IT1182721B - Procedimento di purificazione di proteine ossee - Google Patents

Procedimento di purificazione di proteine ossee

Info

Publication number
IT1182721B
IT1182721B IT47835/85A IT4783585A IT1182721B IT 1182721 B IT1182721 B IT 1182721B IT 47835/85 A IT47835/85 A IT 47835/85A IT 4783585 A IT4783585 A IT 4783585A IT 1182721 B IT1182721 B IT 1182721B
Authority
IT
Italy
Prior art keywords
protein purification
purification procedure
bone protein
bone
procedure
Prior art date
Application number
IT47835/85A
Other languages
English (en)
Other versions
IT8547835A0 (it
IT8547835A1 (it
Inventor
Arnold I Caplan
Glen T Syftestad
Original Assignee
Arnold I Caplan
Glen T Syftestad
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arnold I Caplan, Glen T Syftestad filed Critical Arnold I Caplan
Publication of IT8547835A0 publication Critical patent/IT8547835A0/it
Publication of IT8547835A1 publication Critical patent/IT8547835A1/it
Application granted granted Critical
Publication of IT1182721B publication Critical patent/IT1182721B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
IT47835/85A 1984-03-20 1985-03-20 Procedimento di purificazione di proteine ossee IT1182721B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/591,505 US4608199A (en) 1984-03-20 1984-03-20 Bone protein purification process

Publications (3)

Publication Number Publication Date
IT8547835A0 IT8547835A0 (it) 1985-03-20
IT8547835A1 IT8547835A1 (it) 1986-09-20
IT1182721B true IT1182721B (it) 1987-10-05

Family

ID=24366750

Family Applications (1)

Application Number Title Priority Date Filing Date
IT47835/85A IT1182721B (it) 1984-03-20 1985-03-20 Procedimento di purificazione di proteine ossee

Country Status (5)

Country Link
US (1) US4608199A (it)
EP (1) EP0174993A1 (it)
AU (1) AU4113385A (it)
IT (1) IT1182721B (it)
WO (1) WO1985004173A1 (it)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
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NZ210699A (en) * 1984-01-04 1989-06-28 Int Genetic Eng Isolation of an osteogenic protein of the p3 immunologically related family
US4627982A (en) * 1984-07-16 1986-12-09 Collagen Corporation Partially purified bone-inducing factor
US5108922A (en) * 1986-07-01 1992-04-28 Genetics Institute, Inc. DNA sequences encoding BMP-1 products
US5939388A (en) * 1986-07-01 1999-08-17 Rosen; Vicki A. Methods of administering BMP-5 compositions
US5459047A (en) * 1986-07-01 1995-10-17 Genetics Institute, Inc. BMP-6 proteins
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Factors that soak bone formation
US5187076A (en) * 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
US4877864A (en) * 1987-03-26 1989-10-31 Genetics Institute, Inc. Osteoinductive factors
US5106748A (en) * 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
US6150328A (en) * 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US5543394A (en) * 1986-07-01 1996-08-06 Genetics Institute, Inc. Bone morphogenetic protein 5(BMP-5) compositions
US5366875A (en) * 1986-07-01 1994-11-22 Genetics Institute, Inc. Methods for producing BMP-7 proteins
US6432919B1 (en) 1986-07-01 2002-08-13 Genetics Institute, Inc. Bone morphogenetic protein-3 and compositions
US4743259A (en) * 1986-10-29 1988-05-10 The University Of Virginia Alumni Patents Foundation Use of demineralized bone matrix in the repair of segmental defects
WO1989009605A1 (en) * 1988-04-06 1989-10-19 Collagen Corporation Bone-inducing protein
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
AU632160B2 (en) * 1989-08-21 1992-12-17 Celtrix Pharmaceuticals, Inc. Bone-specific protein
US5688678A (en) * 1990-05-16 1997-11-18 Genetics Institute, Inc. DNA encoding and methods for producing BMP-8 proteins
US7378392B1 (en) 1990-05-16 2008-05-27 Genetics Institute, Llc Bone and cartilage inductive proteins
AU651421B2 (en) * 1990-11-30 1994-07-21 Celtrix Pharmaceuticals, Inc. Use of a bone morphogenetic protein in synergistic combination with TGF-beta for bone repair
CA2363965C (en) * 1991-03-11 2010-05-18 Curis, Inc. Protein-induced morphogenesis
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
US5563124A (en) * 1991-04-22 1996-10-08 Intermedics Orthopedics/ Denver, Inc. Osteogenic product and process
US5290763A (en) * 1991-04-22 1994-03-01 Intermedics Orthopedics/Denver, Inc. Osteoinductive protein mixtures and purification processes
US5118667A (en) * 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
US6287816B1 (en) 1991-06-25 2001-09-11 Genetics Institute, Inc. BMP-9 compositions
US5661007A (en) * 1991-06-25 1997-08-26 Genetics Institute, Inc. Bone morphogenetic protein-9 compositions
WO1993009229A1 (en) 1991-11-04 1993-05-13 Genetics Institute, Inc. Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
JP3310291B2 (ja) * 1992-08-13 2002-08-05 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア 骨組織のｉｎ ｖｉｔｒｏ合成のための生物活性物質テンプレート
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
US5736160A (en) * 1993-10-28 1998-04-07 Thm Biomedical, Inc. Process and device for treating and healing a bone void
AU689184B2 (en) 1993-12-07 1998-03-26 Genetics Institute, Llc BMP-12, BMP-13 and tendon-inducing compositions thereof
US5981825A (en) 1994-05-13 1999-11-09 Thm Biomedical, Inc. Device and methods for in vivo culturing of diverse tissue cells
US6974571B2 (en) * 1995-03-28 2005-12-13 Thomas Jefferson University Isolated stromal cells and methods of using the same
US5716616A (en) * 1995-03-28 1998-02-10 Thomas Jefferson University Isolated stromal cells for treating diseases, disorders or conditions characterized by bone defects
US6653134B2 (en) * 1995-03-28 2003-11-25 Cp Hahnemann University Isolated stromal cells for use in the treatment of diseases of the central nervous system
ATE273723T1 (de) * 1996-02-29 2004-09-15 Bioactive Bone Substitute Oy A Osteogene vorrichtungen und methode zur herstellung derselben
JP2000506738A (ja) 1996-03-18 2000-06-06 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア 細胞付着および機能を強化するための生物活性材料基質
US6927287B1 (en) * 1996-06-03 2005-08-09 United States Surgical Corporation Nucleic acid encoding extracellular matrix protein or fragment thereof
US6492508B1 (en) * 1996-06-03 2002-12-10 United States Surgical Corp. A Division Of Tyco Healthcare Group Nucleic acids encoding extracellular matrix proteins
US5824084A (en) * 1996-07-03 1998-10-20 The Cleveland Clinic Foundation Method of preparing a composite bone graft
US6034062A (en) * 1997-03-13 2000-03-07 Genetics Institute, Inc. Bone morphogenetic protein (BMP)-9 compositions and their uses
DE69840361D1 (de) 1997-07-30 2009-01-29 Univ Emory Neue knochenmineralisierungsproteine, dna, vektoren, expressionssysteme
US7923250B2 (en) 1997-07-30 2011-04-12 Warsaw Orthopedic, Inc. Methods of expressing LIM mineralization protein in non-osseous cells
DE69714035T2 (de) * 1997-08-14 2003-03-06 Sulzer Innotec Ag Zusammensetzung und Vorrichtung zur Reparatur von Knorpelgewebe in vivo bestehend aus Nanokapseln mit osteoinduktiven und/oder chondroinduktiven Faktoren
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
ES2225241T3 (es) 1999-10-15 2005-03-16 Genetics Institute, Llc Formulaciones de acido hialuronico para suministrar proteinas osteogenicas.
US6627230B2 (en) 2000-12-22 2003-09-30 Centerpulse Biologics Inc. Method of preparing a bone product by removing cancellous bone matrix
US7175336B2 (en) * 2001-01-26 2007-02-13 Depuy Acromed, Inc. Graft delivery system
US6723131B2 (en) 2001-02-28 2004-04-20 The Cleveland Clinic Foundation Composite bone marrow graft material with method and kit
JP2005500280A (ja) 2001-06-01 2005-01-06 ワイエス 骨形成タンパク質（ｂｍｐ）をコードする配列の全身投与のための組成物および方法
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
US9969980B2 (en) * 2001-09-21 2018-05-15 Garnet Biotherapeutics Cell populations which co-express CD49c and CD90
US7622562B2 (en) 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
US9969977B2 (en) * 2002-09-20 2018-05-15 Garnet Biotherapeutics Cell populations which co-express CD49c and CD90
SI1675608T1 (sl) 2003-09-12 2007-08-31 Wyeth Corp Injektibilne trdne paličice kalcijevega fosfata za dajanje osteogenih proteinov
WO2008124494A1 (en) * 2007-04-03 2008-10-16 The Cleveland Clinic Foundation Enrichment of tissue-derived adult stem cells based on retained extracellular matrix material
CA2690143A1 (en) * 2007-06-15 2008-12-24 Garnet Biotherapeutics Inc. Treatment of diseases and disorders using self-renewing colony forming cells cultured and expanded in vitro
US20090005868A1 (en) * 2007-06-27 2009-01-01 Depuy Products, Inc. Osteogenic prosthesis, associated instrument, and associated method
AU2017204355B2 (en) 2016-07-08 2021-09-09 Mako Surgical Corp. Scaffold for alloprosthetic composite implant

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4455256A (en) * 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US4294753A (en) * 1980-08-04 1981-10-13 The Regents Of The University Of California Bone morphogenetic protein process
US4434094A (en) * 1983-04-12 1984-02-28 Collagen Corporation Partially purified osteogenic factor and process for preparing same from demineralized bone

Also Published As

Publication number Publication date
WO1985004173A1 (en) 1985-09-26
US4608199A (en) 1986-08-26
EP0174993A1 (en) 1986-03-26
IT8547835A0 (it) 1985-03-20
AU4113385A (en) 1985-10-11
IT8547835A1 (it) 1986-09-20

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