IT1099590B - N-Beta:alkoxyethyl-N-phenoxy:benzyl-di:chloro:acetamide cpds. - useful as anti:amoebic agents in human and veterinary medicine - Google Patents

N-Beta:alkoxyethyl-N-phenoxy:benzyl-di:chloro:acetamide cpds. - useful as anti:amoebic agents in human and veterinary medicine

Info

Publication number
IT1099590B
IT1099590B IT2646678A IT2646678A IT1099590B IT 1099590 B IT1099590 B IT 1099590B IT 2646678 A IT2646678 A IT 2646678A IT 2646678 A IT2646678 A IT 2646678A IT 1099590 B IT1099590 B IT 1099590B
Authority
IT
Italy
Prior art keywords
alkyl
useful
cpds
human
veterinary medicine
Prior art date
Application number
IT2646678A
Other languages
Italian (it)
Other versions
IT7826466A0 (en
Inventor
Paolo Cozzi
Piero Menchetti
De Ivo Carneri
Franca Trane
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Priority to IT2646678A priority Critical patent/IT1099590B/en
Publication of IT7826466A0 publication Critical patent/IT7826466A0/en
Priority to IL7855573A priority patent/IL55573A0/en
Priority to GB7837510A priority patent/GB2005674B/en
Priority to DE19782842752 priority patent/DE2842752A1/en
Priority to FR7828097A priority patent/FR2404627A1/en
Priority to JP12248878A priority patent/JPS5473745A/en
Priority to US06/062,740 priority patent/US4302472A/en
Application granted granted Critical
Publication of IT1099590B publication Critical patent/IT1099590B/en

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Cpds. of formula (I) and their salts are new: In (I) R is 1-6C alkyl, Y is -NR1R2, -NR1-CO-R1, -NR1-CO-NHR2, -NR1-CO-OR2 or -SO2R2, R1 and R2 are each H or 1-6C alkyl, R1 is (a) 1-12c alkyl opt. substd. by >=1 halogen, CN carboxyl, carbamyl, -SEt, -OR1, -NR1R2 or Ph (opt. substd by >=1 OH) gps. or is (b) Ph opt. substd. by >=1 halogen, CN, 1-6C alkyl, 1-6C trihaloalkyl, NO2, -OR1 or -NR1R2 gps. R2 is 1-4C alkyl. (I) are useful in human and veterinary medicine as antiamoebic agents. Activity is higher than previously used dichloroacetamide derivs. Useful for treating intestinal infections caused by Entamoeba histolytica in acute and chronic cases, as well as in prophylaxis where the agent is endemic LD50 is e.g. >800 mg/kg p.p. Adult doses are e.g. 200-1000 mg (pref. 200-500 mg) p.o. 1-3 times/day over 5-10 days.
IT2646678A 1977-10-03 1978-08-04 N-Beta:alkoxyethyl-N-phenoxy:benzyl-di:chloro:acetamide cpds. - useful as anti:amoebic agents in human and veterinary medicine IT1099590B (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IT2646678A IT1099590B (en) 1978-08-04 1978-08-04 N-Beta:alkoxyethyl-N-phenoxy:benzyl-di:chloro:acetamide cpds. - useful as anti:amoebic agents in human and veterinary medicine
IL7855573A IL55573A0 (en) 1977-10-03 1978-09-14 Substituted n-(ss-alkoxy-ethyl)-n-(4-phenoxybenzyl)-dichloroacetamides and process for their preparation
GB7837510A GB2005674B (en) 1977-10-03 1978-09-20 Substituted n-(&-alkoxy-ethyl)-n-(4-phenoxy-benzyl)-dichloracetamides and process for their preparation
DE19782842752 DE2842752A1 (en) 1977-10-03 1978-09-30 SUBSTITUTED N- (BETA-ALKOXYAETHYL) - N- (4-PHENOXYBENZYL) DICHLOROACETAMIDE, THE PROCESS FOR THEIR MANUFACTURING AND THE PHARMACEUTICAL PRODUCTS CONTAINING THEM
FR7828097A FR2404627A1 (en) 1977-10-03 1978-10-02 DICHLORACETAMIDES DISUBSTITUTED IN NITROGEN, THEIR PREPARATION AND THEIR USE, ESPECIALLY IN THE TREATMENT OF AMIBIASES
JP12248878A JPS5473745A (en) 1977-10-03 1978-10-03 Substituted nn*betaaalkoxyyethyl**nn*44 phenoxyybenzyl**dichloroacetamide compound
US06/062,740 US4302472A (en) 1977-10-03 1979-08-01 Substituted N-(β-alkoxy-ethyl)-N-(4-phenoxy-benzyl)-dichloro-acetamides and process for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2646678A IT1099590B (en) 1978-08-04 1978-08-04 N-Beta:alkoxyethyl-N-phenoxy:benzyl-di:chloro:acetamide cpds. - useful as anti:amoebic agents in human and veterinary medicine

Publications (2)

Publication Number Publication Date
IT7826466A0 IT7826466A0 (en) 1978-08-04
IT1099590B true IT1099590B (en) 1985-09-18

Family

ID=11219567

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2646678A IT1099590B (en) 1977-10-03 1978-08-04 N-Beta:alkoxyethyl-N-phenoxy:benzyl-di:chloro:acetamide cpds. - useful as anti:amoebic agents in human and veterinary medicine

Country Status (1)

Country Link
IT (1) IT1099590B (en)

Also Published As

Publication number Publication date
IT7826466A0 (en) 1978-08-04

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