IT1053667B - Compounds of formula (I) and acid addition salts thereof. X = H, Cl, alkoxy, CH3, OH Y = H, alkyl, aralkyl, alkylcycloalkyl, alkylheterocyclic - Google Patents

Compounds of formula (I) and acid addition salts thereof. X = H, Cl, alkoxy, CH3, OH Y = H, alkyl, aralkyl, alkylcycloalkyl, alkylheterocyclic

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Publication number
IT1053667B
IT1053667B IT3181866A IT3181866A IT1053667B IT 1053667 B IT1053667 B IT 1053667B IT 3181866 A IT3181866 A IT 3181866A IT 3181866 A IT3181866 A IT 3181866A IT 1053667 B IT1053667 B IT 1053667B
Authority
IT
Italy
Prior art keywords
alkyl
alkylcycloalkyl
aralkyl
alkoxy
compounds
Prior art date
Application number
IT3181866A
Other languages
Italian (it)
Inventor
P Giraldi
V Mariotti
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT3181866A priority Critical patent/IT1053667B/en
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Priority to ES345784A priority patent/ES345784A1/en
Priority to SE13036/67A priority patent/SE313054B/xx
Priority to CH1326267A priority patent/CH505821A/en
Priority to NL6713002A priority patent/NL6713002A/xx
Priority to GR670137267A priority patent/GR37267B/en
Priority to BE704182D priority patent/BE704182A/xx
Priority to GB43317/67A priority patent/GB1152928A/en
Priority to FR122111A priority patent/FR7234M/fr
Priority to FI672547A priority patent/FI51482C/en
Priority to US812512*A priority patent/US3624206A/en
Priority to US840070*A priority patent/US3636223A/en
Application granted granted Critical
Publication of IT1053667B publication Critical patent/IT1053667B/en

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Abstract

Compounds of formula (I) and acid addition salts thereof. X = H, Cl, alkoxy, CH3, OH Y = H, alkyl, aralkyl, alkylcycloalkyl, alkylheterocyclic group R = where n is 2-6; R' is H, alkyl R2, R3 are alkyl, or together with the attached N atom a heterocyclic group Z = O, S R4 = H or together with R' may form a double bond between the N atom joined to R' and C3 Spasmolytic agents. Papaverine type activity about twice as great as that of atropine while the parasympathicolytic activity e.g. on the pupil of the eye, on cardiac frequency and on salivary secretion is 2-10 times less than that of atropine. 3-Hydroxyphthalimidine + H.R I. Alkylate the product to give I (Y is not = H). 3-Hydroxyphthalimidine (5 g.) in DMF (50 ml) was refluxed for 5 hrs. with p-aminophenylethoxy-piperidine, cooled and ice was added. The solid which separated was collected and crystallised from 99.9% ethanol to give 1-oxo-3-(p-aminophenyl-ethoxypiperidino)isoindoline.
IT3181866A 1966-09-23 1966-12-31 Compounds of formula (I) and acid addition salts thereof. X = H, Cl, alkoxy, CH3, OH Y = H, alkyl, aralkyl, alkylcycloalkyl, alkylheterocyclic IT1053667B (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
IT3181866A IT1053667B (en) 1966-12-31 1966-12-31 Compounds of formula (I) and acid addition salts thereof. X = H, Cl, alkoxy, CH3, OH Y = H, alkyl, aralkyl, alkylcycloalkyl, alkylheterocyclic
SE13036/67A SE313054B (en) 1966-09-23 1967-09-22
CH1326267A CH505821A (en) 1966-09-23 1967-09-22 Process for the preparation of new 3-substituted and 2,3-disubstituted 1-oxoisoindolines
NL6713002A NL6713002A (en) 1966-09-23 1967-09-22
ES345784A ES345784A1 (en) 1966-09-23 1967-09-22 Procedure for the preparation of 3-substitute 1-oxo-isoindolins and 1-oxo-isoindolines 2,3-substitute. (Machine-translation by Google Translate, not legally binding)
GR670137267A GR37267B (en) 1966-09-23 1967-09-22 METHOD FOR THE PREPARATION OF YOUNG 3-SUBSTITUTED 1-OXO-ISOINDOLINES AND 2,3-SUBSTITUTED 1-OXO-ISOINDOLINES.
BE704182D BE704182A (en) 1966-09-23 1967-09-22
GB43317/67A GB1152928A (en) 1966-09-23 1967-09-22 New 3-Substituted 1-OXO-Isoindolines and 2,3-Substituted 1-OXO-Isoindolines and Process for their preparation
FR122111A FR7234M (en) 1966-09-23 1967-09-25
FI672547A FI51482C (en) 1966-09-23 1967-09-25 Process for the preparation of therapeutically useful 3-substituted 1-oxo-isoindolines and 2,3-substituted 1-oxo-isoindolines.
US812512*A US3624206A (en) 1966-09-23 1969-02-03 3-substituted and 2,3-substituted-1-oxo isoindolines and therapeutic use thereof
US840070*A US3636223A (en) 1966-09-23 1969-03-13 Therapeutic treatment of parkinson's disease

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT3181866A IT1053667B (en) 1966-12-31 1966-12-31 Compounds of formula (I) and acid addition salts thereof. X = H, Cl, alkoxy, CH3, OH Y = H, alkyl, aralkyl, alkylcycloalkyl, alkylheterocyclic

Publications (1)

Publication Number Publication Date
IT1053667B true IT1053667B (en) 1981-10-10

Family

ID=11234378

Family Applications (1)

Application Number Title Priority Date Filing Date
IT3181866A IT1053667B (en) 1966-09-23 1966-12-31 Compounds of formula (I) and acid addition salts thereof. X = H, Cl, alkoxy, CH3, OH Y = H, alkyl, aralkyl, alkylcycloalkyl, alkylheterocyclic

Country Status (1)

Country Link
IT (1) IT1053667B (en)

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