IN2014MU00740A - - Google Patents
Info
- Publication number
- IN2014MU00740A IN2014MU00740A IN740MU2014A IN2014MU00740A IN 2014MU00740 A IN2014MU00740 A IN 2014MU00740A IN 740MU2014 A IN740MU2014 A IN 740MU2014A IN 2014MU00740 A IN2014MU00740 A IN 2014MU00740A
- Authority
- IN
- India
- Prior art keywords
- romidepsin
- purification steps
- crystals
- terms
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 abstract 8
- OHRURASPPZQGQM-GCCNXGTGSA-N romidepsin Chemical compound O1C(=O)[C@H](C(C)C)NC(=O)C(=C/C)/NC(=O)[C@H]2CSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N2 OHRURASPPZQGQM-GCCNXGTGSA-N 0.000 abstract 5
- 229960003452 romidepsin Drugs 0.000 abstract 5
- OHRURASPPZQGQM-UHFFFAOYSA-N romidepsin Natural products O1C(=O)C(C(C)C)NC(=O)C(=CC)NC(=O)C2CSSCCC=CC1CC(=O)NC(C(C)C)C(=O)N2 OHRURASPPZQGQM-UHFFFAOYSA-N 0.000 abstract 5
- 108010091666 romidepsin Proteins 0.000 abstract 5
- 238000011097 chromatography purification Methods 0.000 abstract 2
- 239000013078 crystal Substances 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 238000000746 purification Methods 0.000 abstract 2
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000004128 high performance liquid chromatography Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
The present invention describes a process for isolation of romidepsin from fermentation broth and preparation of crystals of romidepsin. The process of the invention includes fewer purification steps and provides romidepsin having purity of greater than 99.5% area by HPLC. The process of the invention involves simple purification steps and hence, does not require multiple chromatographic purification steps to achieve desired quality of romidepsin. The process is advantageous over reported processes in terms of 99.5 % pure yield, fast process, less expensive and less cumbersome as multiple chromatographic purification is not necessary to achieve desired quality. The process for the preparation of crystals of romidepsin provides advantages like simple steps and involves use of single solvent. The process is advantageous in terms of time, cost, and simplicity.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IN2015/000113 WO2015136548A2 (en) | 2014-03-04 | 2015-03-02 | A process for isolation of romidepsin from fermentation broth and preparation of crystals of romidepsin |
IN740MU2014 IN2014MU00740A (en) | 2014-03-04 | 2015-03-02 | |
US15/123,295 US10294276B2 (en) | 2014-03-04 | 2015-03-02 | Process for isolation of romidepsin from fermentation broth and preparation of crystals of romidepsin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN740MU2014 IN2014MU00740A (en) | 2014-03-04 | 2015-03-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014MU00740A true IN2014MU00740A (en) | 2015-09-25 |
Family
ID=54072543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN740MU2014 IN2014MU00740A (en) | 2014-03-04 | 2015-03-02 |
Country Status (3)
Country | Link |
---|---|
US (1) | US10294276B2 (en) |
IN (1) | IN2014MU00740A (en) |
WO (1) | WO2015136548A2 (en) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8817743D0 (en) * | 1988-07-26 | 1988-09-01 | Fujisawa Pharmaceutical Co | Fr901228 substance & preparation thereof |
EP1313872A1 (en) * | 2000-09-01 | 2003-05-28 | Fujisawa Pharmaceutical Co., Ltd. | A method of producing fr901228 |
-
2015
- 2015-03-02 WO PCT/IN2015/000113 patent/WO2015136548A2/en active Application Filing
- 2015-03-02 US US15/123,295 patent/US10294276B2/en active Active
- 2015-03-02 IN IN740MU2014 patent/IN2014MU00740A/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2015136548A4 (en) | 2016-03-31 |
WO2015136548A3 (en) | 2016-01-28 |
US10294276B2 (en) | 2019-05-21 |
US20170073374A1 (en) | 2017-03-16 |
WO2015136548A2 (en) | 2015-09-17 |
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