IT1203166B - Chlorobenzoyl-phenoxymethyl-propionic acid and its ester(s) - obtd. by oxidising chlorobenzyl-phenoxymethyl-propionic acid using e.g. potassium permanganate and esterifying - Google Patents

Chlorobenzoyl-phenoxymethyl-propionic acid and its ester(s) - obtd. by oxidising chlorobenzyl-phenoxymethyl-propionic acid using e.g. potassium permanganate and esterifying

Info

Publication number
IT1203166B
IT1203166B IT6726378A IT6726378A IT1203166B IT 1203166 B IT1203166 B IT 1203166B IT 6726378 A IT6726378 A IT 6726378A IT 6726378 A IT6726378 A IT 6726378A IT 1203166 B IT1203166 B IT 1203166B
Authority
IT
Italy
Prior art keywords
propionic acid
phenoxymethyl
chlorobenzoyl
chlorobenzyl
potassium permanganate
Prior art date
Application number
IT6726378A
Other languages
Italian (it)
Other versions
IT7867263A0 (en
Original Assignee
Sigurta Farmaceutici Spa
Sigurta Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigurta Farmaceutici Spa, Sigurta Srl filed Critical Sigurta Farmaceutici Spa
Priority to IT6726378A priority Critical patent/IT1203166B/en
Publication of IT7867263A0 publication Critical patent/IT7867263A0/en
Priority to BE2056864A priority patent/BE865898A/en
Application granted granted Critical
Publication of IT1203166B publication Critical patent/IT1203166B/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/58Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/373Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in doubly bound form

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Prepn. of (4-chlorobenzoyl)-4-phenoxy -2-methyl-2-propionic acid (I) comprises oxidising (4-chlorobenzyl)-4-phenoxy -2-methyl-2-propionic acid using potassium permanganate, sodium dichromate or ammonium persulphate. The methyl, ethyl or isopropyl esters of (I) may also be prepd. via the above process. The reaction is carried out in acid media with Na2Cr207, in aqueous solution with KMnO4, and in aqueous solution in the presence of a catalyst such as silver nitrate with (NH4)2S2o8. The oxidation of the methylene group to the carbonyl must be controlled to avoid further reactions forming unwanted by-products such as 4-chlorobenzoic acid.
IT6726378A 1978-02-10 1978-02-10 Chlorobenzoyl-phenoxymethyl-propionic acid and its ester(s) - obtd. by oxidising chlorobenzyl-phenoxymethyl-propionic acid using e.g. potassium permanganate and esterifying IT1203166B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IT6726378A IT1203166B (en) 1978-02-10 1978-02-10 Chlorobenzoyl-phenoxymethyl-propionic acid and its ester(s) - obtd. by oxidising chlorobenzyl-phenoxymethyl-propionic acid using e.g. potassium permanganate and esterifying
BE2056864A BE865898A (en) 1978-02-10 1978-04-12 PROCESS FOR THE PREPARATION OF ACID (CHLOROBENZOYL-4) PHENOXY-4) METHYL-2 PROPIONIC-2 AND SOME OF ITS ESTERS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT6726378A IT1203166B (en) 1978-02-10 1978-02-10 Chlorobenzoyl-phenoxymethyl-propionic acid and its ester(s) - obtd. by oxidising chlorobenzyl-phenoxymethyl-propionic acid using e.g. potassium permanganate and esterifying

Publications (2)

Publication Number Publication Date
IT7867263A0 IT7867263A0 (en) 1978-02-10
IT1203166B true IT1203166B (en) 1989-02-15

Family

ID=11300955

Family Applications (1)

Application Number Title Priority Date Filing Date
IT6726378A IT1203166B (en) 1978-02-10 1978-02-10 Chlorobenzoyl-phenoxymethyl-propionic acid and its ester(s) - obtd. by oxidising chlorobenzyl-phenoxymethyl-propionic acid using e.g. potassium permanganate and esterifying

Country Status (2)

Country Link
BE (1) BE865898A (en)
IT (1) IT1203166B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104276950B (en) * 2014-09-19 2016-04-20 徐州工业职业技术学院 A kind of intelligent temperature control, remote monitoring prepare the method for fenofibrate

Also Published As

Publication number Publication date
IT7867263A0 (en) 1978-02-10
BE865898A (en) 1978-07-31

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