IT1050304B - 4-Aryl 5-aminoalkyl 4-thiazoline-2-ones and 2-thiones - CNS depressant and cardiovascular agents having anti-inflammatory, adrenolytic and anti-ulcer activity - Google Patents
4-Aryl 5-aminoalkyl 4-thiazoline-2-ones and 2-thiones - CNS depressant and cardiovascular agents having anti-inflammatory, adrenolytic and anti-ulcer activityInfo
- Publication number
- IT1050304B IT1050304B IT2252175A IT2252175A IT1050304B IT 1050304 B IT1050304 B IT 1050304B IT 2252175 A IT2252175 A IT 2252175A IT 2252175 A IT2252175 A IT 2252175A IT 1050304 B IT1050304 B IT 1050304B
- Authority
- IT
- Italy
- Prior art keywords
- alkyl
- opt
- substd
- amino
- aryl
- Prior art date
Links
Abstract
Cpds. of formula (I) are their salts (where Ar = mono- or polycarboxylic aryl opt. substd. by alkyl, CF3, alkoxy, alkenyloxy, alkylenedioxy, halo, alkylthio, nitro, opt. substd amino etc. and is partic. phenyl, lower alkylphenyl, trifluoromethylphenyl, lower alkoxy phenyl di(lower alkyl) aminophyenyl, halophenyl or alkylmercaptphenyl. Alk = 1-3C straight or branched, opt. unstatd. radical -NR1R2 = monosubstd. amino (e.g. monoalkylamino, mono-hydroxyalkylamino, monoarylalkylamino, monoaryloxyalkylamino, mono N,N-dialkylamino-alkyl amino) or disubstd. amino (e.g. N,N,-dialkylamino, N-cycloalkyl-N-alkylamino, N-alkyl-N-arylalkylamino, N-hydrozylakyl-N-alkylamino, N,N-dihydroxyalkylamino, N,N-alkyleneimine, N-N-oxoalkyleneimine, N,N-thioalkyleneimine, N,N-azaaalkyleneimine (opt. substd. on the aza function by alkyl, hydroxyalkyl, arylalkyl or aryl (opt. substd. by halo or alkoxy)). Z = O or SR3 = H, lowre alkyl, free or etherified lower hydroxyalkyl, arylalkyl dialkylaminoalkyl, lowre aliphatic or aromatic acyl or carbamoyl).act on the CNS and cardiovascular system and have antiinflammatory adrenolytic and anti-ulcer activity. They have anti-arrhythmic activity, prevent platelet agglutination, have anti-convulsant, cataleptic and some analgesic activity. They may be administered orally, parenterally or rectally in the usual formations. LD50 ip in mice vary from 100 to >1000mg/kg.
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2252175A IT1050304B (en) | 1975-04-18 | 1975-04-18 | 4-Aryl 5-aminoalkyl 4-thiazoline-2-ones and 2-thiones - CNS depressant and cardiovascular agents having anti-inflammatory, adrenolytic and anti-ulcer activity |
US05/576,582 US4061637A (en) | 1974-05-14 | 1975-05-12 | Certain 4-aryl-5-(4-phenylpiperazino)alkyl-4-thiazolin-2-ones |
CA226,812A CA1039725A (en) | 1974-05-14 | 1975-05-13 | 4-aryl-5-aminoalkyl-4-thiazoline-2-ones, their derivatives and processes for their preparation |
GB20160/75A GB1494560A (en) | 1974-05-14 | 1975-05-13 | 4-aryl-5-aminoalkyl-4-thiazolin-2-ones and their preparation |
ES437624A ES437624A1 (en) | 1974-05-14 | 1975-05-13 | Certain 4-aryl-5-(4-phenylpiperazino)alkyl-4-thiazolin-2-ones |
DE2521104A DE2521104C3 (en) | 1974-05-14 | 1975-05-13 | 4-Aryl-5-aminoalkyl-4-thiazolin-2-ones, processes for their preparation and pharmaceutical compositions containing these compounds |
BE156349A BE829071A (en) | 1974-05-14 | 1975-05-14 | 4-ARYL-5-AMINDALKYL-4-THIAZOLINE-2-ONES, DERIVATIVES AND METHODS FOR PREPARING THEM |
NL7505642.A NL165736C (en) | 1974-05-14 | 1975-05-14 | PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL PREPARATION WITH AN ACTION ON THE CENTRAL NERVOUS SYSTEM AND THE CARDIO-VASCULAR SYSTEM AND WITH AN ANTI-INFLAMMATIC ADRENOLYTIC AND ANTI-ULCER PREPARATELY PREPARED PRODUCTION. -2-ONES. |
JP50057157A JPS5126873A (en) | 1974-05-14 | 1975-05-14 | 44 ariiru 55 aminoarukiru 44 chiazorin 22 on oyobi sonojudotainochoseiho |
FR7514979A FR2270873B1 (en) | 1974-05-14 | 1975-05-14 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2252175A IT1050304B (en) | 1975-04-18 | 1975-04-18 | 4-Aryl 5-aminoalkyl 4-thiazoline-2-ones and 2-thiones - CNS depressant and cardiovascular agents having anti-inflammatory, adrenolytic and anti-ulcer activity |
Publications (1)
Publication Number | Publication Date |
---|---|
IT1050304B true IT1050304B (en) | 1981-03-10 |
Family
ID=11197375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT2252175A IT1050304B (en) | 1974-05-14 | 1975-04-18 | 4-Aryl 5-aminoalkyl 4-thiazoline-2-ones and 2-thiones - CNS depressant and cardiovascular agents having anti-inflammatory, adrenolytic and anti-ulcer activity |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1050304B (en) |
-
1975
- 1975-04-18 IT IT2252175A patent/IT1050304B/en active
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