IT1104708B - 5-Substd.-4-amino-alkoxy-thiazole derivs. - useful as beta-adrenergic blocking agents, antihypertensives and vasodilators - Google Patents
5-Substd.-4-amino-alkoxy-thiazole derivs. - useful as beta-adrenergic blocking agents, antihypertensives and vasodilatorsInfo
- Publication number
- IT1104708B IT1104708B IT4963878A IT4963878A IT1104708B IT 1104708 B IT1104708 B IT 1104708B IT 4963878 A IT4963878 A IT 4963878A IT 4963878 A IT4963878 A IT 4963878A IT 1104708 B IT1104708 B IT 1104708B
- Authority
- IT
- Italy
- Prior art keywords
- alkyl
- beta
- blocking agents
- carbocyclic aryl
- adrenergic blocking
- Prior art date
Links
- 239000002876 beta blocker Substances 0.000 title abstract 2
- 229940030611 beta-adrenergic blocking agent Drugs 0.000 title abstract 2
- 229940124549 vasodilator Drugs 0.000 title abstract 2
- 239000003071 vasodilator agent Substances 0.000 title abstract 2
- 239000002568 adrenergic antihypertensivea Substances 0.000 title 1
- 229940030600 antihypertensive agent Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- -1 morpholino, piperazino Chemical group 0.000 abstract 2
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Thiazole derivs. of formula (I) and their salts are new: (R is H or 2-12C acyl; R1 is 1-12C alkyl; R2 is H, CF3, 6-12C carbocyclic aryl, 6-membered N-heteroaryl, thienyl, furfuryl, 1-6C alkyl, alkylthio, alkylsulphinyl or alkylsulphonyl; R3 is 1-6C alkyl, COOX, CN, 6-12C carbocyclic aryl, CF3 or CONR4R5; X is 1-6c alkyl or 6-2C carbocyclic aryl; R4 and R5 are H or 1-6C alkyl, or NR4R5 is morpholino, piperazino or 4-methylpiperazino. Provided that when R2 is Ph, R3 is not 1-6C alkyl or COOX with X being 1-6C alkyl). Corresp. cpds. having a 4-substit. of formula (II) are new: (R6 is H, 1-12C alkyl or 6-12C carbocyclic aryl; and R1-3 are as defined above except that when R3 is COOet, R2 is 1-6C alkylthio). (I) are beta-adrenergic blocking agents; some cpds. have immediate onset of antihypertensive effect and/or vasodilator activity. Dose is 1.5-3,000 mg. daily in man. Cpds. with gp. (II) are intermediates for (I).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80240377A | 1977-06-01 | 1977-06-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT7849638A0 IT7849638A0 (en) | 1978-05-31 |
| IT1104708B true IT1104708B (en) | 1985-10-28 |
Family
ID=25183607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT4963878A IT1104708B (en) | 1977-06-01 | 1978-05-31 | 5-Substd.-4-amino-alkoxy-thiazole derivs. - useful as beta-adrenergic blocking agents, antihypertensives and vasodilators |
Country Status (4)
| Country | Link |
|---|---|
| DE (1) | DE2861839D1 (en) |
| DK (1) | DK240878A (en) |
| IE (1) | IE46911B1 (en) |
| IT (1) | IT1104708B (en) |
-
1978
- 1978-05-30 IE IE108078A patent/IE46911B1/en unknown
- 1978-05-31 IT IT4963878A patent/IT1104708B/en active
- 1978-05-31 DK DK240878A patent/DK240878A/en not_active Application Discontinuation
- 1978-06-01 DE DE7878100053T patent/DE2861839D1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IE781080L (en) | 1978-12-01 |
| IE46911B1 (en) | 1983-11-02 |
| IT7849638A0 (en) | 1978-05-31 |
| DK240878A (en) | 1979-02-08 |
| DE2861839D1 (en) | 1982-07-08 |
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