IT1099191B - 1-Thiomethyl-1-de:carboxy-lasalocid derivs. - used as antihypertensive and cardiovascular agents - Google Patents

1-Thiomethyl-1-de:carboxy-lasalocid derivs. - used as antihypertensive and cardiovascular agents

Info

Publication number
IT1099191B
IT1099191B IT2810978A IT2810978A IT1099191B IT 1099191 B IT1099191 B IT 1099191B IT 2810978 A IT2810978 A IT 2810978A IT 2810978 A IT2810978 A IT 2810978A IT 1099191 B IT1099191 B IT 1099191B
Authority
IT
Italy
Prior art keywords
lower alkyl
derivs
carboxy
antihypertensive
lasalocid
Prior art date
Application number
IT2810978A
Other languages
Italian (it)
Other versions
IT7828109A0 (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/921,645 external-priority patent/US4193928A/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IT7828109A0 publication Critical patent/IT7828109A0/en
Application granted granted Critical
Publication of IT1099191B publication Critical patent/IT1099191B/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

(A) Lasalocide derivs. of formula (I) are new (R1 is aryl (opt. substd.), heteroaryl, aralkyl, cycloalkyl, lower alkyl, lower alkenyl, alkoxycarbonyl-lower alkyl, aminoalkyl, lower alkylaminoalkyl, di-(lower alkyl)-aminoalkyl, hydroxyalkyl, alkoxyalkyl, thioalkoxyalkyl, carboxy-lower alkyl or H). (B) Intermediates of formula (II) (see "Preparation) are new. (I) are antihypertensive agents, esp. for oral use. They can also be used for treating other cardiovascular syndromes, e.g. angina pectoris, claudication and reduced cerebral blood flow.
IT2810978A 1977-09-26 1978-09-26 1-Thiomethyl-1-de:carboxy-lasalocid derivs. - used as antihypertensive and cardiovascular agents IT1099191B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83635077A 1977-09-26 1977-09-26
US05/921,645 US4193928A (en) 1977-09-26 1978-07-03 Lasalocid derivatives

Publications (2)

Publication Number Publication Date
IT7828109A0 IT7828109A0 (en) 1978-09-26
IT1099191B true IT1099191B (en) 1985-09-18

Family

ID=27125862

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2810978A IT1099191B (en) 1977-09-26 1978-09-26 1-Thiomethyl-1-de:carboxy-lasalocid derivs. - used as antihypertensive and cardiovascular agents

Country Status (12)

Country Link
AR (1) AR222312A1 (en)
DE (1) DE2861018D1 (en)
DK (1) DK425278A (en)
ES (1) ES473636A1 (en)
FI (1) FI782934A (en)
GR (1) GR72000B (en)
IL (1) IL55619A0 (en)
IT (1) IT1099191B (en)
MC (1) MC1209A1 (en)
NO (1) NO783243L (en)
NZ (1) NZ188484A (en)
PT (1) PT68588A (en)

Also Published As

Publication number Publication date
MC1209A1 (en) 1979-05-18
DK425278A (en) 1979-03-27
ES473636A1 (en) 1979-04-16
FI782934A (en) 1979-03-27
NZ188484A (en) 1981-05-01
PT68588A (en) 1978-10-01
IL55619A0 (en) 1978-12-17
IT7828109A0 (en) 1978-09-26
NO783243L (en) 1979-03-27
DE2861018D1 (en) 1981-11-26
AR222312A1 (en) 1981-05-15
GR72000B (en) 1983-08-26

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