IN2014MU00740A - - Google Patents

Info

Publication number
IN2014MU00740A
IN2014MU00740A IN740MU2014A IN2014MU00740A IN 2014MU00740 A IN2014MU00740 A IN 2014MU00740A IN 740MU2014 A IN740MU2014 A IN 740MU2014A IN 2014MU00740 A IN2014MU00740 A IN 2014MU00740A
Authority
IN
India
Prior art keywords
romidepsin
purification steps
crystals
terms
preparation
Prior art date
Application number
Inventor
Ankur Sudhir Vaid
Anand Mahadev Dhiman
Traunkant Parshuram Sharma
Original Assignee
Concord Biotech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Concord Biotech Ltd filed Critical Concord Biotech Ltd
Priority to PCT/IN2015/000113 priority Critical patent/WO2015136548A2/en
Priority to IN740MU2014 priority patent/IN2014MU00740A/en
Priority to US15/123,295 priority patent/US10294276B2/en
Publication of IN2014MU00740A publication Critical patent/IN2014MU00740A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K11/00Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • C07K5/1005Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The present invention describes a process for isolation of romidepsin from fermentation broth and preparation of crystals of romidepsin. The process of the invention includes fewer purification steps and provides romidepsin having purity of greater than 99.5% area by HPLC. The process of the invention involves simple purification steps and hence, does not require multiple chromatographic purification steps to achieve desired quality of romidepsin. The process is advantageous over reported processes in terms of 99.5 % pure yield, fast process, less expensive and less cumbersome as multiple chromatographic purification is not necessary to achieve desired quality. The process for the preparation of crystals of romidepsin provides advantages like simple steps and involves use of single solvent. The process is advantageous in terms of time, cost, and simplicity.
IN740MU2014 2014-03-04 2015-03-02 IN2014MU00740A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PCT/IN2015/000113 WO2015136548A2 (en) 2014-03-04 2015-03-02 A process for isolation of romidepsin from fermentation broth and preparation of crystals of romidepsin
IN740MU2014 IN2014MU00740A (en) 2014-03-04 2015-03-02
US15/123,295 US10294276B2 (en) 2014-03-04 2015-03-02 Process for isolation of romidepsin from fermentation broth and preparation of crystals of romidepsin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN740MU2014 IN2014MU00740A (en) 2014-03-04 2015-03-02

Publications (1)

Publication Number Publication Date
IN2014MU00740A true IN2014MU00740A (en) 2015-09-25

Family

ID=54072543

Family Applications (1)

Application Number Title Priority Date Filing Date
IN740MU2014 IN2014MU00740A (en) 2014-03-04 2015-03-02

Country Status (3)

Country Link
US (1) US10294276B2 (en)
IN (1) IN2014MU00740A (en)
WO (1) WO2015136548A2 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8817743D0 (en) * 1988-07-26 1988-09-01 Fujisawa Pharmaceutical Co Fr901228 substance & preparation thereof
EP1313872A1 (en) * 2000-09-01 2003-05-28 Fujisawa Pharmaceutical Co., Ltd. A method of producing fr901228

Also Published As

Publication number Publication date
WO2015136548A4 (en) 2016-03-31
WO2015136548A3 (en) 2016-01-28
US10294276B2 (en) 2019-05-21
US20170073374A1 (en) 2017-03-16
WO2015136548A2 (en) 2015-09-17

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