IN2014CN04652A - - Google Patents
Info
- Publication number
- IN2014CN04652A IN2014CN04652A IN4652CHN2014A IN2014CN04652A IN 2014CN04652 A IN2014CN04652 A IN 2014CN04652A IN 4652CHN2014 A IN4652CHN2014 A IN 4652CHN2014A IN 2014CN04652 A IN2014CN04652 A IN 2014CN04652A
- Authority
- IN
- India
- Prior art keywords
- antibodies
- igf
- treatment
- gigantism
- ghr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
The present invention provides antagonizing antibodies that bind to growth hormone receptor (GHR). The invention further relates to therapeutic methods for use of these antibodies to reduce IGF 1 levels and/or for the treatment and/or prevention of diseases associated with excessive IGF 1 including treatment of acromegaly gigantism cancer diabetic nephropathy arthritis and lung inflammation.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161579618P | 2011-12-22 | 2011-12-22 | |
PCT/IB2012/057151 WO2013093707A1 (en) | 2011-12-22 | 2012-12-10 | Human growth hormone receptor antagonist antibodies and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014CN04652A true IN2014CN04652A (en) | 2015-09-18 |
Family
ID=47436138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN4652CHN2014 IN2014CN04652A (en) | 2011-12-22 | 2012-12-10 |
Country Status (16)
Country | Link |
---|---|
US (1) | US9249224B2 (en) |
EP (1) | EP2794659A1 (en) |
JP (1) | JP2015502975A (en) |
KR (1) | KR20140102710A (en) |
CN (1) | CN104169301A (en) |
AU (1) | AU2012356206A1 (en) |
BR (1) | BR112014014824A2 (en) |
CA (1) | CA2859472A1 (en) |
HK (1) | HK1204328A1 (en) |
IL (1) | IL233119A0 (en) |
IN (1) | IN2014CN04652A (en) |
MX (1) | MX2014007644A (en) |
RU (1) | RU2014123030A (en) |
SG (1) | SG11201402828XA (en) |
WO (1) | WO2013093707A1 (en) |
ZA (1) | ZA201404735B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3096788B1 (en) * | 2014-01-24 | 2019-07-31 | Church, William, R. | Antibody specific to staphylococcus aureus, therapeutic method and detection method using same |
NZ734252A (en) * | 2015-02-12 | 2020-06-26 | Univ Southern California | Blockers of the growth hormone receptor in disease prevention and treatment |
US11473088B2 (en) * | 2016-12-02 | 2022-10-18 | Ohio University | Method of treating cancer and method of sensitizing cancer cells to the action of chemotherapeutic agents via growth hormone receptor antagonists or knock down |
AU2019225237A1 (en) * | 2018-02-26 | 2020-09-17 | Minerva Biotechnologies Corporation | Diagnostic methods using anti-MUC1* antibodies |
US20210369714A1 (en) * | 2018-09-27 | 2021-12-02 | The Regents Of The University Of California | Prevention and Treatment of Osteoarthritis by Inhibition of Insulin Growth Factor-1 Signaling |
US11345744B2 (en) | 2019-05-07 | 2022-05-31 | William R Church | Antibody specific to Staphylococcus aureus, therapeutic method and detection method using same |
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-
2012
- 2012-12-10 BR BR112014014824A patent/BR112014014824A2/en not_active IP Right Cessation
- 2012-12-10 IN IN4652CHN2014 patent/IN2014CN04652A/en unknown
- 2012-12-10 US US14/367,483 patent/US9249224B2/en not_active Expired - Fee Related
- 2012-12-10 CN CN201280070288.9A patent/CN104169301A/en active Pending
- 2012-12-10 RU RU2014123030A patent/RU2014123030A/en not_active Application Discontinuation
- 2012-12-10 JP JP2014548270A patent/JP2015502975A/en active Pending
- 2012-12-10 CA CA2859472A patent/CA2859472A1/en not_active Abandoned
- 2012-12-10 EP EP12806702.2A patent/EP2794659A1/en not_active Withdrawn
- 2012-12-10 MX MX2014007644A patent/MX2014007644A/en unknown
- 2012-12-10 KR KR1020147017014A patent/KR20140102710A/en not_active Application Discontinuation
- 2012-12-10 WO PCT/IB2012/057151 patent/WO2013093707A1/en active Application Filing
- 2012-12-10 AU AU2012356206A patent/AU2012356206A1/en not_active Abandoned
- 2012-12-10 SG SG11201402828XA patent/SG11201402828XA/en unknown
-
2014
- 2014-06-12 IL IL233119A patent/IL233119A0/en unknown
- 2014-06-26 ZA ZA2014/04735A patent/ZA201404735B/en unknown
-
2015
- 2015-05-20 HK HK15104823.8A patent/HK1204328A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP2794659A1 (en) | 2014-10-29 |
KR20140102710A (en) | 2014-08-22 |
SG11201402828XA (en) | 2014-10-30 |
WO2013093707A1 (en) | 2013-06-27 |
AU2012356206A1 (en) | 2014-06-26 |
JP2015502975A (en) | 2015-01-29 |
IL233119A0 (en) | 2014-07-31 |
RU2014123030A (en) | 2016-02-20 |
US20140356359A1 (en) | 2014-12-04 |
CA2859472A1 (en) | 2013-06-27 |
ZA201404735B (en) | 2016-10-26 |
MX2014007644A (en) | 2014-09-26 |
BR112014014824A2 (en) | 2019-09-24 |
US9249224B2 (en) | 2016-02-02 |
HK1204328A1 (en) | 2015-11-13 |
CN104169301A (en) | 2014-11-26 |
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