt. unsatd. heterocyclic ring opt. substd. by one or more halo, 1-6C alkyl, 1-6C alkoxy, halo(1-6C)alkyl, etc.; (e) 2-12C alkyl opt. interrupted by one or more O or S and opt. substd. by one or more OH, SH, CN, halo, amino, etc.; (f) a gp. (CH2)n-A-(CH2)p-B contg. 2-12C; (g) a gp. of formula (II) where A=as or trans oxirane ring or opt. masked carbonyl; B=H, 1-4C alkyl, CN, COOH, 1-4C alkoxycarbonyl, etc.; P=H, 1-8C alkyl or (CH2)p1W; NP1P2=primary, secondary or tertiary amino or amidic or imidic residue, etc.; n=1-6; m=1-3; p=0-6; p1=0-3 with the proviso that when Phi is -S(O)nR4 and R4=1-5C alkyl, n is not 0.
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT20966/86A IT1204422B (en) | 1986-06-27 | 1986-06-27 | 6-Methyl-3-carboxy-4-phenyl -2-thio:methyl -1,4-di:hydro:pyridine |
EP86904813A EP0233228A1 (en) | 1985-08-06 | 1986-07-29 | Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines |
AU62245/86A AU593278B2 (en) | 1985-08-06 | 1986-07-29 | Pharmaceutically active 2-thiomethyl-substituted-1,4- dihydropyridines |
HU864090A HU199796B (en) | 1985-08-06 | 1986-07-29 | Process for producing 2-thiomethyl-substituted-1,4-dihydropyridines and pharmaceutical compositions comprising such compounds |
KR1019870700295A KR930011486B1 (en) | 1985-08-06 | 1986-07-29 | Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines |
PCT/EP1986/000445 WO1987000836A1 (en) | 1985-08-06 | 1986-07-29 | Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines |
IL79572A IL79572A0 (en) | 1985-08-06 | 1986-07-30 | 2-thiomethyl-substituted-1,4-dihydropyridines,method for their preparation and pharmaceutical compositions containing them |
IE862066A IE862066L (en) | 1985-08-06 | 1986-08-01 | 2-thiomethyl-substituted-1,4-dihydropyridines, method forĀ¹their preparation and pharmaceutical compositions containingĀ¹them |
PT83143A PT83143B (en) | 1985-08-06 | 1986-08-05 | METHOD FOR THE PREPARATION OF 2-SUBSTITUTED 1,4-DIHYDRO-PYRIDINES WITH TIOMETHYL AND OF PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
ES8600871A ES2009136A6 (en) | 1985-08-06 | 1986-08-05 | Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines. |
CN198686106242A CN86106242A (en) | 1985-08-06 | 1986-08-05 | 2-sulphomethyl-replacement-1,4-dihydropyridine, its manufacture method and the pharmaceutical composition that contains these compounds |
NO871445A NO173544C (en) | 1985-08-06 | 1987-04-06 | Analogous Procedure for Preparation of Therapeutically Active 2-Thiomethyl-substituted 1,4-dihydropyridines |
FI871492A FI92194C (en) | 1985-08-06 | 1987-04-06 | Process for the preparation of 2-thiomethyl-substituted 1,4-dihydropyridines useful as a drug |
DK175487A DK175487D0 (en) | 1985-08-06 | 1987-04-06 | PHARMACEUTICAL ACTIVE 2-THIOMETHYL-SUBSTITUTED-1,4-DIHYDRO-PYRIDINES |
US07/333,080 US4999362A (en) | 1985-08-06 | 1989-04-04 | 2-thiomethyl-substituted-1,4-dihydropyridines, method for their preparation and pharmaceutical compositions containing them |
US07/413,896 US5021436A (en) | 1985-08-06 | 1989-09-28 | 2-thiomethyl-substituted-1,4-dihydropyridines, and pharmaceutical compositions containing same and antihypertensive properties |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT20966/86A IT1204422B (en) | 1986-06-27 | 1986-06-27 | 6-Methyl-3-carboxy-4-phenyl -2-thio:methyl -1,4-di:hydro:pyridine |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8620966A0 IT8620966A0 (en) | 1986-06-27 |
IT1204422B true IT1204422B (en) | 1989-03-01 |
Family
ID=11174733
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT20966/86A IT1204422B (en) | 1985-08-06 | 1986-06-27 | 6-Methyl-3-carboxy-4-phenyl -2-thio:methyl -1,4-di:hydro:pyridine |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1204422B (en) |
-
1986
- 1986-06-27 IT IT20966/86A patent/IT1204422B/en active
Also Published As
Publication number | Publication date |
---|---|
IT8620966A0 (en) | 1986-06-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8206471A1 (en) | Amino acid derivatives, processes for their preparation, compositions containing them and their use. | |
EP0186367A3 (en) | Novel acidic indole compounds and their use as antiallernovel acidic indole compounds and their use as antiallergy agents gy agents | |
FI970526A0 (en) | Estra-1,3,5 (10) triene derivatives, methods for their preparation and pharmaceutical compositions containing these compounds | |
AU6560396A (en) | New substituted 2,2-dimethyl-omega-phenoxyalkanoic acids and esters, process for their preparation and pharmaceutical compositions containing them | |
IT1204422B (en) | 6-Methyl-3-carboxy-4-phenyl -2-thio:methyl -1,4-di:hydro:pyridine | |
NZ214076A (en) | 3-pyridinecarboxylate derivatives and herbicidal compositions | |
ATE61353T1 (en) | 2,3-DIAMINOACRYLONITRILE DERIVATIVES. | |
MY102954A (en) | Carbapenem antibiotics | |
JPS5297934A (en) | N#-arylsulfonyl-l-argininamides and their salts acceptable as medicine s | |
ES2146722T3 (en) | NEW ANALOGS OF ACRONICIN, ITS PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. | |
ES8105319A1 (en) | Pyrazolo[1,5-c]quinazoline derivatives and analgesic compositions containing them | |
GR77967B (en) | ||
DE3561818D1 (en) | Isoxazoloquinolinone derivatives, process and intermediates for their preparation, use as medicaments and compositions containing them | |
AU2670084A (en) | N-sulphenylated phenethylsulphonamides | |
ES480561A1 (en) | Bridged catharanthus alkaloid dimers, their preparation and formulations containing them. | |
IE811777L (en) | Benzoquinolizines. | |
FR2265369A1 (en) | Opt substd benzo isoindolines - as antiaggressive and analgesic agents of low toxicity | |
NL7601632A (en) | Antibacterial 1,8-naphthyridine derivs - viz. 7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acids, by ylid hydrolysis | |
IT1231915B (en) | New glycosamino-glycan salts | |
ES8605145A1 (en) | Ethyl 6:fluoro 4:oxo 7:piperazinyl quinoline 3:carboxylate(s) | |
GB1469200A (en) | 3-thiomethyl-2-2-dialkylamino-ethyl-indoles | |
ES8604099A1 (en) | N-acyl amino acid derivatives, their preparation and their use as fungicides. | |
FR2244514A1 (en) | 1,2-Dihydroquinoline derivs - useful as anti-inflammatories | |
AU564997B2 (en) | Imidazo(1,2-alpha)quinolines | |
AU4126185A (en) | N-iodopropargyl-chloromethanesulphonamides |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970628 |