DE3381540D1 - Arylsubstituierte aminomethylbenzolabkoemmlinge als antiarrythmische agenzien. - Google Patents
Arylsubstituierte aminomethylbenzolabkoemmlinge als antiarrythmische agenzien.Info
- Publication number
- DE3381540D1 DE3381540D1 DE8383902602T DE3381540T DE3381540D1 DE 3381540 D1 DE3381540 D1 DE 3381540D1 DE 8383902602 T DE8383902602 T DE 8383902602T DE 3381540 T DE3381540 T DE 3381540T DE 3381540 D1 DE3381540 D1 DE 3381540D1
- Authority
- DE
- Germany
- Prior art keywords
- collectables
- aminomethylbenzene
- aryl
- substituted
- antiarrythmic agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/401,751 US4562201A (en) | 1982-07-26 | 1982-07-26 | Aminomethyl benzanilides |
PCT/US1983/001088 WO1984000545A1 (en) | 1982-07-26 | 1983-07-18 | Aryl substituted aminomethyl benzene derivatives useful as antiarrhythmic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3381540D1 true DE3381540D1 (de) | 1990-06-13 |
Family
ID=23589085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8383902602T Expired - Lifetime DE3381540D1 (de) | 1982-07-26 | 1983-07-18 | Arylsubstituierte aminomethylbenzolabkoemmlinge als antiarrythmische agenzien. |
Country Status (12)
Country | Link |
---|---|
US (1) | US4562201A (de) |
EP (1) | EP0113778B1 (de) |
AU (1) | AU569477B2 (de) |
CA (1) | CA1241652A (de) |
DE (1) | DE3381540D1 (de) |
ES (3) | ES8502078A1 (de) |
GR (1) | GR77582B (de) |
IT (1) | IT1169065B (de) |
NZ (1) | NZ204884A (de) |
PH (1) | PH18853A (de) |
WO (1) | WO1984000545A1 (de) |
ZA (1) | ZA835188B (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4755527A (en) * | 1982-07-26 | 1988-07-05 | E. I. Du Pont De Nemours And Company | Aryl substituted aminomethyl benzene derivatives |
US4666924A (en) * | 1982-07-26 | 1987-05-19 | E. I. Du Pont De Nemours & Co. | Certain pyridyl substituted aminomethyl benzene derivatives having anti-arrhythmic activity |
US4923873A (en) * | 1982-07-26 | 1990-05-08 | E. I. Du Pont De Nemours And Company | Quinazoline substituted aminomethyl benzene derivatives |
US4720586A (en) * | 1983-12-06 | 1988-01-19 | Fisons, Plc | Substituted 3,4-dihydroxy-phenylethylamino compounds |
US4855497A (en) * | 1985-04-02 | 1989-08-08 | Chugai Seiyaku Kabushiki Kaisha | Novel diamine derivatives |
JPS6272657A (ja) * | 1985-09-27 | 1987-04-03 | Terumo Corp | アミド誘導体およびこれを含有する5−リポキシゲナ−ゼ作用阻害剤 |
US4939133A (en) * | 1985-10-01 | 1990-07-03 | Warner-Lambert Company | N-substituted-2-hydroxy-α-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade |
US5059620A (en) * | 1985-12-27 | 1991-10-22 | The Du Pont Merck Pharmaceutical Company | Aryl substituted aminomethyl benzene derivatives |
US5602174A (en) * | 1986-02-15 | 1997-02-11 | Beecham Wuefling Gmbh & Co. | Treatment |
GB8603765D0 (en) * | 1986-02-15 | 1986-03-19 | Beecham Wuelfung Gmbh & Co Kg | Compounds |
US5177259A (en) * | 1986-04-11 | 1993-01-05 | Warner-Lambert Company | Diarylalkanoids having activity as lipoxygenase inhibitors |
US5077411A (en) * | 1986-04-11 | 1991-12-31 | Warner-Lambert Co. | Dairylalkanoids having activity as lipoxygenase inhibitors |
US5142095A (en) * | 1986-04-11 | 1992-08-25 | Warner-Lambert Company | Diarylalkanoids having activity as lipoxygenase inhibitors |
GB2216515A (en) * | 1988-03-04 | 1989-10-11 | Nippon Shinyaku Co Ltd | Acylphenol derivatives |
EP0365064B1 (de) * | 1988-10-10 | 1992-10-21 | Akzo N.V. | Substituierte aromatische Verbindungen mit zentraler Nervensystem-Wirkung |
CA2049481A1 (en) * | 1990-08-27 | 1992-02-28 | Jill Ann Panetta | Method of treating inflammatory bowel disease |
US5281623A (en) * | 1990-08-27 | 1994-01-25 | Eli Lilly And Company | Method for treating inflammation |
US5280046A (en) * | 1991-02-22 | 1994-01-18 | The University Of Colorado Foundation, Inc. | Method of treating type I diabetes |
ATE204262T1 (de) * | 1991-09-18 | 2001-09-15 | Glaxo Group Ltd | Benzanilidderivate als 5-ht1d-antagonisten |
GB9119932D0 (en) * | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
GB9119920D0 (en) * | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
TW270110B (de) * | 1994-01-28 | 1996-02-11 | Ciba Geigy | |
KR0147963B1 (ko) * | 1995-01-10 | 1998-08-17 | 강박광 | 엔-아릴알킬페닐아세트아미드 유도체와 그의 제조방법 |
EP1430032A2 (de) * | 2001-09-24 | 2004-06-23 | Elan Pharmaceuticals, Inc. | Substituierte amide für die behandlung von neurologischen erkrankungen |
WO2004072018A1 (ja) * | 2003-02-12 | 2004-08-26 | Takeda Pharmaceutical Company Limited | アミン誘導体 |
US20060019954A1 (en) * | 2004-07-20 | 2006-01-26 | Cedars-Sinai Medical Center | Method for reducing the likelihood of the occurrence of cardiac arrhythmias |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2855399A (en) * | 1958-10-07 | Piperroylmethyl | ||
US2220834A (en) * | 1939-03-14 | 1940-11-05 | Resinous Prod & Chemical Co | Phenolic triamines |
US2304729A (en) * | 1940-01-04 | 1942-12-08 | Resinous Prod & Chemical Co | Phenolic amido resin |
US2441576A (en) * | 1944-04-22 | 1948-05-18 | Parke Davis & Co | Amino methyl phenols |
US2553441A (en) * | 1947-03-29 | 1951-05-15 | Universal Oil Prod Co | Stabilization of organic materials |
US2806032A (en) * | 1955-03-07 | 1957-09-10 | Geschickter Found For Medical | Diphenolic therapeutic compounds |
US3077470A (en) * | 1961-03-21 | 1963-02-12 | Univ Kansas Res Foundation | 3-[4-hydroxy-3-(aminomethyl)-phenyl]-4-(4-oxyphenyl)-alkanes and alkenes |
US3285912A (en) * | 1963-10-21 | 1966-11-15 | Richardson Merrell Inc | Substituted diphenyl ketones |
US3591637A (en) * | 1968-03-04 | 1971-07-06 | Uniroyal Inc | Bis((dialkylaminomethyl)hydroxy-benzyl)sulfides |
PH12617A (en) * | 1973-04-13 | 1979-07-05 | Thomae Gmbh Dr K | Aminobenzyl-amides and salts thereof |
DE2926472A1 (de) * | 1979-06-30 | 1981-01-15 | Thomae Gmbh Dr K | Neue benzoylderivate, deren herstellung und deren verwendung als arzneimittel |
JPS568352A (en) * | 1979-07-03 | 1981-01-28 | Shionogi & Co Ltd | Aminoalkylvenzene derivative |
US4323691A (en) * | 1979-10-09 | 1982-04-06 | Abbott Laboratories | Hydroxyaminomethyl derivatives of benzoyl di-substituted α-phenoxyalkanoyl esters |
IT1126509B (it) * | 1979-12-07 | 1986-05-21 | Medea Res Srl | Benzimidi ad attivita' anestetica locale e antiaritmica,processo per la loro preparazione e composizioni farmaceutiche che le contengono |
US4389416A (en) * | 1981-10-09 | 1983-06-21 | Abbott Laboratories | Diphenyl ether, diphenyl thioether and diphenyl methane phenol mannich bases |
-
1982
- 1982-07-26 US US06/401,751 patent/US4562201A/en not_active Expired - Fee Related
-
1983
- 1983-07-13 NZ NZ204884A patent/NZ204884A/en unknown
- 1983-07-15 ZA ZA835188A patent/ZA835188B/xx unknown
- 1983-07-18 DE DE8383902602T patent/DE3381540D1/de not_active Expired - Lifetime
- 1983-07-18 EP EP83902602A patent/EP0113778B1/de not_active Expired - Lifetime
- 1983-07-18 WO PCT/US1983/001088 patent/WO1984000545A1/en active IP Right Grant
- 1983-07-18 AU AU18811/83A patent/AU569477B2/en not_active Ceased
- 1983-07-22 PH PH29272A patent/PH18853A/en unknown
- 1983-07-25 GR GR72020A patent/GR77582B/el unknown
- 1983-07-26 CA CA000433231A patent/CA1241652A/en not_active Expired
- 1983-07-26 ES ES524446A patent/ES8502078A1/es not_active Expired
- 1983-07-26 IT IT48746/83A patent/IT1169065B/it active
-
1984
- 1984-04-16 ES ES531659A patent/ES531659A0/es active Granted
- 1984-04-16 ES ES531660A patent/ES8600211A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
IT8348746A0 (it) | 1983-07-26 |
ES524446A0 (es) | 1984-12-16 |
ES8502078A1 (es) | 1984-12-16 |
ZA835188B (en) | 1984-03-28 |
NZ204884A (en) | 1986-07-11 |
EP0113778B1 (de) | 1990-05-09 |
ES8600210A1 (es) | 1985-10-01 |
GR77582B (de) | 1984-09-24 |
US4562201A (en) | 1985-12-31 |
IT1169065B (it) | 1987-05-27 |
EP0113778A4 (de) | 1985-06-06 |
ES531660A0 (es) | 1985-10-01 |
ES8600211A1 (es) | 1985-10-01 |
ES531659A0 (es) | 1985-10-01 |
EP0113778A1 (de) | 1984-07-25 |
WO1984000545A1 (en) | 1984-02-16 |
PH18853A (en) | 1985-10-21 |
AU569477B2 (en) | 1988-02-04 |
AU1881183A (en) | 1984-02-23 |
CA1241652A (en) | 1988-09-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: THE DU PONT MERCK PHARMACEUTICAL CO., WILMINGTON, |
|
8328 | Change in the person/name/address of the agent |
Free format text: ABITZ, W., DIPL.-ING.DR.-ING. MORF, D., DR. GRITSCHNEDER, M., DIPL.-PHYS. FRHR. VON WITTGENSTEIN, A., DIPL.-CHEM. DR.PHIL.NAT., PAT.-ANWAELTE, 8000 MUENCHEN |
|
8339 | Ceased/non-payment of the annual fee |