IN2014DN04060A - - Google Patents

Info

Publication number
IN2014DN04060A
IN2014DN04060A IN4060DEN2014A IN2014DN04060A IN 2014DN04060 A IN2014DN04060 A IN 2014DN04060A IN 4060DEN2014 A IN4060DEN2014 A IN 4060DEN2014A IN 2014DN04060 A IN2014DN04060 A IN 2014DN04060A
Authority
IN
India
Prior art keywords
quarternary
2choch2ci
2choch2f
sevoflurane
reaction mixture
Prior art date
Application number
Inventor
Ross C Terrell
Joshua A Levinson
Charles W Young
Original Assignee
Piramal Critical Care Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Piramal Critical Care Inc filed Critical Piramal Critical Care Inc
Publication of IN2014DN04060A publication Critical patent/IN2014DN04060A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/12—Saturated ethers containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/13—Saturated ethers containing hydroxy or O-metal groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Anesthesiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

The present invention relates to a process for the preparation of (CF3)2CHOCH2F, said process comprising forming a reaction mixture of (CF3)2CHOCH2CI, potassium fluoride, water and a phase transfer catalyst selected from the group consisting of quarternary ammonium salts, quarternary phosphonium salts, crown ethers, ionic liquids, chiral compounds and high temperature agents such that sevoflurane is formed.
IN4060DEN2014 2004-11-17 2005-11-17 IN2014DN04060A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62870704P 2004-11-17 2004-11-17
PCT/US2005/041752 WO2006055748A2 (en) 2004-11-17 2005-11-17 Method for the preparation of sevoflurane

Publications (1)

Publication Number Publication Date
IN2014DN04060A true IN2014DN04060A (en) 2015-07-10

Family

ID=36407760

Family Applications (1)

Application Number Title Priority Date Filing Date
IN4060DEN2014 IN2014DN04060A (en) 2004-11-17 2005-11-17

Country Status (20)

Country Link
US (2) US8058482B2 (en)
EP (2) EP1812368B1 (en)
JP (1) JP4875626B2 (en)
KR (1) KR101249315B1 (en)
CN (1) CN101065346B (en)
AP (1) AP2350A (en)
AU (1) AU2005306472B2 (en)
BR (1) BRPI0517854A (en)
CA (1) CA2587672C (en)
EA (1) EA200701073A1 (en)
ES (1) ES2402145T3 (en)
HU (1) HUP0700487A2 (en)
IL (1) IL183176A (en)
IN (1) IN2014DN04060A (en)
MX (1) MX2007005899A (en)
NZ (1) NZ555172A (en)
PL (2) PL383328A1 (en)
TR (1) TR200703377T1 (en)
WO (1) WO2006055748A2 (en)
ZA (1) ZA200703957B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6332223B1 (en) 2000-04-05 2001-12-25 Gray Matter Holdings, Llc Apparatus and method for making an ear warmer having interior seams
US6735784B2 (en) 2002-01-28 2004-05-18 180S, Inc. Apparatus and method for making an ear warmer and an ear warmer frame
US7212645B2 (en) 2003-08-12 2007-05-01 180S, Inc. Ear warmer with a speaker system
US7650649B2 (en) 2003-08-12 2010-01-26 180S, Inc. Ear warmer having an external frame
EP2066609B1 (en) * 2006-09-29 2016-01-06 Cristália Produtos Químicos Farmacêuticos Ltda. Process for the preparation of fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl) ethyl ether
US8443466B2 (en) 2007-01-22 2013-05-21 180S, Inc. Ear protection device
JP5163064B2 (en) * 2007-11-13 2013-03-13 ダイキン工業株式会社 Novel carboxylic acid ester, its use and production method
CN101659603B (en) * 2008-08-27 2014-05-07 中化蓝天集团有限公司 Method for preparing fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether
CN102199076B (en) * 2010-03-25 2014-05-14 上海源力生物技术有限公司 Method for preparing sevoflurane
FR2975990B1 (en) 2011-06-01 2013-05-24 Rhodia Operations PROCESS FOR PREPARING A FLUORINE ORGANIC COMPOUND
US8729313B2 (en) * 2011-08-15 2014-05-20 Baxter International Inc. Process for the manufacturing of sevoflurane
RU2479566C1 (en) * 2012-01-11 2013-04-20 Общество с ограниченной ответственностью "Пермская химическая компания" Method of producing sevoflurane
CN103934020B (en) * 2013-01-22 2016-03-30 福建海西联合药业有限公司 Eight Guanoctines replaced are as the application of the synthetic catalyst of methyl fluoride hexafluoroisopropyl ether and process for catalytic synthesis
US8907146B2 (en) * 2013-02-04 2014-12-09 Honeywell International Inc. Process for the preparation of 1-chloro-3,3,3-trifluoropropene using a phase transfer catalyst
BR102014028162A2 (en) 2013-11-12 2015-09-08 Dow Agrosciences Llc process for fluorination of compounds
TW201609651A (en) 2013-11-12 2016-03-16 陶氏農業科學公司 Process for fluorinating compounds
BR102014028164A2 (en) 2013-11-12 2015-09-08 Dow Agrosciences Llc process for fluorination of compounds
JP6375385B2 (en) * 2013-11-18 2018-08-15 ビーエーエスエフ コーティングス ゲゼルシャフト ミット ベシュレンクテル ハフツングＢＡＳＦ Ｃｏａｔｉｎｇｓ ＧｍｂＨ Aqueous dip coating composition for conductive substrates containing both dissolved and undissolved bismuth
TWI726900B (en) 2015-08-04 2021-05-11 美商陶氏農業科學公司 Process for fluorinating compounds
JP6299905B1 (en) * 2017-02-06 2018-03-28 セントラル硝子株式会社 Method for producing sevoflurane
CN108727166B (en) * 2017-04-17 2021-06-29 江苏恒瑞医药股份有限公司 Refining method of chloromethyl hexafluoroisopropyl ether
CN107698430B (en) * 2017-11-01 2021-01-08 华东医药（西安）博华制药有限公司 Post-treatment method of sevoflurane reaction liquid
CN114671742B (en) * 2020-12-24 2026-01-27 鲁南制药集团股份有限公司 Preparation method of sevoflurane

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3476860A (en) 1966-12-08 1969-11-04 Air Reduction Halomethyl fluoroisopropyl ethers as anesthetic agents
US3683092A (en) 1970-07-31 1972-08-08 Baxter Laboratories Inc Method of anesthesia
BR8402990A (en) 1983-06-23 1985-05-28 Du Pont CONTINUOUS PROCESS TO FLUORETATE HALOALKANS
US4874901A (en) * 1988-05-06 1989-10-17 Boc, Inc. Process for the production of polyfluorinated ethers
JPH01301636A (en) 1988-05-31 1989-12-05 Central Glass Co Ltd Production of 1,2,2,2-tetrafluoroethyl difluoromethyl ether
US5294742A (en) * 1992-03-21 1994-03-15 Hoechst Atkiengesellschaft Process for preparing 3,5-difluoroaniline
EP0596395B1 (en) * 1992-11-04 2000-06-28 Clariant GmbH Process for the preparation of fluorinated benzil
JP3778298B2 (en) * 1995-01-13 2006-05-24 ダイキン工業株式会社 Method for producing hexafluoropropene
US5840703A (en) * 1996-11-15 1998-11-24 Corrigan; Patrick J. Phase transfer catalyst for use in the synthesis of polyol fatty acid polyesters
GB9720483D0 (en) * 1997-09-26 1997-11-26 Zeneca Resins Bv Aqueous polymer dispersionsa
US6100434A (en) * 1999-03-26 2000-08-08 Abbott Laboratories Method for synthesizing sevoflurane and an intermediate thereof
US6271422B1 (en) * 2000-06-01 2001-08-07 Abbott Laboratories Method for fluoromethylation of alcohols via halogenative decarboxylation
US6846946B2 (en) * 2002-02-15 2005-01-25 Value Recovery, Inc. Process for making organic products and improving the quality of non-product streams using phase transfer catalysis

Also Published As

Publication number Publication date
NZ555172A (en) 2010-10-29
EP1812368B1 (en) 2012-12-26
AU2005306472A1 (en) 2006-05-26
CA2587672A1 (en) 2006-05-26
EP1812368A4 (en) 2009-10-28
JP4875626B2 (en) 2012-02-15
ZA200703957B (en) 2008-07-30
BRPI0517854A (en) 2008-10-21
HK1114602A1 (en) 2008-11-07
EA200701073A1 (en) 2007-12-28
WO2006055748A3 (en) 2006-09-14
EP2481721A2 (en) 2012-08-01
TR200703377T1 (en) 2007-08-21
IL183176A (en) 2011-07-31
KR20070091619A (en) 2007-09-11
CN101065346A (en) 2007-10-31
PL1812368T3 (en) 2013-07-31
KR101249315B1 (en) 2013-04-01
JP2008520698A (en) 2008-06-19
AU2005306472B2 (en) 2011-05-26
US20120022296A1 (en) 2012-01-26
AP2007003995A0 (en) 2007-06-30
AP2350A (en) 2012-01-16
ES2402145T3 (en) 2013-04-29
CA2587672C (en) 2012-01-03
US8058482B2 (en) 2011-11-15
EP2481721A3 (en) 2013-10-09
PL383328A1 (en) 2008-02-18
EP1812368A2 (en) 2007-08-01
WO2006055748A2 (en) 2006-05-26
MX2007005899A (en) 2007-07-24
US20060205825A1 (en) 2006-09-14
CN101065346B (en) 2012-03-21
IL183176A0 (en) 2007-09-20
HUP0700487A2 (en) 2007-12-28

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