IN2014KN02807A - - Google Patents
Info
- Publication number
- IN2014KN02807A IN2014KN02807A IN2807KON2014A IN2014KN02807A IN 2014KN02807 A IN2014KN02807 A IN 2014KN02807A IN 2807KON2014 A IN2807KON2014 A IN 2807KON2014A IN 2014KN02807 A IN2014KN02807 A IN 2014KN02807A
- Authority
- IN
- India
- Prior art keywords
- polysorbate
- test sample
- internal standard
- wavenumber
- atr
- Prior art date
Links
- 238000005102 attenuated total reflection Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229920000136 polysorbate Polymers 0.000 abstract 2
- 229950008882 polysorbate Drugs 0.000 abstract 2
- 238000000985 reflectance spectrum Methods 0.000 abstract 2
- 238000004483 ATR-FTIR spectroscopy Methods 0.000 abstract 1
- 229920001213 Polysorbate 20 Polymers 0.000 abstract 1
- 229920001219 Polysorbate 40 Polymers 0.000 abstract 1
- 229920001214 Polysorbate 60 Polymers 0.000 abstract 1
- 150000001540 azides Chemical class 0.000 abstract 1
- 238000011088 calibration curve Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 abstract 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 abstract 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 abstract 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 abstract 1
- 235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 abstract 1
- 239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 abstract 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 abstract 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 abstract 1
- 229940068977 polysorbate 20 Drugs 0.000 abstract 1
- 229940101027 polysorbate 40 Drugs 0.000 abstract 1
- 229940113124 polysorbate 60 Drugs 0.000 abstract 1
- 229920000053 polysorbate 80 Polymers 0.000 abstract 1
- 229940068968 polysorbate 80 Drugs 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3577—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N2021/3595—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using FTIR
Landscapes
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
A method for determining a concentration of a polysorbate species, such as polysorbate 20, polysorbate 40, polysorbate 60, or polysorbate 80, in a mixture comprises obtaining a test sample of said mixture, adding an internal standard, preferably azide, to said test sample, obtaining, with a spectrometer, a mid-infrared Attenuated Total Reflectance (ATR) spectrum of the test sample, e.g. by using and ATR-FTIR apparatus, identifying, from the reflectance spectrum, a wavenumber corresponding to the C=0 peak (e. g., 1735 cm-1), identifying, from the reflectance spectrum, a wavenumber corresponding to the internal standard, calculating the area under the curve for said C=O wavenumber, normalized by the internal standard, and comparing said area to a calibration curve to determine the concentration of polysorbate in said test sample.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261650735P | 2012-05-23 | 2012-05-23 | |
| PCT/IB2013/001590 WO2013175312A1 (en) | 2012-05-23 | 2013-05-21 | Method for determining a concentration of a polysorbate species in a mixture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014KN02807A true IN2014KN02807A (en) | 2015-05-08 |
Family
ID=48916129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2807KON2014 IN2014KN02807A (en) | 2012-05-23 | 2013-05-21 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9134228B2 (en) |
| EP (1) | EP2852828B1 (en) |
| JP (1) | JP6129302B2 (en) |
| CN (1) | CN104487823B (en) |
| BR (1) | BR112014029107B1 (en) |
| CA (1) | CA2874077C (en) |
| ES (1) | ES2574614T3 (en) |
| IN (1) | IN2014KN02807A (en) |
| WO (1) | WO2013175312A1 (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2504928A (en) * | 2012-08-06 | 2014-02-19 | Perkinelmer Uk Ltd | Diamond attenuated total reflectance spectrum artefact correction |
| CN103940773B (en) * | 2014-04-09 | 2016-01-06 | 清华大学 | A kind of method of Tween-80 content in Fast Measurement 'Xuebijing ' injection |
| WO2016114226A1 (en) * | 2015-01-13 | 2016-07-21 | 東洋紡株式会社 | Method for evaluating water quality of water to be treated, quantifying method, and water treatment method |
| CN105424636B (en) * | 2015-12-29 | 2018-04-27 | 南京财经大学 | A kind of quick determination method of control pollution condition and its application |
| JP7286536B2 (en) * | 2016-08-15 | 2023-06-05 | ジェネンテック， インコーポレイテッド | CHROMATOGRAPHIC METHOD FOR DETERMINING NONIONIC SURFACTANTS IN COMPOSITIONS COMPRISING NONIONIC SURFACTANTS AND POLYPEPTIDES |
| CN111033261B (en) * | 2017-06-27 | 2024-10-01 | 科里奥利医药研究有限责任公司 | Quantitative analysis of Polysorbate |
| CN112437630B (en) * | 2018-06-29 | 2024-08-13 | 豪夫迈·罗氏有限公司 | Fully implantable sensor element and method for detecting at least one analyte in a body fluid |
| TW202045927A (en) * | 2019-02-27 | 2020-12-16 | 法商賽諾菲公司 | Process for polysorbate quantification in a sample involving lc-ms with an internal standard |
| WO2020223584A1 (en) | 2019-05-01 | 2020-11-05 | Trustees Of Boston University | Systems and methods for bond-selective transient phase imaging |
| WO2021186363A1 (en) * | 2020-03-20 | 2021-09-23 | Glaxosmithkline Intellectual Property Development Limited | Method for detecting polysorbates |
| CN113049727B (en) * | 2021-03-08 | 2024-04-26 | 哈尔滨瀚邦医疗科技有限公司 | Method for detecting content of polysorbate 80 |
| CN116297915B (en) * | 2023-02-10 | 2023-12-01 | 中国食品药品检定研究院 | Analysis and identification method for polysorbate auxiliary materials |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6040191A (en) * | 1996-06-13 | 2000-03-21 | Grow; Ann E. | Raman spectroscopic method for determining the ligand binding capacity of biologicals |
| US5866430A (en) * | 1996-06-13 | 1999-02-02 | Grow; Ann E. | Raman optrode processes and devices for detection of chemicals and microorganisms |
| US7531358B2 (en) * | 2001-04-17 | 2009-05-12 | Chugai Seiyaku Kabushiki Kaisha | Method of quantifying surfactant |
| US7255835B2 (en) | 2001-09-04 | 2007-08-14 | North Carolina State University | Single pass attenuated total reflection fourier transform infrared microscopy apparatus and method for identifying protein secondary structure, surface charge and binding affinity |
| JP2003232727A (en) * | 2001-12-04 | 2003-08-22 | Japan Organo Co Ltd | Method of quantitatively analyzing aqueous solution for organic compound containing sulfonic acid group |
| US7435600B2 (en) * | 2004-06-23 | 2008-10-14 | Johns Manville | Infrared methods of measuring the extent of cure of a binder in fibrous products |
| JP2007117221A (en) * | 2005-10-25 | 2007-05-17 | Hirato Koji | Noninvasive blood test "optical complete medical checkup" using ftir |
| US20100304406A1 (en) * | 2008-09-17 | 2010-12-02 | Cell Signaling Technology, Inc. | Protein Phosphorylation by Serine/Threonine Kinases in Insulin Signaling Pathways |
| CN101943684B (en) * | 2009-07-10 | 2012-12-05 | 华北制药集团制剂有限公司 | Method for detecting related substances of polysorbate 80 |
-
2013
- 2013-05-21 US US14/402,849 patent/US9134228B2/en active Active
- 2013-05-21 CA CA2874077A patent/CA2874077C/en active Active
- 2013-05-21 WO PCT/IB2013/001590 patent/WO2013175312A1/en active Application Filing
- 2013-05-21 IN IN2807KON2014 patent/IN2014KN02807A/en unknown
- 2013-05-21 BR BR112014029107-1A patent/BR112014029107B1/en active IP Right Grant
- 2013-05-21 JP JP2015513294A patent/JP6129302B2/en active Active
- 2013-05-21 ES ES13745180.3T patent/ES2574614T3/en active Active
- 2013-05-21 EP EP13745180.3A patent/EP2852828B1/en active Active
- 2013-05-21 CN CN201380026314.2A patent/CN104487823B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112014029107A2 (en) | 2017-06-27 |
| BR112014029107B1 (en) | 2021-07-13 |
| EP2852828B1 (en) | 2016-04-06 |
| ES2574614T3 (en) | 2016-06-21 |
| JP6129302B2 (en) | 2017-05-17 |
| JP2015523556A (en) | 2015-08-13 |
| US20150129766A1 (en) | 2015-05-14 |
| US9134228B2 (en) | 2015-09-15 |
| BR112014029107A8 (en) | 2020-09-24 |
| EP2852828A1 (en) | 2015-04-01 |
| CA2874077C (en) | 2020-07-07 |
| CA2874077A1 (en) | 2013-11-28 |
| WO2013175312A1 (en) | 2013-11-28 |
| CN104487823B (en) | 2017-02-22 |
| CN104487823A (en) | 2015-04-01 |
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