IN2015DN04151A - - Google Patents

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Publication number
IN2015DN04151A
IN2015DN04151A IN4151DEN2015A IN2015DN04151A IN 2015DN04151 A IN2015DN04151 A IN 2015DN04151A IN 4151DEN2015 A IN4151DEN2015 A IN 4151DEN2015A IN 2015DN04151 A IN2015DN04151 A IN 2015DN04151A
Authority
IN
India
Prior art keywords
same
formulations
compositions
methods
acid esters
Prior art date
Application number
Inventor
Dechi Guan
David I Macdonald
Original Assignee
Methylation Sciences Internat Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Methylation Sciences Internat Srl filed Critical Methylation Sciences Internat Srl
Publication of IN2015DN04151A publication Critical patent/IN2015DN04151A/en

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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Addiction (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Vascular Medicine (AREA)

Abstract

Provided herein are compositions and formulations comprising S adenosyl L methionine ('SAM e' or 'SAMe') and one or more gallic acid esters. Also provided herein are methods for improving the delivery of SAMe. Compositions and formulations provided herein increase SAMe plasma concentrations and area under the curve (AUC) values. Also provided herein are methods of treating a disease or disorder in a subject by administering compositions or formulations comprising exogenous SAMe and one or more gallic acid esters.
IN4151DEN2015 2012-10-17 2013-10-16 IN2015DN04151A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261715138P 2012-10-17 2012-10-17
PCT/CA2013/000876 WO2014059522A1 (en) 2012-10-17 2013-10-16 Compositions comprising s-adenosylmethionine and a gallic acid ester

Publications (1)

Publication Number Publication Date
IN2015DN04151A true IN2015DN04151A (en) 2015-10-16

Family

ID=50487370

Family Applications (1)

Application Number Title Priority Date Filing Date
IN4151DEN2015 IN2015DN04151A (en) 2012-10-17 2013-10-16

Country Status (15)

Country Link
US (7) US9801896B2 (en)
EP (2) EP2753336B1 (en)
JP (2) JP5877935B2 (en)
KR (2) KR20160094451A (en)
CN (2) CN104884067B (en)
AU (1) AU2013332209B2 (en)
CA (1) CA2888302C (en)
DK (1) DK2753336T3 (en)
ES (1) ES2540581T3 (en)
HK (1) HK1217909A1 (en)
IL (1) IL243585A0 (en)
IN (1) IN2015DN04151A (en)
RU (2) RU2016117290A (en)
SG (1) SG11201503048TA (en)
WO (1) WO2014059522A1 (en)

Cited By (1)

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CA2888302C (en) * 2012-10-17 2016-05-31 Methylation Sciences International Srl Compositions comprising s-adenosylmethionine and a gallic acid ester
WO2015159155A2 (en) * 2014-04-14 2015-10-22 Methylation Sciences International Srl Novel ademetionine formulations
RU2587331C1 (en) * 2015-06-19 2016-06-20 Общество с ограниченной ответственностью "Полигепазол" Method of producing pharmaceutical composition ademetionine and dosage form thereof
CN105232515A (en) * 2015-10-10 2016-01-13 齐齐哈尔医学院 Application of ethyl gallate for preparing drugs for treating human colon carcinoma cell apoptosis
CN105476982A (en) * 2016-02-02 2016-04-13 张干 New application of gallic acid
CN108853085A (en) * 2017-05-15 2018-11-23 苏州凯祥生物科技有限公司 Catechin and epicatechin class compound are used to raise the purposes of MicroRNA-126 expression
CN111265509A (en) * 2020-02-19 2020-06-12 齐鲁工业大学 Application of gallic acid derivative in preventing and treating atherosclerosis diseases
CN114931571A (en) * 2022-03-30 2022-08-23 上海中医药大学附属曙光医院 Application of gallic acid methyl ester in preparation of osteoarthritis treatment medicine
US12239623B2 (en) 2023-05-15 2025-03-04 Bonafide Health, Llc Sleep-improving compositions and methods of use
CN119191984B (en) * 2024-10-28 2025-09-26 河南中医药大学 Compound ethyl gallate extracted from Bupleurum chinense and its extraction method and application

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