IN2014MN02436A - - Google Patents

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Publication number
IN2014MN02436A
IN2014MN02436A IN2436MUN2014A IN2014MN02436A IN 2014MN02436 A IN2014MN02436 A IN 2014MN02436A IN 2436MUN2014 A IN2436MUN2014 A IN 2436MUN2014A IN 2014MN02436 A IN2014MN02436 A IN 2014MN02436A
Authority
IN
India
Prior art keywords
gas
subject
petx
inspired
target
Prior art date
Application number
Other languages
English (en)
Inventor
Michael Klein
Joseph Fisher
James Duffin
Marat Slessarev
Cathie Kessler
Shoji Ito
Olivia Sobczyk
Charbonney Anne Battisti
David Mikulis
Daniel Michael Mandell
Original Assignee
Michael Klein
Joseph Fisher
James Duffin
Marat Slessarev
Cathie Kessler
Shoji Ito
Olivia Sobczyk
Charbonney Anne Battisti
David Mikulis
Daniel Michael Mandell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Michael Klein, Joseph Fisher, James Duffin, Marat Slessarev, Cathie Kessler, Shoji Ito, Olivia Sobczyk, Charbonney Anne Battisti, David Mikulis, Daniel Michael Mandell filed Critical Michael Klein
Publication of IN2014MN02436A publication Critical patent/IN2014MN02436A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0057—Pumps therefor
    • A61M16/0066—Blowers or centrifugal pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0045—Means for re-breathing exhaled gases, e.g. for hyperventilation treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/021—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes operated by electrical means
    • A61M16/022—Control means therefor
    • A61M16/024—Control means therefor including calculation means, e.g. using a processor
    • A61M16/026—Control means therefor including calculation means, e.g. using a processor specially adapted for predicting, e.g. for determining an information representative of a flow limitation during a ventilation cycle by using a root square technique or a regression analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
    • A61M16/122—Preparation of respiratory gases or vapours by mixing different gases with dilution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/091—Measuring volume of inspired or expired gases, e.g. to determine lung capacity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0027—Accessories therefor, e.g. sensors, vibrators, negative pressure pressure meter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
    • A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
    • A61M2016/0036—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the breathing tube and used in both inspiratory and expiratory phase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
    • A61M2016/102—Measuring a parameter of the content of the delivered gas
    • A61M2016/1025—Measuring a parameter of the content of the delivered gas the O2 concentration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
    • A61M2016/102—Measuring a parameter of the content of the delivered gas
    • A61M2016/103—Measuring a parameter of the content of the delivered gas the CO2 concentration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0208—Oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0225—Carbon oxides, e.g. Carbon dioxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3303—Using a biosensor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502—User interfaces, e.g. screens or keyboards
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/04—Heartbeat characteristics, e.g. ECG, blood pressure modulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/202—Blood composition characteristics partial carbon oxide pressure, e.g. partial dioxide pressure (P-CO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/205—Blood composition characteristics partial oxygen pressure (P-O2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/208—Blood composition characteristics pH-value
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/40—Respiratory characteristics
    • A61M2230/43—Composition of exhalation
    • A61M2230/432—Composition of exhalation partial CO2 pressure (P-CO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/40—Respiratory characteristics
    • A61M2230/43—Composition of exhalation
    • A61M2230/435—Composition of exhalation partial O2 pressure (P-O2)

Landscapes

  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
IN2436MUN2014 2012-04-30 2013-04-30 IN2014MN02436A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261640570P 2012-04-30 2012-04-30
PCT/CA2013/000427 WO2013163735A1 (fr) 2012-04-30 2013-04-30 Nouveaux procédé et appareil pour obtenir et maintenir des concentrations cibles de gaz sanguin artériel à l'aide de séquences ramp

Publications (1)

Publication Number Publication Date
IN2014MN02436A true IN2014MN02436A (fr) 2015-10-09

Family

ID=49514138

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2436MUN2014 IN2014MN02436A (fr) 2012-04-30 2013-04-30

Country Status (7)

Country Link
US (3) US20150114394A1 (fr)
EP (1) EP2844324B1 (fr)
JP (1) JP2015521059A (fr)
KR (1) KR20150050526A (fr)
CA (1) CA2872055A1 (fr)
IN (1) IN2014MN02436A (fr)
WO (1) WO2013163735A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013138910A1 (fr) 2012-03-19 2013-09-26 Michael Klein Systèmes virtuels d'administration de gaz respiratoire et circuits
SE536642C2 (sv) * 2012-09-24 2014-04-22 Innotek Ab System för optimal mekanisk ventilation
US10449311B2 (en) 2013-06-05 2019-10-22 Thornhill Scientific Inc. Controlling arterial blood gas concentration
CA2914406A1 (fr) * 2013-06-05 2014-12-11 Michael Klein Regulation de la concentration de gaz dans le sang arteriel
US11880989B2 (en) * 2014-04-25 2024-01-23 Thornhill Scientific Inc. Imaging abnormalities in vascular response
US11839717B2 (en) * 2014-12-30 2023-12-12 General Electric Company Minute volume and carbon dioxide clearance as surrogates for EtCO2 in automatic ventilation
CN105457135B (zh) * 2015-12-28 2018-12-28 湖南明康中锦医疗科技发展有限公司 呼吸机压力调整方法、装置及呼吸机
EP3606423A4 (fr) 2017-04-05 2020-12-30 Fisher&Paykel Healthcare Limited Système et procédé de thérapie respiratoire
WO2019028550A1 (fr) * 2017-08-08 2019-02-14 Rostrum Medical Innovations Inc. Méthode et système d'estimation de l'efficacité des poumons d'un patient
JP7091621B2 (ja) * 2017-08-29 2022-06-28 コニカミノルタ株式会社 定着装置および画像形成装置
CN112533533B (zh) * 2018-08-07 2024-04-12 罗斯特姆医疗创新有限公司 用于监测不与患者的通气肺相互作用的血流的系统和方法
KR102420941B1 (ko) * 2019-02-26 2022-07-13 디지털 블러드 코포레이션 혈액 환경 파라미터의 비침습성 검사를 위한 시스템
US20220401676A1 (en) * 2019-10-08 2022-12-22 Fisher & Paykel Healthcare Limited Flow therapy system and method
DE102021000313A1 (de) * 2020-02-06 2021-08-12 Löwenstein Medical Technology S.A. Verfahren zum Betreiben eines Beatmungsgeräts zur künstlichen Beatmung eines Patienten sowie ein solches Beatmungsgerät
WO2022178381A1 (fr) * 2021-02-22 2022-08-25 The Trustees Of The University Of Pennsylvania Systèmes et procédés d'évaluation de réactivité cérébrovasculaire

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4463764A (en) * 1981-09-29 1984-08-07 Medical Graphics Corporation Cardiopulmonary exercise system
US4986268A (en) * 1988-04-06 1991-01-22 Tehrani Fleur T Method and apparatus for controlling an artificial respirator
US6306098B1 (en) * 1996-12-19 2001-10-23 Novametrix Medical Systems Inc. Apparatus and method for non-invasively measuring cardiac output
US6217524B1 (en) * 1998-09-09 2001-04-17 Ntc Technology Inc. Method of continuously, non-invasively monitoring pulmonary capillary blood flow and cardiac output
US6517496B1 (en) * 1999-05-10 2003-02-11 Healthetech, Inc. Airway-based cardiac output monitor and methods for using same
US6796305B1 (en) * 1999-06-30 2004-09-28 University Of Florida Research Foundation, Inc. Ventilator monitor system and method of using same
CA2346517A1 (fr) 2001-05-04 2002-11-04 Joseph Fisher Methode amelioree de maintien de pression partielle de co2 dans le sang arteriel pendant un debit ventilatoire accru et mesure de l'espace alveolaire et anatomique mort
CA2379353C (fr) * 2002-03-28 2012-07-31 Joseph Fisher Nouvelle methode de mesure continue du flux de gaz dans les poumons au cours de la respiration
EP1610852B1 (fr) 2003-02-18 2018-12-05 Joseph Fisher Circuit respiratoire permettant de faciliter la mesure du débit cardiaque pendant une ventilation controlée et spontanée
EP1912694A4 (fr) * 2005-07-28 2011-11-09 Marat Slessarev Procede et appareil permettant d'atteindre et de maintenir des concentrations cibles de gaz de fin d'expiration
US20080230061A1 (en) * 2007-03-23 2008-09-25 General Electric Company Setting expiratory time in mandatory mechanical ventilation based on a deviation from a stable condition of end tidal gas concentrations
KR100868808B1 (ko) * 2008-03-04 2008-11-17 한국과학기술원 호흡가스 및 혈액가스의 측정을 통한 비침습적 호흡특성치 예측 방법 및 표시장치
EP2571422B1 (fr) * 2010-05-18 2017-07-12 Thornhill Scientific Inc. Détermination non-invasive du débit cardiaque
US20120215124A1 (en) * 2011-02-04 2012-08-23 Joseph Fisher Non-invasive arterial blood gas determination
WO2012139204A1 (fr) * 2011-04-13 2012-10-18 Michael Klein Procédé et appareil de distribution de gaz
CA2861506A1 (fr) * 2011-12-05 2013-06-13 Michael Klein Appareil permettant d'obtenir et de maintenir une pression partielle cible d'un gaz en fin d'expiration
WO2013138910A1 (fr) * 2012-03-19 2013-09-26 Michael Klein Systèmes virtuels d'administration de gaz respiratoire et circuits

Also Published As

Publication number Publication date
EP2844324A4 (fr) 2015-12-30
WO2013163735A1 (fr) 2013-11-07
EP2844324A1 (fr) 2015-03-11
US20180311454A1 (en) 2018-11-01
US11077266B2 (en) 2021-08-03
US20220016368A1 (en) 2022-01-20
KR20150050526A (ko) 2015-05-08
EP2844324B1 (fr) 2022-04-06
CA2872055A1 (fr) 2013-11-07
JP2015521059A (ja) 2015-07-27
US20150114394A1 (en) 2015-04-30

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