IN2014MU00328AIN328MU2014AIN2014MU00328AIN 2014MU00328 AIN2014MU00328 AIN 2014MU00328AIN 328MU2014 AIN328MU2014 AIN 328MU2014AIN 2014MU00328 AIN2014MU00328 AIN 2014MU00328A
Authority
IN
India
Prior art keywords
drug
dissolution
nanocrystal
bioavailability
crystallized
Prior art date
Application number
Inventor
Kumar Guntamukkala Santosh
Satyanarayan Pattnaik
Kalpana Swain
Venkateshwar Rao Jupally
Baikuntha Prusty Korada
Sanjeev Kumar Subudhi
Original Assignee
Kumar Guntamukkala Santosh
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Filing date
Publication date
Application filed by Kumar Guntamukkala SantoshfiledCriticalKumar Guntamukkala Santosh
Priority to IN328MU2014priorityCriticalpatent/IN2014MU00328A/en
Publication of IN2014MU00328ApublicationCriticalpatent/IN2014MU00328A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Medicinal Preparation
(AREA)
Abstract
The invention relates to nanocrystal of hydrophobic drugs with low solubility to enhance solubility thereby to improve the dissolution, absorption and bioavailability. The invention provides nanoscopic drug crystals of average particle size less than 1 mm in semi crystalline or partially amorphous or amorphous form, re-crystallized from drug solution in presence of stabilizer. The invention is further directed to cost effective process of preparing, processing parameters, physical characteristics, better dissolution, compositions and method of use of drug nanocrystals.