IN2015KN00350A - - Google Patents
Download PDFInfo
- Publication number
- IN2015KN00350A IN2015KN00350A IN350KON2015A IN2015KN00350A IN 2015KN00350 A IN2015KN00350 A IN 2015KN00350A IN 350KON2015 A IN350KON2015 A IN 350KON2015A IN 2015KN00350 A IN2015KN00350 A IN 2015KN00350A
- Authority
- IN
- India
- Prior art keywords
- present
- cancer
- agents
- methods
- rspo3
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Hospice & Palliative Care (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
The present invention relates to RSPO-binding agents, particularly RSPO3-binding agents and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human RSPO3 proteins and modulate ß-catenin activity. The present invention further provides methods of using agents that modulate the activity of RSPO3 proteins and inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261671421P | 2012-07-13 | 2012-07-13 | |
US201361753184P | 2013-01-16 | 2013-01-16 | |
US201361789156P | 2013-03-15 | 2013-03-15 | |
US201361826747P | 2013-05-23 | 2013-05-23 | |
PCT/US2013/050300 WO2014012007A2 (en) | 2012-07-13 | 2013-07-12 | Rspo3 binding agents and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2015KN00350A true IN2015KN00350A (en) | 2015-07-10 |
Family
ID=49914164
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN350KON2015 IN2015KN00350A (en) | 2012-07-13 | 2013-07-12 |
Country Status (24)
Country | Link |
---|---|
US (3) | US9181333B2 (en) |
EP (1) | EP2872175A4 (en) |
JP (1) | JP6335896B2 (en) |
KR (1) | KR20150036603A (en) |
CN (1) | CN104854132A (en) |
AU (1) | AU2013289990B2 (en) |
BR (1) | BR112015000776A2 (en) |
CA (1) | CA2878868A1 (en) |
CL (1) | CL2015000097A1 (en) |
EA (1) | EA032038B1 (en) |
EC (1) | ECSP15005280A (en) |
HK (1) | HK1208687A1 (en) |
IL (1) | IL236617A0 (en) |
IN (1) | IN2015KN00350A (en) |
MX (1) | MX2015000565A (en) |
NI (1) | NI201500002A (en) |
NZ (1) | NZ704269A (en) |
PE (1) | PE20150360A1 (en) |
PH (1) | PH12015500084A1 (en) |
SG (1) | SG11201500233PA (en) |
TW (2) | TW201906861A (en) |
UA (1) | UA117659C2 (en) |
WO (1) | WO2014012007A2 (en) |
ZA (1) | ZA201500872B (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008042236A2 (en) | 2006-09-29 | 2008-04-10 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
DK2173379T3 (en) | 2007-07-02 | 2015-12-07 | Oncomed Pharm Inc | Compositions and methods for treatment and diagnosis of cancer |
US8551479B2 (en) | 2010-09-10 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating melanoma |
US9260519B2 (en) | 2011-06-17 | 2016-02-16 | President And Fellows Of Harvard College | Frizzled 2 as a target for therapeutic antibodies in the treatment of cancer |
EP2731625B1 (en) | 2011-07-15 | 2018-04-18 | OncoMed Pharmaceuticals, Inc. | Rspo binding agents and uses thereof |
CA2878868A1 (en) | 2012-07-13 | 2014-01-16 | Austin L. Gurney | Rspo3 binding agents and uses thereof |
US20150147333A1 (en) * | 2013-10-18 | 2015-05-28 | Genentech, Inc. | Anti-rspo antibodies and methods of use |
CN106488775A (en) | 2014-07-11 | 2017-03-08 | 基因泰克公司 | NOTCH approach suppresses |
WO2016044295A1 (en) | 2014-09-16 | 2016-03-24 | Oncomed Pharmaceuticals, Inc. | Treatment of fibrotic diseases |
MA41123A (en) * | 2014-12-02 | 2017-10-10 | Oncomed Pharm Inc | POLYTHERAPY FOR CANCER TREATMENT |
WO2017040660A1 (en) * | 2015-08-31 | 2017-03-09 | Oncomed Pharmaceuticals, Inc. | Combination therapy for treatment of disease |
CN106913880B (en) * | 2015-12-24 | 2021-02-12 | 上海交通大学 | RSPO 1-containing targeted drug delivery system and preparation and application thereof |
CN105925576B (en) * | 2016-03-24 | 2018-04-20 | 嘉兴市第一医院 | SiRNA, ShorthairpinRNA and carrier and application for mammal R Spondin3 gene targets |
WO2017180864A1 (en) | 2016-04-14 | 2017-10-19 | Genentech, Inc. | Anti-rspo3 antibodies and methods of use |
WO2018035210A1 (en) * | 2016-08-17 | 2018-02-22 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with an rspo antagonist |
EP3720492A4 (en) * | 2017-12-07 | 2021-12-08 | National Health Research Institutes | Anti-rspo3 antibodies |
CN110339364B (en) * | 2018-04-02 | 2021-02-12 | 上海邦耀生物科技有限公司 | LGR4/RSPO blockers in combination with anti-immune checkpoint inhibitors for immunotherapy of tumors |
CN110467663B (en) * | 2019-06-18 | 2022-05-10 | 华南农业大学 | Application of RSPO3 gene in sow ovarian granulosa cells |
KR102554222B1 (en) * | 2023-03-21 | 2023-07-11 | 순천향대학교 산학협력단 | Novel anti-rspo3 antibodies and uses thereof |
CN116769030B (en) * | 2023-08-21 | 2023-10-20 | 成都大熊猫繁育研究基地 | Panda relaxin 3 monoclonal antibody, hybridoma cell strain and application thereof |
Family Cites Families (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5681718A (en) | 1986-03-14 | 1997-10-28 | Celltech Limited | Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
KR100272077B1 (en) | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | Transgenic non-human animals capable of producing heterologous antibodies |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US20070124581A1 (en) | 1992-05-17 | 2007-05-31 | Reena Khare | Cell adhesion and extracellular matrix proteins |
JP2001527403A (en) | 1997-04-25 | 2001-12-25 | ジェネティックス・インスチチュート・インコーポレーテッド | Secreted proteins and polynucleotides encoding them |
US6004528A (en) | 1997-09-18 | 1999-12-21 | Bergstein; Ivan | Methods of cancer diagnosis and therapy targeted against the cancer stemline |
EP1017811A4 (en) | 1997-09-24 | 2002-08-14 | Merck & Co Inc | G-protein coupled glycoprotein hormone receptor hg38 |
US20020065394A1 (en) | 1998-03-18 | 2002-05-30 | Kenneth Jacobs | Secreted proteins and polynucleotides encoding them |
ATE440865T1 (en) | 1998-03-26 | 2009-09-15 | Univ Leland Stanford Junior | NEW G-PROTEIN-COUPLED MAMMAL RECEPTORS WITH EXTRACELLULAR LEUCINE-RICH REGION |
US6485972B1 (en) | 1998-10-15 | 2002-11-26 | President And Fellows Of Harvard College | WNT signalling in reproductive organs |
US20030166047A1 (en) | 1999-05-06 | 2003-09-04 | Millennium Pharmaceuticals, Inc. | Lgr6 nucleic acids and uses thereof |
JP2003505082A (en) | 1999-07-26 | 2003-02-12 | ジェネンテック・インコーポレーテッド | Novel polynucleotides and their uses |
EP1572987A4 (en) | 2000-02-03 | 2005-11-30 | Nuvelo Inc | Novel nucleic acids and polypeptides |
US6824973B2 (en) | 2000-02-03 | 2004-11-30 | Kirin Beer Kabushiki Kaisha | Method of promoting stem cell proliferation or survival by contacting a cell with a stem cell factor-like polypeptide |
EP1267616B1 (en) | 2000-03-31 | 2007-08-08 | The General Hospital Corporation | Methods of increasing hair growth by wnt polypeptide |
JP2003530124A (en) | 2000-04-05 | 2003-10-14 | 麒麟麦酒株式会社 | Methods and materials for novel stem cell growth factor-like polypeptides and polynucleotides |
EP1156062A1 (en) | 2000-05-12 | 2001-11-21 | GPC Biotech AG | Immunomodulatory human MHC class II antigen-binding peptides/proteins |
AU2001263006A1 (en) | 2000-05-18 | 2001-11-26 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
AU2001281791A1 (en) | 2000-05-30 | 2001-12-11 | Bayer Aktiengesellschaft | Regulation of human lgr4-like g protein-coupled receptor |
US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
WO2003050502A2 (en) | 2001-12-07 | 2003-06-19 | Regents Of The University Of Michigan | Prospective identification and characterization of breast cancer stem cells |
US6768004B2 (en) * | 2001-01-11 | 2004-07-27 | Mueller Sybille | Nucleotide sequences encoding variable regions of heavy and light chains of monoclonal antibody 1F7, an anti-idiotypic antibody reactive with anti-HIV antibodies |
US20040077048A1 (en) | 2002-01-30 | 2004-04-22 | Warren Bridget A. | Protein modification and maintenance molecules |
US20100292155A1 (en) | 2001-03-05 | 2010-11-18 | Arca Biopharma, Inc. | Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides |
US7411052B2 (en) | 2001-03-05 | 2008-08-12 | Nuvelo, Inc. | Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides |
US20030032034A1 (en) | 2001-03-05 | 2003-02-13 | Tang Y. Tom | Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides |
AU2002304249A1 (en) | 2001-06-11 | 2002-12-23 | Kirin Beer Kabushiki Kaisha | Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell and hematopoietic progenitor cell, and dna coding for the same |
ATE440869T1 (en) | 2001-06-20 | 2009-09-15 | Fibron Ltd | FGFR3 BLOCKING ANTIBODIES, METHOD FOR SCREENING THEREOF, AND USES THEREOF |
US20030022217A1 (en) | 2001-07-02 | 2003-01-30 | Pe Corporation (Ny) | Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof |
CA2458818A1 (en) | 2001-08-30 | 2003-04-10 | Nuvelo, Inc. | Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides |
CA2462795A1 (en) | 2001-10-03 | 2003-04-10 | Incyte Genomics, Inc. | Secreted proteins |
US20040197778A1 (en) | 2002-12-26 | 2004-10-07 | Sagres Discovery, Inc. | Novel compositions and methods in cancer |
US20070237770A1 (en) | 2001-11-30 | 2007-10-11 | Albert Lai | Novel compositions and methods in cancer |
EP1504099A4 (en) | 2001-12-10 | 2006-05-10 | Nuvelo Inc | Novel nucleic acids and polypeptides |
US7193069B2 (en) | 2002-03-22 | 2007-03-20 | Research Association For Biotechnology | Full-length cDNA |
EP1499637A1 (en) | 2002-04-26 | 2005-01-26 | Kirin Beer Kabushiki Kaisha | Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell or hematopoietic progenitor cell, and dna coding for the same |
EP1380644A1 (en) | 2002-07-08 | 2004-01-14 | Kylix B.V. | The use of specified TCF target genes to identify drugs for the treatment of cancer, in particular colorectal cancer, in which TCF/beta-catenin/WNT signalling plays a central role |
GB0216648D0 (en) | 2002-07-18 | 2002-08-28 | Lonza Biologics Plc | Method of expressing recombinant protein in CHO cells |
WO2004074436A2 (en) | 2003-02-19 | 2004-09-02 | Incyte Corporation | Methods of use of a gpcr in the diagnosis and treatment of colon and lung cancer |
US20050003405A1 (en) | 2003-04-30 | 2005-01-06 | Hua-Chien Chen | Treatment and diagnostics of cancer |
WO2005005601A2 (en) | 2003-06-09 | 2005-01-20 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
US20050054829A1 (en) | 2003-07-22 | 2005-03-10 | Wiley Steven R. | Compositions and methods relating to TSP-30a, b, c and d |
DE10339820A1 (en) | 2003-08-22 | 2005-03-17 | Hinzmann, Bernd, Dr. | Use of G-protein coupled receptor, GPR49, peptides, protein and nucleic acid, for diagnosis and prognosis of tumors, also in screening for therapeutic and diagnostic agents |
US9046537B2 (en) | 2003-09-22 | 2015-06-02 | Enzo Biochem, Inc. | Method for treating inflammation by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain |
PT2157192E (en) | 2003-10-10 | 2013-11-28 | Deutsches Krebsforsch | Compositions for diagnosis and therapy of diseases associated with aberrant expression of futrins (r-spondins) |
WO2005040828A2 (en) | 2003-10-24 | 2005-05-06 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 49 (gpr49) |
CA2554403A1 (en) | 2004-01-27 | 2005-08-11 | Nuvelo, Inc. | Gastrointestinal proliferative factor and uses thereof |
WO2005074633A2 (en) | 2004-02-03 | 2005-08-18 | The Regents Of The University Of Michigan | Compositions and methods for characterizing, regulating, diagnosing, and treating cancer |
WO2005075514A2 (en) | 2004-03-10 | 2005-08-18 | Lonza Ltd. | Method for producing antibodies |
US7572456B2 (en) | 2004-09-13 | 2009-08-11 | Macrogenics, Inc. | Humanized antibodies against West Nile Virus and therapeutic and prophylactic uses thereof |
AU2005318171B2 (en) | 2004-12-20 | 2011-09-29 | Crucell Holland B.V. | Binding molecules capable of neutralizing West Nile virus and uses thereof |
US7439327B2 (en) | 2005-01-18 | 2008-10-21 | Nuvelo, Inc. | Stem cell factor-like proteins and uses thereof |
US20090220495A1 (en) | 2005-04-07 | 2009-09-03 | Abdallah Fanidi | Cancer Related Genes (PRLR) |
US20090036369A1 (en) | 2005-07-26 | 2009-02-05 | Kirin Pharma Kabushiki Kaisha | Anti-tumor agents comprising r-spondins |
WO2007030290A2 (en) | 2005-09-07 | 2007-03-15 | Maine Medical Center Research | Cristin/r-spondin ligands active in the wnt signaling pathway and methods, compositions and kits relating thereto |
WO2007100357A2 (en) | 2005-10-07 | 2007-09-07 | Nuvelo, Inc. | Stem cell factor-like protein scfa1 and uses thereof |
US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
US7723112B2 (en) | 2005-10-31 | 2010-05-25 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
GB0603683D0 (en) | 2006-02-23 | 2006-04-05 | Novartis Ag | Organic compounds |
KR101196184B1 (en) | 2006-06-02 | 2012-11-01 | 아베오 파마슈티컬즈, 인크. | Hepatocyte growth factor hgf binding proteins |
BRPI0712222B1 (en) | 2006-06-02 | 2021-10-13 | Aveo Pharmaceuticals, Inc. | ISOLATED BINDING PROTEIN WHICH BINDS TO HUMAN HEPATOCYTE GROWTH FACTOR (HGF), ITS USE AND METHOD OF PRODUCTION, NUCLEIC ACID, EXPRESSION VECTOR, HOST CELL, AND METHODS TO PRODUCE A VARIABLE REGION POLYPEPTIDE IMMUNOGLOBULIN AND TO PRODUCE A POLYPEPTIDE THAT COMPRISES A VARIABLE REGION OF THE IMMUNOGLOBULIN LIGHT CHAIN |
ES2413087T3 (en) | 2006-06-13 | 2013-07-15 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for the diagnosis and treatment of cancer |
AU2007274738B2 (en) * | 2006-07-18 | 2013-11-28 | Sanofi-Aventis | Antagonist antibody against EphA2 for the treatment of cancer |
JP2008044926A (en) | 2006-08-14 | 2008-02-28 | Trustees Of Columbia Univ In The City Of New York | SECRETORY PROTEIN RELATED TO Wnt SIGNAL TRANSDUCTION |
WO2008042236A2 (en) | 2006-09-29 | 2008-04-10 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
PL2081586T5 (en) * | 2006-10-20 | 2019-04-30 | Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts | Rspondins as modulators of angiogenesis and vasculogenesis |
WO2008075796A1 (en) | 2006-12-21 | 2008-06-26 | Kyowa Hakko Kirin Co., Ltd. | Agent for promoting recovery from blood cell depletion |
WO2008088524A2 (en) | 2006-12-28 | 2008-07-24 | Nuvelo, Inc. | Thrombospondin-domain-deficient r-spondin 1 protein as gastrointestinal tract epithelial proliferation factor |
BRPI0812562A2 (en) | 2007-06-12 | 2019-09-24 | Trubion Pharmaceuticals Inc | anti-cd20 therapeutic compositions and methods |
DK2173379T3 (en) | 2007-07-02 | 2015-12-07 | Oncomed Pharm Inc | Compositions and methods for treatment and diagnosis of cancer |
CA2700257A1 (en) | 2007-10-02 | 2009-04-09 | Hartmut Land | Methods and compositions related to synergistic responses to oncogenic mutations |
US20120082659A1 (en) | 2007-10-02 | 2012-04-05 | Hartmut Land | Methods And Compositions Related To Synergistic Responses To Oncogenic Mutations |
CN102112492B (en) | 2007-11-14 | 2015-02-25 | 中外制药株式会社 | Diagnosis and treatment of cancer using anti-GPR49 antibody |
EP2313435A4 (en) | 2008-07-01 | 2012-08-08 | Aveo Pharmaceuticals Inc | Fibroblast growth factor receptor 3 (fgfr3) binding proteins |
WO2010016766A2 (en) | 2008-08-08 | 2010-02-11 | Koninklijke Nederlandse Akademie Van Wetenschappen | Antibodies recognizing endogenous human lgr5 and/or lgr6 |
JP5941615B2 (en) * | 2008-10-31 | 2016-06-29 | 東レ株式会社 | Method for immunological measurement of human CXCL1 protein |
US20120039912A1 (en) | 2009-04-15 | 2012-02-16 | Galapagos Sasu | Rspondin-3 inhibition in bone disorders |
US20120165270A1 (en) | 2009-04-27 | 2012-06-28 | Yeon Sook Choi | Inhibition of hair follicle growth by the wnt inhibitor dkk1 |
EP2424567B1 (en) * | 2009-04-27 | 2018-11-21 | OncoMed Pharmaceuticals, Inc. | Method for making heteromultimeric molecules |
KR20120027031A (en) | 2009-06-18 | 2012-03-20 | 와이어쓰 엘엘씨 | Lyophilized formulations for small modular immunopharmaceuticals |
WO2011009090A1 (en) * | 2009-07-16 | 2011-01-20 | Xoma Technology Ltd. | Antibodies to high molecular weight melanoma associated antigen |
EP2473531A4 (en) | 2009-09-03 | 2013-05-01 | Merck Sharp & Dohme | Anti-gitr antibodies |
ES2573643T3 (en) | 2009-12-23 | 2016-06-09 | Deutsches Krebsforschungszentrum | Rspo2 and Rspo3 receptors |
US8663950B2 (en) | 2010-01-11 | 2014-03-04 | Arizona Board Of Regents | Production of a monoclonal antibody therapeutic against west nile virus in plants |
AU2011215685B2 (en) | 2010-02-12 | 2015-08-20 | Oncomed Pharmaceuticals, Inc. | Methods for identifying and isolating cells expressing a polypeptide |
US20150024952A1 (en) * | 2010-12-28 | 2015-01-22 | Arlet Alarcon | Molecular profiling for cancer |
GB201106395D0 (en) | 2011-04-14 | 2011-06-01 | Hubrecht Inst | Compounds |
ES2788183T3 (en) * | 2011-04-28 | 2020-10-20 | Sbi Biotech Co Ltd | Anti-human receptor protein tyrosine phosphatase antibody |
EP2731625B1 (en) | 2011-07-15 | 2018-04-18 | OncoMed Pharmaceuticals, Inc. | Rspo binding agents and uses thereof |
CN104080471B (en) | 2011-10-14 | 2018-08-10 | 诺华股份有限公司 | Antibody and method for Wnt approach relevant diseases |
AU2012332588B2 (en) | 2011-11-01 | 2017-09-07 | Bionomics, Inc. | Methods of blocking cancer stem cell growth |
AU2012332590B2 (en) | 2011-11-01 | 2016-10-20 | Bionomics, Inc. | Anti-GPR49 antibodies |
JP6545959B2 (en) | 2012-02-11 | 2019-07-17 | ジェネンテック, インコーポレイテッド | R-Spondin rearrangement and method of using the same |
AR090549A1 (en) | 2012-03-30 | 2014-11-19 | Genentech Inc | ANTI-LGR5 AND IMMUNOCATE PLAYERS |
CA2878868A1 (en) | 2012-07-13 | 2014-01-16 | Austin L. Gurney | Rspo3 binding agents and uses thereof |
WO2014165232A1 (en) | 2013-03-12 | 2014-10-09 | Curegenix, Inc. | Compounds for treatment of cancer |
WO2014192974A1 (en) | 2013-05-30 | 2014-12-04 | 株式会社オーダーメードメディカルリサーチ | Reagent including anti-lgr6 antibodies for detection and diagnosis of cancer |
US20150147333A1 (en) | 2013-10-18 | 2015-05-28 | Genentech, Inc. | Anti-rspo antibodies and methods of use |
MA41123A (en) | 2014-12-02 | 2017-10-10 | Oncomed Pharm Inc | POLYTHERAPY FOR CANCER TREATMENT |
US9777052B2 (en) | 2014-12-02 | 2017-10-03 | The Board Of Regents Of The University Of Oklahoma | R-spondin variants, compositions, and methods of use |
-
2013
- 2013-07-12 CA CA2878868A patent/CA2878868A1/en not_active Abandoned
- 2013-07-12 AU AU2013289990A patent/AU2013289990B2/en not_active Ceased
- 2013-07-12 PE PE2015000037A patent/PE20150360A1/en active IP Right Grant
- 2013-07-12 WO PCT/US2013/050300 patent/WO2014012007A2/en active Application Filing
- 2013-07-12 EP EP13816428.0A patent/EP2872175A4/en not_active Withdrawn
- 2013-07-12 JP JP2015521849A patent/JP6335896B2/en not_active Expired - Fee Related
- 2013-07-12 NZ NZ704269A patent/NZ704269A/en not_active IP Right Cessation
- 2013-07-12 IN IN350KON2015 patent/IN2015KN00350A/en unknown
- 2013-07-12 EA EA201590144A patent/EA032038B1/en not_active IP Right Cessation
- 2013-07-12 BR BR112015000776A patent/BR112015000776A2/en not_active Application Discontinuation
- 2013-07-12 MX MX2015000565A patent/MX2015000565A/en unknown
- 2013-07-12 CN CN201380047332.9A patent/CN104854132A/en active Pending
- 2013-07-12 KR KR1020157003862A patent/KR20150036603A/en not_active Application Discontinuation
- 2013-07-12 SG SG11201500233PA patent/SG11201500233PA/en unknown
- 2013-07-12 US US13/940,834 patent/US9181333B2/en not_active Expired - Fee Related
- 2013-07-15 TW TW107121349A patent/TW201906861A/en unknown
- 2013-07-15 TW TW102125212A patent/TWI636061B/en not_active IP Right Cessation
- 2013-12-07 UA UAA201500865A patent/UA117659C2/en unknown
-
2015
- 2015-01-11 IL IL236617A patent/IL236617A0/en unknown
- 2015-01-12 NI NI201500002A patent/NI201500002A/en unknown
- 2015-01-13 CL CL2015000097A patent/CL2015000097A1/en unknown
- 2015-01-13 PH PH12015500084A patent/PH12015500084A1/en unknown
- 2015-02-06 ZA ZA2015/00872A patent/ZA201500872B/en unknown
- 2015-02-12 EC ECIEPI20155280A patent/ECSP15005280A/en unknown
- 2015-09-24 HK HK15109369.7A patent/HK1208687A1/en unknown
- 2015-09-30 US US14/870,145 patent/US9598497B2/en active Active
-
2017
- 2017-02-22 US US15/439,288 patent/US20170267776A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH12015500084A1 (en) | Rspo3 binding agents and uses thereof | |
MX2014000555A (en) | Rspo binding agents and uses thereof. | |
CY1121148T1 (en) | VEGF / DLL4 CONNECTING FACTORS AND THEIR USES | |
PH12018501264A1 (en) | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | |
MX2020003719A (en) | Therapy involving antibodies against claudin 18.2 for treatment of cancer. | |
PH12016501728A1 (en) | Anti-angiogenesis therapy for the treatment of ovarian cancer | |
EA033400B1 (en) | Anti-cd3 antibody and use thereof | |
WO2010019702A3 (en) | Ddr1-binding agents and methods of use thereof | |
PH12015500297A1 (en) | Adoptosis-inducing agents for the treatment of cancer and immune and automoimmune disease | |
MX2021010672A (en) | Diagnosis and therapy of cancer involving cancer stem cells. | |
SG185638A1 (en) | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | |
SG10201908388UA (en) | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | |
MX341076B (en) | Stable formulations of antibodies to human programmed death receptor pd-1 and related treatments. | |
AU2011328009A8 (en) | Compounds and methods for treating pain | |
MY173377A (en) | Anti-b7-h3 antibody | |
EA201390506A1 (en) | POLYPEPTIDES THAT BIND THE COMPONENT C5 OF THE HUMAN COMPLEX | |
WO2011063237A3 (en) | Jagged-binding agents and uses thereof | |
EP3991749A3 (en) | A therapeutic agent for a tumor comprising an ido inhibitor administered in combination with an antibody | |
BR112016023011A2 (en) | gastric cancer treatment | |
EA201491352A1 (en) | METHOD OF TREATMENT OF BREAST CANCER | |
MX2017001983A (en) | Rspo1 binding agents and uses thereof. | |
TH163450A (en) | VEGF / DLL4 adhesion agent and its use | |
UA112522C2 (en) | METHOD OF THERAPY TUMOR THERAPY |