IT1175919B - New p-substd.-phenyl-oxazoline derivs. - Google Patents
New p-substd.-phenyl-oxazoline derivs.Info
- Publication number
- IT1175919B IT1175919B IT21417/83A IT2141783A IT1175919B IT 1175919 B IT1175919 B IT 1175919B IT 21417/83 A IT21417/83 A IT 21417/83A IT 2141783 A IT2141783 A IT 2141783A IT 1175919 B IT1175919 B IT 1175919B
- Authority
- IT
- Italy
- Prior art keywords
- alkyl
- substd
- opt
- halogen
- derivs
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000001188 haloalkyl group Chemical group 0.000 abstract 3
- 125000005837 1,2-cyclopentylene group Chemical group [H]C1([H])C([H])([H])C([H])([*:1])C([H])([*:2])C1([H])[H] 0.000 abstract 1
- IMSODMZESSGVBE-UHFFFAOYSA-N 2-Oxazoline Chemical compound C1CN=CO1 IMSODMZESSGVBE-UHFFFAOYSA-N 0.000 abstract 1
- 101100496169 Arabidopsis thaliana CLH1 gene Proteins 0.000 abstract 1
- 101100295741 Gallus gallus COR4 gene Proteins 0.000 abstract 1
- 101100044057 Mesocricetus auratus SYCP3 gene Proteins 0.000 abstract 1
- 230000006181 N-acylation Effects 0.000 abstract 1
- DYUQAZSOFZSPHD-UHFFFAOYSA-N Phenylpropanol Chemical compound CCC(O)C1=CC=CC=C1 DYUQAZSOFZSPHD-UHFFFAOYSA-N 0.000 abstract 1
- 101100080600 Schizosaccharomyces pombe (strain 972 / ATCC 24843) nse6 gene Proteins 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 101150111293 cor-1 gene Proteins 0.000 abstract 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 125000006372 monohalo methyl group Chemical group 0.000 abstract 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 abstract 1
- 229950009195 phenylpropanol Drugs 0.000 abstract 1
- -1 silyloxy, tetrahydropyranyloxy, tetrahydro-furanyloxy Chemical group 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Oxazoline derivs. of formula (I) are new. R = MeS, MeSO, MeSO2 or NO2; X1 = H, 1-6C alkyl, 1-6C haloalkyl, 3-6C cycloalkyl, or Ph or Ph-(1-6C) alkyl in which the Ph ring is opt. substd. by 1 or 2 halogen, 1-3C alkyl, 1-3C or X1 + X2 = O or 2-5C alkylene; or X1 + X2 + R4 = (CH2)p-CH-(CH2)q; p = 3 or 4; q = 1 or 2; X2 = H, 1-6C alkyl, 1-6C haloalkyl, 3-6C cycloalkyl, or Ph opt. substd. by 1 or 2 halogen, 1-3C alkyl, 1-3C alkoxy or NO2; or X2 + X3 = covalent bond; or X2 + R4 = (CH2)m-CH=CH, (CH2)m-CH2CH2, 1,2-cyclopentylene, 1,2-cyclohexylene, o-phenylene-(CH2)m opt. ring substd. by a halogen, 1-3C alkyl, 1-3C alkoxy or NO2; X3 = H or COR4; R4 = H, 1-6C alkyl, 1-6C haloalkyl, 3-6C cycloalkyl, Ph or Ph-(1-6C) alkyl in which the Ph ring is opt. substd. by 1 or 2 halogen, 1-3C alkyl, 1-3C alkoxy or NO2; X4 = OH, (1-4C) alkoxycarbonyl, F, tri-(1-6C) silyloxy, tetrahydropyranyloxy, tetrahydro-furanyloxy or R6SO2O; R6 = Me, CF3, Ph or p-tolyl. Provided that X4 is not OH when R = NO2. Prepn. of a phenylpropanol of formula (II; R7 = COR1) comprises hydrolysis of a cpd. (I) to give (II; R7 = H) followed by N-acylation with R1COOH. R1 = mono-, di or tri-halomethyl.
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT21417/83A IT1175919B (en) | 1983-06-02 | 1983-06-02 | New p-substd.-phenyl-oxazoline derivs. |
| EP95201523A EP0678506A3 (en) | 1983-06-02 | 1984-05-29 | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives. |
| DE3486438T DE3486438T2 (en) | 1983-06-02 | 1984-05-29 | Process for the preparation of 1- (phenyl) -1-hydroxy-2-amino-3-fluoropropane derivatives |
| EP95201522A EP0677511A3 (en) | 1983-06-02 | 1984-05-29 | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives. |
| EP84200772A EP0130633B1 (en) | 1983-06-02 | 1984-05-29 | Process for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives |
| AT84200772T ATE143953T1 (en) | 1983-06-02 | 1984-05-29 | METHOD FOR PRODUCING 1-(PHENYL)-1-HYDROXY-2-AMINO-3-FLUORO-PROPANE DERIVATIVES |
| ES533355A ES8505927A1 (en) | 1983-06-02 | 1984-06-01 | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives. |
| JP59113774A JPH0819085B2 (en) | 1983-06-02 | 1984-06-02 | Intermediate for producing 1- (phenyl) -1-hydroxy-2-amino-3-fluoropropane derivative |
| US07/162,247 US5105009A (en) | 1983-06-02 | 1988-02-29 | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoropropane derivatives |
| US07/841,075 US5243056A (en) | 1983-06-02 | 1992-02-25 | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives |
| US08/070,869 US5908937A (en) | 1983-06-02 | 1993-06-03 | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives |
| JP7287772A JP2721959B2 (en) | 1983-06-02 | 1995-09-29 | Intermediate for producing 1- (phenyl) -1-hydroxy-2-amino-3-fluoropropane derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT21417/83A IT1175919B (en) | 1983-06-02 | 1983-06-02 | New p-substd.-phenyl-oxazoline derivs. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8321417A0 IT8321417A0 (en) | 1983-06-02 |
| IT1175919B true IT1175919B (en) | 1987-08-12 |
Family
ID=11181455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT21417/83A IT1175919B (en) | 1983-06-02 | 1983-06-02 | New p-substd.-phenyl-oxazoline derivs. |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1175919B (en) |
-
1983
- 1983-06-02 IT IT21417/83A patent/IT1175919B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| IT8321417A0 (en) | 1983-06-02 |
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| TA | Fee payment date (situation as of event date), data collected since 19931001 |
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