IT1053667B - Compounds of formula (I) and acid addition salts thereof. X = H, Cl, alkoxy, CH3, OH Y = H, alkyl, aralkyl, alkylcycloalkyl, alkylheterocyclic - Google Patents
Compounds of formula (I) and acid addition salts thereof. X = H, Cl, alkoxy, CH3, OH Y = H, alkyl, aralkyl, alkylcycloalkyl, alkylheterocyclicInfo
- Publication number
- IT1053667B IT1053667B IT3181866A IT3181866A IT1053667B IT 1053667 B IT1053667 B IT 1053667B IT 3181866 A IT3181866 A IT 3181866A IT 3181866 A IT3181866 A IT 3181866A IT 1053667 B IT1053667 B IT 1053667B
- Authority
- IT
- Italy
- Prior art keywords
- alkyl
- alkylcycloalkyl
- aralkyl
- alkoxy
- compounds
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compounds of formula (I) and acid addition salts thereof. X = H, Cl, alkoxy, CH3, OH Y = H, alkyl, aralkyl, alkylcycloalkyl, alkylheterocyclic group R = where n is 2-6; R' is H, alkyl R2, R3 are alkyl, or together with the attached N atom a heterocyclic group Z = O, S R4 = H or together with R' may form a double bond between the N atom joined to R' and C3 Spasmolytic agents. Papaverine type activity about twice as great as that of atropine while the parasympathicolytic activity e.g. on the pupil of the eye, on cardiac frequency and on salivary secretion is 2-10 times less than that of atropine. 3-Hydroxyphthalimidine + H.R I. Alkylate the product to give I (Y is not = H). 3-Hydroxyphthalimidine (5 g.) in DMF (50 ml) was refluxed for 5 hrs. with p-aminophenylethoxy-piperidine, cooled and ice was added. The solid which separated was collected and crystallised from 99.9% ethanol to give 1-oxo-3-(p-aminophenyl-ethoxypiperidino)isoindoline.
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT3181866A IT1053667B (en) | 1966-12-31 | 1966-12-31 | Compounds of formula (I) and acid addition salts thereof. X = H, Cl, alkoxy, CH3, OH Y = H, alkyl, aralkyl, alkylcycloalkyl, alkylheterocyclic |
SE13036/67A SE313054B (en) | 1966-09-23 | 1967-09-22 | |
CH1326267A CH505821A (en) | 1966-09-23 | 1967-09-22 | Process for the preparation of new 3-substituted and 2,3-disubstituted 1-oxoisoindolines |
NL6713002A NL6713002A (en) | 1966-09-23 | 1967-09-22 | |
ES345784A ES345784A1 (en) | 1966-09-23 | 1967-09-22 | Procedure for the preparation of 3-substitute 1-oxo-isoindolins and 1-oxo-isoindolines 2,3-substitute. (Machine-translation by Google Translate, not legally binding) |
GR670137267A GR37267B (en) | 1966-09-23 | 1967-09-22 | METHOD FOR THE PREPARATION OF YOUNG 3-SUBSTITUTED 1-OXO-ISOINDOLINES AND 2,3-SUBSTITUTED 1-OXO-ISOINDOLINES. |
BE704182D BE704182A (en) | 1966-09-23 | 1967-09-22 | |
GB43317/67A GB1152928A (en) | 1966-09-23 | 1967-09-22 | New 3-Substituted 1-OXO-Isoindolines and 2,3-Substituted 1-OXO-Isoindolines and Process for their preparation |
FR122111A FR7234M (en) | 1966-09-23 | 1967-09-25 | |
FI672547A FI51482C (en) | 1966-09-23 | 1967-09-25 | Process for the preparation of therapeutically useful 3-substituted 1-oxo-isoindolines and 2,3-substituted 1-oxo-isoindolines. |
US812512*A US3624206A (en) | 1966-09-23 | 1969-02-03 | 3-substituted and 2,3-substituted-1-oxo isoindolines and therapeutic use thereof |
US840070*A US3636223A (en) | 1966-09-23 | 1969-03-13 | Therapeutic treatment of parkinson's disease |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT3181866A IT1053667B (en) | 1966-12-31 | 1966-12-31 | Compounds of formula (I) and acid addition salts thereof. X = H, Cl, alkoxy, CH3, OH Y = H, alkyl, aralkyl, alkylcycloalkyl, alkylheterocyclic |
Publications (1)
Publication Number | Publication Date |
---|---|
IT1053667B true IT1053667B (en) | 1981-10-10 |
Family
ID=11234378
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT3181866A IT1053667B (en) | 1966-09-23 | 1966-12-31 | Compounds of formula (I) and acid addition salts thereof. X = H, Cl, alkoxy, CH3, OH Y = H, alkyl, aralkyl, alkylcycloalkyl, alkylheterocyclic |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1053667B (en) |
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1966
- 1966-12-31 IT IT3181866A patent/IT1053667B/en active
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