IN2014DN08783A - - Google Patents

Info

Publication number
IN2014DN08783A
IN2014DN08783A IN8783DEN2014A IN2014DN08783A IN 2014DN08783 A IN2014DN08783 A IN 2014DN08783A IN 8783DEN2014 A IN8783DEN2014 A IN 8783DEN2014A IN 2014DN08783 A IN2014DN08783 A IN 2014DN08783A
Authority
IN
India
Prior art keywords
chitosan
low endotoxin
alkali
mixture
producing
Prior art date
Application number
Inventor
June Gladman
Craig Hardy
Andrew Hoggarth
Original Assignee
Medtrade Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtrade Products Ltd filed Critical Medtrade Products Ltd
Publication of IN2014DN08783A publication Critical patent/IN2014DN08783A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/009—Materials resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Abstract

The present invention relates to a process for producing a low endotoxin alkali chitosan and also to a process for producing low endotoxin neutral chitosan chitosan salt and chitosan derivatives and to the products of such processes. The process comprises contacting chitosan with an alkali solution to form a mixture and leaving the mixture for at least about 12 hours. The low endotoxin alkali chitosan may be used in the manufacture of other useful chitosan based products.
IN8783DEN2014 2012-03-23 2013-03-25 IN2014DN08783A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1205174.4A GB201205174D0 (en) 2012-03-23 2012-03-23 Process for producing low endotoxin chitosan
PCT/GB2013/050775 WO2013140190A1 (en) 2012-03-23 2013-03-25 Process for producing low endotoxin chitosan

Publications (1)

Publication Number Publication Date
IN2014DN08783A true IN2014DN08783A (en) 2015-05-22

Family

ID=46087039

Family Applications (1)

Application Number Title Priority Date Filing Date
IN8783DEN2014 IN2014DN08783A (en) 2012-03-23 2013-03-25

Country Status (15)

Country Link
US (2) US11485798B2 (en)
EP (1) EP2828300B1 (en)
JP (1) JP6226950B2 (en)
CN (2) CN113773411A (en)
AU (1) AU2013237185B2 (en)
BR (1) BR112014023585B1 (en)
CA (1) CA2868148C (en)
DK (1) DK2828300T3 (en)
ES (1) ES2667271T3 (en)
GB (2) GB201205174D0 (en)
IN (1) IN2014DN08783A (en)
NO (1) NO2828300T3 (en)
PL (1) PL2828300T3 (en)
PT (1) PT2828300T (en)
WO (1) WO2013140190A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201309607D0 (en) * 2013-05-29 2013-07-10 Medtrade Products Ltd Process for producing low endotoxin chitosan
GB201309606D0 (en) * 2013-05-29 2013-07-10 Medtrade Products Ltd Process for producing low endotoxin chitosan
GB2514592A (en) * 2013-05-30 2014-12-03 Medtrade Products Ltd Degradable haemostat composition
GB2514597A (en) 2013-05-30 2014-12-03 Medtrade Products Ltd Degradable haemostat composition
US9259357B2 (en) 2014-04-16 2016-02-16 Loma Linda University Composition, preparation, and use of chitosan shards for biomedical applications
CN105256650B (en) * 2015-10-05 2017-03-29 福建农林大学 Immobilized lactic acid/multi-functional papermaking paint of chitosan drug-loading Nano microsphere of a kind of nano-cellulose and preparation method thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4195175A (en) * 1978-01-03 1980-03-25 Johnson Edwin L Process for the manufacture of chitosan
US4946870A (en) * 1986-06-06 1990-08-07 Union Carbide Chemicals And Plastics Company Inc. Delivery systems for pharmaceutical or therapeutic actives
US5169535A (en) * 1989-09-22 1992-12-08 Kurita Water Industries Ltd. Method of removing endotoxin
JP2000256403A (en) * 1999-03-05 2000-09-19 Ymc Co Ltd Partially acylated chitosan particle and its preparation
US7080688B2 (en) * 2003-08-14 2006-07-25 Halliburton Energy Services, Inc. Compositions and methods for degrading filter cake
US7125967B2 (en) * 2003-10-08 2006-10-24 Adjuvant Pharmaceuticals, Llc Water-soluble chitosan having low endotoxin concentration and methods for making and using the same
CN1833732A (en) 2005-03-17 2006-09-20 李毅彬 Making method of and use of antibiotic surgical dressing
HUE035956T2 (en) * 2005-06-14 2018-05-28 Genis Hf Compositions of partially deacetylated chitin derivatives
CA2848653A1 (en) * 2006-06-02 2007-12-13 Synedgen, Inc. Chitosan-lysine derivative compounds
US20080248508A1 (en) * 2006-08-17 2008-10-09 Shenda Baker Methods of making a chitosan product having an ultra-low endotoxin concentration and the ultra-low endotoxin chitosan product derived therefrom and method of accurately determining inflammatory and anti-inflammatory cellular response to such materials
WO2008063503A2 (en) * 2006-11-13 2008-05-29 Hawaii Chitopure, Inc. Methods of making a chitosan product having an ultra-low endotoxin concentration and the ultra-low endotoxin chitosan product derived therefrom and method of accurately determining inflammatory and anti-inflammatory cellular response to such materials.
GB2461019B (en) * 2008-04-25 2013-06-05 Medtrade Products Ltd Haemostatic material
GB2463523B (en) * 2008-09-17 2013-05-01 Medtrade Products Ltd Wound care device
CN101579353A (en) * 2009-06-09 2009-11-18 中国人民解放军第二军医大学 Temperature sensitive chitosan preparation and preparation and application thereof
JP5653068B2 (en) * 2010-05-06 2015-01-14 焼津水産化学工業株式会社 Method for producing low molecular weight chitosan
CN102086239A (en) * 2011-01-17 2011-06-08 西南大学 Preparation method of silkworm chrysalis chitosan derivatives with anticoagulation activities

Also Published As

Publication number Publication date
CA2868148A1 (en) 2013-09-26
BR112014023585A2 (en) 2017-06-20
WO2013140190A1 (en) 2013-09-26
US20150080335A1 (en) 2015-03-19
EP2828300B1 (en) 2018-01-31
CN104603155B (en) 2021-08-17
ES2667271T3 (en) 2018-05-10
US11498981B2 (en) 2022-11-15
BR112014023585B1 (en) 2022-01-04
JP2015511663A (en) 2015-04-20
PT2828300T (en) 2018-04-09
PL2828300T3 (en) 2018-09-28
GB201205174D0 (en) 2012-05-09
US11485798B2 (en) 2022-11-01
CN104603155A (en) 2015-05-06
CN113773411A (en) 2021-12-10
CA2868148C (en) 2019-05-28
JP6226950B2 (en) 2017-11-08
DK2828300T3 (en) 2018-05-22
GB201305417D0 (en) 2013-05-08
EP2828300A1 (en) 2015-01-28
US20160168277A1 (en) 2016-06-16
GB2500817A (en) 2013-10-02
AU2013237185A1 (en) 2014-11-13
AU2013237185B2 (en) 2017-10-05
NO2828300T3 (en) 2018-06-30

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