IT1203166B - Chlorobenzoyl-phenoxymethyl-propionic acid and its ester(s) - obtd. by oxidising chlorobenzyl-phenoxymethyl-propionic acid using e.g. potassium permanganate and esterifying - Google Patents
Chlorobenzoyl-phenoxymethyl-propionic acid and its ester(s) - obtd. by oxidising chlorobenzyl-phenoxymethyl-propionic acid using e.g. potassium permanganate and esterifyingInfo
- Publication number
- IT1203166B IT1203166B IT6726378A IT6726378A IT1203166B IT 1203166 B IT1203166 B IT 1203166B IT 6726378 A IT6726378 A IT 6726378A IT 6726378 A IT6726378 A IT 6726378A IT 1203166 B IT1203166 B IT 1203166B
- Authority
- IT
- Italy
- Prior art keywords
- propionic acid
- phenoxymethyl
- chlorobenzoyl
- chlorobenzyl
- potassium permanganate
- Prior art date
Links
- 239000012286 potassium permanganate Substances 0.000 title abstract 3
- QXQQSBPRCFZKAT-UHFFFAOYSA-N 2-(chloromethyl)-3-oxo-2-(phenoxymethyl)-3-phenylpropanoic acid Chemical compound ClCC(C(=O)O)(COC1=CC=CC=C1)C(C1=CC=CC=C1)=O QXQQSBPRCFZKAT-UHFFFAOYSA-N 0.000 title 1
- OATFIRNNSKBQNO-UHFFFAOYSA-N 2-benzyl-2-(chloromethyl)-3-phenoxypropanoic acid Chemical compound ClCC(C(=O)O)(COC1=CC=CC=C1)CC1=CC=CC=C1 OATFIRNNSKBQNO-UHFFFAOYSA-N 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 abstract 2
- JHWIEAWILPSRMU-UHFFFAOYSA-N 2-methyl-3-pyrimidin-4-ylpropanoic acid Chemical compound OC(=O)C(C)CC1=CC=NC=N1 JHWIEAWILPSRMU-UHFFFAOYSA-N 0.000 abstract 1
- XRHGYUZYPHTUJZ-UHFFFAOYSA-N 4-chlorobenzoic acid Chemical compound OC(=O)C1=CC=C(Cl)C=C1 XRHGYUZYPHTUJZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000004160 Ammonium persulphate Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 abstract 1
- 235000019395 ammonium persulphate Nutrition 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 229910001961 silver nitrate Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/373—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in doubly bound form
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Prepn. of (4-chlorobenzoyl)-4-phenoxy -2-methyl-2-propionic acid (I) comprises oxidising (4-chlorobenzyl)-4-phenoxy -2-methyl-2-propionic acid using potassium permanganate, sodium dichromate or ammonium persulphate. The methyl, ethyl or isopropyl esters of (I) may also be prepd. via the above process. The reaction is carried out in acid media with Na2Cr207, in aqueous solution with KMnO4, and in aqueous solution in the presence of a catalyst such as silver nitrate with (NH4)2S2o8. The oxidation of the methylene group to the carbonyl must be controlled to avoid further reactions forming unwanted by-products such as 4-chlorobenzoic acid.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT6726378A IT1203166B (en) | 1978-02-10 | 1978-02-10 | Chlorobenzoyl-phenoxymethyl-propionic acid and its ester(s) - obtd. by oxidising chlorobenzyl-phenoxymethyl-propionic acid using e.g. potassium permanganate and esterifying |
BE2056864A BE865898A (en) | 1978-02-10 | 1978-04-12 | PROCESS FOR THE PREPARATION OF ACID (CHLOROBENZOYL-4) PHENOXY-4) METHYL-2 PROPIONIC-2 AND SOME OF ITS ESTERS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT6726378A IT1203166B (en) | 1978-02-10 | 1978-02-10 | Chlorobenzoyl-phenoxymethyl-propionic acid and its ester(s) - obtd. by oxidising chlorobenzyl-phenoxymethyl-propionic acid using e.g. potassium permanganate and esterifying |
Publications (2)
Publication Number | Publication Date |
---|---|
IT7867263A0 IT7867263A0 (en) | 1978-02-10 |
IT1203166B true IT1203166B (en) | 1989-02-15 |
Family
ID=11300955
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT6726378A IT1203166B (en) | 1978-02-10 | 1978-02-10 | Chlorobenzoyl-phenoxymethyl-propionic acid and its ester(s) - obtd. by oxidising chlorobenzyl-phenoxymethyl-propionic acid using e.g. potassium permanganate and esterifying |
Country Status (2)
Country | Link |
---|---|
BE (1) | BE865898A (en) |
IT (1) | IT1203166B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104276950B (en) * | 2014-09-19 | 2016-04-20 | 徐州工业职业技术学院 | A kind of intelligent temperature control, remote monitoring prepare the method for fenofibrate |
-
1978
- 1978-02-10 IT IT6726378A patent/IT1203166B/en active
- 1978-04-12 BE BE2056864A patent/BE865898A/en unknown
Also Published As
Publication number | Publication date |
---|---|
IT7867263A0 (en) | 1978-02-10 |
BE865898A (en) | 1978-07-31 |
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