IT1167038B - Procedimento per la sintesi di acido ursodesossicolico coniugato con la taurina - Google Patents
Procedimento per la sintesi di acido ursodesossicolico coniugato con la taurinaInfo
- Publication number
- IT1167038B IT1167038B IT23951/83A IT2395183A IT1167038B IT 1167038 B IT1167038 B IT 1167038B IT 23951/83 A IT23951/83 A IT 23951/83A IT 2395183 A IT2395183 A IT 2395183A IT 1167038 B IT1167038 B IT 1167038B
- Authority
- IT
- Italy
- Prior art keywords
- deoxycholic acid
- prodn
- taurourso
- urso
- deriv
- Prior art date
Links
- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 title abstract 3
- RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 title abstract 2
- BHTRKEVKTKCXOH-UHFFFAOYSA-N Taurochenodesoxycholsaeure Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(=O)NCCS(O)(=O)=O)C)C1(C)CC2 BHTRKEVKTKCXOH-UHFFFAOYSA-N 0.000 title abstract 2
- BHTRKEVKTKCXOH-LBSADWJPSA-N tauroursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)CC1 BHTRKEVKTKCXOH-LBSADWJPSA-N 0.000 title abstract 2
- 229960001661 ursodiol Drugs 0.000 title abstract 2
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 abstract 2
- IRFSXVIRXMYULF-UHFFFAOYSA-N 1,2-dihydroquinoline Chemical compound C1=CC=C2C=CCNC2=C1 IRFSXVIRXMYULF-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000007810 chemical reaction solvent Substances 0.000 abstract 1
- 239000007822 coupling agent Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- -1 isobutylisobutoxycarbonyl Chemical group 0.000 abstract 1
- 229960003080 taurine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT23951/83A IT1167038B (it) | 1983-11-30 | 1983-11-30 | Procedimento per la sintesi di acido ursodesossicolico coniugato con la taurina |
| BE0/214015A BE901069A (fr) | 1983-11-30 | 1984-11-16 | Procede de synthese d'acide ursodesoxycholique conjugue avec la taurine et produit ainsi obtenu. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT23951/83A IT1167038B (it) | 1983-11-30 | 1983-11-30 | Procedimento per la sintesi di acido ursodesossicolico coniugato con la taurina |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8323951A0 IT8323951A0 (it) | 1983-11-30 |
| IT1167038B true IT1167038B (it) | 1987-05-06 |
Family
ID=11211090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT23951/83A IT1167038B (it) | 1983-11-30 | 1983-11-30 | Procedimento per la sintesi di acido ursodesossicolico coniugato con la taurina |
Country Status (2)
| Country | Link |
|---|---|
| BE (1) | BE901069A (fr) |
| IT (1) | IT1167038B (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH674369A5 (fr) * | 1986-11-26 | 1990-05-31 | Jago Res Ag | |
| IT1219733B (it) * | 1988-06-28 | 1990-05-24 | Istituto Chemioterapico Di Lod | Derivato dell' acido ursodesossicolico |
| IT1230796B (it) * | 1989-05-30 | 1991-10-29 | Prodotti Chimici Alimentari | Procedimento per la preparazione di acido tauroursodesossicolico biidrato. |
| EP1985622A1 (fr) * | 2007-04-23 | 2008-10-29 | Prodotti Chimici E Alimentari Spa | Procédé pour la préparation de l' acide tauroursodésoxycholique |
-
1983
- 1983-11-30 IT IT23951/83A patent/IT1167038B/it active Protection Beyond IP Right Term
-
1984
- 1984-11-16 BE BE0/214015A patent/BE901069A/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IT8323951A0 (it) | 1983-11-30 |
| BE901069A (fr) | 1985-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ITCP | Complementary protection certificate |
Free format text: CCP 292 |
|
| MEDD | Supplementary protection certificate for pharmaceutical products: granted |
Free format text: CCP 292, 19920513; PRODOTTI CHIMICI E ALIMENTARI SPA |
|
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19971127 |