IT1169065B - Derivati amminometil-benzenici aril sostituiti ad attivita' regolatrice del ritmo cardiaco e composizioni che li contengono - Google Patents

Derivati amminometil-benzenici aril sostituiti ad attivita' regolatrice del ritmo cardiaco e composizioni che li contengono

Info

Publication number
IT1169065B
IT1169065B IT48746/83A IT4874683A IT1169065B IT 1169065 B IT1169065 B IT 1169065B IT 48746/83 A IT48746/83 A IT 48746/83A IT 4874683 A IT4874683 A IT 4874683A IT 1169065 B IT1169065 B IT 1169065B
Authority
IT
Italy
Prior art keywords
aril
aminomethylene
derivatives
compositions containing
substituted
Prior art date
Application number
IT48746/83A
Other languages
English (en)
Other versions
IT8348746A0 (it
Inventor
David M Stout
William L Matier
Original Assignee
American Hospital Supply Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Hospital Supply Corp filed Critical American Hospital Supply Corp
Publication of IT8348746A0 publication Critical patent/IT8348746A0/it
Application granted granted Critical
Publication of IT1169065B publication Critical patent/IT1169065B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT48746/83A 1982-07-26 1983-07-26 Derivati amminometil-benzenici aril sostituiti ad attivita' regolatrice del ritmo cardiaco e composizioni che li contengono IT1169065B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/401,751 US4562201A (en) 1982-07-26 1982-07-26 Aminomethyl benzanilides

Publications (2)

Publication Number Publication Date
IT8348746A0 IT8348746A0 (it) 1983-07-26
IT1169065B true IT1169065B (it) 1987-05-27

Family

ID=23589085

Family Applications (1)

Application Number Title Priority Date Filing Date
IT48746/83A IT1169065B (it) 1982-07-26 1983-07-26 Derivati amminometil-benzenici aril sostituiti ad attivita' regolatrice del ritmo cardiaco e composizioni che li contengono

Country Status (12)

Country Link
US (1) US4562201A (it)
EP (1) EP0113778B1 (it)
AU (1) AU569477B2 (it)
CA (1) CA1241652A (it)
DE (1) DE3381540D1 (it)
ES (3) ES524446A0 (it)
GR (1) GR77582B (it)
IT (1) IT1169065B (it)
NZ (1) NZ204884A (it)
PH (1) PH18853A (it)
WO (1) WO1984000545A1 (it)
ZA (1) ZA835188B (it)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923873A (en) * 1982-07-26 1990-05-08 E. I. Du Pont De Nemours And Company Quinazoline substituted aminomethyl benzene derivatives
US4755527A (en) * 1982-07-26 1988-07-05 E. I. Du Pont De Nemours And Company Aryl substituted aminomethyl benzene derivatives
US4666924A (en) * 1982-07-26 1987-05-19 E. I. Du Pont De Nemours & Co. Certain pyridyl substituted aminomethyl benzene derivatives having anti-arrhythmic activity
US4720586A (en) * 1983-12-06 1988-01-19 Fisons, Plc Substituted 3,4-dihydroxy-phenylethylamino compounds
US4855497A (en) * 1985-04-02 1989-08-08 Chugai Seiyaku Kabushiki Kaisha Novel diamine derivatives
JPS6272657A (ja) * 1985-09-27 1987-04-03 Terumo Corp アミド誘導体およびこれを含有する５−リポキシゲナ−ゼ作用阻害剤
US4939133A (en) * 1985-10-01 1990-07-03 Warner-Lambert Company N-substituted-2-hydroxy-α-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade
US5059620A (en) * 1985-12-27 1991-10-22 The Du Pont Merck Pharmaceutical Company Aryl substituted aminomethyl benzene derivatives
US5602174A (en) * 1986-02-15 1997-02-11 Beecham Wuefling Gmbh & Co. Treatment
GB8603765D0 (en) * 1986-02-15 1986-03-19 Beecham Wuelfung Gmbh & Co Kg Compounds
US5177259A (en) * 1986-04-11 1993-01-05 Warner-Lambert Company Diarylalkanoids having activity as lipoxygenase inhibitors
US5142095A (en) * 1986-04-11 1992-08-25 Warner-Lambert Company Diarylalkanoids having activity as lipoxygenase inhibitors
US5077411A (en) * 1986-04-11 1991-12-31 Warner-Lambert Co. Dairylalkanoids having activity as lipoxygenase inhibitors
GB2216515A (en) * 1988-03-04 1989-10-11 Nippon Shinyaku Co Ltd Acylphenol derivatives
ATE81651T1 (de) * 1988-10-10 1992-11-15 Akzo Nv Substituierte aromatische verbindungen mit zentraler nervensystem-wirkung.
ZA916555B (en) * 1990-08-27 1993-04-28 Lilly Co Eli Method of treating inflammatory bowel disease
US5281623A (en) * 1990-08-27 1994-01-25 Eli Lilly And Company Method for treating inflammation
US5280046A (en) * 1991-02-22 1994-01-18 The University Of Colorado Foundation, Inc. Method of treating type I diabetes
GB9119932D0 (en) * 1991-09-18 1991-10-30 Glaxo Group Ltd Chemical compounds
GB9119920D0 (en) * 1991-09-18 1991-10-30 Glaxo Group Ltd Chemical compounds
ES2162792T3 (es) * 1991-09-18 2002-01-16 Glaxo Group Ltd Derivados de benzanilida como antagonistas de 5-ht1d.
TW270110B (it) * 1994-01-28 1996-02-11 Ciba Geigy
KR0147963B1 (ko) * 1995-01-10 1998-08-17 강박광 엔-아릴알킬페닐아세트아미드 유도체와 그의 제조방법
US20060100196A1 (en) * 2001-09-24 2006-05-11 Andrea Gailunas Substituted amines for the treatment of alzheimer's disease
EP1593667A4 (en) * 2003-02-12 2009-03-04 Takeda Pharmaceutical AMINE DERIVATIVE
US20060019954A1 (en) * 2004-07-20 2006-01-26 Cedars-Sinai Medical Center Method for reducing the likelihood of the occurrence of cardiac arrhythmias

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2855399A (en) * 1958-10-07 Piperroylmethyl
US2220834A (en) * 1939-03-14 1940-11-05 Resinous Prod & Chemical Co Phenolic triamines
US2304729A (en) * 1940-01-04 1942-12-08 Resinous Prod & Chemical Co Phenolic amido resin
US2441576A (en) * 1944-04-22 1948-05-18 Parke Davis & Co Amino methyl phenols
US2553441A (en) * 1947-03-29 1951-05-15 Universal Oil Prod Co Stabilization of organic materials
US2806032A (en) * 1955-03-07 1957-09-10 Geschickter Found For Medical Diphenolic therapeutic compounds
US3077470A (en) * 1961-03-21 1963-02-12 Univ Kansas Res Foundation 3-[4-hydroxy-3-(aminomethyl)-phenyl]-4-(4-oxyphenyl)-alkanes and alkenes
US3285912A (en) * 1963-10-21 1966-11-15 Richardson Merrell Inc Substituted diphenyl ketones
US3591637A (en) * 1968-03-04 1971-07-06 Uniroyal Inc Bis((dialkylaminomethyl)hydroxy-benzyl)sulfides
US3950393A (en) * 1973-04-13 1976-04-13 Boehringer Ingelheim Gmbh Aminobenzyl-amides and salts thereof
DE2926472A1 (de) * 1979-06-30 1981-01-15 Thomae Gmbh Dr K Neue benzoylderivate, deren herstellung und deren verwendung als arzneimittel
JPS568352A (en) * 1979-07-03 1981-01-28 Shionogi & Co Ltd Aminoalkylvenzene derivative
US4323691A (en) * 1979-10-09 1982-04-06 Abbott Laboratories Hydroxyaminomethyl derivatives of benzoyl di-substituted α-phenoxyalkanoyl esters
IT1126509B (it) * 1979-12-07 1986-05-21 Medea Res Srl Benzimidi ad attivita' anestetica locale e antiaritmica,processo per la loro preparazione e composizioni farmaceutiche che le contengono
US4389416A (en) * 1981-10-09 1983-06-21 Abbott Laboratories Diphenyl ether, diphenyl thioether and diphenyl methane phenol mannich bases

Also Published As

Publication number Publication date
DE3381540D1 (de) 1990-06-13
ES531660A0 (es) 1985-10-01
ES8502078A1 (es) 1984-12-16
ES524446A0 (es) 1984-12-16
ES531659A0 (es) 1985-10-01
NZ204884A (en) 1986-07-11
ZA835188B (en) 1984-03-28
AU1881183A (en) 1984-02-23
PH18853A (en) 1985-10-21
EP0113778A4 (en) 1985-06-06
ES8600211A1 (es) 1985-10-01
EP0113778B1 (en) 1990-05-09
US4562201A (en) 1985-12-31
GR77582B (it) 1984-09-24
ES8600210A1 (es) 1985-10-01
WO1984000545A1 (en) 1984-02-16
IT8348746A0 (it) 1983-07-26
CA1241652A (en) 1988-09-06
AU569477B2 (en) 1988-02-04
EP0113778A1 (en) 1984-07-25

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