IT1155772B - Acylated L-carnitine derivs. - useful for treating myocardial anoxia, ischaemia, arrhythmic syndromes, cardiac insufficiencies, etc. - Google Patents
Acylated L-carnitine derivs. - useful for treating myocardial anoxia, ischaemia, arrhythmic syndromes, cardiac insufficiencies, etc.Info
- Publication number
- IT1155772B IT1155772B IT4767678A IT4767678A IT1155772B IT 1155772 B IT1155772 B IT 1155772B IT 4767678 A IT4767678 A IT 4767678A IT 4767678 A IT4767678 A IT 4767678A IT 1155772 B IT1155772 B IT 1155772B
- Authority
- IT
- Italy
- Prior art keywords
- derivs
- carnitine
- acylated
- ischaemia
- useful
- Prior art date
Links
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical class C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title abstract 2
- 206010002660 Anoxia Diseases 0.000 title abstract 2
- 241000976983 Anoxia Species 0.000 title abstract 2
- 206010019280 Heart failures Diseases 0.000 title abstract 2
- 206010021143 Hypoxia Diseases 0.000 title abstract 2
- 230000007953 anoxia Effects 0.000 title abstract 2
- 230000002763 arrhythmic effect Effects 0.000 title abstract 2
- 208000028867 ischemia Diseases 0.000 title abstract 2
- 230000002107 myocardial effect Effects 0.000 title abstract 2
- 208000011580 syndromic disease Diseases 0.000 title abstract 2
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Acylated carnitine derivs. of formula (I), esp. the l-isomers, for therapeutic use and their salts, are new: (where R is acyl of a 2-30C aliphatic satd. fatty acid having an even no. of C atoms). Acetyl-l-carnitine (II) and other acylated derivs. of l-carmitine are new. (I) and (II) are useful for treating myocardial anoxia, ischaemia, arrhythmic syndromes, cardiac insufficiencies, and when the energy demand at cardiac level is raised as a result of fatigue.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT4767678A IT1155772B (en) | 1978-01-18 | 1978-01-18 | Acylated L-carnitine derivs. - useful for treating myocardial anoxia, ischaemia, arrhythmic syndromes, cardiac insufficiencies, etc. |
| ZA00786191A ZA786191B (en) | 1978-01-18 | 1978-11-02 | New therapeutical use of acetyl-1-carnitine and of further acylated derivatives of 1-carnitine |
| IE1850/85A IE51712B1 (en) | 1977-11-03 | 1978-11-03 | Pharmaceutical compositions containing carnitine derivatives |
| IE217578A IE51711B1 (en) | 1977-11-03 | 1978-11-03 | Carnitine derivatives |
| GB7843156A GB2008578A (en) | 1977-11-03 | 1978-11-03 | I-Carnitine derivatives |
| FR7832407A FR2414914A1 (en) | 1978-01-18 | 1978-11-16 | Acylated L-carnitine derivs. - useful for treating myocardial anoxia, ischaemia, arrhythmic syndromes, cardiac insufficiencies, etc. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT4767678A IT1155772B (en) | 1978-01-18 | 1978-01-18 | Acylated L-carnitine derivs. - useful for treating myocardial anoxia, ischaemia, arrhythmic syndromes, cardiac insufficiencies, etc. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT7847676A0 IT7847676A0 (en) | 1978-01-18 |
| IT1155772B true IT1155772B (en) | 1987-01-28 |
Family
ID=11261835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT4767678A IT1155772B (en) | 1977-11-03 | 1978-01-18 | Acylated L-carnitine derivs. - useful for treating myocardial anoxia, ischaemia, arrhythmic syndromes, cardiac insufficiencies, etc. |
Country Status (2)
| Country | Link |
|---|---|
| IT (1) | IT1155772B (en) |
| ZA (1) | ZA786191B (en) |
-
1978
- 1978-01-18 IT IT4767678A patent/IT1155772B/en active Protection Beyond IP Right Term
- 1978-11-02 ZA ZA00786191A patent/ZA786191B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA786191B (en) | 1979-10-31 |
| IT7847676A0 (en) | 1978-01-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MEDI | Supplementary protection certificate for pharmaceutical products: court of cassation |
Free format text: CCP 501, 19950511; SIGMA-TAU INDUSTRIE FARMACEUTICHE R IUNITE S.P.A. |
|
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19961205 |
|
| MEDD | Supplementary protection certificate for pharmaceutical products: granted |
Free format text: CCP 501, 19950511; SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. |